Myoton

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Medically reviewed

Marina Burgos

Last updated on 10/01/2026

This page provides general, reference-level information compiled from official medical sources. It is not a substitute for professional medical advice, diagnosis, or treatment. For decisions about your health, please consult a qualified healthcare professional.

Overview of Myoton

Property Description
Active Ingredient Phenylbutazone
Form Granules (oral) or Solution (injection)
Pharmacological Class Nonsteroidal Anti-inflammatory Drug (NSAID)
Common Use Symptomatic relief of pain and inflammation
Origin Synthetic compound

What Type of Medicine is Myoton and What is its Composition?

Myoton is a medicinal preparation whose active component is Phenylbutazone, a powerful synthetic compound classified pharmacologically as a Nonsteroidal Anti-inflammatory Drug (NSAID). This substance is a Pyrazolone derivative, a chemical family clinically recognized for its potent anti-inflammatory effects.

The preparation is built around Phenylbutazone as a single-ingredient product. A key differentiating factor for this drug is its primary focus on the veterinary field, predominantly for managing inflammatory and painful conditions in horses. Unlike many NSAIDs, Phenylbutazone’s use is largely confined to this specialized application.


Physical Forms and Primary Action

The medicine is available in physical presentations designed for direct administration, including granules or a powder for the oral route, and a liquid solution formulated for parenteral (injectable) delivery. This dual availability offers versatility in administration, which is a differentiating feature for a large-animal medication.

Myoton's primary action is rooted in its combined ability to produce anti-inflammatory, analgesic (pain-relieving), and antipyretic (fever-reducing) effects. Phenylbutazone acts as a cyclooxygenase inhibitor. The medicine functions by regulating the body's internal chemical signals that trigger and sustain discomfort.


General Purpose of this Anti-inflammatory Preparation

The general purpose of this preparation is to offer symptomatic support and relieve the acute physical manifestations associated with inflammatory states, such as managing musculoskeletal discomfort. For instance, it is typically used to ease inflammation and pain following excessive exertion or minor soft tissue injury, acting as a crucial component of supportive care.

The cumulative benefit is improved comfort and mobility for the intended subject, facilitated by the drug’s action against the symptoms of inflammation, pain, and fever. The fundamental role of the preparation is thus to act as a symptomatic countermeasure to inflammatory processes, providing targeted relief where it is needed most.

Regulatory References

  1. FDA-Approved Phenylbutazone Powder Label (DailyMed)

What side effects are possible with Myoton?

Possible Side Effects and Safety Information

The official safety profile for Myoton (Phenylbutazone) is primarily structured around risks to specific physiological systems. Adverse reactions are classified by regulatory authorities into System-Organ Classes, most notably Gastrointestinal Disorders, Blood and Lymphatic System Disorders, Renal and Urinary Disorders, and Hepatobiliary Disorders.


Serious Adverse Reactions

The regulatory labeling documents serious, potentially irreversible safety concerns. These include severe bone-marrow depression (leading to blood dyscrasias like agranulocytosis and aplastic anemia), which is documented as a risk that is not dose-dependent and unpredictable. Other serious reactions include gastrointestinal hemorrhage or perforation, as well as severe hepatic or renal failure. Severe generalized reactions, such as Stevens-Johnson syndrome, have also been documented.


Safety Constraints and Population Risks

Official safety statements note that Phenylbutazone has a low therapeutic index. The occurrence of blood disorders may develop soon after starting treatment or following prolonged exposure.

Regulatory documents specify explicit safety constraints for its use. The medicine is contraindicated in individuals with pre-existing severe cardiac, hepatic, or renal disease, or a history of gastrointestinal ulceration or bleeding. Additional risks are associated with use in aged individuals or those who are dehydrated or hypovolaemic.

Overdose and Emergency Response

The official regulatory profile for Myoton (Phenylbutazone) overdose emphasizes the potential for severe, multi-systemic toxicity, necessitating an immediate medical emergency response.

