Oligocare

Copper (Oligocare) 0.4 mg/mL (Cupric Chloride Injection, USP) is indicated for use as a supplement to intravenous solutions given for total parenteral nutrition (TPN). Administration helps to maintain Copper (Oligocare) serum levels and to prevent depletion of endogenous stores and subsequent deficiency symptoms.

Folic acid (Oligocare) is used in the treatment and prevention of the folate deficiency state. It does not correct folate deficiency due to dihydrofolate reductase inhibitors. Folic acid (Oligocare) is also used in women of child-bearing potential and pregnant women to protect against neural tube defects in their offspring. It is also used for the treatment of folate-deficient megaloblastic anaemia, chronic haemolytic states such as thalassaemia major or sickle-cell anaemia.

CNS depressant, tranquilizer.

Sedative, relaxant.

Treatment for Insomnia, anxiety, poor appetite.

Agitation.

Increase vitality in conditions of weakness, prolonged stress, poor immunity, or chronic disease.

Hypotensive.

Improves gastro-intestinal motility.

Immune system stimulant.

Increase synthesis of cholesterol in liver.

Helps to regulate blood sugar and lipid levels.

Regulates adrenal gland function.

Film-Coated Tablet: Treatment of Iron (Oligocare) deficiency. Prevention of Iron (Oligocare) deficiency during pregnancy.

Syrup: All cases of Iron (Oligocare) deficiency and Iron (Oligocare) deficiency anaemia.

Drops: General: Hypochromic or masked Iron (Oligocare) deficiency anaemias. General weakness. Convalescence. Blood losses. Tropical microcytic anaemia. Anaemias due to infections. For maintenance therapy in pernicious anaemia. As an adjuvant in treating chronically ill or undernourished patients.

Women: Iron (Oligocare) deficiency due to menstruation. During and after pregnancy and lactation. Menorrhagia.

Children: All types of hypochromic anaemias and masked Iron (Oligocare) deficiencies. Inappetence. Retarded growth. Weakness. Unsound dietary habits. To speed up restoration of depleted Iron (Oligocare) reserves.

Used for nutritional supplementation, also for treating dietary shortage or imbalance. (Acromegaly; Gigantism; Hyperammonemia; Hypophysectomy; Panhypopituitarism; Pituitary dwarfism; chromophobe adenoma; pituitary trauma; postsurgical craniopharyngioma; problems of growth and stature; urea cycle disorders;)

These compounds act mainly as normalizatoare of cellular metabolic process. ale fenomenelor oxidative si de imbatranire. Alterations mentioned processes underlying degenerative processes of cell aging and oxidative phenomena

Manganese (Oligocare) 0.1 mg/mL (Manganese (Oligocare) Chloride Injection, USP) is indicated for use as a supplement to intravenous solutions given for total parenteral nutrition (TPN).

Administration helps to maintain Manganese (Oligocare) serum levels and to prevent depletion of endogenous stores and subsequent deficiency symptoms.

Mecobalamin (Oligocare) (doxacurium chloride) is a long-acting neuromuscular blocking agent, indicated to provide skeletal muscle relaxation as an adjunct to general anesthesia, for endotracheal intubation or to facilitate mechanical ventilation.

Oral

Selenium (Oligocare) deficiency

Adult: 100-500 mcg of Selenium (Oligocare) daily.

Intramuscular

Selenium (Oligocare) deficiency

Adult: 100-500 mcg of Selenium (Oligocare) daily.

Intravenous

Selenium (Oligocare) deficiency

Adult: 100-500 mcg of Selenium (Oligocare) daily.

R & D - Ubidecarenone (Oligocare) (Origin) is used as a heart energizer and antioxidant to fight against free radicals in the body. It serves as an energy booster for patients suffering from high-cholesterol, hypertension, congestive heart failure (CHF), and other heart related problems.

Vitamin A (Oligocare) injection is effective for the treatment of Vitamin A (Oligocare) deficiency.

The parenteral administration is indicated when the oral administration is not feasible as in anorexia, nausea, vomiting, pre- and postoperative conditions, or it is not available as in the "Malabsorption Syndrome" with accompanying steatorrhea.

Pediatric Use: Vitamin A (Oligocare) treatment for deficiency states has been recognized as an especially effective and important therapy in the pediatric population.

Vitamin A (Oligocare) supplementation for deficiency states in this population has been addressed by the Committee on Clinical Practice Issues of the American Society for Clinical Nutrition, by the American Society for

Parenteral and Enteral Nutrition, and by the World Health Organization.

thiamine deficiency or in complex treatment of the following conditions:

thiamine deficiency * Metabolic acidosis

* Acidosis in hyperglycemic coma

* Acidosis in respiratory and cardio-pulmonary insufficiency

* Chronic heart failure

* Coronary heart disease

* Preinfarction conditions

* Myocardial infarction

* Postinfarction cardiosclerosis

* Renal or liver insufficiency

* Chronic alcoholism

* Acute alcohol toxicity

* Barbiturate and cardiac glycosides intoxications

* Neuralgia

* Infectious diseases

* Multiple sclerosis

* Peripheral neuritis

* Sideroblastic anaemia

* Treatment and prophylaxis of Vitamin B6 (Oligocare) deficiency states

For systemic use of All Natural Source Juicy Orange Vitamin C (Oligocare): prevention and treatment of hypo- and avitaminosis of Vitamin C (Oligocare); providing increased need for Vitamin C (Oligocare) during growth, pregnancy, lactation, with heavy loads, fatigue and during recovery after prolonged severe illness; in winter with an increased risk of infectious diseases.

For intravaginal use: chronic or recurrent vaginitis (bacterial vaginosis, nonspecific vaginitis) caused by the anaerobic flora (due to changes in pH of the vagina) in order to normalize disturbed vaginal microflora.

Vitamin D3 (Oligocare) has an important role in energize the intestinal absorption for calcium and phosphor, to regulate their metabolism and balance in blood. It helps bone calcification. Deficiency of Vitamin D3 (Oligocare) in the body causes deficiency of the calcium in the bone, weakness of its resistance and deformity.

Oral

Vitamin E (Oligocare) deficiency

Adult: 40-50 mg of d-α tocopherol daily.

Child: Neonate: 10 mg/kg once daily; 1 mth-18 yr: 2-10 mg/kg/day, up to 20 mg/kg.

Oral

Supplementation in cystic fibrosis

Adult: 100-200 mg daily of dl-α-tocoferil acetate or 67-135 mg daily of d-α-tocopherol.

Child: As α- tocopheryl acetate: 1 mth-1 yr 50 mg once daily; 1-12 yr 100 mg once daily; 12-18 yr 200 mg once daily. Dose to be adjusted as needed.

Oral

Abetalipoproteinaemia

Adult: 50-100 mg/kg daily of dl-α-tocoferil acetate or about 33-67 mg/kg daily of d-α-tocopherol.

Child: Neonate: 100 mg/kg once daily; 1 mth-18 yr: 50-100 mg/kg once daily.

Patients with deficiency of B-complex vitamins, Zinc (Oligocare) and Zinc (Oligocare) or where supplementation of these vitamins and Zinc (Oligocare) can be beneficial. Such patients and conditions include: Patients who are on prolonged antibiotic therapy; those who are suffering from infection, injuries, burns, fever, illness; patients with diarrhoea and GI disorders; patients who have undergone surgical operations; patients on diet restrictions eg, in diabetes, anorexia and alcoholism and in elderly persons; pregnant and lactating women due to increased nutritional needs.

Vitamins are compounds that you must have for growth and health. They are needed in small amounts only and are usually available in the foods that you eat. Folic acid (Oligocare) (vitamin B 9) is necessary for strong blood.

Lack of Folic acid (Oligocare) may lead to anemia (weak blood). Your health care professional may treat this by prescribing Folic acid (Oligocare) for you.

Some conditions may increase your need for Folic acid (Oligocare). These include:

• Alcoholism
• Anemia, hemolytic
• Diarrhea (continuing)
• Fever (prolonged)
• Hemodialysis
• Illness (prolonged)
• Intestinal diseases
• Liver disease
• Stress (continuing)
• Surgical removal of stomach

In addition, infants smaller than normal, breast-fed infants, or those receiving unfortified formulas (such as evaporated milk or goat's milk) may need additional Folic acid (Oligocare).

Increased need for Folic acid (Oligocare) should be determined by your health care professional.

Some studies have found that Folic acid (Oligocare) taken by women before they become pregnant and during early pregnancy may reduce the chances of certain birth defects (neural tube defects).

Claims that Folic acid (Oligocare) and other B vitamins are effective for preventing mental problems have not been proven. Many of these treatments involve large and expensive amounts of vitamins.

Injectable Folic acid (Oligocare) is given by or under the direction of your health care professional. Another form of Folic acid (Oligocare) is available without a prescription.

The use of Ginseng extract (Oligocare) in cultural and traditional settings may differ from concepts accepted by current Western medicine. When considering the use of herbal supplements, consultation with a primary health care professional is advisable. Additionally, consultation with a practitioner trained in the uses of herbal/health supplements may be beneficial, and coordination of treatment among all health care providers involved may be advantageous.

A number of Ginseng extract (Oligocare) species used in herbal products grow around the world. Some of these plants include American Ginseng extract (Oligocare), Korean Ginseng extract (Oligocare), Sanchi Ginseng extract (Oligocare), Chikusetsu Ginseng extract (Oligocare), Himalayan Ginseng extract (Oligocare), zhuzishen, and dwarf Ginseng extract (Oligocare). Ginseng extract (Oligocare) is also known as Siberian Ginseng extract (Oligocare), devil's shrub, eleuthero, touch-me-not, and wild pepper.

Ginseng extract (Oligocare) has been used to improve the body's resistance to stress and to increase vitality.

Ginseng extract (Oligocare) has not been evaluated by the FDA for safety, effectiveness, or purity. All potential risks and/or advantages of Ginseng extract (Oligocare) wort may not be known. Additionally, there are no regulated manufacturing standards in place for these compounds. There have been instances where herbal/health supplements have been sold which were contaminated with toxic metals or other drugs. Herbal/health supplements should be purchased from a reliable source to minimize the risk of contamination.

Ginseng extract (Oligocare) may also have uses other than those listed in this product guide.

Supplementing Iron (Oligocare) in the diet and treating or preventing low levels of Iron (Oligocare) in the blood. It may also be used for other conditions as determined by your doctor.

Iron (Oligocare) suspension is a mineral. It works by providing Iron (Oligocare) to the body.

Manganese (Oligocare) supplements are used to prevent or treat Manganese (Oligocare) deficiency.

The body needs Manganese (Oligocare) for normal growth and health. For patients who are unable to get enough Manganese (Oligocare) in their regular diet or who have a need for more Manganese (Oligocare), Manganese (Oligocare) supplements may be necessary. Manganese (Oligocare) helps your body break down fats, carbohydrates, and proteins. It does so as part of several enzymes.

Manganese (Oligocare) deficiency has not been reported in humans. Lack of Manganese (Oligocare) in animals has been found to cause improper formation of bone and cartilage, may decrease the body's ability to use sugar properly, and may cause growth problems.

Injectable Manganese (Oligocare) supplements are given by or under the supervision of a health care professional.

Selenium (Oligocare) is mineral that is found in soil and occurs naturally in certain foods (such as whole grains, Brazil nuts, sunflower seeds, and seafood). Selenium (Oligocare) is not produced in the body, but it is needed for proper thyroid and immune system function.

Selenium (Oligocare) is used to treat or prevent Selenium (Oligocare) deficiency.

Selenium (Oligocare) has been used in alternative medicine as an aid to treat Hashimoto's thyroiditis (an autoimmune disorder of the thyroid), and to treat high cholesterol.

Not all uses for Selenium (Oligocare) have been approved by the FDA. Selenium (Oligocare) should not be used in place of medication prescribed for you by your doctor.

Selenium (Oligocare) may also be used for purposes not listed in this product guide.

