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Openvas (Olmesartan)

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Openvas (Olmesartan)

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Treatment option:

Medically reviewed

Marina Burgos

Last updated on 22/12/2025

This page provides general, reference-level information compiled from official medical sources. It is not a substitute for professional medical advice, diagnosis, or treatment. For decisions about your health, please consult a qualified healthcare professional.

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Overview of Openvas (Olmesartan)

Property Description
Active Ingredient Olmesartan medoxomil
Form Oral Tablets
Pharmacological Class Angiotensin II Receptor Blocker (ARB)
General Purpose Lowering high blood pressure (Hypertension)
Origin Synthetic

What Type of Medicine is Openvas (Olmesartan)?

Openvas is a synthetic, prescription-only medicine whose active component is Olmesartan medoxomil, which is an Angiotensin II Receptor Blocker (ARB). This pharmacological class, also known as an Angiotensin Receptor Antagonist, is generally clinically recognized for providing effective systemic management of high blood pressure and is integral to modulating the body's Renin-angiotensin-aldosterone system (RAAS). Olmesartan medoxomil is distinctly a pro-drug—an inactive compound that is rapidly converted into the pharmacologically active substance, Olmesartan, immediately following oral administration and absorption into the bloodstream.


Composition and Form: The Olmesartan Tablet

Openvas is provided as a single-entity product (monotherapy), consisting of the active ingredient Olmesartan medoxomil combined with necessary excipients to form an oral formulation in tablet form. This solid form is administered via the oral route, ensuring its action is systemic across the body's vasculature. The drug's mechanism is specific: it directly targets and blocks the AT1 receptor—a unique feature of the ARB class—ensuring a highly selective action against the pressor effects of Angiotensin II, a potent hormone responsible for vasoconstriction.


General Purpose of an Angiotensin Receptor Antagonist

The general purpose of this medicine is the sustained lowering of high blood pressure (hypertension) by inducing vasodilation, which is the relaxation and widening of the blood vessels. Olmesartan achieves this by acting as a selective antagonist that prevents the powerful hormone Angiotensin II from binding to receptors that would otherwise cause arteries to constrict. By systematically reducing this vascular resistance, the drug decreases the mechanical strain on the heart and maintains consistent blood flow, a fundamental benefit for stable cardiovascular function, which is a typical use scenario for this class of medicine.

Regulatory References

  1. NIH MedlinePlus Drug Information on Olmesartan
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What side effects are possible with Openvas (Olmesartan)?

Possible Side Effects and Safety Information

Openvas (Olmesartan) is associated with several important safety considerations documented in regulatory labeling.

Serious and Clinically Significant Risks

  • Fetal Toxicity (Boxed Warning): Use during the second and third trimesters of pregnancy can cause injury and death to the developing fetus. The medication must be discontinued as soon as possible if pregnancy is detected.
  • Sprue-like Enteropathy: This post-marketing adverse reaction involves severe, chronic diarrhea with substantial weight loss, which may develop months to years after starting olmesartan. In some cases, it has led to villous atrophy (a gut lining abnormality) and required hospitalization.
  • Angioedema: Swelling of the face, lips, tongue, and/or throat, which requires immediate medical attention due to the potential for breathing difficulty.
  • Hypotension and Impaired Renal Function: The drug can cause symptomatic low blood pressure, especially in patients who are volume- or salt-depleted. Worsening of kidney function, including acute renal failure, is a known risk, particularly in patients with severe congestive heart failure or bilateral renal artery stenosis.
  • Hyperkalemia: Elevated serum potassium levels have been reported, particularly in patients with kidney impairment or those taking other potassium-raising agents.

Common Adverse Reactions

The most frequently reported adverse reaction in clinical trials is dizziness. Other common reactions include upper respiratory tract infections, headache, and flu-like symptoms.

Specific Safety Restrictions

Olmesartan is contraindicated in patients who are pregnant and in patients with diabetes taking aliskiren. Monitoring of renal function and serum potassium levels is generally required for susceptible patient populations.

