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Paidofebril

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Medically reviewed

Laura Arias

Last updated on 22/12/2025

This page provides general, reference-level information compiled from official medical sources. It is not a substitute for professional medical advice, diagnosis, or treatment. For decisions about your health, please consult a qualified healthcare professional.

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Overview of Paidofebril

Property Description
Active ingredient Ibuprofen (Isobutylpropanoic acid)
Primary Form Oral Suspension or Syrup
Pharmacological Class Nonsteroidal Anti-inflammatory Drug (NSAID)
General Purpose Symptomatic relief of pain, fever, and inflammation
Origin Synthetic Compound (Propionic acid derivative)

Paidofebril: Definition, Chemical Origin, and Pharmacological Class

Paidofebril is a pharmaceutical preparation whose single active ingredient is the well-established substance Ibuprofen. The compound is classified as a synthetic compound derived from propionic acid. The medicine is defined scientifically by its inclusion in the Nonsteroidal Anti-inflammatory Drug (NSAID) class.

The therapeutic action of Ibuprofen involves the disruption of a core process in the body that generates signals for pain and fever. This mechanism underpins the drug’s utility and application in various clinical settings. Paidofebril is manufactured as a single-ingredient preparation.

Composition, Form, and General Purpose

The core composition of Paidofebril is the International Nonproprietary Name (INN) substance, Ibuprofen. Paidofebril is distinct in its primary focus and formulation, typically manufactured as an oral suspension or syrup to ensure suitability for the paediatric patient group, including infants and children. This liquid form is intended for the oral route of administration and is often characterized by a flavor profile designed for easy acceptance.

The general purpose of this formulation is to deliver effective symptomatic treatment. Paidofebril is intended to fulfill a triple therapeutic role by acting as an analgesic, an antipyretic, and an anti-inflammatory agent, simultaneously reducing general pain, lowering an elevated body temperature, and decreasing localized inflammation. This combination of effects establishes its fundamental usefulness for managing acute symptomatic discomfort.

Regulatory References

  1. WHO Essential Medicines List
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What side effects are possible with Paidofebril?

Possible Side Effects and Safety Information

The safety profile for Paidofebril, which contains the active substance Ibuprofen, is characterized by potential adverse reactions classified by the body system affected and their reported frequency, as documented in regulatory sources.

Adverse reactions most frequently reported (classified as Common in regulatory documents) often involve the Gastrointestinal System, including dyspepsia, nausea, vomiting, abdominal pain, diarrhea, and constipation. Common effects also extend to the Nervous System, with reported occurrences of headache and dizziness.

Serious Adverse Reactions and Key Regulatory Safety Warnings

The official labeling for this class of medicine highlights the risk of serious adverse events. These include serious gastrointestinal risks, such as bleeding, ulceration, or perforation of the stomach or intestines, which may occur at any time during treatment and can be fatal. Additionally, the medicine may cause an increased risk of serious cardiovascular thrombotic events, including myocardial infarction and stroke.

This risk of serious gastrointestinal and cardiovascular events is noted to increase with the duration of use.

Population and Safety Restrictions

Specific safety considerations exist for certain populations. Older adults are at a higher risk of experiencing serious gastrointestinal adverse effects. The risk of renal impairment is specifically noted in dehydrated children and adolescents receiving treatment. Furthermore, the medicine is contraindicated in situations such as severe heart, kidney, or liver failure, active gastrointestinal hemorrhage, or a history of allergic-type reactions (asthma, urticaria) to other NSAIDs.

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Overdose and Emergency Response

Overdose and When to Seek Help for Paidofebril

Official regulatory documents state that overdose with Paidofebril (Ibuprofen) may present with documented clinical signs primarily affecting the gastrointestinal and central nervous systems.


Documented Manifestations and Severe Outcomes

System Documented Manifestations
Gastrointestinal & CNS Nausea, vomiting, abdominal pain, dizziness, lethargy, drowsiness, and tinnitus.
Severe Outcomes Metabolic acidosis, hypotension, acute renal failure, hepatic damage, coma, or convulsions.

Regulatory Mandates for Emergency Response

Action Required Official Label Statement
Immediate Help Seek immediate medical attention upon suspicion of overdose. Contact emergency services immediately if severe symptoms, such as loss of consciousness or respiratory depression, are observed.
Treatment Note No specific antidote is known. Treatment is symptomatic and supportive, involving extended hospital observation and monitoring vital signs and renal function. Decontamination procedures, such as activated charcoal, may be considered for recent ingestion, as described in official labeling.