Ubiquinone is a vitamin-like substance that is made naturally in the body. Ubiquinone is also known as Coenzima, Ubidcarenone, Ubidécarénone, and Ubiquinol.

Ubiquinone has been used in alternative medicine as a likely effective aid in treating coenzyme Q-10 deficiency, or reducing the symptoms of mitochondrial disorders (conditions that affect energy-production in the cells of the body).

Ubiquinone is also possibly effective in preventing migraine headaches, lowering blood pressure, preventing a second heart attack, or slowing the progression of early Parkinson's disease. Ubiquinone is also possibly effective in improving symptoms in people with congestive heart failure, nerve problems caused by diabetes, Huntington's disease, muscular dystrophy, or macular degeneration (age-related vision loss).

Ubiquinone has also been used to treat Alzheimer's disease, high cholesterol, or amyotrophic lateral sclerosis (Lou Gehrig's disease). However, research has shown that ubiquinone may not be effective in treating these conditions.

Research also has shown that ubiquinone is not likely to be effective in increasing athletic performance.

Other uses not proven with research have included treating asthma, COPD, cancer, diabetes, certain heart problems, fibromyalgia, hepatitis C, kidney problems, high blood pressure during pregnancy, muscle problems caused by taking "statin" cholesterol medicine, and other conditions.

Ubiquinone is often sold as an herbal supplement. There are no regulated manufacturing standards in place for many herbal compounds and some marketed supplements have been found to be contaminated with toxic metals or other drugs. Herbal/health supplements should be purchased from a reliable source to minimize the risk of contamination.

Ubiquinone may also be used for purposes not listed in this product guide.

Vitamins are compounds that you must have for growth and health. They are needed in small amounts only and are usually available in the foods that you eat. Vitamin A (Oligocare) is needed for night vision and for growth of skin, bones, and male and female reproductive organs. In pregnant women Vitamin A (Oligocare) is necessary for the growth of a healthy fetus.

Lack of Vitamin A (Oligocare) may lead to a rare condition called night blindness (problems seeing in the dark), as well as dry eyes, eye infections, skin problems, and slowed growth. Your health care professional may treat these problems by prescribing Vitamin A (Oligocare) for you.

Some conditions may increase your need for Vitamin A (Oligocare). These include:

• Diarrhea
• Eye diseases
• Intestine diseases
• Infections (continuing or chronic)
• Measles
• Pancreas disease
• Stomach removal
• Stress (continuing)

In addition, infants receiving unfortified formula may need Vitamin A (Oligocare) supplements.

Vitamin A (Oligocare) absorption will be decreased in any condition in which fat is poorly absorbed.

Increased need for Vitamin A (Oligocare) should be determined by your health care professional.

Claims that Vitamin A (Oligocare) is effective for treatment of conditions such as acne or lung diseases, or for treatment of eye problems, wounds, or dry or wrinkled skin not caused by lack of Vitamin A (Oligocare) have not been proven. Although Vitamin A (Oligocare) is being used to prevent certain types of cancer, some experts feel there is not enough information to show that this is effective, particularly in well-nourished individuals.

Injectable Vitamin A (Oligocare) is given by or under the supervision of a health care professional. Other forms of Vitamin A (Oligocare) are available without a prescription.

Pyridoxine is Vitamin B6 (Oligocare). Vitamins occur naturally in foods such as meat, poultry, nuts, whole grains, bananas, and avocados. Vitamin B6 (Oligocare) is important for many processes in the body.

Pyridoxine is used to treat or prevent Vitamin B6 (Oligocare) deficiency. It is also used to treat a certain type of anemia (lack of red blood cells). Pyridoxine injection is also used to treat some types of seizure in babies.

Pyridoxine taken by mouth (oral) is available without a prescription. Injectable pyridoxine must be given by a healthcare professional.

Pyridoxine may also be used for purposes not listed in this medication guide.

Ascorbic acid (Vitamin C (Oligocare)) occurs naturally in foods such as citrus fruit, tomatoes, potatoes, and leafy vegetables. Vitamin C (Oligocare) is important for bones and connective tissues, muscles, and blood vessels. Vitamin C (Oligocare) also helps the body absorb iron, which is needed for red blood cell production.

Ascorbic acid is used to treat and prevent Vitamin C (Oligocare) deficiency.

Ascorbic acid may also be used for purposes not listed in this medication guide.

Cholecalciferol is a Vitamin D3 (Oligocare). Vitamin D is important for the absorption of calcium from the stomach and for the functioning of calcium in the body.

Cholecalciferol is used to treat or prevent many conditions caused by a lack of vitamin D, especially conditions of the skin or bones.

Cholecalciferol may also be used for purposes not listed in this medication guide.

Vitamin E (Oligocare) is an antioxidant that occurs naturally in foods such as nuts, seeds, and leafy green vegetables. Vitamin E (Oligocare) is a fat-soluble vitamin important for many processes in the body.

Vitamin E (Oligocare) is used to treat or prevent Vitamin E (Oligocare) deficiency. People with certain diseases may need extra Vitamin E (Oligocare).

Vitamin E (Oligocare) may also be used for purposes not listed in this medication guide.

Zinc (Oligocare) is a naturally occurring mineral. Zinc (Oligocare) is important for growth and for the development and health of body tissues.

Zinc (Oligocare) sulfate is used to treat and to prevent Zinc (Oligocare) deficiency.

Zinc (Oligocare) sulfate may also be used for purposes not listed in this medication guide.

Copper (Oligocare) 0.4 mg/mL (Cupric Chloride Injection, USP) contains 0.4 mg Copper (Oligocare)/mL and is administered intravenously only after dilution. The additive should be diluted in a volume of fluid not less than 100 mL. For the adult receiving TPN, the suggested additive dosage is 0.5 to 1.5 mg Copper (Oligocare)/day (1.25 to 3.75 mL/day). For pediatric patients, the suggested additive dosage is 20 mcg Copper (Oligocare)/kg/day (0.05 mL/kg/day). Infants weighing less than 1500 gm may have increased requirements because of their low body reserves and increased requirements for growth.

Parenteral drug products should be inspected visually for particulate matter and discoloration prior to administration, whenever solution and container permit.

Usual Adult Dose for Megaloblastic Anemia

1 mg orally, intramuscularly, subcutaneously or IV once a day. May continue until clinical symptoms of folate deficiency and the hematological profile have normalized.

Usual Adult Dose for Folic acid (Oligocare) Deficiency

400 to 800 mcg orally, intramuscularly, subcutaneously or IV once a day.

Women of childbearing age, pregnant, and lactating women: 800 mcg orally, intramuscularly, subcutaneously or IV once a day.

Usual Pediatric Dose for Folic acid (Oligocare) Deficiency

Infant:

0.1 mg orally, intramuscularly, subcutaneously or IV once a day.

Child:

Less than 4 years: up to 0.3 mg orally, intramuscularly, subcutaneously or IV once a day.

4 years or older: 0.4 mg orally, intramuscularly, subcutaneously or IV once a day.

Usual Pediatric Dose for Vitamin/Mineral Supplementation

Recommended daily allowance (RDA):

Premature neonates: 50 mcg/day (15 mcg/kg/day).

Full-term neonates and infants 1 to 6 months: 25 to 35 mcg/day.

Children:

1 to 3 years: 150 mcg/day.

4 to 8 years: 200 mcg/day.

9 to 13 years: 300 mcg/day.

14 years and older: 400 mcg/day.

Renal Dose Adjustments

Data not available

Liver Dose Adjustments

Data not available

Dose Adjustments

Rarely, a dosage of 2 mg/day may be required, particularly in patients with malabsorption, alcoholism, chronic hemolysis, chronic exfoliative skin disease or who are on concomitant anticonvulsant therapy.

Dialysis

Folic acid (Oligocare) is removed by both hemodialysis and peritoneal dialysis. The amount removed varies with type equipment used.

Because folate may accumulate in patients with end-stage renal disease, side effects may be more likely in this patient who is undergoing dialysis. Once this patient's body stores of folate are replete, three times a week dosing may be just as beneficial as once daily dosing but should portend a lower risk of side effects.

Other Comments

The recommended daily allowance of Folic acid (Oligocare) for adult males and females ranges from 150 to 200 and 150 to 180 mcg/day, respectively.

There is a potential danger in administering Folic acid (Oligocare) to patients with undiagnosed anemia, since Folic acid (Oligocare) may obscure the diagnosis of pernicious anemia by alleviating the hematologic manifestations of the disease while allowing the neurologic complications to progress.

Severe megaloblastic anemia may require therapy for 4 to 5 weeks. Once stabilized, if dietary intake is inadequate, maintenance therapy can be started.

2 caps daily.

Film-Coated Tablet: Treatment of Iron (Oligocare) Deficiency with Reduced Number of Red Blood Cells in Adults and Children over 12 Years: 1 to 3 tablets once daily or divided into separate doses for about 3 to 5 months.

After normalisation of the red blood pigment (haemoglobin) value, continue with 1 tablet once daily for several weeks. This will replenish the Iron (Oligocare) stores.

Treatment of Iron (Oligocare) Deficiency with Reduced Number of Red Blood Cells in Pregnancy: 2 to 3 tablets once daily or divided into separate doses.

After normalisation of the red blood pigment value, continue with 1 tablet once daily until, at least, the end of pregnancy. This will replenish the Iron (Oligocare) stores and provide the increased amount of Iron (Oligocare) required during pregnancy.

Treatment of Iron (Oligocare) Deficiency with Normal Number of Red Blood Cells in Adults, Pregnancy, and Children over 12 years, and Prevention of Iron (Oligocare) Deficiency in Pregnancy: 1 tablet once daily for 1 to 2 months.

Syrup:

Children: 5 mL 1 to 2 times daily before meals.

Infants: Begin with 2.5 mL daily and gradually increase to 5 mL daily.

Drops: Adults: 20 drops 2 to 3 times daily during or after a meal.

Children: 20 drops 1 to 2 times daily during or after a meal.

Infants: Begin with 6 drops daily and gradually increase to 20 drops daily.

Iron (Oligocare) may be mixed with fruit, vegetable juices or other liquids if desired.

Best results are obtained by adequate dosage and regular administration. It is recommended that the therapy in conformity to the degree of Iron (Oligocare) deficiency should be continued for at least 1 to 2 months.

Administration: Take Iron (Oligocare) during or immediately after meal.

Duration of use depends upon the degree of Iron (Oligocare) deficiency.

Do not discontinue sooner than recommended as this may reduce the success of therapy.

Dosage depends on the severity of the catabolic state & amino acid requirement. Daily dose: 10-20ml/kg body wt equiv to 1-2g amino acids/kg body wt. Maximum daily dosage not >2g amino acids/kg body wt.

Dosage Forms

Excipient information presented when available (limited, particularly for generics); consult specific product labeling. [DSC] = Discontinued product

Capsule,

Oral, as chelated:

MN-50: Elemental Manganese (Oligocare) 16.67 mg

Solution,

Intravenous, as chloride:

Generic: Elemental Manganese (Oligocare) 0.1 mg/mL (10 mL)

Solution,

Intravenous, as sulfate [preservative free]:

Generic: Elemental Manganese (Oligocare) 0.1 mg/mL (10 mL)

Tablet,

Oral, as aspartate:

Generic: 93 mg [elemental Manganese (Oligocare) 25 mg]

Tablet,

Oral, as chelated:

Manganese (Oligocare): Elemental Manganese (Oligocare) 10 mg [corn free, rye free, wheat free]

Generic: Elemental Manganese (Oligocare) 15 mg [DSC], Elemental Manganese (Oligocare) 50 mg

Tablet,

Oral, as gluconate:

Generic: 50 mg [elemental Manganese (Oligocare) 5.7 mg]

Dosing: Adult

Parenteral nutrition, maintenance requirement:

Expert recommendations favor the use of lower doses in the range of 60 to 100 mcg/day to avoid neurotoxicity with routine use and those with cholestatic jaundice. However, these recommendations are difficult to follow with the current sources of parenteral Manganese (Oligocare) (ASPEN [Vanek 2012]).