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Overdose and Emergency Response

Overdose and When to Seek Help

Official regulatory information describes overdose of Olmesartan primarily through its effects on the cardiovascular system. The most likely clinical manifestations of an acute overdosage are hypotension (excessively low blood pressure) and tachycardia (increased heart rate); however, bradycardia (decreased heart rate) may also occur.

When Urgent Medical Help is Required

If a suspected overdose occurs, patients or caregivers must immediately contact a regional poison control centre or seek emergency medical attention. This action is specifically mandated if manifestations like symptomatic hypotension develop, or if the individual has collapsed, had a seizure, or cannot be awakened.

Documented Management and Considerations

Management of overdosage focuses on symptomatic and supportive treatment. Should symptomatic hypotension occur, regulatory guidance describes measures such as placing the patient in the supine position and administering an intravenous infusion of normal saline.

Regulatory labeling notes that the dialyzability of olmesartan is unknown. Furthermore, infants with histories of in utero exposure require close observation for severe outcomes, including oliguria (reduced urine output) and hyperkalemia, with procedures like exchange transfusion or dialysis potentially being required to manage severe, drug-related complications.

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Therapeutic Uses of Openvas (Olmesartan)

What Openvas (Olmesartan) Treats: Main Uses and Benefits

Openvas (Olmesartan) is a medication used to provide supportive management for conditions characterized by increased cardiovascular stress and fluctuating blood pressure. Its primary role is to help patients achieve and maintain better health and comfort during periods marked by heightened physiological tension.

Support for High Blood Pressure Management

Olmesartan is commonly used to treat high blood pressure, medically known as hypertension. It is applied across therapeutic domains where assistance with functional strain is needed, offering supportive relief for systemic discomfort. This medication is relevant in clinical settings where symptoms cluster into patterns requiring supportive management to ease the overall burden on the system.

Quick Fact: Support for Symptoms of Cardiovascular Strain

Improving Daily Stability and Comfort

Openvas is used across conditions characterized by episodic or fluctuating symptom patterns tied to cardiovascular health. By helping to stabilize blood pressure, it contributes to improved day-to-day comfort and may help patients cope more steadily with difficult episodes, thereby assisting with maintaining a sense of stability when symptoms become more noticeable. It is applied in contexts where additional support for symptom and condition management is needed. In these situations, the support generally helps ease the overall symptom burden.

Regulatory References

  1. NIH MedlinePlus overview
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Eligibility and Restrictions for Use

Eligibility for Openvas (Olmesartan) Use

This section outlines who is eligible and who is prohibited from using olmesartan, strictly based on official regulatory labeling.


Populations Who Must Not Use Olmesartan (Contraindications)

Contraindicated Group Reason
Pregnancy Prohibited during the second and third trimesters due to risk of fetal injury.
Infants Prohibited for children under 1 year of age.
Diabetic Patients on Aliskiren Prohibited due to dual action on the Renin-Angiotensin System (RAAS).
Hypersensitivity Prohibited for patients with known allergy to olmesartan or any component.

Populations Requiring Caution or Restriction

Special Population Restriction/Caution
Renal Impairment Not generally recommended for severe renal impairment (CrCl < 20 mL/ min); lower maximum dose in moderate impairment.
Hepatic Impairment Not recommended for patients with severe hepatic impairment.
Breastfeeding Use requires a decision to discontinue nursing or the drug.
Volume-Depleted Patients Requires close medical supervision at the start of therapy due to risk of low blood pressure.

Use is established and generally allowed for adults and children aged 6 to 16 years who do not have the above contraindications or special conditions.

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What should I know about interactions with other medicines?

Interactions with other medicines and products

Official regulatory documentation outlines specific restrictions and interaction patterns for Olmesartan medoxomil.

Documented Pharmacodynamic and Regulatory Constraints

The co-administration of Aliskiren is formally contraindicated in patients with diabetes mellitus or renal impairment (Glomerular Filtration Rate < 60 mL/min/1.73m^2) due to the risks associated with dual inhibition of the Renin-Angiotensin System (RAS). Combining Olmesartan with Nonsteroidal Anti-inflammatory Drugs (NSAIDs), particularly in elderly or volume-depleted patients, may increase the risk of worsening renal function and reduce the drug's antihypertensive effect.

