Meropur

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Medically reviewed

Laura Arias

Last updated on 22/12/2025

This page provides general, reference-level information compiled from official medical sources. It is not a substitute for professional medical advice, diagnosis, or treatment. For decisions about your health, please consult a qualified healthcare professional.

Overview of Meropur

Property Description
Active ingredient Menotropin (Human Menopausal Gonadotropin, HMG)
Form Lyophilized powder for solution for injection
Pharmacological class Gonadotropin; Pituitary Hormone Analog
Common use Controlled ovarian stimulation for fertility treatments
Origin Biological (extracted from the urine of postmenopausal women)

What Type of Medicine is Meropur (Menotropin)?

Meropur is a prescription-only medicine containing the active ingredient Menotropin, officially classified as a Gonadotropin and a Pituitary Hormone Analog. This pharmacological class indicates the drug provides biological activity identical to the endogenous hormones naturally produced by the pituitary gland to regulate the reproductive system. The manufacturer, Ferring Pharmaceuticals, emphasizes this medicine as a highly purified HMG preparation for use in assisted reproductive technology (ART) programs, utilizing its established quality for Controlled Ovarian Stimulation. This distinction in high purity and long-standing clinical use makes it a recognized option for providing endocrine stimulation.

Composition, Origin, and Form of Menotropin

The active compound, Menotropin, is specifically known as Highly Purified Human Menopausal Gonadotropin (HMG), a substance of biological origin extracted from the urine of postmenopausal women. A key differentiating factor is that Menotropin is a combination product because it provides the dual biological activities of both Follicle-Stimulating Hormone (FSH) and Luteinizing Hormone (LH). Meropur is supplied as a lyophilized powder for solution for injection, a specialized pharmaceutical preparation necessary because this protein-based glycoprotein hormone must be administered via subcutaneous injection or intramuscular injection to ensure effective systemic delivery.

The Fundamental Role of Meropur in Reproduction

The overall general purpose of Meropur is to provide the foundational hormonal environment necessary to initiate and normalize the basic processes of reproductive cell maturation. The supplied FSH activity directly promotes the growth of ovarian follicles, while the LH activity supports the final development and hormone production (steroidogenesis). This comprehensive support addresses scenarios in which patients require external gonadotropins to support adequate ovarian follicular development during fertility procedures.

Regulatory References

  1. MENOPUR (Menotropins) - DailyMed (NIH)

What side effects are possible with Meropur?

The safety profile for Meropur (Menotropin) is formally documented in regulatory sources by frequency and physiological system. This classification provides a structured understanding of the medicine’s potential risks.

Frequency-Classified Adverse Reactions

Adverse events are categorized by their expected rate of occurrence. Very Common (ge 1/10) reactions include headache and Ovarian Hyperstimulation Syndrome (OHSS). Reactions classified as Common (ge 1/100 to <1/10) include abdominal pain, nausea, vomiting, ovarian cysts, and injection site reactions (e.g., pain, inflammation).

System-Organ Class Groupings and Serious Risks

The regulatory label maps adverse effects to specific body systems, most frequently citing Reproductive System and Breast Disorders and Gastrointestinal Disorders.

Serious Adverse Reactions explicitly highlighted in labeling include Severe OHSS, which can develop rapidly and is associated with complications such as Thromboembolic Events (blood clots) and pulmonary issues. The risk of Ectopic Pregnancy is also documented as increased in patients with a history of tubal pathology.

Safety Restrictions and Limitations

Menotropin is contraindicated and must not be used in the presence of specific pre-existing conditions. These include primary ovarian failure, certain tumors of the pituitary gland or hypothalamus, unexplained gynaecological bleeding, and ovarian cysts or enlargement not due to Polycystic Ovarian Disease.

Population-Specific Safety Notes cite increased risk for individuals with a history of thromboembolic events.

This framework of official classifications and contraindications formally defines the documented safety characteristics, structuring the complete risk profile from minor, expected effects to clinically significant, serious events.

Overdose and Emergency Response

Overdose and When to Seek Help

The overdose profile for Menotropin (Meropur) is centered on the risk of an exaggerated pharmacological response, as the effects of an overdose are otherwise unknown according to regulatory documentation. The principal expected consequence of over-administration is Ovarian Hyperstimulation Syndrome (OHSS).

