Nozinan

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Nozinan

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Method of action: Antipsychotic, Psycholeptics

Treatment option:

Medically reviewed

Marina Burgos

Last updated on 10/01/2026

This page provides general, reference-level information compiled from official medical sources. It is not a substitute for professional medical advice, diagnosis, or treatment. For decisions about your health, please consult a qualified healthcare professional.

Overview of Nozinan

Property Description
Active Ingredient Levomepromazine (Methotrimeprazine)
Forms Tablet, Oral Solution (Drops), Solution for Injection
Pharmacological Class Antipsychotic Agent (Neuroleptic)
Origin Synthetic Compound
General Purpose Profound Sedation, Calming of Agitation, Pain Management Adjuvant

What Type of Medicine is Nozinan (Levomepromazine)?

Nozinan is the trade name for the active substance Levomepromazine, which carries the International Non-proprietary Name (INN) Methotrimeprazine. This medicine is formally classified as an antipsychotic agent and a neuroleptic, designed to affect the central nervous system. Levomepromazine is a synthetic compound derived from the phenothiazine chemical structure, defining it as a potent phenothiazine derivative. Pharmacological studies consistently support its classification as a low-potency neuroleptic, a distinction that confirms its notably pronounced sedative action compared to other agents in the phenothiazine class.


Composition, Origin, and Available Forms

The core composition is the active substance Levomepromazine (usually the maleate salt), which is produced entirely through chemical synthesis. Nozinan is typically manufactured and prescribed as a prescription-only medicine (Rx). It is supplied in multiple pharmaceutical preparations to ensure flexibility in treatment: the standard oral tablet, an oral solution (drops) which allows for highly precise dose titration often favored in palliative settings, and a sterile solution for injection suitable for urgent administration via the intramuscular or intravenous route.


General Therapeutic Role of This Neuroleptic

The general therapeutic purpose of Levomepromazine is to achieve intensive symptomatic control, primarily through its powerful sedative and anxiolytic (anxiety-reducing) properties. The established role of this drug includes addressing pronounced agitation and severely disturbed emotional states, often utilized in acute situations requiring rapid tranquilization. Beyond this primary psychiatric role, Levomepromazine is valuable as an adjuvant (supporting agent) in pain management protocols, where its unique properties help to modulate the body's perception of pain, thereby supporting the overall relief provided by primary analgesics.

What side effects are possible with Nozinan?

Possible Side Effects and Safety Information

The safety profile of Nozinan (Levomepromazine) is formally documented in regulatory texts by classifying potential adverse reactions according to frequency and affected body system, consistent with other phenothiazine neuroleptics.

Adverse Reaction Scope Official Regulatory Classification
Frequency Classification Very Common events (1/10) include sedation and orthostatic hypotension (postural drop in blood pressure), which are often more prominent at the start of treatment. Common events include extrapyramidal symptoms, dry mouth, and constipation [Levomepromazine Maleate SmPC].
System-Organ Classes Adverse effects are documented across multiple systems, including Nervous System (sedation, Neuroleptic Malignant Syndrome), Cardiac (QTc prolongation, arrhythmias), Vascular (VTE), Blood and Lymphatic (agranulocytosis), and Gastrointestinal (ileus paralytic) [Nozinan Data Sheet - Medsafe].

Serious Adverse Reactions

Official labeling highlights several rare but clinically critical reactions: Neuroleptic Malignant Syndrome (NMS), a severe idiosyncratic reaction; agranulocytosis (a severe reduction in white blood cells); and a documented risk of QT interval prolongation, which potentiates severe ventricular arrhythmias, including Torsades de Pointes [Levomepromazine Maleate SmPC]. Cases of Venous Thromboembolism (VTE) have also been reported with antipsychotics.

Population-Specific Safety Considerations

The label notes that older adults exhibit increased susceptibility to effects such as sedation, orthostatic hypotension, and extrapyramidal effects. Special caution is required in patients with severe hepatic or renal impairment due to the risk of drug accumulation. Additionally, regulatory warnings for antipsychotics regarding an increased risk of mortality and cerebrovascular events in older patients with dementia-related psychosis apply to this class of medicine [Nozinan Data Sheet - Medsafe]. The risk of Tardive Dyskinesia is associated with long-term exposure, particularly in the elderly.