Agents that increase serum potassium, such as potassium-sparing diuretics, supplements, or heparin, are documented to increase the risk of hyperkalemia. Concomitant use with Lithium has been reported to cause reversible increases in serum lithium concentrations and toxicity.

Pharmacokinetic and Administration Timing

Olmesartan does not show clinically relevant inhibitory or inducing effects on major Cytochrome P450 enzymes. However, co-administration with Colesevelam hydrochloride reduces the systemic exposure ( AUC and Cmax) of Olmesartan. To mitigate this pharmacokinetic interaction, a timing separation rule is advised: Olmesartan administration should be considered at least 4 hours prior to the dose of Colesevelam. Regulatory profiles also note that alcohol consumption may increase the documented risk of dizziness.

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Mechanism of Action

Openvas acts as a selective inhibitor of angiotensin II AT1 receptor binding. Its primary mechanism involves the selective blockade of the Angiotensin II Type 1 (AT1) receptor located on the smooth muscle of blood vessels and other tissues throughout the body.

When Olmesartan binds to the AT1 receptor, it functions as a competitive antagonist, preventing the vasoconstrictor and aldosterone secretagogue, angiotensin II, from activating the receptor. This inhibition of AT1 receptor signaling prevents the associated cellular processes that lead to vasoconstriction and aldosterone release. This mechanistic action results in a decrease in total peripheral resistance and a subsequent reduction in arterial pressure. The receptor blockade also permits unopposed activity at the Angiotensin II Type 2 (AT2) receptors.

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Dosage and Administration Information

Openvas (Olmesartan) is administered exclusively through the oral route, primarily using the tablet dosage form, which is used for sustained blood pressure management. The standard administration is once daily, and it is generally advised to consume it at a consistent time each day to maintain a stable therapeutic schedule. The intake of Olmesartan is not dependent on meals, allowing the tablet to be taken with or without food. A key procedural instruction is that the tablet must be swallowed whole with fluid, and it should not be chewed.

Therapy for the majority of adults typically commences with a starting dose of 20 mg once daily. The standard regimen allows for dose adjustments, or titration, which should occur only after a minimum period of two weeks has passed, allowing the full effect of the initial dose to be assessed. The dose may range up to 40 mg, which constitutes the maximum recommended daily dose for Olmesartan monotherapy.

Specific restrictions exist for certain clinical situations. For individuals with moderate renal or hepatic impairment, the maximum allowable daily dose is restricted to 20 mg. Dividing the total dose into twice-daily administration offers no additional clinical advantage compared to the standard once-daily schedule.

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Recent Clinical Evidence

Openvas (Olmesartan): Recent Clinical Evidence


Evidence for Use in Managing High Blood Pressure (Hypertension)

Research has extensively explored the use of Olmesartan in adults and children with high blood pressure, monitored using objective functional metrics. Studies primarily include short-term and intermediate-term Randomized Controlled Trials (RCTs) examining the change from baseline in seated systolic and diastolic blood pressure readings and the achievement of target blood pressure goals. Findings describe patterns observed in these measured changes across evaluated populations. While many studies describe these short-term measurements, long-term effects are not fully established for all outcomes, and evidence for the comparative long-term outcomes related to larger cardiovascular events remains limited.


Understanding Study Outcomes Beyond Blood Pressure Control

Studies have also explored Olmesartan in high-risk groups, such as patients with Type 2 Diabetes who have existing cardiovascular risk factors. This long-term research monitored specific outcomes related to kidney health, including the time to the onset of microalbuminuria and the progression of renal disease. Findings related to cardiovascular outcomes in these high-risk cohorts were observed to be mixed. Some studies described an unexpected increase in the reported rate of cardiovascular death in certain diabetic subgroups, leading to uncertainty as the evidence quality varies and sample sizes were modest.


Long-Term Study Durations and Evidence in Specific Patient Groups

The research base includes studies that evaluated outcomes over both short-term and multi-year time intervals. Beyond adults, Olmesartan was evaluated in specific groups, including elderly patients and pediatric populations. While data show patterns related to blood pressure changes in these groups, the results apply only to the populations studied. Data for certain groups, particularly concerning long-term effects and specific outcomes, remain insufficient or are still emerging.