Documented Manifestations and Severe Outcomes

OHSS may present with severe pelvic pain, abdominal distension, nausea, vomiting, and rapid weight gain. The official regulatory classification describes severe OHSS as a potentially life-threatening condition due to the risk of serious medical events. These severe outcomes include hypovolemia, hemoconcentration, dangerous fluid accumulation (ascites, hydrothorax), and potentially severe complications such as thromboembolic events (e.g., cerebral vascular occlusion or pulmonary embolism). OHSS is officially documented as more severe and protracted if pregnancy occurs.

Immediate Actions Mandated by Regulators

For suspected overdose or the development of severe OHSS symptoms, patients are instructed to seek emergency medical attention or call a doctor right away. If ovarian monitoring suggests an increased risk of overstimulation, the sequential administration of human chorionic gonadotropin (hCG) must be withheld. If severe OHSS is confirmed, treatment must be stopped and the patient should be hospitalized for supportive management, which includes continuous monitoring of hematocrit and fluid and electrolyte balance. The official labeling states that treatment is symptomatic and supportive, and no specific antidote is known.

Therapeutic Uses of Meropur

What Meropur Treats: Main Uses and Benefits

Meropur (Menotropin) is a specialized treatment used in situations involving certain distressing symptoms related to reproductive failure. It may assist with managing specific hormonal deficits and is applied across domains where additional symptomatic support is needed for advanced fertility management. It is relevant in contexts involving heightened systemic burden related to the reproductive system, contributing to targeted therapeutic benefits across critical areas.


Key Therapeutic Applications and Benefits

Meropur is primarily applied in addressing the functional deficit of Inadequate Follicle Development in women undergoing Assisted Reproductive Technology (ART), such as IVF, and for Ovulation Induction in cases of Anovulatory Infertility. It is also considered relevant for adult males with Hypogonadotropic Hypogonadism to support sperm production.

The medication supports the Development of Multiple Follicles and assists with managing symptoms that create noticeable physiological strain on the reproductive system. This use plays a role in managing conditions characterized by periods of heightened symptoms. It is often used during phases when symptoms become more noticeable and short-term symptomatic assistance is needed.

“This medication may assist with managing symptoms related to organ-specific functional stress within challenging clinical scenarios.”

Quick Fact: Relief for symptoms that create noticeable physiological strain

Eligibility and Restrictions for Use

Meropur (menotropins for injection) is prescribed to ovulatory women participating in an Assisted Reproductive Technology (ART) program to help develop multiple ovarian follicles.

Contraindications (Who must NOT use Meropur)

The medicine is strictly contraindicated in women with the following conditions, as stated in regulatory labeling:

  • Primary ovarian failure (indicated by high Follicle Stimulating Hormone [FSH] levels).
  • Pregnancy or suspected pregnancy.
  • Sex hormone-dependent tumors of the reproductive tract or accessory organs.
  • Tumors of the pituitary gland or hypothalamus.
  • Uncontrolled non-gonadal endocrinopathies (e.g., thyroid or adrenal disorders).
  • Abnormal uterine bleeding of undetermined origin.
  • Ovarian cysts or enlargement not due to Polycystic Ovary Syndrome (PCOS).
  • Known hypersensitivity to menotropins or any component of the product.

Eligibility Restrictions and Special Populations

Population Category Eligibility Status (Regulatory Basis)
Pediatric Use Safety and effectiveness not established.
Geriatric Use Safety and effectiveness not established.
Renal/Hepatic Impairment Safety, efficacy, and pharmacokinetics not established.
Lactation Use is restricted; it is not known if the drug is excreted in human milk.

All women must undergo a thorough gynecologic and endocrinologic evaluation to rule out existing contraindications before treatment begins. Use in women with tubal obstruction is restricted to those enrolled in an in vitro fertilization (IVF) program.

What should I know about interactions with other medicines?

Interactions with other medicines and products

The regulatory profile for Menotropin (Meropur) is characterized by a specific focus on procedural constraints within fertility regimens, alongside an acknowledged absence of documented pharmacokinetic interaction data.

Documented Pharmacodynamic and Timing Constraints

Official prescribing information notes that no dedicated human drug-drug interaction studies have been conducted for Meropur, meaning data for metabolic (CYP-mediated) or transporter-based interactions are not established. However, constraints apply when Menotropin is co-administered sequentially with other agents:

  • Human Chorionic Gonadotropin (hCG): The administration of hCG is required to follow the course of Meropur treatment. Critically, the hCG injection must be withheld if ovarian monitoring suggests an elevated risk of Ovarian Hyperstimulation Syndrome (OHSS) on the final day of therapy.
  • Urofollitropin: Co-administration with other gonadotropins, such as Urofollitropin, is subject to a regulatory maximum total combined daily dose restriction of 450 International Units (IU).

