Мериоферт

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Мериоферт

Medically reviewed

Marina Burgos

Last updated on 22/12/2025

This page provides general, reference-level information compiled from official medical sources. It is not a substitute for professional medical advice, diagnosis, or treatment. For decisions about your health, please consult a qualified healthcare professional.

Overview of Мериоферт

Quick Facts

Property Description
Active ingredient Menotropin (Human Menopausal Gonadotropin, hMG)
Form Lyophilizate (powder) for solution for injection
Pharmacological class Gonadotropins
Common use Stimulating ovarian follicular growth
Origin Natural (purified from postmenopausal urine)

Defining Мериоферт: Class, Composition, and Origin

Мериоферт is a highly purified, hormone-based biological preparation intended for prescription use, whose core active substance is menotropin (hMG), placing it within the specialized pharmacological classification of Gonadotropins. This medication is distinguished by its natural origin; it is meticulously purified and extracted from the urine of postmenopausal women, a characteristic that provides a natural balance of the active hormones. The menotropin in Мериоферт is a dual-activity product, specifically formulated to provide both Follicle-Stimulating Hormone (FSH) and Luteinizing Hormone (LH) activities, which is a key differentiator from monotherapy preparations.


What is the Pharmaceutical Form of Мериоферт?

The physical structure of Мериоферт is supplied as a lyophilizate, a sterile, freeze-dried powder contained in a glass vial. This formulation is designed for ensuring the stability of the complex protein hormones over time. Prior to use, the powder must be fully dissolved using a supplied sterile aqueous solvent, transforming it into a clear solution. This prepared solution is designed exclusively for parenteral administration—delivery via a subcutaneous or an intramuscular injection—a necessary route that ensures the active proteins are reliably delivered into the systemic circulation.


General Purpose: Why is Menotropin Used?

The fundamental purpose of Мериоферт is to provide a comprehensive and controlled hormonal stimulus to the female reproductive system in situations requiring assisted follicular development. By delivering the combined FSH and LH activity, the medicine is utilized in clinical settings to initiate and support the early phases of egg maturation by promoting ovarian follicular growth. This targeted hormonal support is crucial for regulating the basic physiological environment required for specific reproductive cycles.

Regulatory References

  1. Menotropins (hMG) - MeSH - NIH

What side effects are possible with Мериоферт?

Possible Side Effects and Safety Information

The safety profile for menotropin is structured by regulatory documents based on the likelihood and physiological system of the observed reactions. Side effects are classified by frequency, ranging from Very Common to Rare, as documented by official government health authorities. The principal safety concerns involve the Reproductive System and Vascular System, reflecting the drug's hormonal action.


Official Adverse Reaction Frequencies

The official labeling classifies the following adverse reactions:

Frequency Classification Key Adverse Reactions (Examples)
Very Common (ge 1/10) Ovarian Hyperstimulation Syndrome (OHSS), Headache
Common (ge 1/100 to < 1/10) Nausea, Abdominal Pain, Injection Site Reactions
Uncommon (ge 1/1,000 to < 1/100) Deep Vein Thrombosis

Serious Adverse Reactions and Key Safety Constraints

Ovarian Hyperstimulation Syndrome (OHSS) is documented as a serious, potentially life-threatening complication that requires specific monitoring. This condition often reaches its maximum severity approximately seven to ten days following the last administration of the medicine. The official safety documentation also highlights the risk of Thromboembolic Events, which include severe arterial and venous complications such as pulmonary embolism and stroke.

Safety notes specify that the treatment is officially associated with an increased risk of multiple gestation (e.g., twins, triplets) and a higher incidence of ectopic pregnancy in patients with tubal abnormalities. Use is formally contraindicated in pregnant or lactating women, as stated in regulatory prescribing information.

Overdose and Emergency Response

The official regulatory documents state that the primary risk associated with excessive exposure to menotropin is the development of Ovarian Hyperstimulation Syndrome (OHSS). This condition is a dose-related complication that can range from mild to severe, and in its most serious instances, may be potentially fatal.