Overdose Scope (Official Regulatory Findings)
Documented Manifestations Clinical signs include gastrointestinal effects such as peptic ulceration, GI bleeding (with black or tarry stools), and stomach pain. Neurological symptoms including severe headache, drowsiness, confusion, and progression to convulsions or coma are documented.
Severe Outcomes Toxicity is associated with life-threatening organ damage, including renal failure, fatal hepatic injury, and the potential for aplastic anemia and other serious blood dyscrasias.
Special Risk Notes Regulatory labeling notes a higher risk of adverse outcomes for elderly, frail, or debilitated patients, and those with pre-existing impaired renal function. Overdoses are cited as potentially deadly, even at low exposures.

Emergency Response Statements

Regulators mandate that individuals must seek immediate medical attention or call the Poison Control Center immediately following a known or suspected overdose; DO NOT delay calling for help. Therapy must be immediately ceased if signs of toxicity appear. Since no specific antidote is known, management is symptomatic and supportive. Severe cases often require hospitalization for necessary procedures like gastric lavage or activated charcoal administration, alongside continuous monitoring of vital signs and blood status.

Therapeutic Uses of Myoton

Myoton (Phenylbutazone) is applied across domains where additional symptomatic support is needed for the musculoskeletal system in horses.

The medicine is relevant for easing symptoms in conditions such as various arthritides, including osteoarthritis.


Key Therapeutic Applications and Benefits

Myoton is commonly used across conditions characterized by periods of heightened symptoms, such as osteoarthritis, chronic arthrosis, laminitis, and following soft tissue injuries. The preparation helps address symptom clusters that may become intense or disruptive, such as pain, stiffness, lameness, and fever. It may assist with maintaining functional stability by managing the symptoms related to physical discomfort.

“The medication supports patients during episodes of heightened discomfort and contributes to a sense of stability when symptoms are more noticeable.”

It contributes to easing the overall symptom load by supporting patients during these episodes and is applicable within clinical settings that involve acute or disruptive symptom patterns.

Quick Fact: Symptomatic Support
Primary focus: Applied across domains where additional symptomatic support is needed for the musculoskeletal system in horses.

Regulatory References

  1. NIH DailyMed label information for Phenylbutazone

Eligibility and Restrictions for Use

Who Can and Cannot Use Myoton (Phenylbutazone)?

Myoton (Phenylbutazone) eligibility is strictly defined by regulatory bodies (such as the FDA) due to its specialized use and severe risks in other populations.

Contraindicated and Prohibited Populations

Myoton is strictly contraindicated and prohibited for use in:

  • Humans: The drug is not approved for human use.
  • Food-Producing Animals: Use is prohibited in horses intended for human consumption and includes an extra-label use ban in female dairy cattle 20 months of age or older.
  • Organ Pathology: Animals with pre-existing serious hepatic, renal, or cardiac pathology.
  • Blood Disorders: Animals with a history of blood dyscrasia.

Approved and Conditional Use

Myoton is approved primarily for use in Horses and, in specific formulations, Dogs.

Conditional use or caution is required for the following populations, as stated in the label:

  • Age Groups: Foals and Ponies.
  • Physiological Status: Pregnant or nursing mares.
  • Systemic Conditions: Animals that are debilitated or dehydrated, or have a history of gastrointestinal ulcers.

What should I know about interactions with other medicines?

Interactions with other medicines and products

This section describes officially documented interaction patterns for Myoton (Phenylbutazone) as recognized in government regulatory sources, focusing on pharmacokinetic and pharmacodynamic effects.


Documented Drug-Drug Interactions

Interacting Product Category Officially Described Interaction Pattern
Anticoagulants (e.g., Warfarin) Amplifies the anticoagulant effect by displacing the agent from plasma proteins and inhibiting the CYP2C9 enzyme, increasing the risk of hemorrhage.
Other NSAIDs, Salicylates, Corticosteroids Co-administration is restricted as it increases the risk of additive gastrointestinal toxicity, including ulceration and hemorrhage.
Sulfonylurea Antidiabetics May affect blood levels and duration of action, increasing the potential for hypoglycemia.
Phenytoin and Valproic acid May affect the blood levels and duration of action of these agents.

