Components:
Medically reviewed by Fedorchenko Olga Valeryevna, PharmD. Last updated on 26.06.2023
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Noxidol (chlortenoxicam) is a new nonsteroidal anti-inflammatory drug (NSAID) of the oxicam class with analgesic, anti-inflammatory and antipyretic properties. Noxidol differs from other oxicam compounds in its potent inhibition of prostaglandin biosynthesis, a property that explains the particularly pronounced efficacy of the drug. Noxidol is approved for use in Japan.
Noxidol is used to treat acute mild to moderate pain, and to treat pain and inflammation of the joints caused by certain types of rheumatic diseases.
Oral
Pain relief
Adult: 8-16 mg daily. Max: 24 mg daily.
Oral
Osteoarthritis; Rheumatoid arthritis
Adult: 12 mg daily in 2-3 divided doses, up to 16 mg daily if needed.
Parenteral
Pain relief
Adult: 8 mg once or twice daily by IM/IV inj. Max: 24 mg daily.
It is contra-indicated in the following groups of patients those allergic to Noxidol, or any of its excipients
Noxidol is used in short-term treatment of pain after dental surgery, pain associated with acute sciatica and pain and inflammation in osteoarthritis and rheumatoid arthritis.
Increased Noxidol blood conc when given concomitantly with cimetidine. Enhanced effects of anticoagulants, sulfonylureas, methotrexate, ciclosporin, digoxin. Decreased effects of diuretics, ACE inhibitors.
Potentially Fatal: Increased risk of lithium toxicity.
General : Headache, dizziness, somnolence, changes in appetite, increased sweating, loss of weight, oedema, allergic reactions, debility, weight increase.
Central nervous system (CNS): Depression, insomnia.
Eyes : Conjunctivitis, vision disorders.
Gastro-intestinal: Abdominal pain, diarrhoea, dyspepsia, nausea, vomiting, flatulence, dysphagia, constipation, gastritis, dry mouth, stomatitis, gastro-esophageal reflux, peptic ulceration with or without bleeding, esophagitis, haemorrhoidal or rectal bleeding.
Haematological : Anemia, ecchymosis, prolonged bleeding time, thrombocytopenia
Liver: Increased transaminases.
Musculo-skeletal: Cramps in leg, myalgia.
Neurological : Migraine, paraesthesia, taste perversion, tinnitus and tremor.
Respiratory : Dyspnoea, symptoms of irritation in upper respiratory tract.
Skin: Allergic skin reactions such as dermatitis, flushing and pruritis, loss of hair.
Urogenital : Micturition disorders.
Vascular : Palpitations, tachycardia, changes in blood pressure.