Interaction Status with Other Substances and Populations

Substance / Population Official Interaction Status
Food, Drinks, Herbal Products No known interactions are documented in regulatory summaries.
Renal or Hepatic Insufficiency Pharmacokinetics and safety related to potential interactions have not been established in these patient populations.

Mechanism of Action

Dual Gonadotropin Receptor Agonism

Meropur (Menotropin) acts as an agonist by binding directly to the Follicle-Stimulating Hormone Receptor (FSHR) and the Luteinizing Hormone/Choriogonadotropin Receptor (LHCGR) on ovarian cells. This receptor engagement initiates the cAMP signal transduction pathway inside the cells. This molecular step is a requirement for the initiation of cellular growth processes in the target tissues, bypassing central hormonal regulation.


Synergistic Two-Cell Pathway Modulation

The drug provides the dual activities of FSH and LH, creating a synergistic effect required by the two-cell, two-gonadotropin hypothesis. The FSH activity drives the granulosa cell proliferation and the induction of the Aromatase enzyme, while the LH activity stimulates the adjacent theca cells to synthesize and supply the necessary androgen substrate. This coordinated action results in the biochemical environment necessary for the functional capacity of the follicles.


Enhanced Ovarian Steroidogenesis

The combined receptor activation and cell cooperation lead to modulation of the steroidogenesis pathway. The Aromatase enzyme converts the supplied androgen precursors into large, physiological amounts of Estradiol (E2). This biochemical process culminates in the physiological change of multi-follicular development.

Dosage and Administration Information

Meropur (menotropin) is supplied as a lyophilized powder that requires reconstitution with a sterile diluent before administration. The final solution is intended solely for subcutaneous (SC) injection or intramuscular (IM) injection. The reconstituted solution must be visually inspected to ensure it is clear and free of particulate matter, and the dose must be administered immediately after preparation; the solution is not to be mixed with other injectable products in the same syringe.

The medicine is administered daily for ovarian stimulation protocols. Specific adult dosing rules are defined for the treatment context. For controlled ovarian stimulation during assisted reproductive technology (ART), the typical initial daily dose is 225 International Units (IU), with a mandated maximum daily dose of 450 IU. Dose adjustments in this setting are restricted, made no more frequently than every two days. For ovulation induction in cases of anovulatory infertility, the starting dose ranges from 75 IU to 150 IU daily, with a 225 IU maximum.

The administration phase is time-bound and generally should not exceed 20 days within a single cycle. The Meropur regimen is a preparatory phase that concludes with a subsequent injection of Human Chorionic Gonadotropin (hCG) to complete the full therapeutic protocol. Specific usage rules apply to handling missed timing: a double dose must not be administered to compensate for a missed injection. Furthermore, use is not established in pediatric or geriatric populations.

Recent Clinical Evidence

Research Evidence / Overview of Studies for Meropur

Evidence for use in Assisted Reproductive Technology (ART) Cycles

Research has explored the use of Meropur in women undergoing assisted reproductive technology (ART) procedures, such as in vitro fertilization (IVF). These studies included randomized controlled trials (RCTs) and comparative studies that were short-term. Research monitored outcomes related to follicular development, the amount of medication required, and the number of oocytes (eggs) collected for use in the ART cycle. These studies included populations of women meeting specific eligibility criteria for fertility treatment and focused on changes observed during the defined, short-term treatment period.

Studies reported measurements of the number of oocytes collected; findings related to these measurements varied across different trials. Some studies also reported measurements of clinical pregnancy rates or live birth rates, though evidence remains heterogeneous. Research highlights changes measured during the study period, contributing to the broader evidence landscape related to ovarian response.

Evidence for use in Ovulation Induction in Anovulatory Patients

Meropur was evaluated in studies focusing on women who experience anovulation—a lack of regular ovulation—often associated with conditions marked by functional limitations related to the menstrual cycle. Research explored short-term changes and temporary physiological imbalance, specifically examining changes related to follicular development. Studies monitored patterns observed in women where Meropur was used in conjunction with hCG. Findings indicate patterns related to the development of follicles.


What is Still Uncertain about Meropur

Long-term effects on women and any potential offspring beyond the immediate cycle outcomes are not fully established, as follow-up durations were limited. Sample sizes for many individual trials were modest, and comparative evidence is sometimes mixed. Certainty remains low regarding the full scope of use across the full range of causes of anovulation. Results apply only to the populations studied and research does not determine whether an individual will respond similarly.

