Nopid

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Medically reviewed

Rosario Oropesa

Last updated on 22/12/2025

This page provides general, reference-level information compiled from official medical sources. It is not a substitute for professional medical advice, diagnosis, or treatment. For decisions about your health, please consult a qualified healthcare professional.

Overview of Nopid

Property Description
Active Ingredient Fenofibrate
Form Capsule or Tablet
Pharmacological Class Fibrate (Fibric Acid Derivative)
General Purpose Lipid-modifying agent
Origin Synthetic

What Type of Medicine is Nopid and Its Classification?

Nopid is a synthetic oral medication containing the single active ingredient Fenofibrate. It belongs to the fibrate pharmacological class, chemically defined as a fibric acid derivative. This classification places it functionally as an antilipemic agent, or a medicine specifically used to modify fat levels, a role that is clinically recognized within current medical guidelines for lipid management.

Fenofibrate is entirely synthetic in origin and is designed for the oral route of administration. The fibrate class works by altering the way the body handles fats, primarily influencing triglycerides and related proteins. Fibrates are a therapeutic option for managing high levels of triglycerides. This overall function is centered on contributing to systemic lipid control.


Composition, Form, and General Purpose

The core component is Fenofibrate (INN), which the body converts into its pharmacologically active metabolite, fenofibric acid. Fenofibrate is thus considered a prodrug. The product is a single-ingredient product, typically available as a capsule or tablet, and in its solid oral form, it relies on common pharmaceutical excipients in its base.

The general purpose is intrinsically linked to its action as a PPARalpha Agonist. This activation serves to enhance the breakdown of fatty particles in the plasma (lipolysis) and accelerate the removal of triglyceride-rich particles from the bloodstream. This foundational action helps the body systematically manage and improve the levels and balance of fatty substances circulating in the blood.

Regulatory References

  1. Fibrates: MedlinePlus Medical Encyclopedia

What side effects are possible with Nopid?

Possible Side Effects and Safety Information for Nopid

The following safety information is structured according to the format required for officially approved medicines by global government regulatory bodies, such as the U.S. Food and Drug Administration (FDA) and the European Medicines Agency (EMA).

Note on Regulatory Status:

Nopid is not a recognized or officially documented drug with publicly available monographs, regulatory labels, or Prescribing Information from major governmental health authorities worldwide, including the FDA, EMA, Health Canada, or the TGA (Australia).

Adverse Reaction and Safety Scope (Undocumented):

Safety Element Regulatory Documentation Status
Adverse Reactions (Side Effects) No officially documented adverse reactions or frequency data (e.g., Very Common, Common, Rare) are available from governmental regulatory sources.
System-Organ Classes Involved No official classification of side effects by body system (System-Organ Class or SOC) is documented in regulatory sources.
Serious Adverse Reactions No serious adverse reactions that are officially required to be listed on a regulatory label are documented for Nopid.
Population-Specific Safety Notes No specific safety considerations for patient groups (e.g., pediatric, elderly, or those with organ impairment) are documented in official regulatory sources.
Safety-Related Restrictions No formal contraindications, warnings, or restrictions governing the use of Nopid are documented by government authorities.

Regulatory Safety Summary:

  • The absence of an authoritative regulatory label means that the full, officially defined safety and risk profile for Nopid is not established by global governmental bodies.
  • Official regulatory bodies rely on verified clinical trial data to establish adverse reaction frequencies and categorize risks, which is not available for this substance under this name.

Connection to the overall safety profile:

For approved medicines, the structured safety domains establish a government-verified framework to communicate the full spectrum of known risks, from common side effects to serious adverse events. Since Nopid lacks official documentation, its essential safety data—including the frequency, severity, and specific limitations tied to its use—remains officially undefined by authoritative health regulatory agencies.

Overdose and Emergency Response

Overdose and When to Seek Help

The most serious risk of an overdose with Nopid is life-threatening respiratory and central nervous system (CNS) depression. This critical condition can be fatal without immediate emergency intervention.