When to Seek Immediate Medical Help

Urgent medical attention is required if signs of severe OHSS manifest. Patients are mandated to seek immediate medical attention or go to the nearest hospital emergency room right away if they experience symptoms such as severe pelvic pain, sudden weight gain, trouble breathing (dyspnea), nausea, vomiting, or decreased urine output (oliguria).

Documented Manifestations and Management

Documented severe manifestations include significant fluid accumulation (ascites, hydrothorax) and thromboembolic reactions, which are vascular complications listed in the prescribing information. Should an excessive response be suspected, regulatory instruction is to stop the menotropin treatment immediately and withhold the administration of Human Chorionic Gonadotropin (hCG). No specific antidote is known; therefore, management of severe OHSS is strictly symptomatic and supportive, often requiring hospitalization and close monitoring for at least two weeks. This condition is documented to be more protracted if pregnancy occurs.

Therapeutic Uses of Мериоферт

What Meriofert Treats: Main Uses and Benefits

Meriofert (menotrophin) is a medication used in fertility treatment to offer support for specific challenges related to ovarian function and the release of eggs.

The medication is applied in situations involving certain distressing symptoms related to anovulatory infertility, helping to address conditions such as Polycystic Ovarian Disease (PCOD) and also supporting Controlled Ovarian Stimulation during Assisted Reproductive Technology (ART) procedures like IVF and ICSI.

It is applied with the aim of providing supportive relief during symptomatic periods, commonly used across conditions presenting with acute episodes.

Quick Fact: Support for Functional Strain

Meriofert is relevant for managing the functional strain associated with anovulatory infertility and supports the controlled stimulation required for assisted reproductive procedures. This may contribute to easing the overall symptom load related to these conditions.

Regulatory References

  1. Therapeutic Goods Administration (TGA)

Eligibility and Restrictions for Use

Who Can and Cannot Use Meriofert (Menotropin)

The population eligibility for Meriofert is strictly defined by regulatory documents, focusing on women seeking fertility treatment who meet specific medical criteria.

Contraindications and Absolute Non-Eligibility

Official labeling contraindicates the use of Meriofert in several specific groups:

  • Patients with documented hypersensitivity to Menotropin or any excipients.
  • Individuals diagnosed with ovarian, uterine, or breast carcinoma, or tumours of the hypothalamus or pituitary gland.
  • Women experiencing gynaecological bleeding of unknown cause.
  • Patients with Primary Ovarian Failure, as an effective response cannot be achieved.
  • When structural incompatibilities (e.g., uterine fibroids or organ malformations) or ovarian cysts unrelated to PCOS are present.
  • Individuals with uncontrolled thyroid or adrenal dysfunction.

Age and Physiological Restrictions

Meriofert is contraindicated during both pregnancy and lactation.

Use is not intended for pediatric or adolescent populations, as safety and efficacy have not been established. The medicine has no relevant use in the geriatric (older adult) population. Furthermore, official data on the safety and efficacy in patients with renal or hepatic insufficiency have not been studied.

What should I know about interactions with other medicines?

Interactions with other medicines and products

Meriofert's official regulatory documentation defines its interaction profile based on documented pharmacodynamic effects and essential administration restrictions.

The principal documented drug-drug interaction involves the sequential co-administration of Human Chorionic Gonadotrophin (hCG). This is formally classified as a pharmacodynamic reinforcement because hCG is officially noted to increase the likelihood of developing Ovarian Hyperstimulation Syndrome (OHSS) when used to complete the fertility treatment course. This additive effect is the central interaction pattern specified in the product labeling.

A mandatory procedural restriction applies to the administration method: Meriofert must not be mixed with any other medicinal product in the same syringe. This clear rule is established by regulatory authorities due to a documented absence of compatibility studies for the reconstituted solution.

