Microgynon CD

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Medically reviewed

Laura Arias

Last updated on 22/12/2025

This page provides general, reference-level information compiled from official medical sources. It is not a substitute for professional medical advice, diagnosis, or treatment. For decisions about your health, please consult a qualified healthcare professional.

Overview of Microgynon CD

Property Description
Active ingredient Ethinyl Estradiol, Levonorgestrel
Form Oral Tablet (Monophasic Preparation)
Pharmacological class Hormonal Contraceptive
Common use Pregnancy Prevention (Contraception)
Origin Synthetic (Steroid Hormones)

Defining the Combined Oral Contraceptive

Microgynon CD is a Combined Oral Contraceptive (COC), recognized as a prescription-only medicine (POM) delivered as an oral preparation in tablet form. This medication belongs to the high-level pharmacological class of Hormonal Contraceptives, specifically categorized under the Sex hormones and modulators of the genital system. It is a combination product that utilizes two distinct synthetic steroid hormones, which has been consistently clinically recognized for providing a reliable method of reversible contraception for women of reproductive age. The classification of Ethinyl Estradiol and Levonorgestrel under the ATC code G03AA07 confirms its established role within this therapeutic area.

Core Composition: Ethinyl Estradiol and Levonorgestrel

The active constituents of Microgynon CD are the synthetic estrogen known as Ethinyl Estradiol and the synthetic progestin (progestogen) known as Levonorgestrel. Both active ingredients are entirely synthetic in origin, developed to optimize their action through the oral route of administration. This pairing is considered a second-generation COC, distinguishing it from newer formulations. The medication is a fixed-dose combination presented as a monophasic preparation, meaning the hormone concentrations remain uniform across all hormonally active tablets in the cycle. Other common brands sharing this exact Ethinyl Estradiol/Levonorgestrel composition include Leeloo and Aviane.

General Purpose of the Synthetic Hormone Combination

The general purpose of this medication is effective and reliable pregnancy prevention (contraception). Its core therapeutic use is achieved by establishing a state of ovarian suppression through the combined action of the steroid hormones. This involves the primary goal of preventing the release of an egg, complemented by secondary effects like the thickening of cervical mucus and the alteration of the uterine lining. This strategy provides a robust, multi-layered defense to achieve the intended contraception for the user.

What side effects are possible with Microgynon CD?

Possible Side Effects and Safety Information

The information presented here reflects the officially documented adverse reactions and safety characteristics of this combined oral contraceptive, categorized according to regulatory guidelines. This content is based strictly on government-approved prescribing information and is not intended as clinical advice or usage instruction.

Adverse Reactions Classified by Frequency

Adverse reactions are formally grouped by the frequency with which they are reported, consistent with regulatory standards for documenting side effects:

  • Very Common (ge 1/10): Headache, nausea, breast pain, and breakthrough bleeding or spotting.
  • Common (ge 1/100 to <1/10): Weight gain, vomiting, diarrhea, migraine, fluid retention, and breast tenderness.
  • Uncommon (ge 1/1,000 to <1/100): Increase in blood pressure and contact lens intolerance.
  • Rare (ge 1/10,000 to <1/1,000): Hypersensitivity reactions and serious vascular events.

Serious Adverse Reactions and Safety Constraints

The official safety profile highlights the risk of Serious Adverse Reactions, which are classified under the Vascular and Hepatobiliary System-Organ Classes:

  1. Thromboembolic Events: The use of combined oral contraceptives is associated with a risk of Venous Thromboembolism (VTE) and Arterial Thromboembolism (ATE), including deep vein thrombosis, pulmonary embolism, myocardial infarction, and stroke.
  2. Hepatic Neoplasms: Rare cases of benign liver tumors (hepatic adenomas) and, very rarely, malignant liver tumors (hepatic carcinoma) have been documented.

Safety restrictions prohibit the use of this medicine in individuals with severe pre-existing hepatic disease or known risk factors for thromboembolism (e.g., specific hereditary clotting disorders). Regulatory documents also note that common adverse reactions are often more frequent during the initial phase of treatment, while tumor risks are generally associated with long-term exposure.