What the Research Shows About Consistency and Limitations

The research conducted so far contributes to the broader evidence landscape. However, consistency varies across studies, and certainty remains low in certain areas. The research landscape indicates limited comparative information for long-term outcomes across all established treatments. The mixed findings regarding cardiovascular event patterns observed in the high-risk diabetic patient research emphasizes that certain aspects of the data are still emerging.

Key Studies & References Olmesartan: MedlinePlus Drug Information (National Institutes of Health)

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Frequently Asked Questions (FAQ)

Common questions about Openvas (Olmesartan) (FAQ)


Q: How quickly should I expect Openvas to start lowering my blood pressure?

Studies indicate that the active drug levels reach a steady amount in the body within 3 to 5 days. However, the maximum blood pressure lowering effect is typically achieved after taking the medication for approximately two weeks, either after initial treatment begins or following a dose adjustment.


Q: What are the most common side effects people report when starting Openvas?

According to official product information, the most common adverse reactions reported in clinical trials are dizziness, headache, upper respiratory tract infections, and flu-like symptoms. Dizziness is noted to be a frequently reported side effect when patients first begin taking the medication.


Q: Do the side effects of Openvas usually go away after a few weeks?

Regulatory patient information often notes that common side effects like dizziness are more noticeable when treatment is initiated. This may suggest they become less frequent as the body adjusts. If side effects persist, this should be discussed with a healthcare provider.


Q: Is it normal to feel a bit dizzy when first taking Openvas?

Yes, dizziness is the most frequently reported adverse reaction in the medication’s clinical trials. Official patient information confirms that it is often more common when therapy first begins, as the body adapts to the reduction in blood pressure.


Q: Are there any common over-the-counter pain relievers that interact badly with Openvas?

Yes, combining olmesartan with Nonsteroidal Anti-inflammatory Drugs (NSAIDs), such as common over-the-counter ibuprofen or naproxen, is documented to require caution. This combination may reduce the blood pressure-lowering effect of olmesartan and could increase the risk of worsening kidney function.


Q: Does Openvas affect kidney function over time?

Official warnings state that olmesartan can cause worsening of kidney function, including acute renal failure, particularly in susceptible patients. Monitoring of kidney function is recommended, but the long-term impact on all individuals is not detailed in the product information.


Q: Is Openvas used to treat heart failure in some cases?

Olmesartan is approved primarily for high blood pressure. However, the official label includes a warning about the risk of symptomatic low blood pressure in patients with severe congestive heart failure, which suggests its use may be considered in this patient population, although it requires close medical supervision.


Q: What is the typical time of day recommended for taking Openvas?

Olmesartan is a once-a-day medication. While it can be taken at any time of day, it is advised to take it at around the same time every day to help maintain a stable therapeutic schedule. The time of day does not affect its absorption, as it can be taken with or without food.


Q: What should I do if my blood pressure remains high even after starting Openvas?

The medication reaches its maximum effect after about two weeks, and dosage adjustments can be made by a clinician after that period, if necessary. If blood pressure remains elevated, further assessment and potential treatment adjustment by a healthcare provider would be necessary.


Q: Is it OK to take anti-inflammatory drugs occasionally while on Openvas?

The label notes that combining olmesartan with anti-inflammatory drugs (NSAIDs) may increase the risk of worsening kidney function and can reduce the blood pressure-lowering effect. The use of anti-inflammatory drugs while on olmesartan is generally advised to be done with caution.


Q: Can Openvas cause problems with my electrolytes?

Yes, official warnings list a risk of hyperkalemia, which is an elevated level of potassium in the blood. This risk is greater in patients who have pre-existing kidney impairment or who are using other medications that increase potassium levels.


Q: Is it normal to have mild headaches when adjusting to Openvas?

Yes, headache is listed as a common adverse reaction that was reported in clinical trials. It is one of the more frequently observed effects when starting the medication.


Q: Does Openvas cause weight gain or weight loss?