Regarding systemic pharmacokinetics, regulatory labels explicitly state that no human drug-drug interaction studies have been conducted to assess enzyme-mediated metabolic interactions, such as those involving CYP pathways. This results in no official documentation for interactions that would alter the plasma concentration or exposure of Meriofert. Similarly, no formal interaction statements are documented concerning food, alcohol, or herbal products in the official prescribing information.

Mechanism of Action

The mechanism of Мериоферт (Menotropin) operates by stimulating the reproductive system through direct engagement with two specific receptor systems in the ovary.

Direct Activation of Ovarian Gonadotropin Receptors

The drug's action begins at the cellular level by functioning as an agonist for the body's natural gonadotropin receptors, binding to and activating the Follicle-Stimulating Hormone Receptor ( FSHR) and the Lutropin-Choriogonadotropin Receptor ( LHCGR) on ovarian cells. This receptor engagement triggers the cAMP/PKA pathway, initiating the cellular proliferation and growth necessary for a developing follicle.

Synergistic Cascade for Steroid Hormone Synthesis

The core mechanism is defined by the coordinated action of both FSH and LH activities within the preparation. FSH promotes the expression of the aromatase enzyme within the granulosa cells, while the LH activity facilitates the supply of androgen precursors from the theca cells. This synergistic process drives a significant local increase in estradiol synthesis, which is the primary physiological signal for follicular maturation and progression towards the pre-ovulatory stage.

Dosage and Administration Information

How to Use Meriofert: Official Administration Guidelines

The usage of Meriofert (menotropin) is strictly defined by regulatory guidelines and is administered as part of a short-term, cyclical treatment protocol under specialist supervision. This section describes the high-level, label-based instructions for its use, excluding safety, efficacy, or mechanism of action.


Administration Scope

Feature Official Regulatory Instruction
Route of administration Subcutaneous (SC) injection or Intramuscular (IM) injection.
Dosing schedule (OI) Initial dose is typically 75 IU to 150 IU daily. The dose is adjusted no more frequently than every 2 days.
Dosing schedule (ART/COS) Initial dose is typically 150 IU to 225 IU daily; the maximum daily dose is generally 450 IU.
Preparation requirements The lyophilized powder must be reconstituted immediately before use with the provided solvent. The vial must be gently swirledshaking is prohibited—to yield a clear, colorless solution.
Age-group rules Not recommended for use in children or adolescents. Data on dose adjustments for renal or hepatic impairment are not available.
Special procedural conditions The first injection must be administered under the direct supervision of a medical specialist. Each vial is for single use only; any remaining solution must be discarded.

Official Use Protocol

Meriofert is used following a daily injection frequency as part of a controlled cycle. The injection phase duration typically lasts 7 to 12 days for Ovulation Induction (OI) and should generally not exceed 20 days for Assisted Reproductive Technology (ART) cycles. This parenteral administration method requires specialized training and close medical monitoring throughout the entire defined treatment period.

Recent Clinical Evidence

Мериоферт: Recent Clinical Evidence


Clinical Research on Controlled Ovarian Stimulation (COS) for ART

The largest body of highly controlled clinical research, including large Randomized Controlled Trials (RCTs) and meta-analyses, has been studied for use in women undergoing Assisted Reproductive Technology (ART) procedures like IVF (In Vitro Fertilization) and ICSI. The primary goal of these studies was to evaluate ovarian response and measure the clinical outcomes associated with the entire treatment cycle.

Researchers primarily examined and measured the Ongoing Pregnancy Rate (OPR) and the Cumulative Live Birth Rate (LBR) over multiple cycles. Studies reported patterns in the measured outcomes when comparing menotropin to other common ovarian stimulants in the observed patient populations. For instance, some trials focusing on women predicted to be high responders reported comparable live birth rates between the menotropin group and the rFSH group. The findings describe group patterns and contribute to the broader evidence landscape for this indication.