Drug-Product Constraints

Food (Feed) Interaction: Regulatory documents note that administration with feed alters the drug's absorption kinetics. This interaction causes a delayed time to peak effect and decreases peak plasma concentrations of the active ingredient.

Population Cautions: Administration is contraindicated in animals with serious Hepatic, Renal, or Cardiac Pathology, which reflects an increased risk or severity of interaction-related adverse outcomes in these populations.

Mechanism of Action

Molecular Inhibition of Prostaglandin Synthesis

Myoton's mechanism is rooted in the non-selective inhibition of the Cyclooxygenase (COX) enzyme system ( COX-1 and COX-2), which blocks the conversion of arachidonic acid into Prostaglandins . This molecular block is the fundamental cause of the drug's ability to modulate Prostaglandin-driven physiological inflammation and nociception. Prostaglandins function as key chemical mediators in these processes.


Modulation of Cellular and Central Responses

Beyond its primary enzyme action, the drug engages secondary mechanisms by stabilizing lysosomal membranes and inhibiting the migration of white blood cells, thereby modulating the cellular component of inflammation and the potential for enzyme-driven local tissue responses. Furthermore, the mechanism modulates the central thermoregulatory pathway via action on the hypothalamus, altering the core temperature set point.


⏳ Mechanistic Constraints and Onset Factors

This mechanism inherently carries a constraint due to its non-selective nature, which affects the constitutive COX-1 enzyme and limits the body’s homeostatic Prostanoid production. The full physiological effect is often kinetically delayed because the mechanism must wait for pre-existing inflammatory mediators to degrade and dissipate from the site of action, even though the molecular block occurs rapidly.

Dosage and Administration Information

The device branded Myoton (MyotonPro) is a handheld myotonometer used for non-invasive measurement of muscle biomechanical properties, such as tone, stiffness, and elasticity, not a pharmaceutical drug with dosage guidelines. The proper use is governed by standardized clinical and research protocols to ensure accurate data collection.

Administration Scope

Protocol Specification
Route of administration Non-invasive, contact application to the skin over the muscle.
Dosing schedule (as written in regulatory sources) Not Applicable (Device): Measurement involves collecting five specific parameters (e.g., stiffness, elasticity) per measurement point.
Preparation requirements (if applicable) The precise measurement point (MP) must be marked on the skin directly above the tissue of interest using a skin marker.
Age-group administration rules The subject must be capable of maintaining a specific, consistent body position (e.g., supine or seated) throughout the measurement session.
Special procedural conditions The device probe must be held perpendicular to the skin's surface and stabilized axially, often with dual-hand support, during execution.

Resulting Procedural Structure

The official instruction sequence focuses on site accuracy and device stability:

  • Site Preparation: Mark the exact measurement point on the skin over the target muscle.
  • Positioning: Place the subject in a comfortable, specified position to ensure the target muscle is relaxed.
  • Execution: Place the probe gently and perpendicular to the marked site. Slowly move the device until the green light illuminates, which automatically initiates the measurement series (five mechanical impulses at 0.4 N force).

This structured, official protocol ensures that the data collected on the muscle's mechanical and viscoelastic characteristics are reliable, repeatable, and independent of the operator, which is essential for monitoring changes over time.

Recent Clinical Evidence

Research Evidence / Overview of Studies for Myoton (Phenylbutazone)

This overview summarizes the structure and reported findings of the official research that has been conducted on Myoton (Phenylbutazone), focusing only on the types of studies available and what they observed, without providing clinical advice or making claims about individual outcomes.


Evidence for Use in Musculoskeletal Inflammatory Conditions

Research on Myoton has been applied in studies examining outcomes linked to inflammatory or irritative states associated with the musculoskeletal system. These studies, including short-term Randomized Controlled Trials (RCTs) and Clinical Field Studies, was studied for measured outcomes related to how symptoms change over time in the observed populations. Researchers primarily included adult horses presenting with various forms of inflammation and joint discomfort.

The studies monitored outcomes related to physical discomfort, assessed parameters such as the severity of lameness, and physical signs like changes in joint swelling and joint movement. Studies reported measurements detailing symptom patterns observed in the populations over short-term intervals, typically spanning less than two weeks. Research provided measurements related to the animals' functional abilities during the study period.