Overdose and Emergency Response

Overdose Manifestations and Clinical Signs

The officially documented clinical profile for an overdose of Microgynon CD (Ethinyl Estradiol and Levonorgestrel) is detailed in government regulatory prescribing information. The expected manifestations are primarily focused on the gastrointestinal and central nervous systems. Documented signs include nausea and vomiting, alongside drowsiness or fatigue. A specific hormonal manifestation is the occurrence of withdrawal bleeding, which may be observed in females following an acute overdose exposure. These symptoms are noted to occur in both the adult and pediatric populations according to official regulatory documents.

Required Management and Emergency Response

Regulatory guidance on managing an overdose confirms that there is no specific antidote known or available to counteract the effects of this combination product. Given this constraint, the required management strategy is strictly symptomatic and supportive. Any necessary further treatment is mandated to be directed solely to the clinical signs presented by the patient. The official labeling confirms that medical assistance should be sought to properly address the reported manifestations and determine the need for supportive treatment. The overdose profile is defined by these expected manifestations, the explicit lack of a specific antidote, and the requirement for symptomatic management. This structure is intended solely to describe the official regulatory position on overdose and the required general response, establishing a high-level, regulatory understanding of the condition.

Therapeutic Uses of Microgynon CD

Quick Facts: Primary Uses

  • Supports pregnancy prevention.
  • May contribute to menstrual cycle regularity.
  • May be associated with a decrease in the severity of period pain.
  • May be linked to lighter menstrual flow.

Microgynon CD is a prescribed medication utilized primarily for the purpose of preventing pregnancy in individuals of reproductive potential. This application is the main therapeutic focus of the drug.

In addition to its primary use, the medication may offer other health-related outcomes. It may help establish a more predictable menstrual cycle pattern. Some users have reported that the medication is associated with a reduced experience of menstrual discomfort (period pain) and a lighter overall menstrual flow.

Microgynon CD is a specific combination of hormonal components commonly used in oral contraceptive regimens. Its therapeutic profile and indications are well-established for this category of medication.

Eligibility and Restrictions for Use

Eligibility Map: Who Can and Cannot Use Microgynon CD — Official Regulatory Information

The eligibility profile for Microgynon CD is based on its intended use as a contraceptive for women of reproductive potential, with numerous absolute exclusions defined by regulatory bodies.

Eligibility Scope Status Official Statements (Based on Regulatory Labels)
Approved Population Indicated Females of reproductive potential for pregnancy prevention (contraception).
Age-Related Rules Approved Use is approved after menarche (onset of menstruation).
Not Indicated Not indicated for females before menarche or post-menopausal women.
Contraindicated Females over 35 years of age who smoke are formally excluded.
Physiological State Contraindicated Pregnancy (known or suspected) is an absolute contraindication.
Not Recommended Generally not recommended during the period of breastfeeding (lactation).
Absolute Contraindications Contraindicated History of or current venous or arterial thromboembolism (e.g., DVT, stroke).
Contraindicated Known thrombophilias (hereditary or acquired clotting disorders).
Contraindicated Severe hepatic disease or the presence of liver tumours (benign or malignant).
Contraindicated Migraine with focal neurological symptoms (migraine with aura).
Contraindicated Sex-hormone-dependent malignancies (e.g., breast cancer).
Contraindicated Severe uncontrolled hypertension or diabetes mellitus with vascular damage.

Connection to the overall eligibility profile: Regulatory documents define who can and cannot use Microgynon CD by explicitly approving its use for reproductive-age women seeking contraception, while simultaneously mandating absolute non-eligibility (contraindication) for populations exhibiting pre-existing cardiovascular risks (thromboembolism, severe hypertension), specific liver or neoplastic diseases, and certain age-and-lifestyle combinations.

What should I know about interactions with other medicines?