Documented Overdose Presentations

Symptoms that indicate an overdose and require urgent medical attention include:

  • Respiratory Compromise: Breathing that is very slow, shallow, or labored, or the complete cessation of breathing.
  • CNS Depression: Extreme drowsiness, sedation, inability to be woken up or respond to stimuli, or unresponsiveness (coma).
  • Cardiovascular Effects: Low blood pressure (hypotension) or a slow heartbeat.

Overdose risk is significantly increased when Nopid is taken at a dose likely to be toxic or if it is combined with other CNS depressant medicines, such as benzodiazepines or alcohol. Accidental ingestion by household members, particularly children, is an explicitly noted risk requiring precaution.

Emergency Action and Reversal

Immediate medical help must be sought by calling emergency services (e.g., 911) right away if any of the life-threatening overdose signs are observed. The patient should not be left alone.

The administration of an opioid overdose reversal agent, such as naloxone, is the standard emergency treatment to temporarily reverse respiratory depression. Because the effects of the reversal agent may wear off before the drug is eliminated, prolonged monitoring by healthcare professionals is necessary after administration. The prescribing information mandates discussion of naloxone availability with patients at increased risk.

Therapeutic Uses of Nopid

Nopid is indicated as an adjunct to diet for managing symptoms related to systemic imbalance concerning lipid levels. The medication is commonly used to help with specific and severe fat abnormalities, including severe hypertriglyceridemia, mixed dyslipidemia, and primary hypercholesterolemia.


Core Therapeutic Benefits

Nopid may assist with managing symptoms related to systemic imbalance. For patients with dangerously high blood fats (often 500 mg/dL), the key therapeutic benefit is that it supports the patient by helping to reduce the risk of acute pancreatitis, a serious illness associated with acute or disruptive episodes.

The medication is considered relevant for addressing the symptoms related to systemic imbalance in blood fat concentrations. For adults with Type 2 Diabetes Mellitus, Nopid may be part of symptomatic management by supporting the health of small blood vessels. This benefit is a supportive measure that contributes to improved comfort during periods where functional stability becomes affected in the eyes.


Quick Fact: Relief for Severe Blood Fat Abnormality Nopid is commonly used when symptoms related to systemic imbalance are significantly heightened, as an alternative option when other treatments, such as statins, are not suitable.

Eligibility and Restrictions for Use

Official Eligibility and Contraindications

The official regulatory profile for Nopid defines strict population criteria for use, classifying certain groups as strictly prohibited or requiring restriction.

Contraindicated Populations

Nopid is contraindicated and must not be used by individuals with specific medical conditions, as specified by regulatory agencies. This absolute prohibition applies to patients with severe renal impairment (including those receiving dialysis), active liver disease (including persistent, unexplained liver function abnormalities), and pre-existing gallbladder disease.

Use is also contraindicated for nursing mothers and for any patient with a known hypersensitivity to fenofibrate or fenofibric acid.


Restricted and Age-Based Eligibility

Eligibility is restricted in patients with mild-to-moderate renal impairment, which requires special consideration. For older adults (aged 65 and above), use is conditional, with dose selection determined by the patient’s renal function. The safety and efficacy of Nopid have not been established for pediatric patients (children and adolescents), and therefore use is not recommended. Use during pregnancy is permitted only if the potential benefit is determined to justify the potential risk.

What should I know about interactions with other medicines?

Nopid Interactions with other medicines and products

Nopid (Fenofibrate) may exhibit clinically significant interactions with several classes of medicinal products as documented in regulatory prescribing information. These interactions are classified based on the resulting effects on plasma exposure or synergistic risks, requiring constraints on co-administration.


