Menofem

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Menofem

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Medically reviewed

Rosario Oropesa

Last updated on 22/12/2025

This page provides general, reference-level information compiled from official medical sources. It is not a substitute for professional medical advice, diagnosis, or treatment. For decisions about your health, please consult a qualified healthcare professional.

Overview of Menofem

What is Menofem? The Identity and Composition

Property Description
Active ingredient Standardized extract of Cimicifuga racemosa rhizome
Form Oral tablets
Pharmacological class Botanical agent / Climacteric remedy
Common use Relief of general menopausal symptoms
Origin Natural source (Herbal)

What Type of Preparation is Menofem?

Menofem is classified as a monocomponent pharmaceutical product, specifically a botanical agent and a climacteric remedy, administered in the form of oral tablets. This product is typically available non-prescription (OTC), positioning it as an accessible option for adult women. Its identity is separate from conventional hormonal treatments. For instance, the therapeutic use of Cimicifuga racemosa for neurovegetative menopausal complaints is clinically recognized within regulatory frameworks.

What is the Active Ingredient in Menofem?

The active substance in Menofem is a standardized dry extract obtained from the rhizome of Cimicifuga racemosa, commonly known as Black cohosh. The therapeutic properties of this extract are primarily attributed to specific natural compounds, the triterpene glycosides. Standardization is a critical process, ensuring that each tablet delivers a consistent, measured quantity of the active components, a key differentiating feature from unquantified herbal supplements. This focus on verifiable concentration provides a predictable intervention; published data have supported its mechanism as distinct from classical estrogenic action.

What is the General Purpose of Taking Menofem?

The primary general purpose of Menofem is to provide support in managing the common neurovegetative symptoms experienced during the menopausal syndrome. The preparation is intended to help reduce the intensity and frequency of physical manifestations like disruptive hot flashes and episodes of excessive sweating. This action is understood to be non-hormonal, targeting the central regulatory systems of the body, particularly the hypothalamus, to stabilize functions disrupted by the climacteric transition. Menofem is typically positioned for the patient group of perimenopausal and postmenopausal women seeking relief from moderate symptoms.

What side effects are possible with Menofem?

Possible Side Effects and Safety Information

Official regulatory documents detail the known risks and safety considerations associated with this medicine. The safety profile is structured by classifying adverse reactions based on how often they occur and what body system they affect.

Common Adverse Reactions

Adverse reactions reported as Common (occurring frequently) primarily involve the gastrointestinal system and the nervous system. These include:

  • Gastrointestinal upset (such as indigestion, nausea, or vomiting)
  • Headache
  • Changes in blood pressure (either high or low)
  • General effects such as weight gain or a feeling of heaviness in the legs
Classification Examples of Reactions
Common Indigestion, Nausea, Headache, Low/High Blood Pressure
Very Rare Liver failure, Hypersensitivity reactions

Serious Adverse Reactions and Restrictions

In very rare cases, one of the components (black cohosh) has been associated with liver failure. This is considered a serious adverse event in regulatory documentation. Use of the medicine should be stopped immediately if symptoms suggesting liver injury develop, such as:

  • Yellowing of the skin or eyes (jaundice)
  • Unusual dark urine or light-colored stool
  • Persistent nausea, vomiting, stomach pain, or loss of appetite

Safety Contraindications

Official safety information states that this medicine is Contraindicated (should not be used) in certain populations due to documented risks:

  • Women who are pregnant
  • Women who are breastfeeding

Additionally, use must be discontinued if any hypersensitivity or allergic reactions occur.

Overdose and Emergency Response

Overdose and when to Seek Help

The official regulatory information for Menofem focuses on the risk of severe hepatotoxicity (liver toxicity) as the principal concern that dictates mandatory emergency action. Symptoms suggestive of liver injury are the critical signs of overexposure and may include jaundice (yellowing of the skin or eyes), severe upper stomach pain, persistent nausea or vomiting, dark urine, light-colored stool, unusual tiredness, and loss of appetite.

The most serious, though rare, outcomes reported in regulatory documents are acute hepatic failure and, in isolated instances, death. Severe allergic reactions, such as swelling of the face, lips, or throat, are also documented as a potential serious consequence.


Emergency Actions

Immediate medical help is required when any signs or symptoms of liver trouble are observed. If these manifestations occur, it is officially mandated that the user stop taking the medicinal product and consult a doctor immediately.

Management and Monitoring

Management of overexposure is generally limited to providing symptomatic and supportive treatment. Official regulatory documents note that no specific antidote is known for this preparation. Furthermore, individuals with a history of liver disorder should seek medical advice prior to use, as this population may carry a heightened risk for severe outcomes.

Therapeutic Uses of Menofem

What Menofem Treats: Main Uses and Benefits

Menofem is commonly applied as a non-hormonal option for symptomatic support during the climacteric transition, addressing a cluster of symptoms known as the menopausal syndrome. The traditional use of its active ingredient for menopausal complaints, such as hot flushes and profuse sweating, is established as a recognized approach for symptom management. The preparation is generally considered relevant in clinical settings marked by the onset of disruptive manifestations that interfere with daily stability, providing assistance in symptom management.


The product is generally considered relevant for easing symptom clusters that may become intense or disruptive, including vasomotor instability, associated neurovegetative symptoms, and secondary sleep disturbances. By easing these symptom clusters, Menofem provides support that helps ease the overall symptom burden during phases of heightened emotional or physiological tension.

“Applied in contexts where additional supportive symptom management is appropriate.”