Overdose and Emergency Response

Overdose and When to Seek Help: Official Regulatory Information

The information in this section outlines the official overdose profile for Levomepromazine (Nozinan), detailing documented manifestations and the required immediate emergency response, as described in government regulatory documents.

Documented Overdose Manifestations

Overdose is officially documented to present primarily with profound Central Nervous System (CNS) depression, ranging from somnolence and loss of consciousness to coma. Other acute neurological signs may include convulsions, spasms, tremor, and severe extrapyramidal dyskinesias (involuntary movements).

Severe systemic effects include hypotension (low blood pressure) and hypothermia (abnormally low body temperature).

Serious Outcomes and Emergency Action

Severe Outcome Emergency Action Supportive Measures
Serious ventricular arrhythmias, including potentially fatal Torsade de pointes, respiratory depression and sudden death. Seek immediate medical attention. Contact the nearest hospital casualty department immediately upon accidental high intake. Treatment is symptomatic and supportive after gastric lavage. No specific antidote exists. Adrenaline (epinephrine) must not be used.

The risk of these severe cardiac outcomes is officially stated to be exacerbated by pre-existing conditions such as bradycardia, hypokalemia, or acquired QT prolongation.

This profile defines the overdose as a serious, life-threatening event requiring specific supportive management, underscoring the necessity to seek urgent medical intervention.

Therapeutic Uses of Nozinan

What Nozinan Treats: Main Uses and Benefits

Levomepromazine, the active ingredient in Nozinan, is used in situations involving certain distressing symptoms across multiple therapeutic contexts. This therapeutic profile includes its use in psychiatry and general medicine.

The medication is commonly applied in scenarios where additional symptomatic support is needed, such as in the stabilization of acute behavioral disorders, management of treatment-resistant nausea and vomiting, and as an adjuvant for severe chronic pain. It helps address symptom clusters that may become intense, including pronounced agitation, severe restlessness, and acute confusion (delirium) that often accompany complex conditions.

This supportive function is relevant in contexts involving heightened systemic burden in palliative care, where the focus is on easing discomfort. It provides supportive relief when symptoms interfere with routine activities and general comfort.


Quick Fact: Relevant for Multiple Symptom Patterns

Quick Fact: Relevant for Multiple Symptom Patterns (Used when symptoms cluster into distressing manifestations)

This symptomatic support may assist with maintaining functional stability and contributes to improved comfort during periods of heightened symptoms. It is relevant when symptoms become temporarily overwhelming, helping patients cope more steadily with difficult episodes.

Regulatory References

  1. Nozinan 25 mg Tablets Summary of Product Characteristics

Eligibility and Restrictions for Use

The eligibility for using Nozinan (levomepromazine) is strictly defined by regulatory documents, focusing on absolute prohibitions and use restrictions in specific populations.

Contraindications (Must Not Use)

Contraindication Group Examples of Conditions
Absolute Hypersensitivity, severe CNS depression, coma, history of agranulocytosis.
Systemic Risk of closed-angle glaucoma, risk of urinary retention (e.g., prostatic hypertrophy), and specific cardiac conditions (e.g., bradycardia <55 bpm, uncorrected hypokalemia, 2nd/3rd degree heart block).

Age and Physiological Restrictions

Population Regulatory Status
Children/Adolescents Contraindicated in some regions (typically under 18 years); Not recommended due to safety concerns.
Elderly Use requires caution and careful monitoring due to increased risks (e.g., hypotension, sedation, extrapyramidal effects).
Pregnancy/Lactation Not recommended. Safety is not established in pregnancy, and the drug is excreted into breast milk.

Use with Caution (Conditional Eligibility)

Caution is mandated for patients with hepatic dysfunction or renal impairment (due to accumulation risk), epilepsy (lowered seizure threshold), Parkinson's disease (only in exceptional situations), diabetes mellitus (requires monitoring), and cardiovascular disease (risk of hypotension/QT prolongation).

What should I know about interactions with other medicines?