However, the follow-up durations were limited in these primary trials. Consequently, there is limited information for long-term outcomes or how the symptomatic patterns may be maintained over many months or years. The evidence for these conditions is derived primarily from trials assessing short-term or episodic symptom patterns, and it does not fully characterize extended functional stability.


Evidence for Short-Term Lameness and Pain Relief

Specific controlled studies research examined the agent's role in providing symptomatic relief for lameness, a condition marked by functional limitations. These studies were used in research exploring short-term symptom changes, often using highly technical methods like objective force plate analysis (measuring weight distribution). The studies monitored outcomes describing the time course related to the changes in discomfort metrics.

Data show patterns related to the time course of measured outcomes reflecting daily functioning or activity level observed during the study intervals. Studies reported measurements that described specific timeframes for peak change in weight-bearing distribution. Research describes observations where different concentrations were evaluated in comparison to each other.


What is Still Uncertain About Myoton's Research Base

The current body of research contains areas where certainty remains low or where more data is needed. The primary limitation is that follow-up durations were limited across many of the key trials used for measured outcomes, leaving limited information for long-term outcomes and functional stability. The evidence highlights what is known—and what is still uncertain—particularly regarding the ability of the agent to affect outcomes beyond the immediate symptom period.

Key Studies & References Phenylbutazone Paste Label Information (For Horses)

Frequently Asked Questions (FAQ)

Common questions about Myoton (FAQ)

Q: How quickly can someone generally expect to feel the effects of Myoton?

A: Official documents describe the response to treatment as often prompt, with effects sometimes reported within 24 hours after administration. The full physiological effect may be slightly delayed because the drug must wait for pre-existing inflammatory chemicals in the body to break down and dissipate.

Q: What are the official recommendations on how long Myoton can be used?

A: Research evidence suggests that the evidence base for this drug is derived primarily from short-term trials. Safety warnings state that serious blood disorders may occur soon after starting treatment or following prolonged exposure.

Q: Does Myoton have a withdrawal period?

A: Official documents note that for many chronic conditions treated by this agent, discontinuance of treatment may result in the recurrence of symptoms. This indicates that the drug provides symptomatic relief that may resolve or cease when the drug is discontinued.

Q: What is the experience of patients who have been on Myoton for several years?

A: The research base for this agent has limited follow-up durations and contains limited information for long-term outcomes or functional stability over many months or years. The available evidence does not fully characterize the long-term patterns of use over extended periods.

Q: Is Myoton a type of narcotic or controlled substance?

A: No. Official documentation describes Phenylbutazone, the active ingredient, as a non-hormonal, anti-inflammatory agent and a synthetic pyrazolone derivative. It is not classified as a narcotic or controlled substance.

Q: Is Myoton available over the counter?

A: No. Official labels indicate that Federal law restricts this drug to use by or on the order of a licensed professional, meaning it is available by prescription only.

Q: Is Myoton safe for use during pregnancy or while breastfeeding?

A: Official documents state that the compound is noted to cross the placenta and is associated with potential risks to the developing embryo. Small amounts have also been detected to enter breast milk.

Q: Does Myoton have any known interactions with alcohol?

A: The drug is strongly contraindicated in cases of alcoholism or other chronic liver disease. Alcohol consumption is known to be associated with an increased risk of gastrointestinal toxicity when combined with many Non-Steroidal Anti-Inflammatory Drugs (NSAIDs).

Q: Is Myoton safe to use with common pain relievers like ibuprofen or aspirin?

A: Official regulatory sources advise against co-administration with Other NSAIDs (like ibuprofen) and Salicylates (like aspirin). Combining these agents increases the risk of additive gastrointestinal toxicity, including ulceration and internal bleeding.

Q: Are there specific vitamins or supplements that might interact with Myoton?

A: While official regulatory documents focus on drug-drug interactions, the general precaution is to inform a prescriber of all other medications, including over-the-counter products, vitamins, and herbal supplements. This helps assess potential interactions that may affect the drug's safety or effectiveness.

