Microvlar

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Medically reviewed

Laura Arias

Last updated on 22/12/2025

This page provides general, reference-level information compiled from official medical sources. It is not a substitute for professional medical advice, diagnosis, or treatment. For decisions about your health, please consult a qualified healthcare professional.

Overview of Microvlar

Property Description
Active Ingredients Ethinyl Estradiol, Levonorgestrel
Form Oral Tablet
Pharmacological Class Hormonal Contraceptive
Common Use Pregnancy Prevention
Origin Synthetic

Microvlar is a Combined Oral Contraceptive (COC) tablet used for Systemic hormonal contraception. It is a prescription-only medicine classified within the pharmacological group of Hormonal Contraceptives, specifically a combined estrogen and progestogen preparation. This dual hormonal structure is clinically recognized for its reliability in preventing pregnancy.


What Type of Medicine is Microvlar?

Microvlar is classified as a Combined Oral Contraceptive (COC), meaning it contains two distinct synthetic hormonal components. This combined approach utilizes the synergistic effects of both an estrogen and a progestogen to achieve its therapeutic goal. It is typically a monophasic formulation, where every active oral tablet delivers the same fixed dose of both hormones throughout the administration cycle, offering consistent hormonal input.


What is the Composition of Microvlar?

The two essential active ingredients in Microvlar are the synthetic estrogen, Ethinyl Estradiol, and the synthetic progestogen, Levonorgestrel. Both compounds are synthetic in origin, chemically created to function similarly to naturally occurring sex hormones. This combination is commonly referenced as a low-dose or second-generation pill within the broader category of COCs.


What is the General Purpose of Microvlar?

The general purpose of Microvlar is pregnancy prevention for women of childbearing age, as observed in a neutral use scenario requiring reliable contraception. This is achieved by the systemic hormonal action causing three simultaneous effects: stopping the release of an egg, thickening cervical mucus to block sperm, and altering the uterine lining to impede implantation. This systemic action serves as a highly effective method of female contraception.

Regulatory References

  1. NIH StatPearls: Oral Contraceptive Pills

What side effects are possible with Microvlar?

Possible Side Effects and Safety Information

Microvlar, a combination oral contraceptive containing levonorgestrel and ethinylestradiol, carries risks associated with this class of medication, including serious and common adverse reactions documented in regulatory sources.

Serious and Clinically Significant Risks

The most significant safety concern is an increased risk of thromboembolic events, including deep vein thrombosis (DVT), pulmonary embolism, myocardial infarction (heart attack), and stroke. This risk is notably elevated in smokers aged 35 years and older and in patients with other risk factors such as hypertension or obesity. Regulatory documents also cite risks of hepatic neoplasia (liver tumors, both benign and malignant) and the development or exacerbation of hypertension (high blood pressure).

Common Adverse Reactions

Adverse reactions that are frequently reported, particularly during the initial cycles of use, include menstrual irregularities such as breakthrough bleeding or spotting, headache (including migraines), nausea, breast tenderness or pain, and mood changes (e.g., depressed mood). Other common effects involve the gastrointestinal system (abdominal pain) and the skin (acne, chloasma/melasma).

Safety Restrictions and Limitations

Microvlar is contraindicated in patients with a history of or current thromboembolic disorders, severe liver disease, known or suspected sex-steroid-influenced malignancies (like breast cancer), or undiagnosed abnormal genital bleeding. The medication must be discontinued immediately if symptoms of thrombosis, severe new headaches, or jaundice occur. Use in the immediate postpartum period or by nursing mothers may require particular caution based on regulatory guidance.

Overdose and Emergency Response

Microvlar Overdose and When to Seek Help

The section "Overdose and when to seek help" reflects the official regulatory status for Microvlar, a combined oral contraceptive. The acute overdose profile is based exclusively on documented clinical manifestations and regulator-mandated emergency actions.