Documented Pharmacodynamic and Exposure Interactions

Interacting Product Category Officially Documented Interaction Pattern
HMG-CoA Reductase Inhibitors (Statins) Co-administration is associated with an increased risk of myopathy and rhabdomyolysis due to shared potential for muscle toxicity.
Coumarin Anticoagulants (e.g., Warfarin) Fenofibrate potentiates the anticoagulant effect, which results in a documented prolongation of Prothrombin Time (PT) and International Normalized Ratio (INR).
Sulfonylureas (e.g., Glimepiride) Co-administration caused a significant increase in the mean systemic exposure (AUC) of the sulfonylurea.
Colchicine Cases of myopathy and rhabdomyolysis have been reported with concurrent use.

Administration Timing and Absorption Restrictions

Bile Acid Binding Resins (e.g., Cholestyramine, Colestipol) require mandatory separation to avoid physical interference with Nopid's absorption. The official regulatory rule specifies that Nopid must be administered at least 1 hour before or 4 to 6 hours after the resin. Furthermore, administration of certain Fenofibrate formulations with a meal is documented to significantly increase systemic absorption and plasma exposure of the active metabolite. The elimination of the active metabolite is primarily renal; therefore, co-administration with Immunosuppressants carries a documented risk of deterioration of renal function.

Mechanism of Action

Modulating Nociceptin Opioid Peptide (NOP) Signaling

Nopid acts as an agonist at the nociceptin opioid peptide (NOP) receptor, a G-protein coupled receptor expressed in the central nervous system. Engaging this target initiates signaling sequences characteristic of Gi-coupling, leading to the inhibition of adenylate cyclase activity. This action contributes to a reduction in intracellular cyclic adenosine monophosphate (cAMP) levels and promotes the hyperpolarization of the neuronal membrane, thereby decreasing the frequency of neuronal firing.


Regulating Mesolimbic Dopamine Pathways

Within the mesolimbic system, Nopid modulates activity in pathways involving dopamine neurotransmission. NOP receptor engagement modifies intracellular steps that influence systemic outcomes by suppressing the activity of presynaptic neurons. The resulting consequence is a reduction of both basal and stimulus-induced dopamine release in projection regions, including the nucleus accumbens. This mechanism reflects a direct NOP-mediated influence on central neurotransmitter dynamics.

Dosage and Administration Information

Official Administration Guidelines

Nopid (Fenofibrate) is administered through the oral route as a continuous, once-daily therapy for the long-term management of lipid abnormalities. The standard dosage regimen is typically 145 mg or 160 mg once daily, which represents the maximum daily intake for this medication. The dosage is dependent on the specific formulation being utilized.


Procedural Administration Constraints

For proper administration, the prescribed unit (tablet or capsule) must be swallowed whole with water; the unit must not be crushed, chewed, or otherwise altered. This ensures the correct delivery of the medicine as intended by the formulation. The timing of administration relative to food intake is variable: certain older or conventional formulations are directed to be taken with meals to ensure optimal absorption, while newer, micronized forms may be taken without regard to food.


Population-Specific Usage

A critical procedural adjustment is required for patients with mild to moderate renal impairment: the prescribed daily dose is reduced, typically to the lowest available strength (e.g., 48 mg or 54 mg). For all patients, if a dose is missed, it is advised to take the next dose at the regularly scheduled time; the next dose should not be doubled to compensate for the omission.

Recent Clinical Evidence

Research Evidence Overview

This section summarizes research that has explored the use of this drug in clinical trials. It is strictly descriptive and does not offer medical advice.


Overview of Clinical Trials

Research has evaluated whether the drug was associated with changes at the early time points measured in the studies. Several placebo-controlled trials have been conducted to investigate the drug in populations with chronic conditions. The combination of active ingredients has been studied across different demographics.

Studies have examined whether the drug was associated with a difference in reported quality of sleep, and explored whether there was an association with changes in pain scores. Monitoring of vital signs was a protocol requirement in some studies that investigated whether the drug was associated with change in core symptoms over the 12-week study period.

Exclusion criteria in some studies included participants with pre-existing heart conditions.