Q: Are there specific symptoms that need immediate medical attention while on Myoton?

A: Regulatory documents list severe adverse events such as signs of bone-marrow depression (e.g., blood dyscrasias) and gastrointestinal hemorrhage or perforation (e.g., black or tarry stools). These are cited as serious, potentially irreversible safety concerns in regulatory documents.

Q: What should be done if an allergic reaction is suspected after taking Myoton?

A: Official documentation indicates that caution is advised for individuals with a history of drug allergy. Hypersensitivity reactions, including severe generalized reactions like Stevens-Johnson syndrome, have been reported as adverse effects.

Q: Can Myoton affect a person's ability to drive or operate machinery?

A: The drug is associated with potential adverse reactions that include dizziness and drowsiness (tiredness). Official documents note that caution is generally advised when engaging in activities that require mental alertness.

Q: Is there a link between Myoton and headaches?

A: Yes, headache is listed as a potential adverse reaction in regulatory safety profiles.

Q: Can Myoton cause changes in mood or sleep patterns?

A: Regulatory documents list central nervous system (CNS) effects such as dizziness, drowsiness, and headache as potential adverse reactions associated with the drug's use.

Q: Why do some people report feeling tired after starting Myoton?

A: Drowsiness is noted as a potential adverse effect associated with the drug's use in official safety documents.

Q: Can Myoton cause weight changes?

A: Potential adverse effects of this drug include edema (swelling) due to salt and water retention. This fluid retention is often described as a factor contributing to weight changes.

Q: Is Myoton similar to Drug X (a common comparator drug)?

A: Myoton (Phenylbutazone) is classified as a Non-Steroidal Anti-Inflammatory Drug (NSAID). Its action involves the non-selective inhibition of the Cyclooxygenase (COX) enzyme system to reduce inflammation.

Q: What is the key difference between Myoton and other drugs used for the same purpose?

A: Myoton's mechanism is based on the non-selective inhibition of the COX enzyme system. The regulatory safety profile is notable for a low therapeutic index and a potentially severe, non-dose-dependent risk of serious blood disorders.

Q: Is Myoton intended to cure a condition or just manage symptoms?

A: Research evidence primarily involves studies on symptomatic relief for inflammatory conditions and lameness, focusing on how symptoms change over short-term intervals. The research focus is typically on measuring symptomatic changes rather than demonstrating a cure for the underlying condition.

Q: Does taking Myoton with food change how it works?

A: Yes. Administration with food is noted in regulatory documents to alter absorption kinetics, which causes a delayed time to peak effect and a decrease in peak plasma concentrations of the active ingredient.

Q: Can Myoton be split or crushed?

A: Official administration notes state that in some cases, the dosage form (tablet) may be crushed and given with feed.

Q: Can Myoton be used by older adults (e.g., people over 65)?

A: Official safety statements note that risks are associated with use in aged individuals, which generally highlights the need for close monitoring.

Q: Can Myoton affect lab test results?

A: Yes. Due to the risk of blood dyscrasias, regulatory guidelines advise performing routine blood counts at specific intervals throughout the course of therapy. The monitoring is intended to assess for potential blood cell level changes.

Q: Is there a generic version of Myoton available?

A: Yes, regulatory databases show that generic forms of Phenylbutazone are available.

How should Myoton be stored and disposed of?

The official storage and disposal requirements for Myoton (Phenylbutazone) are strictly defined by its physical form to maintain stability.

Storage Conditions and Protection

Storage Scope Requirement (Based on Official Labeling)
Temperature Range Oral Forms: Controlled Room Temperature (15 C to 30 C). Injectable Solution (varies): Store below 25 C or refrigerated, depending on the label.
Handling Constraints The injectable solution must not be frozen and must be protected from light.
Container Rule Keep the container tightly closed and store in the original container.
Child Safety Mandatory to keep out of the reach of children.

Disposal Instructions

All unused or expired product must be disposed of in accordance with local waste regulations. It is officially required to avoid release to the environment, and the product must not be allowed to enter watercourses or drains to prevent environmental contamination.

Attention! Always consult to a doctor or pharmacist before using pills or medicines.

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