Documented Manifestations

Overdose may present with signs that are generally transient. Officially documented manifestations include the gastrointestinal symptoms of nausea and vomiting. A specific gynecological manifestation is withdrawal bleeding, which is noted to occur in females who have ingested a dose exceeding the prescribed amount. Regulatory labeling highlights that this manifestation may also be observed in prepubertal girls.

Emergency Response and Management

Immediate medical attention must be sought in all cases where an overdose is suspected or a large quantity of tablets has been ingested. The regulatory guidance mandates this action for any ingestion outside of normal use. According to official documents, there is no specific antidote known for the Ethinyl Estradiol and Levonorgestrel combination. Therefore, the required management protocol is limited to providing treatment that is symptomatic and supportive, designed to address only the specific clinical manifestations that are observed. Close medical observation may be necessary for assessment following ingestion.

Therapeutic Uses of Microvlar

What Microvlar Treats: Main Uses and Benefits

Microvlar, a type of Combined Oral Contraceptive (COC), is commonly used for pregnancy prevention and for managing certain hormone-related symptomatic conditions. Its core therapeutic domain is to provide support for fertility control for females of reproductive potential. This medication helps manage symptoms related to systemic imbalance, specifically addressing menstrual cycle dysregulation, related symptomatic discomfort, and pronounced skin manifestations like acne.


Therapeutic Applications

The medication is commonly used to help with conditions characterized by recurrent or episodic manifestations such as irregular periods, painful cramping, and hormone-driven acne. It may be used for managing symptoms that interfere with daily functioning, and may assist with easing the overall symptom load associated with heavy bleeding and severe discomfort. Its primary use focuses on managing fertility control, which supports reproductive autonomy and planning.

“This medication is considered relevant when supportive symptom management is appropriate alongside the need for fertility control.”


Quick Fact: Managing Cycle Predictability

Microvlar supports patients during episodes of heightened discomfort by assisting with functional stability and contributes to day-to-day comfort during symptomatic periods.

Regulatory References

  1. NIH MedlinePlus overview on Combined Oral Contraceptives

Eligibility and Restrictions for Use

Who can and cannot use Microvlar?

Microvlar (Levonorgestrel and Ethinyl Estradiol) is an oral contraceptive intended for use by females of reproductive potential seeking pregnancy prevention. Eligibility is strictly defined by regulatory documents, which list specific conditions and populations for whom the medicine is contraindicated (must not be used).


Absolute Contraindications

The medicine is prohibited for individuals with a high risk of blood clots or with specific health conditions, including:

  • Females over the age of 35 who smoke.
  • A history of deep vein thrombosis, pulmonary embolism, or cerebrovascular disease (e.g., stroke).
  • Known or suspected pregnancy.
  • History of breast cancer or other hormone-sensitive cancers.
  • Severe liver disease (e.g., decompensated cirrhosis or liver tumors) or uncontrolled hypertension.
  • Migraine headaches with focal neurological symptoms.

Restricted and Non-Recommended Use

Population Status Regulatory Rule
Postpartum Must not be started until 4 weeks after delivery in non-breastfeeding women.
Lactation Not recommended during breastfeeding (may decrease milk production).
Age Limits Not indicated for postmenopausal women or females who have not started menarche (onset of menstruation).

Eligibility also restricts use in patients with diabetes mellitus if associated with vascular disease or organ damage.

What should I know about interactions with other medicines?

Microvlar, a combined oral contraceptive containing ethinylestradiol and levonorgestrel, is subject to clinically significant drug interactions that can reduce its effectiveness or alter the effects of co-administered medicines.

Interaction Mechanism and Risk

Reduced Efficacy: The primary concern is pharmacokinetic interaction where other substances increase the metabolism of the contraceptive hormones. This occurs through the induction of hepatic microsomal enzymes, primarily Cytochrome P450 (CYP) enzymes, which increase the clearance of ethinylestradiol and levonorgestrel from the body. This reduction in hormone levels carries the risk of contraceptive failure (pregnancy) and is classified as a clinically significant interaction.

