Panace

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Medically reviewed

Laura Arias

Last updated on 22/12/2025

This page provides general, reference-level information compiled from official medical sources. It is not a substitute for professional medical advice, diagnosis, or treatment. For decisions about your health, please consult a qualified healthcare professional.

Overview of Panace

What Type of Medicine Is Panace? (Identity and Classification)

Panace is a medicinal product defined by its single active compound, Aceclofenac, and is pharmacologically classified as an anti-inflammatory and antirheumatic product, non-steroid. This classification signifies its systemic role in addressing symptoms of persistent pain and tissue inflammation associated with chronic conditions. Aceclofenac is utilized for providing symptomatic relief in various musculoskeletal disorders. This designation reflects its use in helping to ease discomfort and improve mobility in inflammatory states. Panace is typically provided as a prescription-only medicine (POM) due to its strength and requirements for clinical supervision.

Aceclofenac: The Composition and Form of Panace (Composition and Form)

The core composition of Panace is the active ingredient Aceclofenac, a synthetic substance developed as a chemical derivative of Phenylacetic Acid. This chemical origin distinguishes it as a compound within the NSAID family. Aceclofenac functions as a pro-drug, as it undergoes processing by the body to produce its primary therapeutic effect. The standard dosage form is an oral tablet, commonly film-coated, designed for systemic action after absorption in the gastrointestinal tract, allowing it to target inflammatory sites throughout the body.

How Does Panace Generally Help? (General Purpose)

Panace provides therapeutic support by delivering dual anti-inflammatory and analgesic effects. The utility of this NSAID class stems from its ability to regulate the chemical compounds that mediate swelling and discomfort. By impeding the synthesis of these pro-inflammatory substances, the medicine's systemic presence helps to reduce irritation and stiffness. This action is used for providing general symptomatic relief, for instance, in managing the discomfort experienced with morning joint stiffness.

Regulatory References

  1. Clinical Review, 2024

What side effects are possible with Panace?

Possible Side Effects and Safety Information

Panace, containing aceclofenac, possesses an official safety profile structured by governmental regulatory agencies based on the frequency and system-organ class affected by adverse reactions.

Component Regulatory Classification
Common Side Effects Dizziness, dyspepsia, abdominal pain, nausea, diarrhoea, and elevated hepatic enzymes.
Uncommon Side Effects Flatulence, gastritis, constipation, vomiting, mouth ulceration, pruritus, rash, and increased blood urea or creatinine.
Rare Side Effects Anaemia, visual disturbance, gastrointestinal haemorrhage or ulceration, anaphylactic reaction including shock, hypertension, and cardiac failure.

Serious Adverse Reactions

Regulatory documentation highlights the risk of serious adverse reactions consistent with the NSAID class. These include potentially fatal events such as Gastrointestinal bleeding, ulceration, or perforation, as well as severe, life-threatening skin reactions, including Stevens-Johnson syndrome (SJS) and Toxic Epidermal Necrolysis (TEN). The risk of arterial thrombotic events (such as myocardial infarction or stroke) is also documented in epidemiological data, particularly with prolonged use.

Population and Exposure Considerations

The official labeling notes that the Elderly population is at an increased risk of serious adverse reactions, especially GI bleeding. Constraints also apply to patients with pre-existing conditions such as established cardiovascular disease, severe hepatic impairment, or advanced renal disease. Furthermore, the risk of gastrointestinal complications is documented as being higher during the initial stages of treatment, while cardiovascular risk may increase with the duration of use.

Overdose and Emergency Response

Overdose and When to Seek Help

The official regulatory documentation for Panace (Aceclofenac) describes the documented manifestations and mandatory actions required in case of suspected overexposure.

