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Medically reviewed by Oliinyk Elizabeth Ivanovna, PharmD. Last updated on 26.06.2023
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A methylxanthine naturally occurring in some beverages and also used as a pharmacological agent. Paradine&
Paradine (Orphenadrine (Paradine) citrate, asprin and caffeine tablets) (Orphenadrine (Paradine) Citrate, Aspirin and Caffeine 25mg/385mg/30 mg) and Paradine (Orphenadrine (Paradine) citrate, asprin and caffeine tablets) Forte (Orphen-adrine Citrate, Aspirin and Caffeine 50 mg/770 mg/60 mg)
Tablets are indicated in:
- Symptomatic relief of mild to moderate pain of acute musculoskeletal disorders.
- The Orphenadrine (Paradine) compon-nent is indicated as an adjunct to rest, physical therapy, and other measures for the relief of discomfort associated with acute painfulmusculoskel-etal conditions.
The mode or action of or-phenadrine has not been clearly identified, but may be related to its analgesic properties. Paradine (Orphenadrine (Paradine) citrate, asprin and caffeine tablets) Tablets and Paradine (Orphenadrine (Paradine) citrate, asprin and caffeine tablets) Forte Tablets do not directly relax tense skeletal muscles in man.
Aspirin is in a class of drugs called salicylates. Aspirin works reducing substances in the body that cause pain and inflammation. It is used to reduce pain, inflammation, and fever.
Caffeine is used in this combination to increase the pain relieving effects of aspirin and Orphenadrine (Paradine).
Orphenadrine (Paradine) is a muscle relaxant. It works by blocking nerve impulses (or pain sensations) that are sent to the brain.
Paradine (aspirin/caffeine/Orphenadrine (Paradine)) is used, along with rest and physical therapy, to treat injuries and other painful muscular conditions.
This medicine may also be used for purposes other than those listed in this medication guide.
Paradine (Orphenadrine (Paradine) citrate with aspirin and caffeine) : Adults 1 to 2 tablets 3 to 4 times daily.
Paradine (Orphenadrine (Paradine) citrate with aspirin and caffeine) Forte: Adults ½ to 1 tablet 3 to 4 times daily.
How supplied
Paradine (Orphenadrine (Paradine) citrate with aspirin and caffeine) tablets can be identified by their two layers colored white and yellow. Each round tablet is embossed “Paradine (Orphenadrine (Paradine) citrate with aspirin and caffeine) ” on one side and “3M” on the other and contains Orphenadrine (Paradine) citrate (2-dimethylaminoethyl 2-methylbenzhydryl ether citrate) 25 mg, aspirin 385 mg, and caffeine 30 mg.
Paradine (Orphenadrine (Paradine) citrate with aspirin and caffeine) Forte tablets are exactly twice the strength of Paradine (Orphenadrine (Paradine) citrate with aspirin and caffeine). They are identified by their scored capsule shape and by their two layers colored white and yellow. Each capsule shaped tablet is embossed “Paradine (Orphenadrine (Paradine) citrate with aspirin and caffeine) FORTE” on one side and “3M” on the other and contains Orphenadrine (Paradine) citrate 50 mg, aspirin 770 mg, and caffeine 60 mg.
Paradine (Orphenadrine (Paradine) citrate with aspirin and caffeine) and Paradine (Orphenadrine (Paradine) citrate with aspirin and caffeine) Forte also contain: lactose, polyethylene glycol, povidone, starch, sucrose, zinc stearate, and D&C yellow #10.
Paradine (Orphenadrine (Paradine) citrate with aspirin and caffeine) : Bottles of 100 tablets (NDC 0089-0231-10) and 500 tablets (NDC 0089-0231-50).
Paradine (Orphenadrine (Paradine) citrate with aspirin and caffeine) Forte: Bottles of 100 tablets (NDC 0089-0233-10) and 500 tablets (NDC 0089-0233-50).
Store below 30°C (86°F).
MAY 1998. 3M Pharmaceuticals, Northridge, CA 91324.