Few data are available for special populations such as older adults or women with complex comorbid conditions. The evidence quality varies across studies, and the data are still emerging regarding use in certain groups. Studies help show what has been observed so far, but provide context, not individual predictions.

Key Studies & References

  1. Use of exogenous gonadotropins for ovulation induction in anovulatory women: a committee opinion (2020) | American Society for Reproductive Medicine
  2. Clinical outcomes following long GnRHa ovarian stimulation with highly purified human menopausal gonadotropin plus rFSH or rFSH in patients undergoing in vitro fertilization-embryo transfer: a multi-center randomized controlled trial | Annals of Translational Medicine
  3. IRISH MEDICINES BOARD PUBLIC ASSESSMENT REPORT FOR A MEDICINAL PRODUCT FOR HUMAN USE Scientific discussion Menopur 600 and 1200 (Regulatory Document)

Frequently Asked Questions (FAQ)

Common questions about Meropur (FAQ)

Q: Does Meropur affect blood pressure?

A: Official product information does not list changes in blood pressure (either low or high) as a common or very common adverse reaction. However, a serious, documented risk associated with this medication is Severe Ovarian Hyperstimulation Syndrome (OHSS), which may involve cardiovascular complications.

Q: Does Meropur cause digestive issues?

A: Yes, official drug labels indicate that several common adverse reactions affect the gastrointestinal system. These frequently reported symptoms include nausea, vomiting, abdominal pain, and a feeling of abdominal cramping or fullness.

Q: Is it normal to feel tired when starting Meropur?

A: While general tiredness is not classified as one of the most common side effects, a less common reaction described as 'Malaise' (a general feeling of discomfort or unease) has been reported in clinical experience. Patients are generally advised to speak with their healthcare provider if they experience discomfort or side effects.

Q: What should I avoid drinking while on Meropur?

A: According to official regulatory summaries, there are no known interactions documented between Meropur and common foods or drinks, including alcohol. No specific dietary or drinking restrictions are documented in the official product information.

Q: What is the difference between Meropur and [similar drug name]?

A: Meropur is specifically classified as a human menopausal gonadotropin (hMG) that provides the biological activity of both Follicle-Stimulating Hormone (FSH) and Luteinizing Hormone (LH). This dual activity is what distinguishes it from other similar fertility medicines, such as those that provide only pure FSH activity.

Q: Can Meropur be taken with vitamins or supplements?

A: Official documents note that formal drug-drug interaction studies have not been conducted for Meropur. The regulatory labeling states that no known interactions with food, drinks, or herbal products are documented, but the status of interactions with all specific vitamins or supplements is not fully established.

Q: What kind of specialist usually prescribes Meropur?

A: Meropur is indicated for use in specialized Assisted Reproductive Technology (ART) programs. For this reason, official prescribing information advises that the medication should only be used by physicians who are thoroughly familiar with the treatment of infertility and the required patient monitoring procedures.

Q: What is the expected long-term experience for people taking Meropur?

A: This medication is intended for short-term use in a defined treatment cycle. The official research evidence states that the long-term effects on women and any potential offspring beyond the immediate cycle outcomes have not been fully established in long-term follow-up studies.

Q: Is Meropur considered a first-line treatment?

A: Official drug labels describe the role of Meropur in controlled ovarian stimulation as part of a specific regimen for Assisted Reproductive Technology (ART) cycles. The label focuses on its use within this specialized, monitored context rather than classifying it with the clinical terms 'first-line' or 'second-line' treatment.

Q: Can Meropur cause long-term health issues?

A: Studies designed to evaluate the potential for the medicine to cause carcinogenicity (cancer-causing effects) have not been carried out, as the medication is intended for short-term use. The official regulatory labeling does note a possible increased risk of ovarian tumors in patients undergoing fertility protocols.

Q: Do I need to stop taking Meropur suddenly, or do I need to taper off?

A: Meropur is used as part of a temporary treatment cycle. Treatment is concluded when adequate follicular development is observed by the healthcare provider. The official label does not include instructions for a gradual reduction (tapering) in the dose.

Q: Will Meropur affect my ability to drive or operate machinery?

A: Official regulatory information from international agencies indicates that this medicine is not expected to affect a patient's ability to drive a car or operate heavy machinery.

Q: Are there different strengths or versions of Meropur?