Interacting Medicinal Products

  • Enzyme Inducers: This class includes certain anticonvulsants (e.g., phenytoin, carbamazepine, barbiturates), the antimycobacterial rifampicin, and the antifungal griseofulvin. Ritonavir and other HIV protease inhibitors or NNRTIs may also increase metabolism.
  • Other Drugs: Certain broad-spectrum antibiotics and herbal products like St. John's wort are cited in regulatory literature as having the potential to interfere with contraceptive hormone levels, though the exact mechanism (e.g., enzyme induction or disruption of enterohepatic circulation) and clinical relevance vary.

Impact on Other Medicines

Microvlar can also act as an enzyme inhibitor, affecting the metabolism of other compounds. This may lead to an increase in the plasma concentration of co-administered drugs, such as cyclosporine or lamotrigine, potentially increasing the risk of adverse effects from those drugs. The official labeling specifies that co-administered drugs may require monitoring or dose adjustment due to this effect.

Mechanism of Action

Microvlar, a combined oral hormonal agent, contains ethinylestradiol (an estrogen) and levonorgestrel (a progestin). These compounds exert their effects primarily on the hypothalamic-pituitary-ovarian axis. Levonorgestrel acts as a progesterone receptor agonist, binding to intracellular progesterone receptors within target tissues, including the hypothalamus and anterior pituitary gland. Ethinylestradiol, an estrogen receptor agonist, also modulates this axis.

This combined agonism establishes a potent negative feedback loop at the level of the hypothalamus and pituitary. Intracellular signaling cascades initiated by receptor binding inhibit the pulsatile secretion of Gonadotropin-Releasing Hormone (GnRH) from the hypothalamus and suppress the release of Luteinizing Hormone (LH) and Follicle-Stimulating Hormone (FSH) from the anterior pituitary.

The absence of the mid-cycle LH surge prevents the final maturation and rupture of the ovarian follicle, resulting in anovulation. Downstream physiological consequences at the system level include a change in cervical physiology, where levonorgestrel induces a significant thickening of the cervical mucus, impeding the passage and motility of sperm. Furthermore, the compounds modulate the endometrial tissue, causing atrophy and rendering it less receptive to potential blastocyst implantation.

Dosage and Administration Information

Administration Guidelines

Microvlar is a Combined Oral Contraceptive (COC) administered via the oral route as a fixed-dose tablet. The prescribed daily dose contains a fixed concentration of Levonorgestrel and Ethinyl Estradiol, which must be taken once daily at the same time each day to maintain consistent systemic levels.


Dosing Schedule and Cycle Structure

The standard regimen is a cyclic administration pattern, typically consisting of a 28-day course. This course involves taking 21 consecutive days of active hormonal tablets followed by 7 days of non-hormonal (inactive) tablets or a tablet-free interval. The tablets must be swallowed whole in the sequential order indicated on the blister pack to follow the correct dosage phase.

For initiation, protocols generally dictate starting the first tablet either on Day 1 of the menstrual cycle or using the first Sunday after the onset of menses. If not started on Day 1, an additional non-hormonal contraceptive method must be used for the first 7 consecutive days of active tablet intake.


Procedural Constraints

The most critical procedural instruction relates to adherence: the time interval between doses must not exceed 24 hours. Specific instructions exist for managing a missed dose, which depends on the number of missed tablets and the week of the cycle. Furthermore, this medication is not indicated for use in women who are postmenopausal, and usage is only appropriate after the onset of menstruation.

Recent Clinical Evidence

Microvlar: Recent Clinical Evidence

Research regarding combined hormonal contraceptives, such as the ethinylestradiol and levonorgestrel combination in Microvlar, centers on confirming efficacy, safety, and specific outcomes related to patient characteristics and regimen use.


Efficacy and Contraceptive Protection

Clinical trials primarily evaluate contraceptive efficacy using the Pearl Index (PI), which measures the number of pregnancies per 100 woman-years of use. Studies on combined oral contraceptives containing ethinylestradiol and levonorgestrel have reported high effectiveness rates when used correctly. One area of research has focused on how efficacy may be affected by Body Mass Index (BMI), with some trials suggesting a potential trend toward higher pregnancy rates in women with a BMI of 30 kg/m^2 or greater compared to those with a lower BMI.