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What is the most important information I should know about Paradine?
Because of the mild anticholinergic effect of Orphenadrine (Paradine), Paradine (Orphenadrine (Paradine) citrate with aspirin and caffeine) or Paradine (Orphenadrine (Paradine) citrate with aspirin and caffeine) Forte should not be used in patients with glaucoma, pyloric or duodenal obstruction, achalasia, prostatic hypertrophy or obstructions at the bladder neck. Paradine (Orphenadrine (Paradine) citrate with aspirin and caffeine) or Paradine (Orphenadrine (Paradine) citrate with aspirin and caffeine) Forte is also contraindicated in patients with myasthenia gravis and in patients known to be sensitive to aspirin or caffeine.
The drug is contraindicated in patients who have demonstrated a previous hypersensitivity to the drug.
Use Paradine as directed by your doctor. Check the label on the medicine for exact dosing instructions.
- Take Paradine by mouth with or without food. If stomach upset occurs, take with food to reduce stomach irritation.
- Take Paradine with a full glass of water (8 oz/240 mL). Do not lie down for 30 minutes after taking Paradine.
- Use Paradine exactly as directed on the package, unless instructed differently by your doctor. If you are taking Paradine without a prescription, follow any warnings and precautions on the label.
- If you miss a dose of Paradine and you are taking it regularly, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.
Ask your health care provider any questions you may have about how to use Paradine.
There are specific as well as general uses of a drug or medicine. A medicine can be used to prevent a disease, treat a disease over a period or cure a disease. It can also be used to treat the particular symptom of the disease. The drug use depends on the form the patient takes it. It may be more useful in injection form or sometimes in tablet form. The drug can be used for a single troubling symptom or a life-threatening condition. While some medications can be stopped after few days, some drugs need to be continued for prolonged period to get the benefit from it.How to use Paradine
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What other drugs will affect Paradine?
Cytochrome P450 1A2 (CYP1A2) is known to be the major enzyme involved in the metabolism of caffeine. Therefore, caffeine has the potential to interact with drugs that are substrates for CYP1A2, inhibit CYP1A2, or induce CYP1A2.
Few data exist on drug interactions with caffeine in preterm neonates. Based on adult data, lower doses of caffeine may be needed following coadministration of drugs which are reported to decrease caffeine elimination (e.g., cimetidine and ketoconazole) and higher caffeine doses may be needed following coadministration of drugs that increase caffeine elimination (e.g., phenobarbital and phenytoin).
Paradine administered concurrently with ketoprofen reduced the urine volume in 4 healthy volunteers. The clinical significance of this interaction in preterm neonates is not known.
Interconversion between caffeine and theophylline has been reported in preterm neonates. The concurrent use of these drugs is not recommended.
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What are the possible side effects of Paradine?
Side effects of Paradine (Orphenadrine (Paradine) citrate with aspirin and caffeine) or Paradine (Orphenadrine (Paradine) citrate with aspirin and caffeine) Forte are those seen with aspirin and caffeine or those usually associated with mild anticholinergic agents. These may include tachycardia, palpitation, urinary hesitancy or retention, dry mouth, blurred vision, dilatation of the pupil, increased intraocular tension, weakness, nausea, vomiting, headache, dizziness, constipation, drowsiness, and rarely, urticaria and other dermatoses. Infrequently, an elderly patient may experience some degree of confusion. Mild central excitation and occasional hallucinations may be observed. These mild side effects can usually be eliminated by reduction in dosage. One case of aplastic anemia associated with the use of Paradine (Orphenadrine (Paradine) citrate with aspirin and caffeine) has been reported. No causal relationship has been established. Rare G.I. hemorrhage due to aspirin content may be associated with the administration of Paradine (Orphenadrine (Paradine) citrate with aspirin and caffeine) or Paradine (Orphenadrine (Paradine) citrate with aspirin and caffeine) Forte. Some patients may experience transient episodes of light-headedness, dizziness or syncope.