Studies on Ovulation Induction (OI) for Anovulatory Infertility

Research has also evaluated menotropin for evaluation in patients with anovulation for women who experience irregular or absent cycles, a condition known as anovulatory infertility. These studies often focus on populations, such as women with Polycystic Ovarian Disease (PCOD), who have not responded to initial oral therapies.

The outcomes measured in this research context included the Ovulation Rate and the resulting Clinical Pregnancy Rate. Early studies and subsequent meta-analyses reported that, under closely monitored conditions, the use of menotropin was associated with the observation of an Ovulation Rate in women with PCOD who were previously resistant to other treatments. Findings for this specific indication rely on a body of evidence that is less extensive than the ART indication, with fewer recent large-scale comparative trials.


Research Gaps and Areas of Uncertainty

Clinical trials typically focus on short-term outcomes. A key outcome measured, the Cumulative Live Birth Rate, tracks patient outcomes over multiple cycles, with follow-up periods generally extending up to one year post-treatment. However, long-term effects are not fully established beyond the period of reproductive treatment. Research regarding the durability of reproductive function or potential long-term health outcomes remains an area where data are still emerging.

Furthermore, the evidence quality varies across studies due to differences in clinical trial protocols. Data for certain groups remain insufficient; for instance, menotropin has not been studied in the pediatric or geriatric populations, and limited information is available for women with underlying serious comorbid conditions.

Key Studies & References

  1. New Clinical Data Published on Menopur® (menotropins for injection) in a Predicted High Responder Population (Referring to MEGASET-HR study findings)

Frequently Asked Questions (FAQ)

Common questions about Мериоферт (FAQ)


Q: Is Мериоферт the same thing as Menopur or Menotropin?

The active ingredient in this drug is menotropins, which is its non-proprietary name. The medication belongs to the menotropins class, and 'Menopur' is a common brand name for a similar preparation used in fertility treatment.


Q: Why is Мериоферт given as an injection instead of a pill?

The drug is formulated as water-soluble, protein-like substances called glycoproteins. Official product information indicates that, because these substances could be broken down in the digestive system, they are administered through parenteral administration (injection). This method ensures the hormones are properly absorbed and remain effective.


Q: Are there different versions or strengths of Мериоферт?

The drug contains specific International Units ( IU) of Follicle-Stimulating Hormone ( FSH) and Luteinizing Hormone ( LH) activity. Although the product comes in specific vial strengths, dosing regimens are determined by the healthcare provider and can specify various IU amounts to meet individualized treatment needs.


Q: Who is generally not eligible to use Мериоферт according to official documents?

The medication is contraindicated (not recommended) for use in individuals with high FSH levels indicating primary ovarian failure, uncontrolled thyroid or adrenal dysfunction, and certain tumors (e.g., pituitary, hypothalamus, or hormone-dependent tumors). The medication is also contraindicated for use in patients with certain reproductive organ conditions, such as specific ovarian cysts of unknown origin or primary ovarian failure.


Q: Is Мериоферт considered safe for long-term use?

Official regulatory protocols define this drug for short-term cyclical use, not long-term chronic treatment. The maximum duration of the stimulation phase is generally limited, for example, not exceeding 20 days in most ART cycles. This structure reflects its authorization for short-term cyclical use.


Q: What is the difference between Мериоферт and FSH medications?

Regulatory documents describe this drug as containing both Follicle-Stimulating Hormone ( FSH) activity and Luteinizing Hormone ( LH) activity. This dual composition is a key characteristic that distinguishes it from medications that contain only FSH activity.


Q: Why is a specific type of monitoring often required when using Мериоферт?

Close medical monitoring, typically involving ovarian ultrasound and blood tests, is required to minimize the risk of developing Ovarian Hyperstimulation Syndrome ( OHSS). Official warnings indicate that OHSS is a potentially serious complication that necessitates constant specialist management.


Q: Is Мериоферт used for both men and women?