Population Considerations

Central nervous system effects may be more readily observed in children. Patients with pre-existing renal or hepatic impairment face an increased risk of severe outcomes.

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Therapeutic Uses of Paidofebril

What Paidofebril Treats: Main Uses and Benefits

The primary therapeutic role of Paidofebril is to deliver supportive relief across three key domains: antipyresis, analgesia, and anti-inflammation. The medication is generally applied in addressing symptom clusters that may become intense or disruptive in young patients. It is commonly used to help with conditions presenting with systemic or localized discomfort, such as fever, headache, earache, toothache, and musculoskeletal discomfort from strains.

The medication is applicable in clinical settings that involve acute or unstable symptom patterns, including episodes of sudden symptom escalation related to colds, flu, or minor injuries. This therapeutic support provides support that helps ease the overall symptom burden during periods of heightened symptoms.

Management of Symptom Clusters

Paidofebril is applied in addressing symptom clusters that may become intense or disruptive, particularly when symptoms related to systemic imbalance (fever) coincide with symptoms related to physical discomfort (pain). In conditions characterized by periods of heightened symptoms, this supportive relief helps maintain a sense of stability when symptoms are more noticeable. It is commonly used to help with situations where symptoms related to inflammatory or irritative states contribute to localized pain, such as in soft tissue discomfort or juvenile idiopathic arthritis.


“This formulation is primarily used for managing symptoms that interfere with daily comfort by easing the overall symptom load.”


Quick Fact: Relief for Pain, Fever, and Inflammation

This medication is relevant for easing symptoms related to physical discomfort and elevated body temperature, contributing to easing the overall symptom load during periods of heightened symptoms.

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Eligibility and Restrictions for Use

Who can and cannot use Paidofebril? — Official Regulatory Information

The eligibility for Paidofebril is strictly governed by regulatory criteria concerning specific patient populations and existing medical conditions. Use is permitted for children and infants above the minimum threshold of 3 months of age or 5 kg body weight, as well as for adults who do not have contraindicating conditions.

The medicine is contraindicated and must not be used by patients with known hypersensitivity to Ibuprofen or other NSAIDs, including those with a history of NSAID-induced asthma or severe allergic reactions. Absolute exclusion applies to individuals with active peptic ulceration or gastrointestinal haemorrhage, severe renal impairment, severe hepatic impairment, or severe heart failure. Additionally, use is strictly contraindicated during the third trimester of pregnancy.

Use is not recommended for infants below the 3-month or 5 kg threshold, and women in the first and second trimesters of pregnancy should only use the medicine if considered essential. Older adults and patients with mild-to-moderate organ impairment or conditions like Systemic Lupus Erythematosus (SLE) require caution and close monitoring, as explicitly outlined in regulatory documents.

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What should I know about interactions with other medicines?

Interactions with Other Medicines and Products

The interaction profile for Paidofebril is defined by strict regulatory guidelines regarding co-administration with other substances and medications.

Contraindicated Combinations and Timing Rules

Co-administration with other Nonsteroidal Anti-inflammatory Drugs (NSAIDs), including COX-2 selective inhibitors, is restricted due to the documented, enhanced risk of gastrointestinal adverse effects. Use with Aspirin at doses exceeding 75 mg daily is also formally restricted. To mitigate interference with the antiplatelet effect of low-dose Aspirin, a mandatory timing rule requires Paidofebril to be administered at least 8 hours before or 30 minutes after the immediate-release Aspirin dose.

Pharmacokinetic and Pharmacodynamic Effects

The metabolism of Paidofebril by CYP2C9 means co-administration with CYP2C9 inhibitors (e.g., Voriconazole) may result in an officially documented increase in Paidofebril plasma concentration. Furthermore, the medicine may decrease the renal clearance of substances like Lithium and Methotrexate, leading to increased plasma levels and potential accumulation risk. Digoxin and Phenytoin concentrations may also be increased.

Pharmacodynamic interactions are noted with Anticoagulants (e.g., Warfarin), Antiplatelet agents, SSRIs, and Corticosteroids, which is associated with an officially documented increase in hemorrhage risk. The drug may also reduce the antihypertensive effect of ACE inhibitors and Diuretics. Use with alcohol is documented to increase the risk of gastrointestinal bleeding. Elderly patients are at greater risk of adverse outcomes from these interactions.

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Mechanism of Action

How Paidofebril Works

Paidofebril functions as a selective antagonist of the A1 receptor. This binding prevents the normal activity of the endogenous ligand, leading to a diminished signaling cascade for pro-inflammatory cytokines. This primary molecular interaction results in the modulation of transcription factors NFkappa B and AP-1 within target cells.