Safety and Tolerability Profiles

  • Adverse Events: The safety profile is generally investigated across large-scale, multi-cycle studies. Reported adverse events are typically consistent with those observed for other combined hormonal contraceptives, including headache and nausea. Discontinuation rates due to adverse events are also monitored and reported.
  • Thromboembolic Risk: Research confirms that all combined hormonal contraceptives carry an increased risk of venous thromboembolism (VTE). Specific trials note that thromboembolic events, while rare, have been reported in participants, particularly among those with existing risk factors.

Cycle Control and Non-Contraceptive Benefits

Studies also evaluate cycle control, including the occurrence of breakthrough bleeding, spotting, and amenorrhea. Non-contraceptive benefits observed in long-term observational studies include a suggested reduction in the risk of certain cancers, such as ovarian and endometrial cancer, with the benefit increasing with the duration of use.

Key Studies & References

  1. Oral contraceptive use and the risk of endometrial cancer: a systematic review and meta-analysis
  2. Contraception - Combined hormonal methods (Clinical Guideline)

Frequently Asked Questions (FAQ)

Common questions about Microvlar (FAQ)

Q: Does Microvlar cause weight gain in most users?

A: Official product information on Microvlar and similar combined oral contraceptives often lists weight changes (either an increase or a decrease) among the potential adverse reactions. These effects are typically reported in the initial cycles of use, but individual responses can vary. Regulatory data reports the possibility of weight change, not that it happens to every user.

Q: Is it normal to have spotting or breakthrough bleeding in the first month of Microvlar?

A: Yes, irregular bleeding, such as spotting or breakthrough bleeding, is commonly reported when women first start Microvlar. According to regulatory data, this is often an expected effect as the body adjusts to the new hormone levels. If this bleeding persists beyond the first few cycles or restarts later in therapy, it may warrant evaluation by a healthcare professional.

Q: How long does it take for side effects from Microvlar to usually go away?

A: Many of the common side effects, such as nausea, breast tenderness, or headaches, are generally expected to be temporary. Official information suggests that these issues typically subside within the first few cycles (often two to three months) as the body adjusts to the hormonal components.

Q: Can Microvlar affect my mood or cause emotional changes?

A: Regulatory documents commonly list mood changes, including depressed mood and nervousness, as potential adverse reactions associated with hormonal contraceptive use. If a user experiences significant or persistent changes in their emotional state while taking Microvlar, a consultation with a healthcare professional may be appropriate.

Q: What should I do if I miss one Microvlar pill?

A: Specific steps for managing a missed dose are outlined in the official patient instructions and depend on how many pills were missed and the week of the cycle. Generally, if a user realizes a dose was missed, the primary guidance is to consult the information provided with the product or contact a healthcare provider for instruction on how to proceed, which may involve using back-up contraception.

Q: Can Microvlar be used by women approaching menopause?

A: Microvlar is not indicated for use in women who are postmenopausal. For women who are approaching menopause (perimenopausal), the decision to use any combined oral contraceptive requires a careful assessment of individual health risks and benefits by a healthcare provider, especially concerning potential cardiovascular risks.

Q: Does Microvlar change the flow or duration of my period?

A: Official information confirms that Microvlar can cause menstrual irregularities, which include changes to the bleeding pattern. This means users may notice a difference in the volume (flow) or the duration of their withdrawal bleeding, or they may experience amenorrhea (a lack of bleeding).

Q: Are there long-term health risks associated with using Microvlar for many years?

A: Regulatory documents state that all combined oral contraceptives carry serious, long-term risks. These include an increased risk of venous thromboembolism (blood clots), arterial thromboembolism (stroke or heart attack), and certain forms of cancer in susceptible individuals. Due to these risks, ongoing health monitoring is an important part of using this medication.