Yes, regulatory indications confirm the drug is used in both sexes. It is indicated for use in women undergoing ART or Ovulation Induction ( OI) protocols, and in certain men to stimulate sperm production ( spermatogenesis) following appropriate pre-treatment.


Q: What types of side effects are commonly mentioned in user discussions about Мериоферт?

Common side effects reported in official documents include headache, abdominal pain, stomach cramps, and abdominal enlargement. Reactions at the injection site, such as pain, redness, swelling, and irritation, are also frequently reported.


Q: Is it true that Мериоферт can cause bloating or weight gain?

Yes, official adverse reaction reports list abdominal enlargement (bloating) and rapid weight gain. These effects are particularly important because they can be signs of Ovarian Hyperstimulation Syndrome ( OHSS), which warrants immediate discussion with a healthcare provider.


Q: How long do the side effects of Мериоферт usually last?

Mild side effects are often expected to resolve within a few days to a couple of weeks following administration. However, symptoms of serious complications like OHSS or blood clots can persist and require immediate, specialized medical attention.


Q: Is there a link between Мериоферт and headaches or dizziness?

Official adverse reaction data reports that headache is one of the most common side effects associated with menotropins therapy. Dizziness is also listed, but it is reported as an uncommon side effect.


Q: Can Мериоферт be used if someone is sensitive to HCG?

Prior hypersensitivity or allergic reaction to menotropins or any of the excipients is a formal contraindication. The drug contains LH activity, which is partly provided by human chorionic gonadotropin ( hCG) found in the urinary extract, meaning patients with known sensitivities to these components may be restricted from use.


Q: Does Мериоферт interact with common pain relievers like ibuprofen?

Regulatory documents generally indicate no known formal interactions with other medications. The drug should not be mixed with any other product except as directed by a healthcare provider.


Q: Are there any specific vitamins or supplements that should not be taken with Мериоферт?

Regulatory documents state there are no known formal interactions with herbs or supplements that would cause a specific contraindication. Patients should still inform their doctor of all concomitant medications and supplements being taken.


Q: Is it safe to drink coffee or tea while using Мериоферт?

Official product information states there are no known interactions between the medication and common foods or drinks. This indicates that regular consumption of coffee or tea is not restricted based on formal drug interaction warnings.


Q: Does alcohol interact with Мериоферт?

Official product information states there are no known formal interactions with alcohol. However, individuals should discuss any alcohol consumption with their healthcare provider.


Q: Why do official sources sometimes use the name 'highly purified menotropin'?

The preparation is extracted from the urine of postmenopausal women and contains naturally occurring gonadotropins. The term 'highly purified' signifies that the substance has undergone additional steps during the manufacturing process to remove impurities and concentrate the active hormones.


Q: Are there any dietary changes people using Мериоферт often discuss?

Regulatory documents state there are no known interactions with food. However, certain symptoms related to the treatment, such as severe vomiting or abdominal swelling from OHSS, may require medical guidance on temporary dietary changes.


Q: Is the tiredness mentioned by some users a recognized side effect of Мериоферт?

Yes, tiredness (fatigue) is listed as an uncommon side effect in regulatory documents associated with menotropins therapy. Patients are advised to discuss any severe or persistent symptoms with their prescribing physician.


Q: What happens if a user misses a dose of Мериоферт (general information)?

Official patient instructions are clear: if a dose is missed, patients are told to contact their healthcare provider immediately for further dosing guidance. Patients are advised not to take a double dose to compensate for a missed one.


Q: Is Мериоферт often prescribed alongside other medicines?

Treatment protocols frequently involve the sequential or simultaneous use of other reproductive medications, such as Human Chorionic Gonadotropin ( hCG) or GnRH agonists/antagonists. The product may also be reconstituted and mixed with certain other specific fertility medicines, but only as directed by a specialist.


Q: Are there concerns about allergic reactions related to Мериоферт?