Dosing: Geriatric

Refer to adult dosing.

Dosing: Pediatric

Parenteral nutrition, maintenance requirement:

Expert recommendations suggest decreasing the daily dose for infants and children to 1 mcg/kg/day (up to a maximum of 50 mcg/day). However, these recommendations are difficult to follow with the current sources of parenteral Manganese (Oligocare) (ASPEN [Vanek 2012]).

Note: Use caution in premature neonates; Manganese (Oligocare) chloride solution for injection contains aluminum.

Mecobalamin (Oligocare) SHOULD ONLY BE ADMINISTERED INTRAVENOUSLY.

Mecobalamin (Oligocare), like other long-acting neuromuscular blocking agents, displays variability in the duration of its effect. The potential for a prolonged clinical duration of neuromuscular block must be considered when Mecobalamin (Oligocare) is selected for administration. The dosage information provided below is intended as a guide only. Doses should be individualized. Factors that may warrant dosage adjustment include: advancing age, the presence of kidney or liver disease, or obesity (patients weighing ≥ 30% more than ideal body weight for height). The use of a peripheral nerve stimulator will permit the most advantageous use of Mecobalamin (Oligocare), minimize the possibility of overdosage or underdosage, and assist in the evaluation of recovery.

Parenteral drug products should be inspected visually for particulate matter and discoloration prior to administration whenever solution and container permit.

Adults

Initial Doses

When administered as a component of a thiopental/narcotic induction-intubation paradigm as well as for production of long-duration neuromuscular block during surgery, 0.05 mg/kg (2 × ED95) Mecobalamin (Oligocare) produces good-to-excellent conditions for tracheal intubation in 5 minutes in approximately 90% of patients. Lower doses of Mecobalamin (Oligocare) may result in a longer time for development of satisfactory intubation conditions. Clinically effective neuromuscular block may be expected to last approximately 100 minutes on average (range: 39 to 232) following 0.05 mg/kg Mecobalamin (Oligocare) administered to patients receiving balanced anesthesia.

An initial Mecobalamin (Oligocare) dose of 0.08 mg/kg (3 × ED95) should be reserved for instances in which a need for very prolonged neuromuscular block is anticipated. In approximately 90% of patients, good-to-excellent intubation conditions may be expected in 4 minutes after this dose; however, clinically effective block may be expected to persist for as long as 160 minutes or more (range: 110 to 338).

If Mecobalamin (Oligocare) is administered during steady-state isoflurane, enflurane, or halothane anesthesia, reduction of the dose of Mecobalamin (Oligocare) by one third should be considered.

When succinylcholine is administered to facilitate tracheal intubation in patients receiving balanced anesthesia, an initial dose of 0.025 mg/kg (ED95) Mecobalamin (Oligocare) provides about 60 minutes (range: 9 to 145) of clinically effective neuromuscular block for surgery. For a longer duration of action, a larger initial dose may be administered.

Maintenance Doses

Maintenance dosing will generally be required about 60 minutes after an initial dose of 0.025 mg/kg Mecobalamin (Oligocare) or 100 minutes after an initial dose of 0.05 mg/kg Mecobalamin (Oligocare) during balanced anesthesia. Repeated maintenance doses administered at 25% T1 recovery may be expected to be required at relatively regular intervals in each patient. The interval may vary considerably between patients. Maintenance doses of 0.005 and 0.01 mg/kg Mecobalamin (Oligocare) each provide an average 30 minutes (range: 9 to 57) and 45 minutes (range: 14 to 108), respectively, of additional clinically effective neuromuscular block. For shorter or longer desired durations, smaller or larger maintenance doses may be administered.

Children

When administered during halothane anesthesia, an initial dose of 0.03 mg/kg (ED95) produces maximum neuromuscular block in about 7 minutes (range: 5 to 11) and clinically effective block for an average of 30 minutes (range: 12 to 54). Under halothane anesthesia, 0.05 mg/kg produces maximum block in about 4 minutes (range: 2 to 10) and clinically effective block for 45 minutes (range: 30 to 80). Maintenance doses are generally required more frequently in children than in adults. Because of the potentiating effect of halothane seen in adults, a higher dose of Mecobalamin (Oligocare) may be required in children receiving balanced anesthesia than in children receiving halothane anesthesia to achieve a comparable onset and duration of neuromuscular block. Mecobalamin (Oligocare) has not been studied in pediatric patients below the age of 2 years.

Compatibility

Y-site Administration

Mecobalamin (Oligocare) Injection may not be compatible with alkaline solutions with a pH greater than 8.5 (e.g., barbiturate solutions).

Mecobalamin (Oligocare) is compatible with:

• 5% Dextrose Injection, USP
• 0.9% Sodium Chloride Injection, USP
• 5% Dextrose and 0.9% Sodium Chloride Injection, USP
• Lactated Ringer's Injection, USP
• 5% Dextrose and Lactated Ringer's Injection
• Sufenta® (sufentanil citrate) Injection, diluted as directed
• Alfenta® (alfentanil hydrochloride) Injection, diluted as directed
• Sublimaze® (fentanyl citrate) Injection, diluted as directed

Mecobalamin (Oligocare) diluted up to 1:10 in 5% Dextrose Injection, USP or 0.9% Sodium Chloride Injection, USP has been shown to be physically and chemically stable when stored in polypropylene syringes at 5° to 25°C (41° to 77°F), for up to 24 hours. Since dilution diminishes the preservative effectiveness of benzyl alcohol, aseptic techniques should be used to prepare the diluted product. Immediate use of the diluted product is preferred, and any unused portion of diluted Mecobalamin (Oligocare) should be discarded after 8 hours.

Selenium (Oligocare) Injection provides 40 mcg Selenium (Oligocare)/mL. For metabolically stable adults receiving TPN, the suggested additive dosage level is 20 to 40 mcg Selenium (Oligocare)/day. For pediatric patients, the suggested additive dosage level is 3 mcg/kg/day.

In adults, Selenium (Oligocare) deficiency states resulting from long-term TPN support, Selenium (Oligocare) as selenomethionine or selenious acid, administered intravenously at 100 mcg/day for a period of 24 and 31 days, respectively, has been reported to reverse deficiency symptoms without toxicity.

Aseptic addition of Selenium (Oligocare) Injection to the TPN solution under laminar flow hood is recommended. Selenium (Oligocare) is physically compatible with the electrolytes and other trace elements usually present in amino-acid/dextrose solution used for TPN. Frequent monitoring of plasma Selenium (Oligocare) levels is suggested as a guideline for subsequent administration. The normal whole blood range for Selenium (Oligocare) is approximately 10 to 37 mcg/100 mL.

Parenteral drug products should be inspected visually for particulate matter and discoloration, whenever solution and container permit.

Oral

Heart failure

Adult: 50-150 mg daily in 2-3 divided doses.

Oral

Angina pectoris

Adult: 150-600 mg daily in divided doses.

Usual Adult Dose for Vitamin A (Oligocare) Deficiency

Initial dose: 100,000 Units intramuscularly once a day for 3 days

Maintenance dose: 50,000 Units intramuscularly once a day for 2 weeks

Use: Treatment of Vitamin A (Oligocare) deficiency when oral administration is not feasible or not available (e.g. anorexia, nausea, vomiting, pre- or post-operative conditions, "Malabsorption Syndrome" with accompanying steatorrhea)

Usual Adult Dose for Vitamin/Mineral Supplementation

US Recommended Dietary Allowance (RDA):

Adult male: 900 mcg retinol activity equivalents (RAE) (3000 international units [IU])

Tolerable Upper Intake Level (UL): 3000 mcg RAE (10,000 IU)

Adult female: 700 mcg RAE (2330 IU)

UL: 3000 mcg RAE (10,000 IU)

Comments:

-The Vitamin A (Oligocare) RDA is given as mcg of retinol activity equivalents (RAE) to account for the different bioactivities of retinol and provitamin A carotenoids.

-The body converts all dietary Vitamin A (Oligocare) into retinol; 2 mcg of beta-carotene from dietary supplements is converted to 1 mcg of retinol.

-The tolerable upper intake level is the maximum daily intake that is unlikely to have adverse health effects.

Usual Pediatric Dose for Vitamin A (Oligocare) Deficiency

Infants (under 1 year): 7500 to 15,000 Units intramuscularly once a day

Duration of therapy: 10 days

1 to 8 years: 17,500 to 35,000 Units intramuscularly once a day

Duration of therapy: 10 days

Adult dose:

Initial dose: 100,000 Units intramuscularly once a day for 3 days

Maintenance dose: 50,000 Units intramuscularly once a day for 2 weeks

Use: Treatment of Vitamin A (Oligocare) deficiency when oral administration is not feasible or not available (e.g. anorexia, nausea, vomiting, pre- or post-operative conditions, "Malabsorption Syndrome" with accompanying steatorrhea)

Usual Pediatric Dose for Vitamin/Mineral Supplementation

US Recommended Dietary Allowance (RDA):

0 to 6 months: 400 mcg retinol activity equivalents (RAE) (1332 international units [IU])

Tolerable Upper Intake Level (UL): 600 mcg RAE (2000 IU)

7 to 12 months: 500 mcg RAE (1665 IU)

UL: 600 mcg RAE (2000 IU)

1 to 3 years: 300 mcg RAE (1000 IU)

UL: 900 mcg RAE (3000 IU)

4 to 8 years: 400 mcg RAE (1332 IU)

UL: 900 mcg RAE (3000 IU)

9 to 13 years: 600 mcg RAE (2000 IU)

UL: 1700 mcg RAE (5667 IU)

14 to 18 years, male: 900 mcg RAE (3000 IU)

UL: 2800 mcg RAE (9333 IU)

14 to 18 years, female: 700 mcg RAE (2330 IU)

UL: 2800 mcg RAE (9333 IU)

Comments:

-The Vitamin A (Oligocare) RDA is given as mcg of retinol activity equivalents (RAE) to account for the different bioactivities of retinol and provitamin A carotenoids.

-The body converts all dietary Vitamin A (Oligocare) into retinol; 2 mcg of beta-carotene from dietary supplements is converted to 1 mcg of retinol.

-The tolerable upper intake level is the maximum daily intake that is unlikely to have adverse health effects.

Renal Dose Adjustments

Data not available

Liver Dose Adjustments

Data not available

Dose Adjustments

US Recommended Dietary Allowance (RDA):

Pregnancy:

14 to 18 years: 750 mcg retinol activity equivalents (RAE) (2500 international units [IU])

UL: 2800 mcg RAE (9333 IU)

18 to 50 years: 770 mcg RAE (2564 IU)

UL: 3000 mcg RAE (10,000 IU)

Lactation:

14 to 18 years: 1200 mcg RAE (2564 IU)

UL: 2800 mcg RAE (9333 IU)

18 to 50 years: 1300 mcg RAE (4329 IU)

UL: 3000 mcg RAE (10,000 IU)

Comments:

-The Vitamin A (Oligocare) RDA is given as mcg of retinol activity equivalents (RAE) to account for the different bioactivities of retinol and provitamin A carotenoids.

-The body converts all dietary Vitamin A (Oligocare) into retinol; 2 mcg of beta-carotene from dietary supplements is converted to 1 mcg of retinol.

-The tolerable upper intake level is the maximum daily intake that is unlikely to have adverse health effects.

Precautions

CONTRAINDICATIONS:

-Administration of the intramuscular formulation intravenously

-Hypervitaminosis A

-Hypersensitivity to any of the ingredients

-The safety of doses exceeding 6000 units Vitamin A (Oligocare) in pregnancy has not been established. Use of high doses in pregnancy or patients who may become pregnant is contraindicated. Doses above the recommended dietary allowance (RDA) may cause fetal harm; fetal abnormalities (central nervous system, eye, and palate malformations) were seen in animal overdose models. If patients become pregnant, apprise them of potential fetal harms.