Property Description
Documented overdose presentations Symptoms may include gastrointestinal disturbances (nausea, vomiting, epigastric pain) and central nervous system effects such as headache, drowsiness, and dizziness [2.1].
Physiological systems affected (as stated in label) Cases of significant poisoning note the possibility of acute renal failure and liver damage (hepatic damage) [2.1].
Population-specific overdose notes (if applicable) Elderly patients are recognized as having an increased risk for severe adverse reactions, including gastrointestinal bleeding and perforation, which may be fatal [2.2].
Emergency-response statements Treatment is symptomatic and supportive management as required, since no specific antidote is known for this medicine [2.1].
When immediate medical help is required Patients who have accidentally taken too many tablets must contact a doctor immediately or go to the nearest hospital emergency department [2.1].

Overdose Management in Regulatory Context

Official overdose statements indicate that decontamination measures such as administering activated charcoal should be considered within one hour of ingesting a potentially toxic amount [2.1]. In cases of frequent or prolonged convulsions (seizures), patients should be treated with intravenous diazepam [2.1]. Close medical monitoring of renal and liver function is mandated in the event of significant poisoning [2.1].

The regulatory profile defines the clinical course by listing common, initial symptoms and establishing the urgent need for supportive care to address the risk of serious, non-antidote-dependent organ damage. The instruction to seek immediate medical attention for any suspected over-ingestion is critical due to the potential for delayed, severe complications like kidney or liver failure.

Therapeutic Uses of Panace

What Panace treats: Main Uses and Benefits

Panace, containing Aceclofenac, is commonly used across therapeutic domains involving chronic joint inflammation and acute pain management. The medicine is applied where additional symptomatic support is needed, specifically in conditions characterized by periods of heightened symptoms. These primary conditions include Osteoarthritis (OA), Rheumatoid Arthritis (RA), and Ankylosing Spondylitis (AS), as well as acute pain in scenarios like Low Back Pain and following trauma.


The medicine helps address symptom clusters that may become intense or disruptive, such as persistent pain, tenderness, and morning stiffness. The use of Panace is intended to assist with managing difficult episodes and supports patients during periods of heightened discomfort. It is applied in conditions where symptoms create noticeable functional strain and is relevant for managing symptoms that interfere with daily comfort. This supportive relief assists with maintaining functional stability and contributes to improved comfort during periods of heightened symptoms.


Quick Fact: Key Symptom Relief

Panace is commonly used to help manage symptoms related to physical discomfort and inflammatory or irritative states.

Eligibility and Restrictions for Use

Panace (Aceclofenac) eligibility is strictly defined by regulatory guidelines based on age, physiological status, and the presence of severe comorbidities. The medicine is primarily intended for adults (generally 18 years and older).

Contraindicated Populations (Must Not Use)

Official labeling contraindicates use in patients with:

  • Known hypersensitivity to Aceclofenac or cross-reactivity with aspirin or other Nonsteroidal Anti-inflammatory Drugs (NSAIDs) that causes asthma or rhinitis.
  • Established severe cardiovascular disease, including congestive heart failure (NYHA Class II–IV), ischemic heart disease, and peripheral arterial disease.
  • Severe impairment of hepatic or renal function.
  • Active or recurrent gastrointestinal bleeding/ulceration or history of perforation related to previous NSAID therapy.
  • The last trimester of pregnancy (from 30 weeks gestation).

Restricted and Non-Eligible Groups

  • Pediatric Use: The medicine is not recommended for children and adolescents under 18 years of age due to a lack of clinical data on safety and efficacy in this population.
  • Pregnancy and Lactation: Use is contraindicated in the last trimester and not recommended during the first two trimesters, while breastfeeding, or when attempting to conceive.
  • Conditional Use: Patients who are elderly or have mild-to-moderate hepatic or renal impairment, hypertension, or mild congestive heart failure (NYHA I) must use the medicine only after careful medical consideration and under close surveillance.

What should I know about interactions with other medicines?

Official Regulatory Interactions for Panace

The interaction profile of Panace, which contains Aceclofenac, is structured around co-administration restrictions, changes in plasma exposure, and additive pharmacodynamic risks, as documented in official government regulatory information.