Weight changes are not commonly listed as typical side effects. However, unexplained or substantial weight loss is listed as a potential symptom of a rare, serious side effect called sprue-like enteropathy, and this should be reported to a healthcare provider promptly.


Q: Can Openvas affect my energy levels or cause fatigue?

Yes, official regulatory documents list fatigue (unusual tiredness or weakness) and influenza-like symptoms as common side effects reported in clinical trials.


Q: Do supplements like potassium or magnesium interact with Openvas?

Yes, potassium supplements and other products that can raise potassium levels should be avoided or used with caution due to the risk of hyperkalemia. Magnesium supplements are not specifically mentioned in the regulatory warnings for interaction.


Q: Can drinking alcohol while on Openvas be dangerous?

The medication's label cautions that alcohol consumption may increase the documented risk of dizziness. The term 'dangerous' is not universally applied, but patients are generally advised to discuss alcohol use with a healthcare provider.


Q: What happens if I miss a dose of Openvas?

Official patient information generally provides instructions for handling a missed dose, typically advising to take it if remembered soon, or to skip it if the next dose is due. Specific instructions for missed doses can be found in the medication's official patient leaflet.


Q: Can Openvas cause a persistent dry cough like some other blood pressure medicines?

Coughing is listed as a common side effect of olmesartan in regulatory documents. The cough associated with this class of medication is generally less frequent than the persistent, dry cough sometimes linked to ACE inhibitors.


Q: Do certain foods need to be avoided while taking Openvas?

You should avoid salt substitutes containing potassium and over-the-counter potassium supplements unless specifically directed by a healthcare provider. The medication may also interact with the drug Colesevelam hydrochloride, which should be taken at least four hours after olmesartan.


Q: Can Openvas also help protect against stroke or heart attack?

Olmesartan is approved for lowering high blood pressure. By lowering blood pressure, the medication reduces the risk of serious cardiovascular events, which includes the risks of fatal and nonfatal strokes and myocardial infarctions (heart attacks).


Q: Is it possible for Openvas to lower blood pressure too much?

Yes, olmesartan can cause symptomatic low blood pressure (hypotension), particularly in individuals who are dehydrated or salt-depleted. Patients should be aware of symptoms such as dizziness or faintness, as these may indicate blood pressure that is too low.


Q: How does Openvas compare to diuretics for blood pressure control?

Official labeling shows that olmesartan is frequently used in combination with diuretics (sometimes called water pills) to treat hypertension. This combination is often used to achieve a greater overall reduction in blood pressure than either drug can achieve on its own.


Q: Is there a generic version of Openvas available?

Yes, the active ingredient, Olmesartan medoxomil, is available as a generic prescription drug. Generic medications must meet the same quality and effectiveness standards as the original brand-name product.


Q: Do studies show Openvas is effective for people of all ethnic backgrounds?

Regulatory information notes that some antihypertensive drugs have a smaller blood pressure effect when used alone in black patients and suggests this factor be considered when selecting therapy. Olmesartan’s efficacy is established for treating hypertension in adults and children.


Q: What is the average blood pressure drop expected with Openvas?

In clinical studies, the most commonly used doses of olmesartan resulted in an average reduction in blood pressure compared to placebo. The reductions were reported to be approximately 10 to 12 mm Hg for systolic pressure and 6 to 7 mm Hg for diastolic pressure.

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How should Openvas (Olmesartan) be stored and disposed of?

Storage and Disposal of Olmesartan Medoxomil

Olmesartan medoxomil tablets must be stored at Controlled Room Temperature (20 C to 25 C), with excursions permitted up to 30 C. The tablets must be protected from moisture and should not be frozen.


Extemporaneous Suspension Storage

If compounded into an oral suspension, the product requires refrigeration at 2 C to 8 C and has a stability limit of 4 weeks. The suspension must be shaken well before each use and promptly returned to the refrigerator.


Handling and Disposal

The medicine must be kept out of the sight and reach of children. Unused or expired medication should be disposed of through a drug take-back program. If a take-back program is unavailable, mix the tablets with an undesirable substance, place the mixture in a sealed container, and discard it in the household trash, in accordance with local regulations.

Attention! Always consult to a doctor or pharmacist before using pills or medicines.

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