Myoril Plus

Myoril Plus is a muscle relaxant with anti-inflammatory and analgesic effects. It acts as a competitive GABAA receptor antagonist and also glycine receptor antagonist with similar potency and nicotinic acetylcholine receptors to a much lesser extent. It has powerful convulsant activity and should not be used in seizure-prone individuals.

Bromazepam is an intermediate-acting tranquiliser, prescribed for the treatment of moderate to severe anxiety and panic disorders and for the short-term treatment of insomnia. Unlike the benzodiazepine alprazolam it does not possess any antidepressant qualities.

In low doses it diminishes anxiety and tension. In higher doses the sedative and muscle-relaxant properties appear.

Oral

Muscle spasms

Adult: Initially, 16 mg daily.

Intramuscular

Muscle spasms

Adult: Up to 8 mg daily.

If you are allergic to any drugs, or if you have any of the following conditions inform your doctor before using Myoril Plus:

kidney disease;

bleeding problems; The drugs prevent blood clotting [warfarin sodium ( Coumadin )] utilization.

Myoril Plus is used (as an additive treatment) for relieving painful stiffness or constriction in various diseases of the muscles, nerves, spine and the joints.

LEXOTAN undergoes hepatic microsomal oxidation via the cytochrome P450 liver enzymes.

Therefore, caution should be taken in patients taking medicines that inhibit the P450 liver enzymes (e.g. azole antifungals, macrolide antibiotics, HIV protease inhibitors, calcium channel blocking agents).

LEXOTAN undergoes oxidative metabolism and, consequently, may interact with disulfiram or cimetidine resulting in increased plasma levels of LEXOTAN. Patients should be observed closely for evidence of enhanced benzodiazepine response during concomitant treatment with either disulfiram or cimetidine; some patients may require a reduction in benzodiazepine dosage.

The benzodiazepines, including LEXOTAN, produce additive CNS depressant effects when coadministered with other medications which themselves produce CNS depression e.g. barbiturates, alcohol, sedatives, antidepressants, hypnotics, anxiolytics, phenothiazines and other antipsychotics,

skeletal muscle relaxants, antihistamines, narcotic analgesics and anaesthetics.

Alcohol should be avoided in patients receiving LEXOTAN.

In the case of narcotic analgesics enhancement of euphoria may also occur, leading to an increase in psychic drug dependence.

The anticholinergic effects of atropine and similar medicines, antihistamines and antidepressants may be potentiated.

Interactions have been reported between some benzodiazepines and anticonvulsants, with changes in the serum concentration of the benzodiazepine or anticonvulsant. It is recommended that patients be observed for altered responses when benzodiazepines and anticonvulsants are prescribed together and that serum level monitoring of the anticonvulsant be performed more frequently.

Interference with Clinical, Laboratory or Other Tests:

Minor EEG changes, usually low voltage fast activity, of no known clinical significance, has been

reported with benzodiazepine administration.

Photosensitivity reactions,Myoril Plus Tablets and capsules may cause irritation of the digestive system. Therefore, your doctor Myoril Plus tablets / capsules during your use of gastric protective drugs may tell you to use. Follow your doctor’s instructions.

If diarrhea occurs In such a situation should reduce your dosage. Myoril Plus rest, physical therapy and other measures, including pain relief is only one part of the complete treatment program.

Avoid drinking alcohol. Alkol Myoril Plus alcohol may increase some side effects.