Mandatory Restrictions and Contraindicated Combinations

Co-administration with other NSAIDs, including cyclooxygenase-2 (COX-2) selective inhibitors and Acetylsalicylic acid, must be avoided due to the increased risk of gastrointestinal adverse effects. A mandatory timing separation is required when used with Mifepristone; the NSAID must not be administered for 8–12 days following mifepristone use, as the NSAID may reduce its efficacy.

Exposure-Modifying Substances

Aceclofenac has been officially documented to increase the plasma concentrations of certain co-administered substances. This effect is seen with Lithium and Digoxin via renal mechanisms. Similarly, Methotrexate plasma levels may be increased due to reduced elimination, which carries an officially noted increased risk of toxicity. For Oral Antidiabetic Agents, the official label suggests consideration of dosage adjustment due to isolated reports of effects on blood glucose levels.

Pharmacodynamic Interaction Risks

Several combinations pose an officially noted additive pharmacodynamic risk. Use with Anticoagulants (e.g., Warfarin) may enhance their effect, increasing the risk of bleeding. Co-administration with Corticosteroids, Antiplatelet agents, or SSRIs may also increase the risk of gastrointestinal bleeding. An increased risk of nephrotoxicity is noted when combined with Diuretics or Ciclosporin.

Mechanism of Action

The pharmacodynamic action of Panace (Aceclofenac) operates through two primary domains: the modulation of Prostaglandin biosynthesis and the regulation of specific cellular signaling pathways.


Targeting the Prostaglandin Synthesis Pathway

Panace's active metabolite works primarily by inhibition of the Cyclo-oxygenase-2 (COX-2) enzyme. COX-2 is an enzyme induced at sites of cellular stress that produces inflammatory Prostaglandins (PGs). By blocking this enzyme, the drug reduces the synthesis of PGs, which decreases the sensitization of peripheral nociceptors (pain-sensing nerve endings).


️ Modulating Immune Cell Communication

Beyond COX inhibition, the drug engages secondary mechanisms to modulate the inflammatory cascade. This involves reducing the production of key pro-inflammatory cytokines (like IL-1beta) and modulating the expression of adhesion molecules on immune cells, such as neutrophils. This physiological change restricts the migration of circulating white blood cells into the tissue, resulting in diminished fluid extravasation and tissue volume change.

Dosage and Administration Information

How to Use Panace

Panace is administered exclusively via the oral route as a 100 mg film-coated tablet, delivering the active compound Aceclofenac for systemic action. The standardized adult dosing regimen requires a total daily intake of 200 mg. This is achieved by taking a 100 mg dose twice daily, with one tablet administered in the morning and the second taken in the evening.

For proper consumption, the tablet must be swallowed whole with an adequate amount of liquid and should not be crushed or chewed. Standard instructions specify that the medicine is to be taken preferably with or after food. This timing relates to the absorption profile of the drug.

The usage protocol is governed by the principle of prescribing the lowest effective dose for the shortest duration necessary to control symptoms, aligning with general standards for this class of medicine.

Specific adjustments to the standard posology are mandated for certain patient groups. For adults with known hepatic impairment, the recommended initial dose is reduced to 100 mg taken once daily. Conversely, no routine dose modification is typically required for older adults. Available data do not recommend the use of Panace in the pediatric population, defined as those under 18 years of age, due to a lack of sufficient clinical evidence.

Recent Clinical Evidence

Research Evidence: Overview of Studies for Panace

Panace (Aceclofenac) was evaluated in research exploring how symptoms change over time for conditions characterized by fluctuating or episodic manifestations. The evidence available includes findings from formal, short-term Randomized Controlled Trials (RCTs) and systematic reviews that compile data across multiple studies. This evidence contributes to understanding symptom patterns by describing how patients reported their experience of pain and functional status under different research scenarios.


1. Evidence for Symptomatic Relief in Osteoarthritis and Rheumatoid Arthritis

For Osteoarthritis (OA), the evidence base includes multiple comparative clinical trials and systematic reviews applied in studies examining patient-reported experiences. Research primarily explored outcomes related to physical discomfort, such as measurements of pain intensity, and outcomes reflecting daily functioning or activity level over observation periods generally lasting between a few weeks and a few months.