Consult WARNINGS section for additional precautions.

Dialysis

Data not available

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer

This medication administered orally, IM, IV, intravaginally.

For the prevention of deficiency conditions All Natural Source Juicy Orange Vitamin C (Oligocare) dose is 25-75 mg / day, for the treatment - 250 mg / day or more in divided doses.

For intravaginal used ascorbic acid drugs in appropriate dosage forms.

1 tab daily.

Usual Adult Dose for Vitamin E (Oligocare) Deficiency

Treatment: 60 to 75 units orally once daily.

Prevention: 30 units orally once daily.

Usual Adult Dose for Tardive Dyskinesia

600 to 1600 units orally per day.

Usual Adult Dose for Sickle Cell Anemia

450 units orally per day.

Usual Adult Dose for Alzheimer's Disease

1000 units orally twice daily.

Usual Adult Dose for Dietary Supplement

Oral liquid formulation (Vitamin E (Oligocare)): 200 units (10 mL) orally once daily.

Usual Pediatric Dose for Vitamin E (Oligocare) Deficiency

1 unit/kg/day orally of water-miscible Vitamin E (Oligocare).

Usual Pediatric Dose for Retinopathy Prophylaxis

Prevention of retinopathy of prematurity or Bronchopulmonary dysplasia (BPD) secondary to oxygen therapy: 15 to 30 units/kg/day to maintain plasma levels between 1.5 to 2 mcg/mL (may need as high as 100 units/kg/day). Note: AAP considers this use investigational and routine use is not recommended.

Usual Pediatric Dose for Cystic Fibrosis

100 to 400 units/day orally.

Usual Pediatric Dose for Dietary Supplement

Dosing: 1 unit Vitamin E (Oligocare) = 1 mg dl-alpha-tocopherol acetate.

Oral:

Adequate Intake (AI):

1 to less than 6 months: 4 units daily

6 to less than 12 months: 5 units daily

Recommended Daily Allowance (RDA):

1 to 3 years: 6 units daily

4 to 8 years: 7 units daily

9 to 13 years: 11 units daily

13 years and Older: 15 units daily

Renal Dose Adjustments

Data not available

Liver Dose Adjustments

Data not available

Precautions

Although no longer available in the U.S., Vitamin E (Oligocare) injectable administered intravenously to premature infants may result in a potentially fatal syndrome consisting of thrombocytopenia, hepatomegaly, splenomegaly, ascites, and renal, hepatic, and pulmonary dysfunction.

Oral administration of large doses (200 mg per day) of a hyperosmolar Vitamin E (Oligocare) preparation to low-birthweight infants has been associated with the development of necrotizing enterocolitis.

Dialysis

Data not available

Other Comments

The oral liquid formulation (Vitamin E (Oligocare) [R]) is intended to enhance absorption in patients with conditions associated with malabsorption (e.g., Crohn's disease, ulcerative colitis ) or for patients who have difficulty swallowing capsules.

The oral liquid formulation (Vitamin E (Oligocare) [R]) may be taken directly or mixed with water or other beverage. It must be shaken well prior to each use and refrigerated after opening.

Zinc (Oligocare) 1 mg/mL (Zinc (Oligocare) Chloride Injection, USP) contains 1 mg Zinc (Oligocare)/mL and is administered intravenously only after dilution. The additive should be diluted prior to administration in a volume of fluid not less than 100 mL. For the metabolically stable adult receiving TPN, the suggested intravenous dosage is 2.5 to 4 mg Zinc (Oligocare)/day (2.5 to 4 mL/day). An additional 2 mg Zinc (Oligocare)/day (2 mL/day) is suggested for acute catabolic states. For the stable adult with fluid loss from the small bowel, an additional 12.2 mg Zinc (Oligocare)/liter of small bowel fluid lost (12.2 mL/liter of small bowel fluid lost), or an additional 17.1 mg Zinc (Oligocare)/kg of stool or ileostomy output (17.1 mL/kg of stool or ileostomy output) is recommended. Frequent monitoring of Zinc (Oligocare) blood levels is suggested for patients receiving more than the usual maintenance dosage level of Zinc (Oligocare).

For full term infants and children up to 5 years of age, 100 mcg Zinc (Oligocare)/kg/day

(0.1 mL/kg/day) is recommended. For premature infants (birth weight less than 1500 g) up to 3 kg in body weight, 300 mcg Zinc (Oligocare)/kg/day (0.3 mL/kg/day) is suggested.

Parenteral drug products should be inspected visually for particulate matter and discoloration prior to administration, whenever solution and container permit. See PRECAUTIONS.

How supplied

Zinc (Oligocare) 1 mg/mL (Zinc (Oligocare) Chloride Injection, USP) is supplied in 10 mL Plastic Vials (List No. 4090).

Store at 20 to 25°C (68 to 77°F).

HOSPIRA, INC., LAKE FOREST, IL 60045 USA. Revised: October, 2004

Pregnancy or suspected malignant genital tumor of its existence, acute inflammation, subacute or chronic genital tract, congenital or acquired anatomic abnormalities of the uterus and cervix, endometriosis, malposition and malsituaciones accused the uterus, uterine hypoplasia, genital bleeding of unknown etiology blood clotting disorders, Wilson’s disease, allergy to Copper (Oligocare).

See also:
What is the most important information I should know about Folic acid (Oligocare)?

Because it may mask the hematologic abnormalities while neurological damage progresses, Folic acid (Oligocare) should not be used in the therapy of patients with vitamin B12 deficiency of any cause, unless there is associated folate deficiency. The Folic acid (Oligocare) content of one tablet a day however, is unlikely to mask pernicious anemia should this condition be present. Also, pregnancy during pernicious anemia is very rare.

See also:
What is the most important information I should know about Ginseng extract (Oligocare)?

Should not be used by persons with hypoglycaemia, insulin dependent diabetes, high blood pressure or heart disorders, unless approved by their physician.

See also:
What is the most important information I should know about Iron (Oligocare)?

All cases of Iron (Oligocare) overload and disturbances in utilization of Iron (Oligocare).

Film-Coated Tablet: Allergy to Iron (Oligocare) (III)-hydroxide polymaltose complex or any of the other ingredients of Iron (Oligocare).

An Iron (Oligocare) overload in the body.

Disturbed use of Iron (Oligocare) by the body.

Reduced number of red blood cells (anaemia), not caused by Iron (Oligocare) deficiency, such as due to increased red blood cell breakdown, vitamin B₁₂ deficiency.

Most Significant

Lactating Mother, Pregnancy, Prostatic Carcinoma, Selenium Toxicity, Wilson’s Disease

Possibly Significant

Vitamin K Deficiency Induced Hypoprothrombinemia

There are no contraindications listed within the manufacturer's US labeling.

Mecobalamin (Oligocare) (doxacurium chloride) is contraindicated in patients with known hypersensitivity to the product and its components. Mecobalamin (Oligocare) (doxacurium chloride) is contraindicated for use in premature infants because the formulation contains benzyl alcohol.

See also:
What is the most important information I should know about Selenium (Oligocare)?

Selenium (Oligocare) Injection should not be given undiluted by direct injection into a peripheral vein because of the potential for infusion phlebitis.

See also:
What is the most important information I should know about Ubidecarenone (Oligocare)?

Young children, pregnant or lactating women or those with severe liver or kidney diseases.

See also:
What is the most important information I should know about Vitamin A (Oligocare)?

The intravenous administration. Hypervitaminosis A. Sensitivity to any of the ingredients in this preparation. Use in Pregnancy: Safety of amounts exceeding 6,000 Units of Vitamin A (Oligocare) daily during pregnancy has not been established at this time. The use of Vitamin A (Oligocare) in excess of the recommended dietary allowance may cause fetal harm when administered to a pregnant woman. Animal reproduction studies have shown fetal abnormalities associated with overdosage in several species. Malformations of the central nervous system, the eye, the palate, and the urogenital tract are recorded. Vitamin A (Oligocare) in excess of the recommended dietary allowance is contraindicated in women who are or may become pregnant. If Vitamin A (Oligocare) is used during pregnancy, or if the patient becomes pregnant while taking Vitamin A (Oligocare), the patient should be apprised of the potential hazard to the fetus.

Contraindications for Vitamin B1 (Vitamin B1 nitrate (Oligocare))

Hypersensitivity to vitamin B1 or any component of a product containing vitamin B1.

Contraindications for Vitamin B6 (Oligocare) (Vitamin B6 (Oligocare))

Vitamin B6 (Oligocare) is contraindicated in those hypersensitive to any component of a Vitamin B6 (Oligocare)-containing product.

AV-block II and III degree, sinoatrial block, SSS, bradycardia (HR < 40 bpm), hypotension (in case of myocardial infarction, systolic blood pressure less than 100 mm Hg), cardiogenic shock, congestive heart failure IIB-III stages, acute heart failure, Prinzmetal's angina, lactation, concomitant use of MAO inhibitors, hypersensitivity to atenolol.

Contraindications for vitamin D analogues (Vitamin D2, Vitamin D3 (Oligocare), Calcitriol, and Calcidiol)

Vitamin D should not be given to patients with hypercalcemia or evidence of vitamin D toxicity. Use of vitamin D in patients with known hypersensitivity to vitamin D (or drugs of the same class) or any of the inactive ingredients is contraindicated.

See also:
What is the most important information I should know about Vitamin E (Oligocare)?

Hypersensitivity to Vitamin E (Oligocare) or any component of the formulation

See also:
What is the most important information I should know about Zinc (Oligocare)?

Hypersensitivity to any of the ingredients of Zinc (Oligocare).

Use Folic acid (Oligocare) as directed by your doctor. Check the label on the medicine for exact dosing instructions.

• Folic acid (Oligocare) may be administered as an injection by your health care professional.
• If you are using Folic acid (Oligocare) at home, carefully follow the injection procedures taught to you by your health care provider. If the medicine contains particles, is discolored, or if the vial is cracked or damaged in any way, do not use it.
• Do not reuse needles, syringes, or other materials. Dispose of properly after use. Ask your doctor, nurse, or pharmacist to explain local regulations for selecting an appropriate container and properly disposing of the container when full.
• If you miss a dose of Folic acid (Oligocare), use it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not use 2 doses at once.

Ask your health care provider any questions you may have about how to use Folic acid (Oligocare).

Use Ginseng extract (Oligocare) as directed by your doctor. Check the label on the medicine for exact dosing instructions.

• Take Ginseng extract (Oligocare) with a meal.
• There are different types of Ginseng extract (Oligocare), which vary widely in quality. Read product labeling carefully.
• Ginseng extract (Oligocare) may cause trouble sleeping. Do not take it in the early evening or at bedtime.
• If you miss taking a dose of Ginseng extract (Oligocare) for 1 or more days, there is no cause for concern. If your doctor recommended that you take it, try to remember to take your dose every day.

Ask your health care provider any questions you may have about how to use Ginseng extract (Oligocare).

Use Iron (Oligocare) suspension as directed by your doctor. Check the label on the medicine for exact dosing instructions.

• Iron (Oligocare) suspension is absorbed better on an empty stomach but may be taken with food if it upsets your stomach. Some foods (eg, eggs, whole grain breads, cereal, dairy products, coffee, tea) may decrease the amount of Iron (Oligocare) absorbed by your body. Talk with your doctor about the best way to take Iron (Oligocare) suspension with food if it upsets your stomach.
• Shake well before using.
• Use a measuring device marked for medicine dosing. Ask your pharmacist for help if you are unsure of how to measure your dose.
• Take Iron (Oligocare) suspension with a full glass (8 oz [240 mL]) of water.
• Do not lie down for 30 minutes after taking Iron (Oligocare) suspension.
• If you take an antacid, a bisphosphonate (eg, alendronate), cefdinir, eltrombopag, methyldopa, penicillamine, a quinolone antibiotic (eg, ciprofloxacin), or a tetracycline (eg, minocycline), ask your doctor or pharmacist how to take it with Iron (Oligocare) suspension.
• If you miss a dose of Iron (Oligocare) suspension, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Iron (Oligocare) suspension.