Concurrent use of Microgynon CD with certain medications can impact its effectiveness or change the way other drugs work. Medications that induce hepatic enzymes, primarily the cytochrome P450 3A4 system, can increase the clearance of the sex hormones in Microgynon CD, potentially leading to breakthrough bleeding and contraceptive failure.


Medicines that may reduce Microgynon CD effectiveness

Consult your doctor if you are taking any of the following, as additional barrier contraception may be necessary during and for up to 28 days after treatment:

Class Examples of Interacting Drugs
Anticonvulsants Carbamazepine, Phenytoin, Primidone, Phenobarbital, Topiramate
Antibiotics/Antifungals Rifampicin, Griseofulvin
Antiretroviral agents Ritonavir, Nevirapine
Herbal remedies St John's wort (Hypericum perforatum)

Contraindicated Medications

Microgynon CD must not be used concomitantly with medicinal products containing combinations of ombitasvir/paritaprevir/ritonavir and dasabuvir, or those containing glecaprevir/pibrentasvir or sofosbuvir/velpatasvir/voxilaprevir, which are used to treat Hepatitis C virus (HCV) infection.


⬆️ Effects on Other Drugs

Oral contraceptives can also affect the metabolism of other drugs, potentially leading to increased or decreased concentrations in the blood. Examples of drugs whose concentrations may be increased include Cyclosporin, Tizanidine, and Theophylline. Examples of drugs whose concentrations may be decreased include Lamotrigine.

Mechanism of Action

Inhibition of Gonadotropin Secretion

The synthetic hormones in Microgynon CD exert negative feedback on the hypothalamic-pituitary-ovarian (HPO) axis. Specifically, this mechanism suppresses the pulsatile release of pituitary hormones, including luteinizing hormone (LH) and follicle-stimulating hormone (FSH). This hormonal modulation interrupts the normal signaling cascade required for ovarian maturation, leading to the absence of follicular development and ovulation as a key physiological consequence.


Alteration of Endometrial Receptivity

The hormonal balance delivered by the drug causes the endometrium (the lining of the uterus) to develop in an atypical and inactive manner. This action modifies the tissue's signaling and cellular structure, resulting in reduced endometrial receptivity.


Modification of Cervical Mucus Consistency

The synthetic progestin component (levonorgestrel) acts on the cervical glands to thicken the cervical mucus, creating a dense, less permeable barrier. This physical change significantly impedes sperm motility and penetration into the upper reproductive tract.

Dosage and Administration Information

Official Administration Guidelines for Microgynon CD

Route of Administration and Dose The official route of administration for Microgynon CD is oral, by swallowing one coated tablet daily. The active tablets contain a fixed-dose combination of 0.15 mg Levonorgestrel and 0.03 mg Ethinyl Estradiol. The dosing schedule is continuous, with one tablet taken daily for 28 consecutive days. This regimen comprises 21 days of active hormone tablets, followed by 7 days of either inactive (placebo) tablets or a tablet-free interval. Use is restricted to individuals after menarche and is not indicated for post-menopausal women.

Timing, Sequence, and Cycle Tablets must be taken at approximately the same time each day, following the sequence directed on the blister pack. Administration is independent of food, though the tablet may be consumed with a small amount of liquid. The next 28-day pack must be started immediately following the completion of the prior pack, ensuring there is no delay beyond the 7-day inactive period. For individuals who have not previously used hormonal contraception, tablet-taking should commence on the first day of the menstrual cycle.

Managing Missed Doses and Disruptions Proper use requires strict adherence to the 24-hour dosing interval. If an active tablet is missed by more than 12 hours from the usual time, the contraceptive protection is considered reduced, and specific instructions must be followed. These procedures often require the additional use of a non-hormonal barrier method for 7 consecutive days to ensure coverage. Similarly, in cases of severe vomiting or acute diarrhea occurring within 3 to 4 hours of ingestion, the standard protocol is to manage the situation as a missed tablet.

