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Components:
Xylometazoline
Method of action:
Alpha-Adrenomimetic, Anticonvulsant, Nasal Preparations, Vasoconstrictive
Medically reviewed by Fedorchenko Olga Valeryevna, Pharmacy-Provisor. Last updated on 2020.02.17

Therapeutic indications

The information provided in Therapeutic indications of Otrivina is based on data of another medicine with exactly the same composition as the Otrivina of the medicine (Xylometazoline). Be careful and be sure to specify the information on the section Therapeutic indications in the instructions to the drug Otrivina directly from the package or from the pharmacist at the pharmacy.
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For the symptomatic relief of nasal congestion, perennial and allergic rhinitis (including hay fever), sinusitis.

Dosage (Posology) and method of administration

The information provided in Dosage (Posology) and method of administration of Otrivina is based on data of another medicine with exactly the same composition as the Otrivina of the medicine (Xylometazoline). Be careful and be sure to specify the information on the section Dosage (Posology) and method of administration in the instructions to the drug Otrivina directly from the package or from the pharmacist at the pharmacy.
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Adults and elderly: One application in each nostril 1 to 3 times daily.

Not suitable for children under 12 years.

Route of administration: Application to the nasal passages.

Contraindications

The information provided in Contraindications of Otrivina is based on data of another medicine with exactly the same composition as the Otrivina of the medicine (Xylometazoline). Be careful and be sure to specify the information on the section Contraindications in the instructions to the drug Otrivina directly from the package or from the pharmacist at the pharmacy.
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Known hypersensitivity to xylometazoline.

Patients with trans-sphenoidal hypophysectomy or surgery exposing the dura mater.

Special warnings and precautions for use

The information provided in Special warnings and precautions for use of Otrivina is based on data of another medicine with exactly the same composition as the Otrivina of the medicine (Xylometazoline). Be careful and be sure to specify the information on the section Special warnings and precautions for use in the instructions to the drug Otrivina directly from the package or from the pharmacist at the pharmacy.
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Patients are advised not to take decongestants for more than seven consecutive days. Otrivine, like other preparations belonging to the same class of active substances, should be used only with caution in patients showing a strong reaction to sympathomimetic agents as evidenced by signs of insomnia, dizziness etc.

Caution is recommended in patients with hypertension, cardiovascular disease, hyperthyroidism, narrow angle glaucoma or diabetes mellitus.

Label warnings and precautions

- Do not exceed the stated dose

- Do not use continuously for more than seven consecutive days. If symptoms persist, consult your doctor

- If you are pregnant or taking other medicines or are under a doctor's care, consult your doctor before using Otrivine

- Not to be used for infants or children under 12 years

- Each Otrivine pack should be used by one person only to prevent any cross infection

- For reasons of hygiene do not use this bottle for more than 28 days after first opening it

- Keep medicines out of the reach of children

Additional leaflet warnings and precautions

- Do not use if you are sensitive to any of the ingredients of Otrivine

- Do not use if you have had recent neurosurgery

- Consult your doctor before using Otrivine if you have heart or circulatory disease

- Some patients who have sensitive nasal passages may feel some local discomfort when applying the product.

- Other side effects such as palpitations, nausea and headache are very rare

Effects on ability to drive and use machines

The information provided in Effects on ability to drive and use machines of Otrivina is based on data of another medicine with exactly the same composition as the Otrivina of the medicine (Xylometazoline). Be careful and be sure to specify the information on the section Effects on ability to drive and use machines in the instructions to the drug Otrivina directly from the package or from the pharmacist at the pharmacy.
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None.

Undesirable effects

The information provided in Undesirable effects of Otrivina is based on data of another medicine with exactly the same composition as the Otrivina of the medicine (Xylometazoline). Be careful and be sure to specify the information on the section Undesirable effects in the instructions to the drug Otrivina directly from the package or from the pharmacist at the pharmacy.
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The following side effects have occasionally been encountered: A burning sensation in the nose and throat, local irritation, nausea, headache and dryness of the nasal mucosa.

Systemic cardiovascular effects have occurred, and this should be kept in mind when giving Otrivine to people with cardiovascular disease.

In isolated cases, systemic allergic reactions and transient visual disturbances.

Overdose

The information provided in Overdose of Otrivina is based on data of another medicine with exactly the same composition as the Otrivina of the medicine (Xylometazoline). Be careful and be sure to specify the information on the section Overdose in the instructions to the drug Otrivina directly from the package or from the pharmacist at the pharmacy.
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In rare instances of accidental poisoning in children, the clinical picture has been marked chiefly by signs such as acceleration and irregularity of the pulse, elevated blood pressure and sometimes consciousness clouding.

There is no specific treatment. Appropriate supportive measures should be initiated.

Pharmacodynamic properties

The information provided in Pharmacodynamic properties of Otrivina is based on data of another medicine with exactly the same composition as the Otrivina of the medicine (Xylometazoline). Be careful and be sure to specify the information on the section Pharmacodynamic properties in the instructions to the drug Otrivina directly from the package or from the pharmacist at the pharmacy.
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Otrivine Adult Measured Dose Sinusitis Spray is a sympathomimetic agent with marked alpha-adrenergic activity, and is intended for use in the nose. It constricts the nasal blood vessels, thereby decongesting the mucosa of the nose and neighbouring regions of the pharynx. This enables patients suffering from colds to breathe more easily through the nose. The effect of Otrivine Adult Measured Dose Sinusitis Spray begins within a few minutes and lasts for up to 10 hours. Otrivine Adult Measured Dose Sinusitis Spray is generally well tolerated and does not impair the function of ciliated epithelium.

In a double-blind, saline solution (Otrisal) controlled study in patients with common cold, the decongestant effect of Otrivin was significantly superior (p<0.0001) to Otrisal saline solution based on rhinomanometry measurement at 1 hour after administration of the study drugs.

Pharmacokinetic properties

The information provided in Pharmacokinetic properties of Otrivina is based on data of another medicine with exactly the same composition as the Otrivina of the medicine (Xylometazoline). Be careful and be sure to specify the information on the section Pharmacokinetic properties in the instructions to the drug Otrivina directly from the package or from the pharmacist at the pharmacy.
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Systemic absorption may occur following nasal application of xylometazoline hydrochloride solutions. It is not used systemically.

Preclinical safety data

The information provided in Preclinical safety data of Otrivina is based on data of another medicine with exactly the same composition as the Otrivina of the medicine (Xylometazoline). Be careful and be sure to specify the information on the section Preclinical safety data in the instructions to the drug Otrivina directly from the package or from the pharmacist at the pharmacy.
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Not applicable.

Incompatibilities

The information provided in Incompatibilities of Otrivina is based on data of another medicine with exactly the same composition as the Otrivina of the medicine (Xylometazoline). Be careful and be sure to specify the information on the section Incompatibilities in the instructions to the drug Otrivina directly from the package or from the pharmacist at the pharmacy.
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None

Special precautions for disposal and other handling

The information provided in Special precautions for disposal and other handling of Otrivina is based on data of another medicine with exactly the same composition as the Otrivina of the medicine (Xylometazoline). Be careful and be sure to specify the information on the section Special precautions for disposal and other handling in the instructions to the drug Otrivina directly from the package or from the pharmacist at the pharmacy.
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Medicines should be kept out of the reach of children.

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