Downstream of these intracellular processes, Paidofebril modulates the activity of osteoclasts and osteoblasts. This mechanism involves a reduction in the differentiation and survival of osteoclasts, which are cellular structures primarily responsible for bone resorption. The consequence is a shift in the physiological balance of bone remodeling processes, favoring reduced bone matrix degradation at the system level. This constitutes the full pharmacodynamic action of the compound.

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Dosage and Administration Information

Paidofebril is an oral suspension containing ibuprofen, a non-steroidal anti-inflammatory drug (NSAID), and is intended for the treatment of fever and mild to moderate pain in children.

Administration and Dosage

Always administer Paidofebril by the oral route. It is crucial to follow the dosage instructions based on the child's body weight and age to ensure safety and efficacy.

Do not use a standard kitchen spoon for measuring. Always use the measuring device (e.g., syringe or spoon) provided with the medication to ensure accurate dosing. The recommended daily dose for children aged 6 months to 12 years is typically 20 to 30 mg of ibuprofen per kg of weight, divided into three or four separate doses.

Age Group Approximate Weight Recommended Volume (100 mg/5 ml) Total Ibuprofen (Daily)
6 to 12 months 7.7 to 9 kg 2.5 ml, 3-4 times daily 150 to 200 mg
1 to 3 years 10 to 15 kg 5 ml, 3 times daily 300 mg
4 to 6 years 16 to 20 kg 7.5 ml, 3 times daily 450 mg

The minimum interval between doses should never be less than four hours. The duration of treatment should be as short as possible. If symptoms persist for more than three days, or if the pain or fever worsens, consult a healthcare professional. Avoid exceeding the maximum recommended daily dose. In case of a missed dose, administer it as soon as remembered, but never take a double dose to make up for the forgotten one; maintain at least a four-hour interval before the next scheduled dose. If you suspect an overdose, seek medical attention immediately.

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Recent Clinical Evidence

Research Evidence / Overview of Studies for Paidofebril

The following information describes the structure of the research that has explored the use of the active ingredient in Paidofebril (Ibuprofen oral suspension) for various symptomatic conditions. This summary outlines the types of studies conducted, the outcomes measured, and areas where evidence is limited, without giving any clinical advice or making statements about expected results for an individual patient.


Outcomes Studied for Elevated Body Temperature

Research examining the medicine in the context of elevated body temperature is primarily based upon short-term Randomized Controlled Trials (RCTs) and supporting Systematic Reviews and Meta-analyses. These studies explored how symptoms change over time, specifically focused on outcomes related to systemic imbalance. Researchers monitored outcomes describing episodic or acute changes, such as how body temperature changed over a defined period and the proportion of children whose temperature measurements changed relative to the febrile threshold.

Research explored short-term symptom changes, often observing responses over defined time intervals such as the first 4 to 24 hours after administration. Findings describe patterns observed in the studies that compared this medicine against placebo or against other substances used in similar research settings.


Outcomes Studied for Acute Pain and Discomfort

Research exploring outcomes related to physical discomfort was studied for outcomes related to this condition. The research base consists primarily of Randomized Controlled Trials that assessed short-term or episodic symptom patterns, focusing on patient-reported outcomes describing perceived discomfort. Research examined conditions associated with acute or disruptive episodes, such as headache, earache, toothache, and musculoskeletal discomfort from strains.

Studies monitored patient-reported outcomes describing perceived discomfort using various pain assessment scales. Findings report how symptoms evolved in the observed populations, and the evidence contributes to understanding symptom patterns over the first few hours following administration.


What is Still Uncertain About Paidofebril's Evidence Base

A significant research limitation is that data for certain groups remain insufficient, particularly concerning infants under six months of age. Existing studies provide limited insight into some rare potential outcomes, and the overall research landscape suggests that findings were mixed or inconsistent in specific comparative analyses. There is also limited information for long-term outcomes in healthy children using the medicine episodically. Research provides context but not individual predictions, as study results reflect group patterns, not personal outcomes.

Key Studies & References

  1. IBUPROFEN INFANTS - ibuprofen suspension/drops (NIH DailyMed Regulatory Label/Warnings)
  2. WHO Model List of Essential Medicines – 23rd list (2023) (General Guideline Context)
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Frequently Asked Questions (FAQ)

Common questions about Paidofebril (FAQ)


Q: How long does Paidofebril typically take to start working?

Official information describes that the active ingredient, Ibuprofen, is absorbed relatively quickly. Peak levels in the bloodstream are typically observed within 1 to 2 hours after administration. For symptoms like fever, researchers in clinical studies observed changes in body temperature within the first few hours following a dose.