The official regulatory profile for levomepromazine interactions is structured around both pharmacokinetic and pharmacodynamic constraints with other substances.

Formal Contraindications and Prohibitions

Co-administration with specific medicinal products is contraindicated due to a documented increased risk of ventricular rhythm disorders, notably torsades de pointes. These prohibited combinations explicitly include citalopram, escitalopram, hydroxyzine, piperaquine, and domperidone. The combination with dopaminergics is formally contraindicated in patients with Parkinson's disease due to mutual therapeutic antagonism.

Metabolic and Exposure-Altering Interactions

Levomepromazine is officially classified as a potent inhibitor of Cytochrome P450 2D6 (CYP2D6). This pharmacokinetic mechanism can lead to an increase in plasma concentrations of co-administered medicines that are primarily metabolized by this enzyme (e.g., risperidone, amitriptyline, flecainide).

Conversely, co-administration with strong CYP enzyme inducers, such as carbamazepine or barbiturates, may result in decreased levomepromazine plasma concentrations.

Pharmacodynamic Potentiation

Combining levomepromazine with other Central Nervous System (CNS) depressants (including narcotic analgesics and sedatives) results in a potentiation or enhancement of CNS depression. For this reason, consumption of alcohol and medicines containing alcohol is advised against due to the risk of intensifying these effects. The profile also restricts co-administration with other medications known to cause QT interval prolongation or marked bradycardia, as this increases the risk of severe cardiac arrhythmias.

Mechanism of Action

How Nozinan Works: Mechanism of Action

The core mechanism involves the high-affinity antagonism of multiple neurotransmitter receptors, particularly those for Histamine (H1), Alpha-1 Adrenergic (alpha1), and Dopamine (D2). This widespread engagement of regulatory systems rapidly reduces the activity of key arousal and wakefulness pathways, leading to widespread central nervous system depression.

The drug’s high-affinity blockade of alpha1 adrenergic receptors extends to the peripheral vascular system, interfering with the signaling cascade that maintains sympathetic tone. This action results in the physiological consequence of vasodilation (widening of blood vessels), which is responsible for diminishing peripheral resistance and producing orthostatic adjustments in blood pressure.

The broad mechanistic profile allows for the modulation of specialized signaling pathways, including the Chemoreceptor Trigger Zone (CTZ) and descending nociceptive circuits. By blocking multiple activating signals within these systems, the drug mechanism suppresses the pathways that initiate nausea and vomiting (antiemetic action) and supports the modulation of central sensory signal processing.

Dosage and Administration Information

The official administration guidelines for Levomepromazine (Nozinan) detail varied routes and dosing schedules depending on the required use pattern. The medicine is supplied in oral forms (tablets and solutions) and parenteral forms (solution for injection), allowing administration via the intramuscular (IM), intravenous (IV), and subcutaneous (SC) routes, including continuous subcutaneous infusion.

Dosage ranges vary significantly based on the context. For psychiatric use, initial daily oral doses may range from 25 mg to 50 mg for ambulatory patients, or 100 mg to 200 mg for bed patients, with a gradual increase (titration) allowed up to a maximum labeled quantity of 1 g daily if necessary. Conversely, for continuous subcutaneous infusion in palliative settings, daily doses typically range from 25 mg to 200 mg.

The administration schedule is often flexible, employing divided doses throughout the day or concentrating the largest portion of the oral dose at bedtime. Specific preparation is required for parenteral use: IV and continuous SC solutions must be diluted with normal saline immediately prior to administration.

Furthermore, specific instructions apply to certain groups; older adults generally require a lower initial dosage, and the total oral dose for pediatric patients should not exceed 37.5 mg to 40 mg. Patients receiving large initial doses must be kept in bed to manage positional effects. The overall protocol involves starting low, titrating up to a functional level, and then reducing to the lowest adequate maintenance dose.

Recent Clinical Evidence

Research Evidence / Overview of studies for Nozinan

Research Evidence for Severe Agitation and Delirium

Levomepromazine was studied in research exploring acute, disruptive episodes of agitation and delirium, particularly involving adults and geriatric patients with conditions characterized by fluctuating or episodic manifestations, such as those in terminal care. The research examined outcomes related to systemic or functional imbalance, such as changes in agitation severity scores and the documented time to achieve a planned level of calming.