Recent Clinical Evidence

Evidence for Use in Pregnancy Prevention (Contraception)

The primary role of Microgynon CD was evaluated in a large body of research, including short-term Randomized Controlled Trials (RCTs) and systematic reviews. These trials have provided data relevant to the regulatory file. The primary measure studied for this context is the Pearl Index, which is calculated as the rate of pregnancies observed among women over a defined period of use. Studies consistently reported these measurements.

Research was associated with the Pearl Index measurement being highly dependent on the level of user consistent adherence. Additionally, short-term trials have limited information for long-term outcomes regarding the incidence of very rare events that may require many years of observation to track.


Evidence for Impact on Menstrual Cycle Characteristics

Research has explored the study landscape for this combined oral contraceptive concerning the menstrual cycle. RCTs, longitudinal studies, and systematic reviews were applied in studies examining patient-reported experiences. Researchers examined outcomes related to physical discomfort by tracking factors like unscheduled bleeding, spotting, and the ability to establish a predictable withdrawal bleed pattern. Trial findings describe patterns observed in the studies.

Comparative evidence is lacking for distinguishing effects on bleeding characteristics between this specific formulation and all other low-dose combined hormonal contraceptives. Follow-up durations were limited for characterizing the precise stabilization of specific bleeding characteristics beyond one year.


Evidence for Use in Primary Menstrual Pain (Dysmenorrhea)

Clinical research, including controlled trials and systematic reviews, was evaluated in women with conditions characterized by fluctuating or episodic manifestations of pain. The research examined outcomes related to physical discomfort as measured during the study period, using standardized tools like the Visual Analog Scale (VAS). Systematic reviews report how symptoms evolved in the observed populations.

Research data show patterns related to the effect of ovulation suppression, which was measured alongside pain outcomes in some studies. Comparative evidence is lacking for demonstrating a distinct difference in pain relief when comparing this formulation to other modern low-dose COCs.


Research Gaps and Areas of Uncertainty

Most primary efficacy studies utilize short-term study contexts. Long-term effects are not fully established for some outcomes beyond the primary use. Evidence quality varies across studies, and comparative evidence is lacking when trying to distinguish performance for secondary outcomes between all available low-dose combined oral contraceptives. Results apply only to the populations studied under the specific conditions of the trial. Research provides context but not individual predictions; findings describe group patterns, not personal outcomes.

Key Studies & References WHO Anatomical Therapeutic Chemical (ATC) Classification System: G03AA07 Levonorgestrel and ethinylestradiol

Frequently Asked Questions (FAQ)

Common questions about Microgynon CD (FAQ)


Q: How quickly does Microgynon CD start working to prevent pregnancy?

A: If you begin taking Microgynon CD on the first day of your menstrual cycle, contraceptive protection is generally considered established immediately. However, if the start is between days 2 and 5 of the cycle, official information indicates that an additional non-hormonal barrier method is advised for the first 7 days of the first cycle.


Q: What are the non-contraceptive uses for Microgynon CD?

A: The sole official indication (approved use) for Microgynon CD is for the prevention of pregnancy (contraception). While studies have examined the pill's effects on menstrual cycle characteristics and pain, these are not considered official indications or uses.


Q: What is the difference between Microgynon CD and Microgynon 30?

A: Microgynon CD is generally recognized as a 28-day pack designed for continuous dosing, containing 21 active hormone tablets followed by 7 hormone-free (placebo) tablets. In contrast, Microgynon 30 is typically a 21-day active pack that requires the user to take a 7-day tablet-free break.


Q: Do all combined oral contraceptives contain the same ingredients as Microgynon CD?

A: No. Microgynon CD contains the fixed-dose combination of levonorgestrel and ethinyl estradiol. The broad pharmacological class of combined oral contraceptives (COCs) includes many different formulations that utilize various types and dosages of synthetic estrogen and progestin hormones.


Q: Can Microgynon CD affect my mood or cause mood swings?

A: Official safety documents list mood changes, including feelings of depression or a depressed mood, as a potential side effect. Users experiencing concerning mood changes are advised to inform a healthcare provider.