Findings describe patterns observed in the studies where research highlights changes measured during the study period for these outcomes. However, the certainty regarding some specific outcomes, such as pooled pain reduction measurements, remains low in some systematic reviews due to high heterogeneity (variability) across the individual trials. For Rheumatoid Arthritis (RA), research explored the medicine in studies conducted during periods of increased symptom activity and was evaluated in adults with active disease.


2. Research Gaps and What Remains Uncertain About Panace

The majority of available clinical research results apply only to the populations studied, which primarily consisted of adults with common chronic joint conditions. Data for certain groups remain insufficient (e.g., children, pregnant individuals). Furthermore, the formal controlled clinical trials typically involve follow-up durations that were limited to a few weeks or months. There is limited information for long-term outcomes regarding the sustained effects on daily functioning, and the comparative evidence is lacking in certain head-to-head trials against all modern alternatives.

Key Studies & References Aceclofenac: Pharmacological and Clinical Review

Frequently Asked Questions (FAQ)

Common questions about Panace (FAQ)

Q: How quickly does Panace usually start working?

A: Official pharmacokinetic data, which describes how the body handles the medicine, indicates that the active ingredient generally reaches its highest concentration in the bloodstream between 1 and 3 hours after administration. This peak concentration is descriptive of the medicine’s systemic availability.

Q: What should I generally expect Panace to do after taking it?

A: The primary utility of Panace is described in official documents as providing dual anti-inflammatory and analgesic (pain-relieving) effects. The medicine's documented purpose is to help ease discomfort and contribute to improved mobility when managing symptoms of inflammatory conditions.

Q: Is a headache a reported side effect of Panace?

A: Yes, official regulatory documents note that headache is one of the possible effects associated with the use of Panace. This information is included in the official safety profile provided to regulatory bodies.

Q: How often do people experience stomach upset while using Panace?

A: Regulatory information classifies several digestive system issues, such as abdominal pain, dyspepsia (indigestion), and nausea, as 'Common Side Effects.' This classification indicates that these effects have been noted to occur in a defined proportion of the studied population.

Q: If I have a mild side effect, is that normal when starting Panace?

A: Official documentation notes that the risk of gastrointestinal (GI) complications, which can include various side effects, is documented as being higher during the initial stages of treatment. This information describes the timeframe when certain adverse events are more commonly noted.

Q: Does Panace interact with alcohol, according to the official guidance?

A: Official warnings for the class of medicine Panace belongs to (NSAIDs) note that caution is required regarding the combination with alcohol. This is stated due to a potentially increased risk of gastrointestinal irritation and bleeding.

Q: What is the half-life of Panace as reported in drug facts?

A: The mean plasma elimination half-life of Panace is officially reported in pharmacokinetic studies to be approximately 4 hours. The half-life refers to the time it takes for half of the drug to be eliminated from the bloodstream.

Q: Is Panace an antibiotic or something else?

A: Panace is classified as a Nonsteroidal Anti-inflammatory Drug (NSAID) with anti-inflammatory and analgesic effects. This pharmacological classification means it is used to manage pain and inflammation, and it is not intended for the treatment of bacterial infections.

Q: Does Panace cause any long-term health concerns that studies have found?

A: The official labeling highlights that for this class of medicine, the risk of cardiovascular events, such as myocardial infarction or stroke, may increase with the duration of use. Official guidance specifies that usage should be limited to the shortest duration of treatment necessary.

Q: What if I forget to take a dose of Panace?

A: Official patient information leaflets describe the recommended action when a dose is missed. This typically states that the dose may be administered when remembered, unless it is close to the time for the next scheduled dose, in which case the missed dose may be omitted.

Q: Is there a generic version of Panace available, or is it only branded?

A: The active ingredient in Panace is Aceclofenac, which is the International Nonproprietary Name (INN). Medicines containing Aceclofenac are available under multiple trade names and as generic versions of the compound.