Use Selenium (Oligocare) lotion as directed by your doctor. Check the label on the medicine for exact dosing instructions.

• Shake well before each use.
• Remove jewelry before using Selenium (Oligocare) lotion.
• Do not use on broken or inflamed skin or scalp.
• To use Selenium (Oligocare) lotion on the scalp - Massage 1 or 2 teaspoonfuls of the medicine on the wet scalp. Leave on the scalp for 2 to 3 minutes. Rinse scalp thoroughly. Wash hands well after treatment. If you are using Selenium (Oligocare) lotion before or after bleaching, tinting, or permanent waving of hair, rinse hair for at least 5 minutes in cool running water.
• To use Selenium (Oligocare) lotion on the skin - Apply a sufficient amount to cover affected areas of the body. Lather well with a small amount of water. Leave the medicine on the skin for 10 minutes. Rinse thoroughly in the shower. Wash hands well after treatment.
• If you miss a dose of Selenium (Oligocare) lotion, use it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not use 2 doses at once

Ask your health care provider any questions you may have about how to use Selenium (Oligocare) lotion.

Follow all directions on your prescription label. Do not use this medicine in larger or smaller amounts or for longer than recommended.

Pyridoxine tablets are taken by mouth. Injectable pyridoxine is injected into a muscle or into a vein through an IV. You may be shown how to use injections at home. Do not self-inject this medicine if you do not understand how to give the injection and properly dispose of used needles, IV tubing, and other items used to inject the medicine.

The recommended dietary allowance of pyridoxine increases with age. Follow your healthcare provider's instructions. You may also consult the Office of Dietary Supplements of the National Institutes of Health, or the U.S. Department of Agriculture (USDA) Nutrient Database (formerly "Recommended Daily Allowances") listings for more information.

Pyridoxine is only part of a complete program of treatment that may also include a special diet. It is very important to follow the diet plan created for you by your doctor or nutrition counselor. You should become very familiar with the list of foods you should eat or avoid to help control your condition.

Store at room temperature away from moisture and heat.

Use: Labeled Indications

Trace element added to parenteral nutrition (PN) to prevent Copper (Oligocare) deficiency; orally as a dietary supplement

Folic acid (Oligocare) is the man-made form of folate. Folate is a B-vitamin naturally found in some foods. It is needed to form healthy cells, especially red blood cells.

Folic acid (Oligocare) supplements may come in different forms (such as L-methylfolate, levomefolate, methyltetrahydrofolate). They are used to treat or prevent low folate levels. Low folate levels can lead to certain types of anemia. Conditions that can cause low folate levels include poor diet, pregnancy, alcoholism, liver disease, certain stomach/intestinal problems, kidney dialysis, among others. Women of childbearing age should receive adequate amounts of Folic acid (Oligocare) either through their diet or supplements to prevent infant spinal cord birth defects.

How to use Folic acid (Oligocare)

Take this product by mouth with or without food as directed by your doctor, usually once daily. If you are taking the over-the-counter product, follow all directions on the product package. If you have any questions, ask your doctor or pharmacist.

Dosage is based on your medical condition and response to treatment. Do not increase your dose or take this product more often than directed.

Take this product regularly to get the most benefit from it. To help you remember, take it at the same time each day. Follow the diet plan recommended by your doctor or dietician. See also Notes section.

If your condition persists or worsens, or if you think you may have a serious medical problem, get medical help right away.

L-arginine (Oligocare) is used for congestive heart failure, chest pain, high blood pressure, and coronary artery disease. L-arginine (Oligocare) is also used for recurrent pain in the legs due to blocked arteries, decreased mental capacity in the elderly, erectile dysfunction, male infertility. L-arginine (Oligocare) for preventing the common cold, improving kidney function after a kidney transplant, high blood pressure during pregnancy (pre-eclampsia), improving athletic performance, boosting the immune system, and preventing inflammation of the digestive tract in premature infants.

Use: Labeled Indications

Trace element added to parenteral nutrition (PN) to prevent Manganese (Oligocare) deficiency; orally as a dietary supplement

Selenium (Oligocare) is used as a dietary supplement mainly in the treatment of Selenium (Oligocare) deficiency affecting young women and children with Keshan disease. It is also used for treatment of osteoarthiritis associated with poor Selenium (Oligocare) levels in body called Kashin-Beck Disease. Selenium (Oligocare) supplements are also used in patients with HIV/ AIDS to maintain the adequate Selenium (Oligocare) levels.

Coenzyme Q10 has been used for heart problems (e.g., heart failure, angina), high blood pressure, Parkinson's disease, gum disease, and certain diseases passed down through families (Huntington's disease, muscular dystrophy). It has also been used for preventing migraine headaches and for preventing cell damage that may occur after surgery or treatment with certain anti-cancer drugs. If you have or think you have any of the conditions listed above, consult your doctor for advice on proper care and treatment.

Coenzyme Q10 is a substance that your body normally makes. Your body uses it to help keep in good health.

Some herbal/diet supplement products have been found to contain possibly harmful impurities/additives. Check with your pharmacist for more details about the brand you use.

The FDA has not reviewed this product for safety or effectiveness. Consult your doctor or pharmacist for more details.

How to use Ubidecarenone (Oligocare)

This product is taken by mouth as directed. Follow all directions on the product package. If you are uncertain about any of the information, consult your doctor or pharmacist.

If you are using a liquid or powder form, carefully measure your dose using a medication-measuring device or spoon. Do not use a household spoon because you may not get the correct dose. If your liquid form is a suspension, shake the bottle well before measuring each dose. If your liquid comes in a tube/ampule, take the dose immediately after opening and discard any left over liquid. Follow the manufacturer's directions for mixing the powder form.

If you are using chewable tablets or wafers, chew each dose thoroughly before swallowing.

If you are using a tablet made to dissolve in the mouth, dry your hands before handling the tablet. Place each dose on the tongue and allow to dissolve completely, then swallow it with saliva or water.

Do not crush or chew extended-release tablets. Doing so can release all of the drug at once, increasing the risk of side effects. Also, do not split the tablets unless they have a score line and your doctor or pharmacist tells you to do so. Swallow the whole or split tablet without crushing or chewing.

If your condition persists or worsens, or if you think you may have a serious medical problem, seek immediate medical attention.

Vitamin A (Oligocare) is used to prevent or treat low levels of the vitamin in people who do not get enough of it from their diets. Most people who eat a normal diet do not need extra Vitamin A (Oligocare). However, some conditions (such as protein deficiency, diabetes, hyperthyroidism, liver/pancreas problems) can cause low levels of Vitamin A (Oligocare). Vitamin A (Oligocare) plays an important role in the body. It is needed for growth and bone development and to maintain the health of the skin and eyesight. Low levels of Vitamin A (Oligocare) may cause vision problems (such as night blindness) and permanent eye damage.

How to use Vitamin A (Oligocare)

Take this vitamin by mouth with or without food, usually once daily. Follow all directions on the product package, or take as directed by your doctor. If you are uncertain about any of the information, consult your doctor or pharmacist.

If you are using the liquid form of this medication, carefully measure the dose using a special measuring device/spoon. Do not use a household spoon because you may not get the correct dose.

Dosage is based on your age, medical condition, and response to treatment.

Use this vitamin regularly to get the most benefit from it. To help you remember, take it at the same time each day. Do not increase your dose or use this vitamin more often than recommended. Your condition will not improve any faster, and your risk of side effects will increase.

Tell your doctor if your condition persists or worsens. If you think you may have a serious medical problem, seek immediate medical attention.

It is used for the treatment and prevention of Vitamin B6 (Oligocare) deficiency. It is important for the breakdown of protein, fats, and carbohydrates from foods.

Ascorbic acid (Vitamin C (Oligocare)) is used to prevent or treat low levels of Vitamin C (Oligocare) in people who do not get enough of the vitamin from their diets. Most people who eat a normal diet do not need extra ascorbic acid. Low levels of Vitamin C (Oligocare) can result in a condition called scurvy. Scurvy may cause symptoms such as rash, muscle weakness, joint pain, tiredness, or tooth loss.

Vitamin C (Oligocare) plays an important role in the body. It is needed to maintain the health of skin, cartilage, teeth, bone, and blood vessels. It is also used to protect your body's cells from damage. It is known as an antioxidant.

OTHER USES: This section contains uses of this drug that are not listed in the approved professional labeling for the drug but that may be prescribed by your health care professional. Use this drug for a condition that is listed in this section only if it has been so prescribed by your health care professional.

This vitamin may also be used with other vitamins for a certain eye condition (macular degeneration).

How to use Vitamin C (Oligocare)

Take this vitamin by mouth with or without food, usually 1 to 2 times daily. Follow all directions on the product package, or take as directed by your doctor.

If you are taking the extended-release capsules, swallow them whole. Do not crush or chew extended-release capsules or tablets. Doing so can release all of the drug at once, increasing the risk of side effects. Also, do not split extended-release tablets unless they have a score line and your doctor or pharmacist tells you to do so. Swallow the whole or split tablet without crushing or chewing. Take this product with a full glass of water (8 ounces/240 milliliters) unless your doctor directs you otherwise.

If you are taking the wafers or chewable tablets, chew them thoroughly and then swallow. If you are taking the lozenges, place the lozenge in your mouth and allow it to slowly dissolve.

If you are taking the powder, mix it thoroughly in the proper amount of liquid and stir well. Drink all of the liquid right away. Do not prepare a supply for future use. If you are using the liquid form of this vitamin, carefully measure the dose using a special measuring device/spoon. Do not use a household spoon because you may not get the correct dose.

Dosage is based on your medical condition and response to treatment.

Use this vitamin regularly to get the most benefit from it. To help you remember, take it at the same time(s) each day.

If you think you may have a serious medical problem, seek immediate medical attention.

Vitamin D3 (Oligocare) is used for the prevention and treatment of vitamin D deficiency. Vitamin D3 (Oligocare) is important for absorption of calcium in the body. It is also used to prevent bone disorders such as osteomalacia and rickets.

This supplement is used to prevent or treat a lack of Vitamin E (Oligocare) in the body. A low body level of Vitamin E (Oligocare) is rare. Most people who eat a normal diet do not need extra Vitamin E (Oligocare). However, Vitamin E (Oligocare) supplements are used in premature newborns and in people who have problems absorbing enough Vitamin E (Oligocare) from their diets. Vitamin E (Oligocare) is important in protecting your body's cells from damage. It is known as an antioxidant.

How to use Vitamin E (Oligocare)

Take this product by mouth as directed. Follow all directions on the product package. If you are uncertain about any of the information, consult your doctor or pharmacist.

If you are using a liquid form of this product, carefully measure your dose using a medication-measuring device or spoon. Do not use a household spoon because you may not get the correct dose. If your liquid form is a suspension, shake the bottle well before each dose.

Dosage is based on your medical condition and response to treatment. Do not increase your dose or take it more often than recommended. Taking too much Vitamin E (Oligocare) may increase your risk of side effects.

High doses of Vitamin E (Oligocare) (400 units or more per day) may increase the chance of rare but very serious side effects. There is no proof that high doses of Vitamin E (Oligocare) help to prevent or treat heart disease. There is very little evidence that it helps prevent or treat Alzheimer's disease. In some people, taking these high doses may even be harmful. Talk to your doctor or pharmacist and discuss the risks and benefits before taking Vitamin E (Oligocare) supplements.

If your doctor prescribes this product for Vitamin E (Oligocare) deficiency, use it regularly to get the most benefit from it. To help you remember, take it at the same time each day. You should see improvement of symptoms such as numbness/tingling of the hands/feet and weakness. If your condition persists or worsens, or if you think you may have a serious medical problem, seek immediate medical attention.