Q: Is it normal to experience spotting or breakthrough bleeding when starting Microgynon CD?

A: Yes, spotting or breakthrough bleeding is listed in official documents as a Very Common side effect, meaning it is classified as a Very Common side effect. Irregular bleeding is often noted to be more frequent during the first few cycles of use while the body adjusts to the hormones.


Q: Are there any long-term effects associated with taking Microgynon CD for many years?

A: Regulatory information indicates that certain very rare but serious risks, such as developing some types of hepatic neoplasms (liver tumors), are generally associated with prolonged use. The overall risk of serious vascular events, like blood clots, is primarily observed during the first year of use or upon restarting the medication.


Q: Is it true that the risk of blood clots is highest during the first year of Microgynon CD use?

A: Official patient information states that the risk of developing a venous thromboembolism (VTE) is highest during the first year a woman begins using any combined hormonal contraceptive. This increased risk is also observed when a user restarts the medicine after a break of 4 or more weeks.


Q: Are there any antibiotics that can reduce the effectiveness of Microgynon CD?

A: Yes. Official interaction information specifically names the antibiotics Rifampicin and Griseofulvin as drugs that can reduce the pill’s effectiveness because they are hepatic enzyme inducers. The potential for other prescribed medications to have this enzyme-inducing property is noted in official information.


Q: Does taking Microgynon CD with food or alcohol affect how it works?

A: Official guidance states that taking the tablet is independent of food, meaning it can be consumed with or without a meal. However, regulatory documents do not provide specific safety information or warnings regarding the effects of alcohol on the drug's effectiveness.


Q: Is protection from pregnancy maintained during the hormone-free interval of the Microgynon CD pack?

A: Contraceptive protection is maintained during the 7-day hormone-free interval, provided the active tablets preceding the break were taken correctly and the next pack is started on time. Protection can be compromised if an active tablet is missed or if the hormone-free interval is extended beyond 7 days.


Q: Can Microgynon CD cause changes in my menstrual cycle regularity after I stop taking it?

A: Official patient guidance notes that, after discontinuation, it can take some time for the body to return to its natural hormone production and ovulatory cycle. For some women, the natural menstrual cycle may take a few months to fully return to their individual normal pattern.


Q: Does Microgynon CD offer any protection against sexually transmitted infections (STIs)?

A: No. The official labeling of Microgynon CD clearly states that combined oral contraceptives do not protect against sexually transmitted infections (STIs), including HIV/AIDS. Protection against STIs generally requires the use of barrier methods.


Q: Is the 'period' I get while on Microgynon CD a real menstrual period?

A: The bleeding that occurs during the hormone-free interval of the pill pack is referred to in regulatory documents as a withdrawal bleed, not a true menstrual period. This bleeding is caused by the drop in hormone levels when the user switches from active pills to inactive (placebo) pills.


Q: Can I use Microgynon CD to intentionally delay or skip my withdrawal bleed?

A: Official administration guidance provides instructions for delaying menstruation by skipping the inactive tablet interval and immediately starting a new pack of active tablets. It is noted that breakthrough bleeding or spotting may occur during this extended period of use.


Q: What should I know about switching from a different birth control pill to Microgynon CD?

A: If switching from a 21-day combined pill, Microgynon CD should be started the day after taking the last active tablet of the previous pill. If switching from a progestogen-only pill, a non-hormonal barrier method must generally be used for the first 7 days of taking Microgynon CD.


Q: Are there any common health supplements or herbal products that interact with Microgynon CD?

A: The official interaction list specifically identifies the herbal remedy St John's wort (Hypericum perforatum) as one that can reduce the contraceptive effectiveness of Microgynon CD. The effect of other common supplements is generally a topic of discussion in a patient’s health review.


Q: Can Microgynon CD affect blood test results?

A: Yes, official patient information advises that combined oral contraceptives can interfere with the results of some laboratory tests. Official guidance notes that the patient should inform their doctor or laboratory staff that they are taking the pill before having blood tests performed.