Q: How long until fertility returns after stopping Microvlar?

A: Official pharmacological information indicates that the hormonal suppression of ovulation reverses once the medicine is stopped and cleared from the body. The return of fertility is expected once the hormonal suppression is lifted. Individual timelines for the return of a typical menstrual cycle can vary.

Q: Why do some women experience nausea when they first start Microvlar?

A: Nausea is a common, listed adverse effect of combined oral contraceptives like Microvlar. Official pharmacological explanations attribute this effect to the hormonal content, particularly the estrogen component, as the body adjusts to the systemic hormone levels.

Q: Is my cycle protected during the 'placebo' or inactive week of Microvlar?

A: Protection is generally maintained during the 7 days of inactive tablets, provided that the preceding 21 active tablets were taken correctly and consistently, and that the next pack is started on schedule. Interruptions in the active pill schedule may compromise this protection.

Q: What if I vomit shortly after taking a Microvlar pill?

A: The official instructions outline specific steps for managing potential non-absorption due to severe vomiting or diarrhea that occurs shortly after taking an active pill. Users should consult the product information, as the recommended steps often involve immediate action to ensure contraceptive efficacy, which may require using a back-up method of contraception.

Q: Is Microvlar different from other 'mini-pills'?

A: Yes, Microvlar is a Combined Oral Contraceptive (COC) because it contains two types of hormones: an estrogen and a progestogen. A 'mini-pill' is specifically a Progestogen-Only Pill (POP) and is formulated without the estrogen component.

Q: What is the risk of accidental pregnancy if a dose of Microvlar is taken late?

A: Regulatory instructions define lateness based on a specific time limit, often 12 hours. If an active pill is taken less than 12 hours late, its contraceptive protection is usually maintained. If it is taken more than 12 hours late, it is classified as a missed dose, and the reliability in preventing pregnancy may be reduced.

Q: Can Microvlar be taken by women with a history of migraines?

A: Microvlar is absolutely contraindicated (must not be used) in women who experience migraine headaches with focal neurological symptoms (migraine with aura), due to a significantly increased risk of stroke. Use in women with migraines without aura requires a careful individual risk assessment by a healthcare provider.

Q: Is Microvlar associated with changes in vision or contact lens comfort?

A: Regulatory data lists the possibility of adverse effects on the eyes, which can include intolerance to contact lenses or visual disturbances. If vision changes occur or if wearing contact lenses becomes uncomfortable, these effects may warrant a consultation with a healthcare professional.

Q: Is it true that Microvlar can sometimes cause changes in hair growth or loss?

A: Yes, official regulatory documents list potential adverse effects related to hair, which can include both alopecia (hair loss) or hirsutism (excessive hair growth). These are hormonal effects that can occur, though they are not experienced by all users.

Q: Are there any specific lifestyle factors that can reduce Microvlar's effectiveness?

A: While effectiveness relies primarily on correct usage, the most critical lifestyle factor cited in regulatory documents is smoking. Smoking, particularly in women aged 35 years or older, significantly increases the risk of serious side effects like blood clots, which is why it is listed as an absolute contraindication in this patient group.

How should Microvlar be stored and disposed of?

How to Store and Dispose of Microvlar?

The storage and disposal of Microvlar (levonorgestrel/ethinylestradiol) must adhere strictly to the conditions specified in official regulatory documents to ensure product integrity.

Storage Requirements

Microvlar must be stored below 30 C and should be kept in a cool, dry place. The tablets must remain protected from light and moisture; therefore, storage areas like bathrooms or near sinks are prohibited. To maintain stability, the medicine must be kept in the original package (blister strip) until the time of use and not used after the expiry date.

Disposal Instructions

Unused or expired Microvlar should not be disposed of in household waste or wastewater. The official procedure requires the medicine to be returned to a pharmacist or a designated pharmaceutical take-back program for proper disposal. Furthermore, this medicine must always be kept out of the sight and reach of children.

Attention! Always consult to a doctor or pharmacist before using pills or medicines.

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