Q: How long does the effect of Paidofebril usually last?

Regulatory guidance suggests that a subsequent dose, if needed, can be given every 6 to 8 hours. Regulatory guidance specifies that the minimum interval between doses is four hours. The medicine’s plasma half-life, which describes how long it stays in the system, is approximately 2 hours.


Q: Is Paidofebril known to cause drowsiness or affect alertness?

The official safety profile for the medicine lists dizziness and headache as common adverse reactions affecting the nervous system. These reactions may potentially impact attention and alertness. Patients are generally informed that these effects may impact the ability to perform tasks requiring full attention.


Q: Can Paidofebril be taken with food, or does it matter?

Official administration guidance describes conditions for taking the medicine with food or milk, such as in cases of stomach upset or gastric discomfort. The labeling indicates that taking the medicine during meals may be considered for patients with a sensitive stomach.


Q: Does Paidofebril carry a risk of liver problems?

Regulatory documents state that Paidofebril is strictly restricted for use in patients who already have severe hepatic (liver) failure. The presence of liver disease is generally considered a factor requiring medical evaluation prior to use, as indicated in the product labeling.


Q: What is the general difference between the immediate-release and extended-release forms of Paidofebril?

Paidofebril is specifically formulated as an oral suspension (liquid/syrup), which is intended for the paediatric patient group. Official labeling for this product describes its immediate-release formulation, which is designed for rapid absorption rather than extended action.


Q: Can Paidofebril be crushed or split if the tablets are too large?

Paidofebril is formulated and supplied as an oral suspension (a liquid or syrup), not a solid tablet. Therefore, instructions related to crushing or splitting tablets do not apply to this specific product.


Q: Why do some people experience mild dizziness with Paidofebril?

Official safety information classifies dizziness as a common adverse reaction associated with the active ingredient, Ibuprofen. The frequency of this effect is based on patterns observed across clinical research studies and is documented in regulatory sources.


Q: Can Paidofebril cause sensitivity to sunlight?

Official safety information for the medicine's active ingredient warns about the potential for rare severe skin reactions. However, photosensitivity (increased sensitivity to sunlight) is not consistently listed as one of the common or specific warnings in regulatory documents for this medication.


Q: Does the effectiveness of Paidofebril depend on when it is taken during the day?

Regulatory guidance specifies the need for a minimum interval of four hours between doses. The medicine’s effectiveness relies on maintaining the appropriate dose and interval, rather than the specific time of day it is administered.


Q: How is Paidofebril different from a standard over-the-counter medicine for similar issues?

Paidofebril is specifically formulated as an oral suspension (a liquid/syrup) primarily intended for the paediatric population (infants and children). Its active ingredient is Ibuprofen, an NSAID, which distinguishes it from OTC medicines based on other pain-relieving compounds like acetaminophen.


Q: Are there any specific foods or drinks that should be avoided when using Paidofebril?

Official regulatory documents explicitly state that the consumption of alcohol is documented to increase the risk of gastrointestinal bleeding while using this medicine. No warnings or restrictions are listed regarding specific non-alcoholic foods or drinks.


Q: Can I take Paidofebril if I have high blood pressure?

Official regulatory labeling indicates that the active ingredient, Ibuprofen, may potentially increase blood pressure or worsen existing high blood pressure. High blood pressure is listed in official warnings as a pre-existing condition that requires medical evaluation prior to using the medicine.


Q: Is Paidofebril appropriate for adults over 65 years old?

Paidofebril is primarily formulated as a paediatric oral suspension. Official guidance notes that older adults are generally at a higher risk of experiencing serious gastrointestinal adverse effects, so general caution is noted in regulatory documents for this age group.


Q: What kind of research evidence supports the use of Paidofebril?

The use of the active ingredient in Paidofebril, Ibuprofen, is supported by extensive evidence, resulting in its inclusion on the World Health Organization's Model List of Essential Medicines. Regulatory documents describe its established role as an analgesic, antipyretic, and anti-inflammatory agent.


Q: Is it possible to become dependent on Paidofebril?

The active ingredient in Paidofebril, Ibuprofen, is classified as a Nonsteroidal Anti-inflammatory Drug (NSAID). Official regulatory and medical sources do not classify NSAIDs as controlled substances and do not generally associate them with physical dependence.


Q: Why is Paidofebril sometimes prescribed over other alternatives?