Q: How long does Panace stay in your system after you stop taking it?

A: Aceclofenac has a half-life of approximately 4 hours. Once use is discontinued, the medicine is largely eliminated over time, with approximately two-thirds of the administered dose being excreted through the urine as inactive compounds.

Q: Is it true that Panace can affect how birth control pills work?

A: Official regulatory documents have noted that caution may be required when combining the active ingredient in Panace with specific components found in certain hormonal contraceptives, such as drospirenone. This is often related to a potential risk of hyperkalemia (high potassium levels) and is not necessarily a warning about reduced efficacy.

Q: I'm a healthy person; is Panace generally well-tolerated?

A: The official safety profile provides frequency data for expected common side effects in the general studied population. While the labeling focuses on serious risks for vulnerable groups, the classification of certain effects as 'common' or 'uncommon' provides context on the expected tolerability.

Q: What happens if I take Panace for longer than expected?

A: The regulatory guidance for this medicine emphasizes using the lowest effective dose for the shortest duration necessary. Prolonged use is documented to increase the potential risk of arterial thrombotic events, which is a known consideration in the official safety profile.

Q: Has Panace been approved in countries outside of the US?

A: Yes, regulatory documentation for the active ingredient in Panace is publicly available from several official bodies outside of the United States. These include the European Medicines Agency (EMA) and the UK's regulatory body, the MHRA.

Q: Is Panace used for long-term or short-term treatment?

A: The official usage protocol for Panace is built upon the regulatory principle of prescribing the medicine for the shortest duration necessary to control symptoms. This approach guides the treatment towards symptom management rather than permanent, long-term use.

Q: Can I take Panace if I am allergic to similar types of medicine?

A: Official labeling contraindicates the use of Panace in any patient with a known hypersensitivity to the active compound, Aceclofenac, or any history of cross-reactivity with aspirin or other Nonsteroidal Anti-inflammatory Drugs (NSAIDs) that results in conditions like asthma or rhinitis.

Q: Can Panace be used if I have a history of seizures?

A: Official safety information for this class of medicine generally includes a note that caution may be required for patients with a history of seizures. This is because some NSAIDs may potentially affect the seizure threshold, and drug interactions with anti-epileptic medications may be a concern.

Q: Why does the leaflet advise caution with sunlight exposure while on Panace?

A: Official guidance often includes a note of caution regarding sunlight exposure. This is due to evidence that the active ingredient is a photoallergic and phototoxic agent, which may increase the skin's sensitivity to light, and cases of photodermatitis have been reported in research.

Q: Does Panace require a specific time of day for the best effect?

A: The standardized regimen is designed to maintain a controlled level of the medicine in the body throughout the day. The protocol achieves this balance by requiring administration in the morning and the evening.

Q: What are the official recommendations for stopping Panace treatment?

A: The official recommendations describe the principle of using the lowest effective dose for the shortest duration necessary to achieve symptom control. Consistent with this regulatory principle, treatment duration is linked to the adequate management of symptoms.

Q: Is there a need to adjust my diet while I am using Panace?

A: The official labeling for Panace specifies a condition of use related to food consumption. The medicine is instructed to be taken preferably with or after food, a condition related to the drug's absorption profile and its potential effects on the gastrointestinal system.

How should Panace be stored and disposed of?

How to Store and Dispose of Panace (Aceclofenac)

Storage Requirements

Panace tablets must be stored according to regulatory labeling to maintain product stability and safety. The medicine is required to be stored below 25°C (or 30 C in some regions).

Storage Constraint Requirement
Container Store in the original package (blister pack).
Protection Store in a manner that protects from light and moisture.
Child Safety Keep out of the sight and reach of children.

Disposal Instructions

Unused or expired Panace must be disposed of safely. The medicine must not be thrown away via wastewater or household waste, as the active substance is known to be toxic to aquatic life. Disposal must be performed in accordance with local regulations and pharmacy take-back programs.

Attention! Always consult to a doctor or pharmacist before using pills or medicines.

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