Key limitations persist: comparative evidence is lacking from large-scale, placebo-controlled trials. The studies that exist often have sample sizes were modest and the results apply only to the populations studied, meaning the overall certainty remains low for definitive conclusions across all patient groups.

Evidence Supporting Anti-Nausea and Antiemetic Use

Levomepromazine was evaluated in studies examining patient-reported experiences of vomiting and nausea, sometimes involving symptoms that were resistant to standard treatments. The research utilized systematic reviews and small, non-randomized prospective studies involving adult patients in palliative care settings. These study designs monitored patient-reported outcomes describing perceived discomfort.

The systematic reviews consistently report a significant research gap: comparative evidence is lacking from published randomized controlled trials (RCTs) specifically for this use in the palliative setting. Because of this, high-level data are still emerging, and the evidence quality varies across studies.

Studies of Levomepromazine in Combination with Pain Medications

Research exploring how Levomepromazine was observed in combination with primary pain medications was studied for how the combination was associated with outcomes related to physical discomfort. These studies monitored patient-reported pain intensity scores and documented the use of supplementary pain medication. Follow-up durations were limited in many of these trials, and dedicated, high-quality studies focusing on episodes where symptoms become more noticeable are not widely available in the current literature.

Frequently Asked Questions (FAQ)

Common questions about Nozinan (FAQ)

Q: How quickly does Nozinan start working after you take it?

A: According to official product information, for the oral tablet form, the effect may begin within 30 minutes of administration. However, the time to reach its full effect can vary significantly among individuals and depending on the formulation (tablet, liquid, or injection) used.

Q: Does Nozinan cause withdrawal symptoms when you stop taking it?

A: Yes, official regulatory documents report that acute withdrawal symptoms can occur following the sudden discontinuation of high doses of neuroleptic medication. Symptoms may include nausea, vomiting, headache, anxiety, and insomnia. For this reason, official guidance typically advises a gradual reduction or withdrawal of the medicine.

Q: Does taking Nozinan long-term change how it works?

A: Long-term exposure is associated with a specific risk called Tardive Dyskinesia, which involves involuntary movements, especially in older adults. Regulatory documents primarily focus on this risk and do not explicitly guarantee sustained efficacy or describe a change in the drug’s fundamental mechanism over time.

Q: Can I drive a car while taking Nozinan?

A: Regulatory safety information warns that Nozinan can cause drowsiness and impair a person's vigilance and reaction time. Because of this potential for impairment, it is advised that activities requiring mental alertness, such as driving or operating heavy machinery, should be avoided if these effects are felt.

Q: Does Nozinan affect blood pressure readings?

A: Yes, official product information lists orthostatic hypotension (a drop in blood pressure when moving from sitting or lying down to standing) as a very common side effect. Due to this potential effect, monitoring blood pressure may be part of the care plan, especially when treatment begins.

Q: What kind of scientific research supports the use of Nozinan for its main indications?

A: Regulatory summaries acknowledge that the evidence, especially for uses in palliative care (anti-nausea, pain adjuvant), often comes from smaller, non-randomized studies or systematic reviews. They note that comparative, large-scale, placebo-controlled trials (Randomized Controlled Trials or RCTs) are often lacking for some of its indications.

Q: Why do some people call Nozinan a 'vintage' or 'older generation' medication?

A: The active substance, Levomepromazine, is formally classified as a phenothiazine derivative and a traditional neuroleptic. This classification places it within an earlier class of antipsychotic agents, which distinguishes it from the newer, second-generation medications.

Q: What is the difference between Nozinan tablets and liquid formulations?

A: Both forms contain the same active ingredient. Regulatory information indicates that the oral solution (liquid) is often favored when highly precise dose titration (fine-tuning the amount taken) is required. The body absorbs the active substance at a similar rate and extent across both formulations.

Q: What are the signs that Nozinan is working for my condition?

A: Nozinan's therapeutic role is to provide strong symptomatic control through its powerful sedative and calming properties. Official indications show it is used to manage severe agitation, anxiety, and to support pain and anti-nausea treatment protocols.