Ascorbic Acid: Copper (Oligocare) may decrease the serum concentration of Ascorbic Acid. Management: To minimize the risk for ascorbic acid degradation, add multivitamin product to TPN solution immediately prior to infusion or administer multivitamin and Copper (Oligocare) in separate containers. Consider therapy modification

See also:
What other drugs will affect Folic acid (Oligocare)?

Medications that interfere with your bodys ability to use folate may also increase the need for this vitamin. Medications can interfere with folate utilization, including: anticonvulsant medications (such as phenytoin, and primidone) metformin (sometimes prescribed to control blood sugar in type 2 diabetes) sulfasalazine (used to control inflammation associated with Crohns disease and ulcerative colitis) triamterene (a diuretic) Methotrexate There has been concern about the interaction between vitamin B12 and Folic acid (Oligocare). Folic acid (Oligocare) supplements can correct the anemia associated with vitamin B12 deficiency. Unfortunately, Folic acid (Oligocare) will not correct changes in the nervous system that result from vitamin B12 deficiency. Permanent nerve damage could theoretically occur if vitamin B12 deficiency is not treated. Therefore, intake of supplemental Folic acid (Oligocare) should not exceed 1000 micrograms (g, sometimes mcg) per day to prevent Folic acid (Oligocare) from masking symptoms of vitamin B12 deficiency. It is important for older adults to be aware of the relationship between Folic acid (Oligocare) and vitamin B12 because they are at greater risk of having a vitamin B12 deficiency. If you are 50 years of age or older, ask your physician to check your B12 status before you take a supplement that contains Folic acid (Oligocare).

See also:
What other drugs will affect Ginseng extract (Oligocare)?

Patients on anticoagulants e.g coumadin should avoid Ginseng extract (Oligocare) because Ginseng extract (Oligocare) is known to increase or decrease blood coagulation. Ginseng extract (Oligocare) has potential to cause hypoglycaemia, because some components of Ginseng extract (Oligocare) can elevate plasma insulin levels. Therefore, diabetics who take Ginseng extract (Oligocare) must have their blood sugars monitored closely.

Drug interactions were not noted and were not studied in clinical studies.

Feridex I.V. (ferumoxides injectable solution) administration provides elemental Iron (Oligocare). In patients who are receiving supplemental Iron (Oligocare) orally or parenterally, the dose of supplemental Iron (Oligocare) may need to be decreased.

The effect of concomitant parenteral Iron (Oligocare) on Feridex I.V. dosing is not known.

Laboratory Test Findings

Serum Iron (Oligocare) levels may be above the normal range following Feridex I.V. (ferumoxides injectable solution) administration. Transient increases in serum Iron (Oligocare) of 15–100% of baseline were observed 18 to 24 hours after Feridex I.V. (ferumoxides injectable solution) administration, and returned to normal in most patients by 7 days after administration. Increases in serum ferritin levels were seen 1 to 7 days after administration.

In a Phase 1 study in normal subjects, PTT was statistically significantly increased; however, all values were within the normal range and no subjects had a more than 40% increase from baseline. In clinical trials of patients who had baseline hematologic abnormalities associated with underlying liver disease, an effect of Feridex I.V. (ferumoxides injectable solution) on platelet or PTT was not demonstrated. In patients with low hematocrit and hemoglobin, over a period of 48 hours to 7 days after Feridex I.V. (ferumoxides injectable solution), the serum Iron (Oligocare), the hematocrit and hemoglobin levels increase slightly.

ALPHA TOCOPHERYL/SELECTED ANTICOAGULANTS - Increased effect of the latter drug

DI-TRIVALENT CATIONS/TETRACYCLINES - Decreased effect of the latter drug

Moderate Interaction:

Assess the risk to the patient and take action as needed.

POLYVALENT CATIONS/ELTROMBOPAG - Decreased effect of the latter drug

SELECTED MINERALS/ORAL IRON SUPPLEMENTS - Decreased effect of the latter drug

DI-; TRIVALENT CATIONS/CHLOROQUINE; HYDROXYCHLOROQUINE - Decreased effect of the former drug

ORAL MULTIVALENT CATIONS/ORAL BISPHOSPHONATES - Decreased effect of the latter drug

FAT SOLUBLE VITAMINS/ORLISTAT - Decreased effect of the former drug

ORAL ZINC PRODUCTS/SELECTED ORAL QUINOLONES - Decreased effect of the latter drug

There are no known significant interactions.

Antibiotics: The use of antibiotics may alter the intestinal microflora and may decrease the possible contribution of Mecobalamin (Oligocare) by certain inhabitants of the microflora (eg, Lactobacillus spp) to the body's requirement for the vitamin. This may particularly be a problem for vegetarians. Garlic, onions, leeks, bananas, asparagus and artichokes, among other vegetables and fruits, contain inulins which promote the growth of certain colonic bacteria including Lactobacillus spp.

Cholestyramine:

Colchicine: Colchicine may cause decreased absorption of Mecobalamin (Oligocare).

Colestipol:

H₂-Blockers (Cimetidine, Famotidine, Nizatidine, Ranitidine): Chronic use of H₂-blockers may result to decreased absorption of Mecobalamin (Oligocare). They are unlikely to affect the absorption of supplemental B₁₂.

Metformin: Metformin may decrease the absorption of Mecobalamin (Oligocare). This possible effect may be reversed with oral calcium supplementation.

Nitrous Oxide: Inhalation of the anesthetic agent nitrous oxide (not to be confused with nitric oxide) can produce a functional deficiency. Nitrous oxide forms a complex with cobalt in Mecobalamin (Oligocare), the cofactor for methionine synthase, resulting in inactivation of the enzyme.

Para-Amino Salicylic Acid: Chronic use of the anti-tuberculosis drug may decrease the absorption of Mecobalamin (Oligocare).

Potassium Chloride: It has been reported that potassium chloride may decrease the absorption of Mecobalamin (Oligocare).

Proton Pump Inhibitors (Lansoprazole, Omeprazole, Pantoprazole, Rabeprazole): Chronic use of proton pump inhibitors may result in decreased absorption, naturally found in food sources.

See also:
What other drugs will affect Selenium (Oligocare)?

Baloxavir Marboxil: Polyvalent Cation Containing Products may decrease the serum concentration of Baloxavir Marboxil. Avoid combination

Bictegravir: Polyvalent Cation Containing Products may decrease the serum concentration of Bictegravir. Management: Administer bictegravir under fasting conditions at least 2 hours before or 6 hours after polyvalent cation containing products. Coadministration of bictegravir with or 2 hours after most polyvalent cation products is not recommended. Consider therapy modification

Bisphosphonate Derivatives: Polyvalent Cation Containing Products may decrease the serum concentration of Bisphosphonate Derivatives. Management: Avoid administration of oral medications containing polyvalent cations within: 2 hours before or after tiludronate/clodronate/etidronate; 60 minutes after oral ibandronate; or 30 minutes after alendronate/risedronate. Exceptions: Pamidronate; Zoledronic Acid. Consider therapy modification

Deferiprone: Polyvalent Cation Containing Products may decrease the serum concentration of Deferiprone. Management: Separate administration of deferiprone and oral medications or supplements that contain polyvalent cations by at least 4 hours. Consider therapy modification

Dolutegravir: Selenium (Oligocare) may decrease the serum concentration of Dolutegravir. Management: Administer dolutegravir at least 2 hours before or 6 hours after oral Selenium (Oligocare). Administer the dolutegravir/rilpivirine combination product at least 4 hours before or 6 hours after oral Selenium (Oligocare). Consider therapy modification

Eltrombopag: Polyvalent Cation Containing Products may decrease the serum concentration of Eltrombopag. Management: Administer eltrombopag at least 2 hours before or 4 hours after oral administration of any polyvalent cation containing product. Consider therapy modification

Elvitegravir: Polyvalent Cation Containing Products may decrease the serum concentration of Elvitegravir. Management: Administer elvitegravir 2 hours before or 6 hours after the administration of polyvalent cation containing products. Consider therapy modification

PenicillAMINE: Polyvalent Cation Containing Products may decrease the serum concentration of PenicillAMINE. Management: Separate the administration of penicillamine and oral polyvalent cation containing products by at least 1 hour. Consider therapy modification

Raltegravir: Polyvalent Cation Containing Products may decrease the serum concentration of Raltegravir. Management: Administer raltegravir 2 hours before or 6 hours after administration of the polyvalent cations. Dose separation may not adequately minimize the significance of this interaction. Consider therapy modification

Trientine: Polyvalent Cation Containing Products may decrease the serum concentration of Trientine. Management: Avoid concomitant administration of trientine and oral products that contain polyvalent cations. If oral iron supplements are required, separate the administration by 2 hours. If other oral polyvalent cations are needed, separate administration by 1 hour. Consider therapy modification

See also:
What other drugs will affect Ubidecarenone (Oligocare)?

If you are taking this product under your doctor's direction, your doctor or pharmacist may already be aware of any possible drug interactions and may be monitoring you for them. Do not start, stop, or change the dosage of any medicine before checking with your doctor or pharmacist first.

Before using this product, tell your doctor or pharmacist of all prescription and nonprescription medications you may use, especially of: drugs for high blood pressure, "blood thinners" (e.g., warfarin), drugs for diabetes, drugs for high cholesterol (e.g., atorvastatin, lovastatin).

This document does not contain all possible interactions. Therefore, before using this product, tell your doctor or pharmacist of all the products you use. Keep a list of all your medications with you, and share the list with your doctor and pharmacist.

See also:
What other drugs will affect Vitamin A (Oligocare)?

The effects of some drugs can change if you take other drugs or herbal products at the same time. This can increase your risk for serious side effects or may cause your medications not to work correctly. These drug interactions are possible, but do not always occur. Your doctor or pharmacist can often prevent or manage interactions by changing how you use your medications or by close monitoring.

To help your doctor and pharmacist give you the best care, be sure to tell your doctor and pharmacist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products) before starting treatment with this product. While using this product, do not start, stop, or change the dosage of any other medicines you are using without your doctor's approval.

Some products that may interact with this vitamin include: acitretin, alitretinoin, bexarotene, cholestyramine, isotretinoin, tretinoin, other products that contain Vitamin A (Oligocare) (such as multivitamins), warfarin.

Avoid taking Vitamin A (Oligocare) at the same time as you take neomycin, orlistat, and mineral oil. If you take any of these medications, separate your doses from your dose of Vitamin A (Oligocare) by at least 2 hours.

This document does not contain all possible drug interactions. Keep a list of all the products you use. Share this list with your doctor and pharmacist to lessen your risk for serious medication problems.