Yes, hypersensitivity or allergic reaction to the drug's components is a formal contraindication. Regulatory documents report that both localized (at the injection site) and systemic (affecting the whole body) hypersensitivity reactions have been reported.


Q: What is the shelf life of Мериоферт when unopened?

The unmixed powder has a specific shelf life, typically indicated on the packaging. Official storage instructions require the product to be kept away from light, either in the refrigerator or at controlled room temperature, as per the specific drug packaging instructions.


Q: Can Мериоферт affect mood or cause emotional changes?

Official reports of adverse reactions indicate that mood changes, including depression and irritability, have been reported in association with menotropins therapy. Any changes in mood or emotional state should be monitored and discussed with a healthcare provider.


Q: Is it normal to feel pain at the injection site after using Мериоферт?

Yes, pain, redness, swelling, and irritation at the injection site are specifically reported among the most common local side effects. This reaction is listed in the official adverse reaction data.


Q: What is the risk classification of Мериоферт during pregnancy (descriptive only)?

The drug is formally contraindicated (not to be used) in women who are pregnant or suspected to be pregnant. This is because official documents indicate that use during pregnancy may cause fetal harm.


Q: Does Мериоферт require any special type of storage?

Yes, the unmixed powder requires specific storage conditions. It must be protected from light and kept within a specified temperature range (refrigerated or room temperature) until it is reconstituted for injection.


Q: Are there any known issues when traveling with Мериоферт?

The official storage instructions (requiring protection from light and specific temperature ranges) necessitate special precautions when traveling. Patients may need to use cool packs or insulated containers to ensure the product remains stable within the regulatory temperature range.


Q: Can Мериоферт affect existing thyroid conditions?

Yes, the drug is contraindicated in women with uncontrolled thyroid or adrenal dysfunction. This means that any existing conditions related to these glands must be properly managed and controlled before the drug is administered.


Q: What are the official warnings listed for Мериоферт regarding multiple pregnancies?

Official warnings state that the use of this drug increases the chance of having a multiple pregnancy (e.g., twins, triplets). The increase in multiple pregnancies is a known risk of assisted reproductive therapies, and multiple pregnancies carry greater health risks for both the mother and the babies.


Q: Is it normal to feel a stinging sensation when Мериоферт is administered?

Yes, a stinging sensation is specifically listed as a type of reaction that can occur at the injection site. This is reported as a common side effect and is included in the official adverse reaction data.


Q: What is the source of the hormones in Мериоферт?

Official product information states that the gonadotropins are extracted and purified from the urine of postmenopausal women. This is the source for menotropins, which are then highly purified for pharmaceutical use.

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Q: Is Мериоферт considered a high-risk medication?

Official documents label the drug as a 'potent gonadotropic substance' because it is intended to cause a strong biological effect. Due to the potential for mild to severe adverse reactions (e.g., OHSS), regulatory bodies specify that it should only be used by specialists familiar with infertility treatment.


Q: Are there common symptoms that require contacting a healthcare provider while on Мериоферт?

Yes, official warnings list symptoms associated with Ovarian Hyperstimulation Syndrome ( OHSS) as requiring immediate medical attention. These symptoms include severe pelvic pain, rapid weight gain, persistent nausea/vomiting, trouble breathing, or decreased urination.

How should Мериоферт be stored and disposed of?

How to Store and Dispose of Meriofert

Meriofert must be stored under specific conditions to maintain its stability. The unopened product, which includes the powder and solvent, must be kept in its original container to protect it from light. Official labeling requires storage at a temperature not exceeding 25 C and explicitly states that the product must not be frozen.

Upon reconstitution, the solution is for immediate and single use only. Any remaining solution after administration must be discarded. All medicines, including Meriofert, must be stored out of the sight and reach of children.

Disposal of any unused or expired product must be managed in accordance with local requirements for pharmaceutical waste, as directed by regulatory authorities.

Attention! Always consult to a doctor or pharmacist before using pills or medicines.

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