Q: Does Microgynon CD affect fertility after discontinuing its use?

A: The medicine is classified as a reversible method of contraception. Official information indicates that after stopping the pill, fertility will typically return to the individual's normal pattern, although this process may take some time.


Q: Can Microgynon CD cause changes in hair growth or skin condition like acne?

A: Official safety documents list potential skin and hair-related side effects, including both an increase in hair growth and hair loss. Acne is also listed as an adverse reaction that may be associated with use.


Q: Does Microgynon CD contain lactose or other ingredients I should be aware of for allergies?

A: Yes, regulatory documents confirm that Microgynon CD contains lactose as an inactive ingredient. Patients with known intolerances to certain sugars, such as those with rare hereditary problems of galactose intolerance, should consider this information.


Q: What level of efficacy is generally associated with Microgynon CD when taken as directed?

A: When taken strictly and correctly, combined oral contraceptives have a general failure rate of approximately 1% per year. This measure, often quantified by the Pearl Index, increases when tablets are missed or taken inconsistently.


Q: Can taking Microgynon CD impact my vision or comfort with contact lenses?

A: Contact lens intolerance—a feeling of discomfort or difficulty wearing them—is listed as an Uncommon adverse reaction associated with use. This side effect may affect between 1 in 100 and 1 in 1,000 users.


Q: Are there any differences in the use conditions for Microgynon CD after childbirth or breastfeeding?

A: Official guidance states that Microgynon CD is generally not recommended during breastfeeding as it may impact the quantity and composition of breast milk. Specific instructions are provided for starting use 21 days after childbirth if the patient is non-lactating.


Q: Are there different formulations or dosages of Microgynon (like 20 ED or 30) and what do the letters stand for?

A: Yes, Microgynon is available in different formulations. The 30 or 20 in the name typically refers to the dose of the estrogen component (ethinyl estradiol) in micrograms. The CD or ED (Every Day) designation indicates a 28-day regimen that includes 7 inactive tablets.


Q: Is Microgynon CD considered a low-dose combined oral contraceptive?

A: Yes. Microgynon CD contains 30, mu g of ethinyl estradiol, and formulations containing leq 35, mu g of the estrogen component are generally classified in medical literature as a low-dose combined oral contraceptive.


Q: How does Microgynon CD affect the likelihood of getting certain types of cancer? (Other than liver)

A: The official safety profile discusses documented associations with an increased relative risk of breast cancer and cervical cancer. Conversely, some studies cited in regulatory documents suggest that long-term use may be associated with a reduced risk of ovarian and endometrial cancers.


Q: Do I need to take extra precautions if I have a family history of blood clots or cancer?

A: Yes. Official patient information advises that if a close relative has, or has ever had, breast cancer or a history of blood-clotting disorders (thrombophilias), a doctor should be informed, as these factors may require special care or further investigation.


Q: What are the general themes of the research evidence regarding Microgynon CD’s long-term use?

A: Research themes noted in regulatory documents include the measurement of efficacy using the Pearl Index and the study of impacts on menstrual cycle characteristics and menstrual pain (dysmenorrhea). Official sources also note that long-term effects for some outcomes are not fully established due to study length limitations.

How should Microgynon CD be stored and disposed of?

How to Store and Dispose of Microgynon CD?

Microgynon CD must be stored in alignment with official regulatory standards to maintain its stability and effectiveness. The medicine must be kept in its original blister pack until the time of use and stored in a cool, dry place. The labeled maximum storage temperature is below 30 C, and it must be protected from both moisture and direct sunlight.

For safety, this medicine must always be stored out of the reach of children. Unused or expired tablets must not be shared with others. To prevent environmental contamination, official instructions mandate proper disposal; do not flush the medicine down a toilet or dispose of it in household waste. Follow local regulations or use an authorized take-back program for pharmaceutical waste.

Attention! Always consult to a doctor or pharmacist before using pills or medicines.

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