Interactions for Vitamin B1 (Vitamin B1 nitrate (Oligocare))

Loop Diuretics,

Oral Contraceptives, Stavudine, Tricyclic Antidepressants

Interactions for Vitamin B6 (Oligocare) (Vitamin B6 (Oligocare))

Amiodarone: Concomitant use of Vitamin B6 (Oligocare) and amiodarone may enhance amiodarone-induced photosensitivity reactions. Doses of Vitamin B6 (Oligocare) greater than 5-10 milligrams/day should be avoided by those taking amiodarone Carbamazepine: Chronic use of carbamazepine may result in a significant decrease in plasma pyridoxal 5-phosphate levels Cycloserine: Cycloserine may react with pyridoxal 5-phosphate to form a metabolically inactive oxime, which may result in a functional Vitamin B6 (Oligocare) deficiency Ethionamide: The use of ethionamide may increase Vitamin B6 (Oligocare) requirements Fosphenytoin: High doses of Vitamin B6 (Oligocare) may lower plasma levels of phenytoin. Fosphenytoin is a prodrug of phenytoin Hydralazine: The use of hydralazine may increase Vitamin B6 (Oligocare) requirements Isoniazid: (isonicotinic acid, INH). Isoniazid reacts with pyridoxal 5-phosphate to form a metabolically inactive hydrazone, which may result in functional Vitamin B6 (Oligocare) deficiency Levodopa: Concomitant use of levodopa and Vitamin B6 (Oligocare) in doses of 5 milligrams or more daily may reverse the therapeutic effects of levodopa. Vitamin B6 (Oligocare) does not reverse the therapeutic effects of levodopa if levodopa is taken concurrently with the levodopa decarboxylase inhibitor carbidopa. Levodopa is typically administered as a combination product with carbidopa

Oral contraceptives: The use of oral contraceptives may increase Vitamin B6 (Oligocare) requirements. This was more the case with the older oral contraceptive agents with high-dose estrogen/progestin. It appears to be less the case with the newer low-dose estrogen/progestin products Penicillamine: Penicillamine may react with pyridoxal 5-phosphate to form a metabolically inactive thiazolidine, which may result in a functional Vitamin B6 (Oligocare) deficiency Phenelzine: Phenelzine may react with pyridoxal 5-phosphate to yield a metabolically inactive hydrazone compound Phenobarbital: High doses of Vitamin B6 (Oligocare) may lower plasma levels of phenobarbital Phenytoin: High doses of Vitamin B6 (Oligocare) may lower plasma levels of phenytoin Theophylline: Theophylline may react with pyridoxal 5-phosphate leading to low plasma levels of the coenzyme. This may increase the risk of theophylline-induced seizures Valproic acid: Chronic use of valproic acid may result in a significant decrease in plasma pyridoxal 5-phosphate levels.

In an application with barbiturates, primidone increases the excretion of ascorbic acid in the urine.

With the simultaneous use of oral contraceptives reduces the concentration of ascorbic acid in blood plasma.

In an application of All Natural Source Juicy Orange Vitamin C (Oligocare) with iron preparations ascorbic acid, due to its regenerative properties, transforms ferric iron in the bivalent, which improves its absorption.

Ascorbic acid in high doses can decrease urine pH that while the application reduces the tubular reabsorption of amphetamine and tricyclic antidepressants.

With the simultaneous use of aspirin reduces the absorption of ascorbic acid by about a third.

All Natural Source Juicy Orange Vitamin C (Oligocare) in an application with warfarin may decrease effects of warfarin.

With the simultaneous application of ascorbic acid increases the excretion of iron in patients receiving deferoxamine. In the application of ascorbic acid at a dose of 500 mg / day possibly left ventricular dysfunction.

In an application with tetracycline is increased excretion of ascorbic acid in the urine.

There is a described case of reducing the concentration of fluphenazine in plasma in patients treated with ascorbic acid 500 mg 2 times / day.

May increase the concentration of ethinyl estradiol in the blood plasma in its simultaneous application in the oral contraceptives.

Interactions for vitamin D analogues (Vitamin D2, Vitamin D3 (Oligocare), Calcitriol, and Calcidiol)

Cholestyramine

Cholestyramine has been reported to reduce intestinal absorption of fat soluble vitamins; as such it may impair intestinal absorption of any of vitamin D

Phenytoin/Phenobarbital

The coadministration of phenytoin or phenobarbital will not affect plasma concentrations of vitamin D, but may reduce endogenous plasma levels of calcitriol/ergocalcitriol by accelerating metabolism. Since blood level of calcitriol/ergocalcitriol will be reduced, higher doses of Rocaltrol may be necessary if these drugs are administered simultaneously

Thiazides

Thiazides are known to induce hypercalcemia by the reduction of calcium excretion in urine. Some reports have shown that the concomitant administration of thiazides with vitamin D causes hypercalcemia. Therefore, precaution should be taken when coadministration is necessary

Digitalis

Vitamin D dosage must be determined with care in patients undergoing treatment with digitalis, as hypercalcemia in such patients may precipitate cardiac arrhythmias

Ketoconazole

Ketoconazole may inhibit both synthetic and catabolic enzymes of vitamin D. Reductions in serum endogenous vitamin D concentrations have been observed following the administration of 300 mg/day to 1200 mg/day ketoconazole for a week to healthy men. However, in vivo drug interaction studies of ketoconazole with vitamin D have not been investigated

Corticosteroids

A relationship of functional antagonism exists between vitamin D analogues, which promote calcium absorption, and corticosteroids, which inhibit calcium absorption

Phosphate-Binding Agents

Since vitamin D also has an effect on phosphate transport in the intestine, kidneys and bones, the dosage of phosphate-binding agents must be adjusted in accordance with the serum phosphate concentration

Vitamin D

The coadministration of any of the vitamin D analogues should be avoided as this could create possible additive effects and hypercalcemia

Calcium Supplements

Uncontrolled intake of additional calcium-containing preparations should be avoided

Magnesium

Magnesium-containing preparations (eg, antacids) may cause hypermagnesemia and should therefore not be taken during therapy with vitamin D by patients on chronic renal dialysis.

See also:
What other drugs will affect Vitamin E (Oligocare)?

Agents with Antiplatelet Properties (e.g., P2Y12 inhibitors, NSAIDs, SSRIs, etc.): Vitamin E (Oligocare) (Systemic) may enhance the antiplatelet effect of Agents with Antiplatelet Properties. Monitor therapy

Anticoagulants: Vitamin E (Oligocare) (Systemic) may enhance the anticoagulant effect of Anticoagulants. Monitor therapy

CycloSPORINE (Systemic): Vitamin E (Oligocare) (Systemic) may decrease the serum concentration of CycloSPORINE (Systemic). Monitor therapy

Ibrutinib: Vitamin E (Oligocare) (Systemic) may enhance the antiplatelet effect of Ibrutinib. Monitor therapy

Orlistat: May decrease the serum concentration of Vitamins (Fat Soluble). Management: Administer oral fat soluble vitamins at least 2 hours before or after the administration of orlistat. Similar precautions do not apply to parenterally administered fat soluble vitamins. Consider therapy modification

Tipranavir: May enhance the adverse/toxic effect of Vitamin E (Oligocare) (Systemic). Management: Patients taking tipranavir oral solution are advised to avoid taking additional Vitamin E (Oligocare), beyond the amounts contained in a multivitamin product. This interaction does not apply to tipranavir capsules. Consider therapy modification

See also:
What other drugs will affect Zinc (Oligocare)?

Pyridoxine reduces the effects of levodopa (but this does not occur if a dopa decarboxylase is also given); decreases serum concentrations of phenobarbitone. Concurrent administration of drugs eg, isoniazid, penicillamine and oral contraceptives increase the requirement for pyridoxine.

Absorption of cyanocobalamin from the GIT may be reduced by neomycin, aminosalicylic acid, histamine H₂-receptor antagonists and colchicine. Serum concentrations may be decreased by concurrent administration of oral contraceptives. Many of these interactions are unlikely to be of clinical significance but should be taken into account when performing assays for blood concentrations.

Parenteral chloramphenicol may attenuate the effect of vitamin B12 in anaemia.

Folate deficiency states may be produced by a number of drugs including antiepileptics, oral contraceptives, antituberculous drugs, alcohol and Zinc (Oligocare) antagonists eg, aminopterin, methotrexate, pyrimethamine, trimethoprim and sulphonamides; Zinc (Oligocare) may decrease serum-phenytoin concentrations.

There may be an increased risk of myopathy or rhabdomyolysis when nicotinic acid is used concurrently with statins. Nicotinamide may increase the requirements for insulin or oral hypoglycaemics.

Ascorbic acid may increase the absorption of iron-deficiency states.

Ascorbic acid is often given in addition to desferrioxamine to patients with iron overload (thalassemia) to achieve better iron excretion. However, early on in treatment when there is excess tissue iron, there is some evidence that ascorbic acid may worsen the iron toxicity, particularly to the heart. Thus, ascorbic acid should not be given for the first month after starting desferrioxamine treatment.

The absorption of Zinc (Oligocare) may be reduced by iron supplements, penicillamine, phosphorus-containing preparations and tetracyclines. Zinc (Oligocare) supplements reduce the absorption of Zinc (Oligocare), ciprofloxacin, iron, norfloxacin, penicillamine and tetracyclines.

Adverse Reactions

Generally well tolerated; excessive Copper (Oligocare) levels may result in the following adverse effect.

Hepatic: Hepatic insufficiency (including hepatic necrosis)

See also:
What are the possible side effects of Folic acid (Oligocare)?

Allergic sensitization has been reported following both oral and parenteral administration of Folic acid (Oligocare).

Folic acid (Oligocare) is relatively nontoxic in man. Rare instances of allergic responses to Folic acid (Oligocare) preparations have been reported and have included erythema, skin rash, itching, general malaise, and respiratory difficulty due to bronchospasm. One patient experienced symptoms suggesting anaphylaxis following injection of the drug. Gastrointestinal side effects, including anorexia, nausea, abdominal distention, flatulence, and a bitter or bad taste, have been reported in patients receiving 15 mg Folic acid (Oligocare) daily for 1 month. Other side effects reported in patients receiving 15 mg daily include altered sleep patterns, difficulty in concentrating, irritability, overactivity, excitement, mental depression, confusion, and impaired judgment. Decreased vitamin B12 serum levels may occur in patients receiving prolonged Folic acid (Oligocare) therapy.

In an uncontrolled study, orally administered Folic acid (Oligocare) was reported to increase the incidence of seizures in some epileptic patients receiving phenobarbital, primidone, or diphenylhydantoin. Another investigator reported decreased diphenylhydantoin serum levels in folate-deficient patients receiving diphenylhydantoin who were treated with 5 mg or 15 mg of Folic acid (Oligocare) daily.

CALL YOUR DOCTOR FOR MEDICAL ADVICE ABOUT SIDE EFFECTS. YOU MAY REPORT SIDE EFFECTS TO THE FDA AT 1-800-FDA-1088 OR LEADING PHARMA, LLC AT 844-740-7500.

See also:
What are the possible side effects of Ginseng extract (Oligocare)?

May cause nervousness, increased blood pressure, irritability in high doses. Ginseng extract (Oligocare) and /or adulterants have estrogenic activity and may cause vaginal bleeding and mastalgia [breast soreness] and patients with estrogen dependent malignancies may need to avoid Ginseng extract (Oligocare).

See also:
What are the possible side effects of Iron (Oligocare)?

Applies to carbonyl Iron (Oligocare): suspension

Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Constipation; darkened or green stools; diarrhea; loss of appetite; nausea; stomach cramps, pain, or upset; vomiting.

Seek medical attention right away if any of these SEVERE side effects occur while taking carbonyl Iron (Oligocare):

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); black or tarry stools; blood or streaks of blood in the stool; fever; severe or persistent nausea, stomach pain, or vomiting; vomit that looks like blood or coffee grounds.

Abdominal bloating, Abdominal pain, Abnormality of blood, Allergy, Decreased blood pressure, Diarrhoea, Gout, Airway inflammation, Worsening of asthma

Rare:

Abdominal Pain with Cramps, Back Pain, Blurred Vision, Constipation, Diarrhea, Dizziness, Dysuria, Erectile Dysfunction, Fatigue, Headache Disorder, Hypertension, Libido Changes, Nausea, Urinary Retention

None known.

The most frequent adverse effect of nondepolarizing blocking agents as a class consists of an extension of the pharmacological action beyond the time needed for surgery and anesthesia. This effect may vary from skeletal muscle weakness to profound and prolonged skeletal muscle paralysis resulting in respiratory insufficiency and apnea which require manual or mechanical ventilation until recovery is judged to be clinically adequate. Inadequate reversal of neuromuscular block from Mecobalamin (Oligocare) (doxacurium chloride) is possible, as with all nondepolarizing agents. Prolonged neuromuscular block and inadequate reversal may lead to postoperative complications.