Q: Does Nozinan affect your ability to feel emotion?

A: Adverse reactions listed in the regulatory documents include psychiatric disorders such as indifference, anxiety, mood swings, and confusional states. While the term 'emotional blunting' is not explicitly used, these reported effects suggest the drug can modulate emotional and mental states.

Q: Can stopping Nozinan suddenly cause a relapse of symptoms?

A: Regulatory guidance confirms that the relapse of the underlying condition is a possibility following the sudden cessation of neuroleptic treatment. For this reason, official protocol advises that treatment should be reduced gradually under professional supervision.

Q: Why is Nozinan sometimes prescribed for sleep issues?

A: Nozinan is known for its potent sedative effects, which are a very common adverse reaction. Regulatory guidelines often recommend taking the largest part of the daily dose at bedtime to utilize this strong calming effect and minimize daytime sleepiness.

Q: What happens if you accidentally miss a dose of Nozinan?

A: Official patient guidance emphasizes that patients should not take a double dose to make up for a missed one. It advises consulting with a doctor or pharmacist for specific guidance on how to proceed after a missed dose.

Q: Can Nozinan make you more sensitive to the sun?

A: Yes, official safety information indicates that Nozinan can cause a photosensitivity reaction, meaning it increases the skin's sensitivity to sunlight. Regulatory sources advise protecting the skin from sunlight while taking this medicine.

Q: Does Nozinan affect contraception or hormone levels?

A: Reported adverse reactions include hyperprolactinaemia, which is an increase in prolactin hormone levels. This may be associated with conditions like galactorrhoea (milk secretion) and amenorrhoea (absence of menstrual periods).

Q: Can Nozinan affect your weight over time?

A: Yes, official adverse event reporting lists weight gain as a potential side effect. Regulatory bodies recommend that a patient’s body weight and blood glucose should be monitored regularly during treatment.

Q: What are the non-psychiatric uses for Nozinan?

A: Official indications for Nozinan include its use in psychiatric care, as well as its non-psychiatric role as an anti-emetic to manage intractable (uncontrollable) nausea and vomiting. It is also used as an adjuvant (supporting agent) in pain management protocols, particularly within palliative care settings.

Q: Does Nozinan affect liver function tests?

A: Yes, regulatory documents report potential adverse reactions including jaundice and liver injury. Monitoring of liver function may be recommended by healthcare providers, particularly before and during the initial phase of treatment.

Q: Are there any reported long-term cognitive effects from taking Nozinan?

A: Regulatory documents mention the risk of Tardive Dyskinesia associated with long-term use. Furthermore, in older patients, the drug's effects can lead to increased sensitivity, sometimes manifesting as confusion, disorientation, and altered consciousness.

Q: Does Nozinan require regular blood tests while you are taking it?

A: Official labeling suggests the need for baseline and periodic monitoring of certain metrics, such as blood count (due to the rare risk of agranulocytosis) and blood sugar (glucose).

Q: Does Nozinan cause blurred vision as a side effect?

A: Yes, regulatory reports list blurred vision as a potential side effect. Other vision-related issues, such as accommodation disorders (difficulty focusing) and deposits in the eye, have also been reported.

How should Nozinan be stored and disposed of?

The storage and disposal of Nozinan (Levomepromazine) must adhere strictly to the guidelines specified in official regulatory labeling to maintain product stability and ensure safety.

Official Storage Requirements

Condition
Temperature and Light Tablets must be stored below 25 C and all forms must be protected from light.
Packaging Keep the medicine in its original container and blister pack.
Child Safety It is mandatory to keep Nozinan out of the sight and reach of children.
Stability The oral solution may have an expiry of 3 months after opening. The injection solution must be used immediately after opening and is incompatible with alkaline solutions.

Official Disposal Instructions

Any unused or expired Nozinan product must be disposed of in accordance with local governmental requirements. The official instructions explicitly state that the medicine should not be disposed of in wastewater or thrown in household trash due to potential environmental hazards.

Attention! Always consult to a doctor or pharmacist before using pills or medicines.

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