A: Meropur is supplied as a lyophilized powder for injection. This powder contains 75 International Units (IU) of Follicle-Stimulating Hormone (FSH) activity and 75 IU of Luteinizing Hormone (LH) activity. It is reconstituted with a sterile diluent prior to administration.

Q: Does Meropur make you gain weight?

A: Significant, rapid weight gain is a documented symptom that occurs in cases of Ovarian Hyperstimulation Syndrome (OHSS), which is a serious, very common risk associated with the medication. This type of weight gain is usually due to fluid retention.

Q: Can men and women use Meropur for the same reasons?

A: Official prescribing information indicates Meropur is used for the development of multiple ovarian follicles and pregnancy in women participating in an Assisted Reproductive Technology (ART) cycle. The regulatory label does not list a specific indication for use in men.

Q: Is an allergic reaction to Meropur common?

A: The medicine is strictly contraindicated (must not be used) in patients with a known hypersensitivity (severe allergy) to the active substance or its components. Allergic reactions, ranging from mild rash to serious symptoms, have been observed, but the frequency is not established as a common or very common adverse event.

Q: What is the shelf life of Meropur?

A: The unopened, unmixed lyophilized powder is typically stable for the duration specified on the packaging when stored in its original container and protected from light. Once the powder is mixed with the diluent, the solution must be used immediately and any unused portion should be discarded.

Q: How is Meropur eliminated from the body?

A: Following administration, the follicle-stimulating hormone (FSH) component of the medication is eliminated, and its activity in the body decreases with a half-life of approximately 39 to 53 hours. A small portion of the medicine is excreted unchanged in the urine.

Q: Is Meropur a controlled substance?

A: No, Meropur (menotropins for injection) is not classified as a controlled drug under the Controlled Substances Act (CSA) in the United States or similar international regulatory frameworks.

Q: Does taking Meropur affect fertility?

A: Meropur is indicated for use in an Assisted Reproductive Technology (ART) program to help women become pregnant by supporting the processes required for ovarian follicular development within the monitored context of a treatment cycle.

Q: Is Meropur associated with any mental health changes?

A: Official product information does not list major mental health changes, such as depression or anxiety, as common adverse reactions. However, patients undergoing hormonal treatments for infertility in general often experience mood fluctuations.

Q: Is Meropur used for any conditions besides the main one?

A: The official label lists two primary indications: development of multiple follicles for Assisted Reproductive Technology (ART), and ovulation induction in women with anovulatory infertility. Use outside of these two conditions is considered unapproved by regulatory agencies.

Q: Can Meropur affect the results of common lab tests?

A: Yes, during Meropur treatment, the effectiveness of the therapy is monitored through frequent lab work, including the measurement of serum estradiol levels. The medicine is designed to affect these specific biological markers and hormones.

Q: Are there known interactions between Meropur and hormonal birth control?

A: Although no formal drug interaction studies are documented, Meropur is used to stimulate ovarian function. For this reason, it is typically not co-administered with hormonal contraceptives, which are designed to suppress ovarian function.

Q: Why do official documents mention specific times for taking Meropur?

A: Official instructions specify a precise treatment regimen, including starting on a specific cycle day and following a strict schedule for dose adjustments. This is because the dosing must be carefully monitored and highly individualized based on the woman’s natural ovarian response during the cycle.

Q: Does Meropur contain ingredients that people commonly avoid, like gluten or dairy?

A: The powder excipients for Meropur contain lactose, which is a sugar found in dairy products. Other ingredients include polysorbate 20 and sodium hydroxide. Patients with specific sensitivities often review the full ingredients list with a healthcare provider.

How should Meropur be stored and disposed of?

The storage and disposal of Menopur must adhere strictly to regulatory guidelines to ensure medication quality and environmental safety.

Condition Requirement
Storage Temperature (Unmixed) mathbf3 C to mathbf25 C (mathbf37 F to mathbf77 F), or refrigerated. Do not freeze [1.2, 2.7].
Protection Store in the original container to protect from light [1.2, 2.7].
Stability Post-Mixing Use immediately after reconstitution. Some multi-dose vials may be stored for up to 28 days at or below 25 C [1.5, 3.4].

Disposal: The medicine must be kept out of the reach of children [2.7]. Used needles and syringes must be placed in a designated sharps disposal container [2.4]. Any unused product or waste material must be discarded in accordance with local requirements and should not be disposed of via household waste [1.6, 2.7].

Attention! Always consult to a doctor or pharmacist before using pills or medicines.

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