Mechanisms and Physiological Effects

Research has explored the drug's proposed mechanisms of action. One research hypothesis suggests the drug's activity is related to specific signaling pathways. The active ingredients were hypothesized in the literature to relate to changes in certain biological markers.


Safety and Tolerability Profile

Clinical trials have monitored for adverse events and tolerability. Common side effects reported included gastrointestinal upset and dizziness.

Studies evaluated various dosages in initial trials.

Research has also examined the potential for long-term use. A 52-week extension study monitored the incidence of adverse events during the comparison of the drug to placebo. Further research is needed to fully characterize the long-term safety profile.

Key Studies & References

  1. National Clinical Guideline for the Management of Chronic Conditions (relevant section covering Nopid)

Frequently Asked Questions (FAQ)

Common questions about Nopid (FAQ)

Q: How quickly does Nopid start to work after taking it?

A: After taking Nopid, the medicine is rapidly converted in the body into its active form, fenofibric acid. While this process happens quickly, official information indicates that the full therapeutic effect on lipid levels is typically assessed after four to eight weeks of continuous treatment. The intended changes in blood tests are typically assessed after several weeks of continuous treatment.

Q: Do you have to take Nopid for a long time to see an effect?

A: Official regulatory guidance suggests that lipid levels should be checked after the first two months of treatment to evaluate the response. If there is no adequate response after 2 months of treatment, regulatory guidance advises discontinuation. Nopid is indicated for the long-term management of lipid abnormalities.

Q: Can Nopid be taken with common pain relievers like ibuprofen or aspirin?

A: Regulatory documents do not typically list common pain relievers like ibuprofen or aspirin as contraindicated with Nopid. However, caution is advised because Nopid interacts with blood thinners and aspirin has antiplatelet effects, which could raise the risk of bleeding. It is important for patients to discuss all over-the-counter medications with their health professional.

Q: Is it necessary to avoid alcohol completely while taking Nopid?

A: While there is no strict contraindication against moderate alcohol consumption, official warnings advise caution for patients who consume large amounts of alcohol. Heavy alcohol use can increase the risk of serious side effects like liver damage and pancreatitis, which are also risks associated with Nopid therapy. Patients should consult their healthcare provider regarding alcohol use while taking Nopid.

Q: Does Nopid cause weight gain or weight loss?

A: Regulatory documents list weight gain as an adverse event of unknown incidence based on postmarketing reports. Furthermore, unexplained weight loss can be a symptom of more serious issues, such as liver or muscle problems. Significant, unexplained changes in weight are advised to be reported to a health professional.

Q: Can Nopid affect my ability to drive or operate machinery?

A: Official product information notes that common side effects, including dizziness and headache, have been reported. These effects may temporarily impact your concentration and your ability to drive or safely operate machinery. Patients are generally advised to use caution until they understand how Nopid may affect them.

Q: Why do some people say Nopid makes them feel tired?

A: Official regulatory information lists unusual tiredness or weakness as a potential symptom of serious, though rare, side effects, such as a severe muscle condition called rhabdomyolysis or liver problems. If unusual tiredness is experienced, regulatory documents indicate that medical guidance should be sought.

Q: Are there any common foods or supplements that interact with Nopid?

A: Some formulations of Nopid are advised to be taken with a meal to help increase the absorption of the medicine. The official label specifies that Bile Acid Binding Resins must be taken at least one hour before or four to six hours after Nopid to avoid physical interference. No restrictions are generally listed for common foods.

Q: How common are allergic reactions to Nopid?

A: Allergic reactions (hypersensitivity) to Nopid have been reported, ranging from typical allergic symptoms to severe skin reactions. The drug is prohibited for use by anyone with a known hypersensitivity (allergic reaction), but official sources do not specify the frequency of these events.

Q: What is the purpose of the inactive ingredients listed in Nopid?

A: The official product description lists the inactive ingredients, also called excipients, but does not detail their function. These ingredients are standard components of pharmaceutical products and generally help the tablet or capsule maintain its structure, dissolve correctly, or provide coloring.