Observed in Clinical Trials

Adverse experiences were uncommon among the 1034 surgical patients and volunteers who received Mecobalamin (Oligocare) (doxacurium chloride) and other drugs in US clinical studies in the course of a wide variety of procedures conducted during balanced or inhalational anesthesia. The following adverse experiences were reported in patients administered Mecobalamin (Oligocare) (doxacurium chloride) (all events judged by investigators during the clinical trials to have a possible causal relationship):

Incidence Greater than 1%

None

Incidence Less than 1%

Observed During Clinical Practice

There have been post-marketing reports of severe allergic reactions (anaphylactic and anaphylactoid reactions) with the use of neuromuscular blocking agents of which Mecobalamin (Oligocare) (doxacurium chloride) is a member. These reactions, in some cases, have been life threatening and fatal. Because these reactions were reported voluntarily from a population of uncertain size, it is not possible to reliably estimate their frequency.

See also:
What are the possible side effects of Selenium (Oligocare)?

Applies to Selenium (Oligocare) sulfide topical: topical cream, topical foam, topical lotion, topical shampoo, topical suspension

As well as its needed effects, Selenium (Oligocare) sulfide topical may cause unwanted side effects that require medical attention.

Severity: Moderate

If any of the following side effects occur while taking Selenium (Oligocare) sulfide topical, check with your doctor or nurse as soon as possible:

Less common or rare:

• Skin irritation

Minor Side Effects

Some Selenium (Oligocare) sulfide topical side effects may not need any medical attention. As your body gets used to the medicine these side effects may disappear. Your health care professional may be able to help you prevent or reduce these side effects, but do check with them if any of the following side effects continue, or if you are concerned about them:

More common:

• Unusual dryness or oiliness of hair or scalp

• Increase in normal hair loss

See also:
What are the possible side effects of Ubidecarenone (Oligocare)?

This product usually has very few side effects. Nausea, loss of appetite, upset stomach, or diarrhea may rarely occur. If any of these effects persist or worsen, contact your doctor promptly.

A very serious allergic reaction to this product is rare. However, seek immediate medical attention if you notice any of the following symptoms of a serious allergic reaction: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.

This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

In the US -

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch.

In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.

See also:
What are the possible side effects of Vitamin A (Oligocare)?

This vitamin usually has no side effects when used in recommended doses. If you have any unusual effects, contact your doctor or pharmacist promptly.

A very serious allergic reaction to this vitamin is rare. However, seek immediate medical attention if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.

This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

In the US -

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch.

In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.

anaphylactic reactions rarely, severe cases can cause death, urine yellow colouration,peripheral neuropathy in case of prolonged useage, arrythmias,

Applies to pyridoxine: capsule, injectable, solution, tablet, tablet enteric coated, tablet extended release

As well as its needed effects, pyridoxine (the active ingredient contained in Vitamin B6 (Oligocare)) may cause unwanted side effects that require medical attention.

Severity: Moderate

If any of the following side effects occur while taking pyridoxine, check with your doctor or nurse as soon as possible:

With large doses

• Clumsiness
• numbness of hands or feet

Applies to ascorbic acid: oral capsule, oral capsule extended release, oral capsule liquid filled, oral granule, oral liquid, oral lozenge/troche, oral powder, oral powder for solution, oral powder for suspension, oral solution, oral syrup, oral tablet, oral tablet chewable, oral tablet extended release, oral wafer

As well as its needed effects, ascorbic acid (the active ingredient contained in Vitamin C (Oligocare)) may cause unwanted side effects that require medical attention.

Severity: Moderate

If any of the following side effects occur while taking ascorbic acid, check with your doctor or nurse as soon as possible:

Less common or rare: - with high doses

• Side or lower back pain

Minor Side Effects

Some ascorbic acid side effects may not need any medical attention. As your body gets used to the medicine these side effects may disappear. Your health care professional may be able to help you prevent or reduce these side effects, but do check with them if any of the following side effects continue, or if you are concerned about them:

Less common or rare: - with high doses

• Diarrhea
• dizziness or faintness (with the injection only)
• flushing or redness of skin
• headache
• increase in urination (mild)
• nausea or vomiting
• stomach cramps

Applies to cholecalciferol: oral capsule, oral capsule liquid filled, oral solution, oral tablet, oral tablet chewable, oral wafer

As well as its needed effects, cholecalciferol (the active ingredient contained in Vitamin D3 (Oligocare)) may cause unwanted side effects that require medical attention.

Major Side Effects

If any of the following side effects occur while taking cholecalciferol, check with your doctor immediately:

Incidence not known:

• Cough
• difficulty swallowing
• dizziness
• fast heartbeat
• hives or itching
• puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
• skin rash
• tightness in the chest
• unusual tiredness or weakness

See also:
What are the possible side effects of Vitamin E (Oligocare)?

Applies to Vitamin E (Oligocare): oral capsule, oral capsule liquid filled, oral liquid, oral powder for solution, oral solution, oral tablet, oral tablet chewable

In addition to its needed effects, some unwanted effects may be caused by Vitamin E (Oligocare) (the active ingredient contained in Centrum Singles-Vitamin E (Oligocare)). In the event that any of these side effects do occur, they may require medical attention.

Severity: Moderate

If any of the following side effects occur while taking Vitamin E (Oligocare), check with your doctor or nurse as soon as possible:

With doses greater than 400 Units a day and long-term use

• Blurred vision
• diarrhea
• dizziness
• headache
• nausea or stomach cramps
• unusual tiredness or weakness

See also:
What are the possible side effects of Zinc (Oligocare)?

Applies to Zinc (Oligocare) sulfate: capsules, tablets

Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Nausea; vomiting.

Seek medical attention right away if any of these SEVERE side effects occur while taking Zinc (Oligocare) sulfate (the active ingredient contained in Zinc (Oligocare))

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); severe vomiting; unusual restlessness; very dry mouth, eyes, or skin.

Copper (Oligocare) has been designed for the demands of modern life. With a wide range of nutrients and trace minerals, Copper (Oligocare) gives nutritional support to the area of health which are most relevance to women.

Each cap contains starflower oil 100 mg, evening primrose oil 100 mg, citrus bioflavonoids 10 mg, natural mixed carotenoids 2 mg, vitamin D (as D3 200 IU) 5 mcg, vitamin E 30 mg, vitamin C 60 mg, vitamin K 90 mcg, thiamin (vitamin B1) 10 mg, riboflavin (vitamin B2) 5 mg, niacin (vitamin B3) 36 mg, vitamin B6 10 mg, folic acid 400 mcg, vitamin B12 20 mcg, biotin 50 mcg, pantothenic acid 6 mg, magnesium 100 mg, iron 12 mg, zinc 12 mg, Copper (Oligocare) 1500 mcg, manganese 2.5 mg, selenium 100 mcg, chromium 50 mcg, para-aminobenzoic acid (PABA) 30 mg.

No artificial colours, gluten, presevatives, starch or sugar, salt or yeast.

Copper (Oligocare) has not been tested on animals.

A member of the vitamin B family that stimulates the hematopoietic system. It is present in the liver and kidney and is found in mushrooms, spinach, yeast, green leaves, and grasses (poaceae). Folic acid (Oligocare) is used in the treatment and prevention of folate deficiencies and megaloblastic anemia. [PubChem]

Ginseng extract (Oligocare) is promoted as an adaptogen (a product that increases the body's resistance to stress), one which can to a certain extent be supported with reference to its anticarcinogenic and antioxidant properties. Ginseng extract (Oligocare) is also known to contain phytoestrogens.

Each 5 mL syrup contains: Diastase (1:50) 135 mg, pepsin 50 mg, papain BPC 50 mg, vitamin B₁ 5 mg, vitamin B₂ 2 mg, vitamin B₆ 2 mg, vitamin B₁₂ 5 mcg, calcium pantothenate 1 mg and nicotinamide 20 mg.

Iron (Oligocare) is a pleasantly flavoured syrup, containing digestive enzymes and vitamins of the B-complex group. Abdominal cramps, flatulence, heartburn and nausea can occur as a result of indigestion. Iron (Oligocare) is the ideal cure to facilitate digestion and to strengthen the GIT.

Iron (Oligocare)'s balanced formulation provides an ideal supplementation that meets the demands and replenishes vitamins stores in the body.

An essential amino acid that is physiologically active in the L-form. [PubChem]

Lycopene (Oligocare), an antioxidant, is indicated for the treatment and prevention of cancer, cataract, asthma, HPV infection, atherosclerosis, CVD and prostate cancer. Lycopene (Oligocare) is a good anti-inflammatory agent and anti-oxidant.

Manganese (Oligocare) is a transition metal with a molar mass of 54.94g/mol. Manganese (Oligocare) is considered critical for human health, and plays important roles in development, metabolism, and the antioxidant system. That said, excessive Manganese (Oligocare) intake is associated with manganism, a neurodegenerative disorder that causes dopaminergic neuronal death and parkinsonian-like symptoms.

Mecobalamin (Oligocare)/Mecobalamin (Oligocare)-1500 also contains the following inactive ingredients: Lactose, maize starch, microcrystalline cellulose, povidone (K-30), purified talc, anhydrous colloidal silica, hypromellose, macrogol, titanium dioxide, isopropyl alcohol, dicholoromethane, red iron oxide and yellow iron oxide.

Each capsule contains Co-enzyme Q10 25 mg and 50 mg, respectively.

Ubidecarenone (Oligocare) also contains fractionated coconut oil as an inactive ingredient.

Vitamin A (Oligocare) (Glucoenergan, Reactivan) is a stimulant which was developed in the 1960s as an appetite suppressant, but was later withdrawn for this application due to problems with dependence and abuse. It is around half the potency of dexamphetamine, and is prescribed at a dose of 10-60mg, although abusers of the drug tend to rapidly develop tolerance and escalate their dose. Reactivan is still rarely used for treating depressive day-time fatigue, lack of concentration and lethargy, particularly in individuals who have chronic medical conditions, as its favourable safety profile makes it the most suitable drug in some cases.

3-((4-Amino-2-methyl-5-pyrimidinyl)methyl)-5-(2- hydroxyethyl)-4-methylthiazolium chloride.

The 4-methanol form of vitamin B 6 which is converted to pyridoxal phosphate which is a coenzyme for synthesis of amino acids, neurotransmitters (serotonin, norepinephrine), sphingolipids, aminolevulinic acid. Although pyridoxine and Vitamin B 6 are still frequently used as synonyms, especially by medical researchers, this practice is erroneous and sometimes misleading (EE Snell; Ann NY Acad Sci, vol 585 pg 1, 1990).

A six carbon compound related to glucose. It is found naturally in citrus fruits and many vegetables. Ascorbic acid is an essential nutrient in human diets, and necessary to maintain connective tissue and bone. Its biologically active form, Vitamin C (Oligocare), functions as a reducing agent and coenzyme in several metabolic pathways. Vitamin C (Oligocare) is considered an antioxidant.

Vitamin D3 (Oligocare) (Vitamin D2) is a derivative of ergosterol formed by ultraviolet rays breaking of the C9-C10 bond. It differs from cholecalciferol in having a double bond between C22 and C23 and a methyl group at C24.

A methylxanthine naturally occurring in some beverages and also used as a pharmacological agent. Vitamin E (Oligocare)&

Zinc (Oligocare) Capsule: Each capsule contains Zinc (Oligocare) sulphate monohydrate 54.93 mg, thiamine nitrate 10 mg, riboflavin 10 mg, pyridoxine hydrochloride 3 mg, vitamin B12 (coated) equivalent to cyanocobalamin 15 mcg, ascorbic acid 150 mg, Zinc (Oligocare) 1 mg, nicotinamide 50 mg and calcium pantothenate 12.5 mg.

Zinc (Oligocare) Syrup: Each 5 mL contains Zinc (Oligocare) gluconate 34.9 mg, thiamine mononitrate 2.5 mg, riboflavin 2.5 mg, pyridoxine hydrochloride 1 mg, cyanocobalamin 3 mcg, ascorbic acid 50 mg, d-panthenol 12.5 mg and niacinamide 25 mg in a flavoured liquid glucose sorbitol syrup base.