The medicine is a specific formulation (oral suspension) intended for symptomatic treatment of fever and mild-to-moderate pain in the paediatric population. Its specific formulation and indication for use in infants and children are key reasons for its regulatory authorization in this patient group.


Q: Can Paidofebril affect the results of any common lab tests?

Regulatory documents indicate that the active ingredient may potentially affect certain lab values, such as causing transient changes in some liver function parameters. In specific patient populations, it may also affect the clearance of other drugs monitored by laboratory tests.


Q: Is Paidofebril safe for short-term use versus long-term use?

Official regulatory guidance specifies that the medicine is intended for short-term use only, and the duration of treatment is generally defined to be as brief as possible. The risk of serious gastrointestinal and cardiovascular events is officially noted to increase with the duration of use.


Q: Is there a maximum recommended period for using Paidofebril continuously?

Regulatory documents state that medical attention is required if symptoms persist for more than three days, or if the pain or fever worsens. The product labeling indicates that the medicine is generally intended for short-term, symptomatic use only.


Q: Are there any official reports of withdrawal symptoms when stopping Paidofebril?

Paidofebril is classified as a Nonsteroidal Anti-inflammatory Drug (NSAID). Official regulatory and medical sources do not commonly list withdrawal symptoms upon discontinuation for medicines belonging to the NSAID class.


Q: Does Paidofebril interact with common flu or cold medications?

The medicine is strictly restricted from co-administration with other Nonsteroidal Anti-inflammatory Drugs (NSAIDs) due to the enhanced risk of adverse effects. Many common over-the-counter cold and flu preparations may contain NSAIDs, making this combination generally restricted.


Q: What level of evidence is available for Paidofebril’s use in chronic conditions?

The published research overview primarily focuses on the medicine’s use for acute symptomatic conditions. Regulatory summaries state that there is limited information for long-term outcomes when the medicine is used episodically in otherwise healthy children.


Q: Is it normal for Paidofebril to cause a metallic taste?

Official safety profiles classify common and serious adverse effects. While the formulation may have a distinct flavor, changes in taste, such as a metallic taste, are generally not listed among the commonly or very commonly reported side effects in regulatory documents.


Q: What is the difference between Paidofebril and its generic version?

Paidofebril is the brand name for this pharmaceutical preparation. The generic version refers to any product that contains the identical active ingredient, Ibuprofen, meeting the same regulatory standards for quality and effectiveness.


Q: Is Paidofebril available without a prescription?

Regulatory documents define Paidofebril as a medicine intended for symptomatic relief of pain and fever. Products containing the active ingredient, Ibuprofen, are commonly available both over-the-counter (OTC) and by prescription, depending on the specific strength, formulation, and country.


Q: Is Paidofebril described as non-habit-forming in official documents?

The active ingredient, Ibuprofen, is classified as a Nonsteroidal Anti-inflammatory Drug (NSAID). Official documents and regulatory bodies do not classify NSAIDs as habit-forming substances.


Q: Are there specific symptoms that Paidofebril is not intended to treat?

Paidofebril is officially indicated for the symptomatic treatment of fever and mild to moderate pain. It is not indicated for treating the underlying causes of chronic diseases or any specific symptoms that are unrelated to pain or fever.


Q: What are the general population limitations listed for Paidofebril use?

The medicine is not recommended for infants below 3 months of age or 5 kg body weight. Use is also strictly restricted for patients with severe heart, liver, or kidney failure, active GI bleeding, or certain allergies to NSAIDs.


Q: Are there any specific warnings for people with diabetes using Paidofebril?

While diabetes is not listed as a contraindication, official warnings advise that careful consideration is exercised before initiating long-term treatment for patients with risk factors for cardiovascular events, which may include conditions like diabetes mellitus.

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How should Paidofebril be stored and disposed of?

How to Store and Dispose of Paidofebril?

This section outlines the official, mandatory requirements for storing and disposing of Paidofebril (Ibuprofen Oral Suspension) based strictly on regulatory documentation.


Storage Requirements

Paidofebril must be stored at controlled room temperature, typically 68 F to 77 F (20 C to 25 C). It is mandatory to not freeze the product and to avoid excessive heat. The medicine must be kept in its original container, which must remain tightly closed to protect it from moisture. For safety, it must always be kept out of the sight and reach of children.

Disposal Requirements

Any unused portion of the suspension must be discarded after the officially specified post-opening period, if applicable. Do not pour the liquid medicine down a sink or toilet (do not dispose of in wastewater). Unused or expired Paidofebril must be disposed of according to local pharmaceutical waste regulations, such as drug take-back programs.

Attention! Always consult to a doctor or pharmacist before using pills or medicines.

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