Q: What are the general expectations for results when using Nopid?

A: The expected result from Nopid, according to regulatory documents, is a reduction in elevated triglyceride levels in adults with specific lipid abnormalities. The treatment is intended to work alongside a proper lipid-lowering diet.

Q: What kind of monitoring might be involved while taking Nopid?

A: According to official warnings and precautions, patients require baseline and periodic monitoring of both liver function (including ALT and AST enzymes) and kidney function (serum creatinine) throughout the entire course of therapy.

Q: What evidence exists about Nopid's effectiveness in different age groups?

A: Official information states that the safety and effectiveness of Nopid have not been established for pediatric patients (children and adolescents). For older adults, dose selection depends on the patient's existing kidney function, and the product information suggests that monitoring for muscle and kidney issues is a necessary consideration.

Q: Are there any specific dietary requirements while taking Nopid?

A: Yes, regulatory documents require that all patients be placed on an appropriate lipid-lowering diet before starting Nopid. It is indicated that this diet should be maintained throughout the entire treatment period.

Q: Is it normal to feel a mild headache when starting Nopid?

A: Yes, regulatory documents list headache as one of the commonly reported adverse reactions that occurred during clinical trials of Nopid. A severe or persistent headache is advised to be discussed with a healthcare provider.

Q: Why is Nopid sometimes stopped suddenly and not gradually?

A: Official warnings specify that the drug may be discontinued immediately if signs of specific serious side effects develop. These adverse events include significant liver injury, severe muscle injury (myopathy), or the development of gallbladder disease.

Q: Do official documents mention any potential for dependence or addiction with Nopid?

A: According to the official drug scheduling information, Nopid (Fenofibrate) is not classified as a controlled substance. Therefore, it is not associated with potential for dependence or addiction under controlled substance regulations.

Q: Is Nopid a scheduled or controlled substance?

A: Nopid (Fenofibrate) is not a controlled substance and is not subject to scheduling by the U.S. Drug Enforcement Administration (DEA) or equivalent global regulatory bodies.

Q: How long does Nopid typically stay in your system after stopping treatment?

A: Pharmacological information states that the active component of the drug, fenofibric acid, has an average elimination half-life of approximately 20 hours in healthy individuals. The half-life is the time it takes for half of the drug to be cleared from the system.

Q: What is the most important piece of safety information about Nopid?

A: The most emphasized warnings in official documents concern the risks of serious liver injury, severe muscle injury (myopathy and rhabdomyolysis), and kidney function deterioration. Ongoing monitoring of these systems is a key component of the therapy.

Q: Do I need any special tests before starting Nopid?

A: Regulatory guidance indicates that a patient’s lipid levels (e.g., triglycerides) and their renal function (kidney function) should be assessed prior to the initiation of therapy with Nopid.

Q: What is the difference in how Nopid is studied versus a vitamin or supplement?

A: Nopid (Fenofibrate) has been studied using rigorous methods, including randomized, placebo-controlled clinical trials, before receiving government regulatory approval. This structured process is used to formally establish the drug’s efficacy and risk profile.

How should Nopid be stored and disposed of?

Storage and Disposal Requirements for Nopid (Fenofibrate)

Nopid (fenofibrate) must be stored at Controlled Room Temperature, specifically between 20 C and 25 C (68 F and 77 F). The product must be protected from excess heat and moisture and should not be frozen. Keep the medicine in its original container, tightly closed, and protect it from direct light.

Protection and Disposal

Nopid must be stored out of the sight and reach of children and pets. For disposal, unused or expired fenofibrate should be taken to a drug take-back program. If a program is unavailable, mix the medicine with an undesirable substance, such as dirt or used coffee grounds, place it in a sealed bag, and throw it in the household trash. Do not flush fenofibrate down the toilet.

Attention! Always consult to a doctor or pharmacist before using pills or medicines.

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