Quick Fact: Relief for Climacteric Symptoms

Menofem is commonly used to help with symptoms related to physical discomfort, assisting in reducing the burden of hot flashes and night sweating, and contributing to improved comfort during periods of heightened symptoms.

Regulatory References

  1. European Union herbal monograph on Cimicifuga racemosa

Eligibility and Restrictions for Use

Who is Eligible for Menofem?

The eligibility for Menofem (Cimicifuga racemosa extract) is defined by regulatory guidelines, focusing on the approved population and specific health exclusions. The preparation is officially intended only for adult women (18 years and older) who are experiencing climacteric symptoms.


Official Restrictions and Contraindications

Certain populations and conditions are formally defined as non-eligible or require consultation, based on regulatory labeling:

  • Liver Health: Patients with a history of liver disorder should generally not use this medicine. If signs of liver injury (e.g., jaundice, dark urine, or severe upper abdominal pain) develop, use must be immediately discontinued, and medical advice sought.
  • Hormone-Sensitive Conditions: Individuals with or treated for hormone-dependent tumours (such as breast cancer) must consult a physician prior to using Menofem.
  • Age and Physiological Status: Use is not recommended for children and adolescents (under 18 years) as safety is not established. Use is also not recommended during pregnancy or breastfeeding.
  • Concomitant Therapy: Menofem should not be used with estrogens (such as Hormone Replacement Therapy) unless under the direct supervision of a doctor.

What should I know about interactions with other medicines?

Interactions with other medicines and products

The official interaction profile for Menofem (Standardized Cimicifuga racemosa extract) is defined primarily by specific regulatory cautions regarding additive risks and restrictions, rather than known pharmacokinetic interactions.

Interaction Scope and Constraints

Classification Interacting Substance/Condition Constraint as stated in Regulatory Documents
Pharmacodynamic Restriction Oestrogens (Estrogen-containing products) Should not be used together unless specifically advised by a healthcare professional.
Additive Risk Caution Hepatotoxic Agents (e.g., specific medicines, alcohol) Co-administration may theoretically increase the risk of liver injury.
Metabolic Pathways CYP P450 Enzymes (e.g., CYP3A4) No clinically relevant interactions affecting drug clearance or plasma levels are officially reported in core regulatory assessments.
Population-Specific Note History of Liver Disorder Increased caution is required in this population due to the heightened relevance of the potential liver-related interaction risk.

The regulatory documentation emphasizes that formal studies have not reported clinically significant pharmacokinetic effects on common drug-metabolizing enzymes or drug transporters. The core of the interaction profile revolves around a pharmacodynamic caution, specifically the mandated restriction against co-administration with oestrogens and a warning about the theoretical risk of additive hepatotoxicity when used alongside alcohol or other agents known to affect the liver. No mandatory timing separation rules are required in the official labeling.

Mechanism of Action

Menofem's mechanism of action involves the simultaneous pharmacological activities of its botanical components, Black Cohosh and Red Clover, which modulate several distinct biological pathways. This multi-target engagement leads to the adjustment of activity within targeted physiological systems.

Modulating Neurotransmitter Signaling

Menofem engages mechanisms that regulate key neurotransmitter pathways, particularly those involving serotonin receptors in the central nervous system. By interacting with specific receptor subtypes, it modifies early molecular steps that influence hypothalamic thermoregulation. This cascade results in the adjustment of activity within temperature control pathways.

Selective Receptor-Mediated Pathway Adjustment

The botanicals are relevant in systems where targeted pathway adjustment occurs, acting within domains involving receptor-mediated signaling. Certain components exhibit activity as Selective Estrogen Receptor Modulators (SERMs) or possess estrogen-like effects. This allows the drug to subtly affect systems where specific hormone mediators dominate, leading to predictable physiological adjustments that shape the drug's effect profile.

Influencing Inflammatory and Oxidative Processes

Menofem engages mechanisms that regulate overactive or dysregulated processes by exhibiting both antioxidant and anti-inflammatory properties. This domain involves modifying signals within inflammatory pathways and neutralizing reactive species. The resulting biochemical effect reduces the concentration of specific mediators and modifies downstream signaling within target tissues.

Dosage and Administration Information

The official instructions for using Menofem are designed to ensure its correct administration and adherence to the established regimen.

Administration Guidelines

Administration Scope Detail
Route of Administration Oral (Taken by mouth).
Dosage Form Capsule.
Standard Dosing The typical recommended dose is one capsule daily. This may be adjusted up to two capsules a day as advised by a healthcare practitioner, based on individual patient response.
Dosing Frequency The medicine is taken once daily.
Timing and Consistency The capsule should be taken at the same time each day to maintain consistent levels in the body.
Preparation The capsule must be swallowed whole with liquid. No crushing, chewing, or dissolution is required.

Procedural Structure

The approved use of Menofem involves a simple, non-cycling daily regimen:

  1. Obtain the product.
  2. Take the capsule orally, once per day.
  3. Swallow the capsule whole.
  4. Adhere to the daily schedule by taking the medicine at the same time each day.

These official instructions define the standardized, daily protocol for Menofem, ensuring its use follows the requirements for the oral dosage form.

Recent Clinical Evidence

Research Evidence / Overview of Studies for Menofem


Evidence for Relief of General Menopausal Symptoms

Research has examined a standardized Cimicifuga racemosa extract in studies designed to measure outcomes related to climacteric symptoms. These include Randomized Controlled Trials (RCTs), where the extract was studied alongside an inactive substance (placebo) over short to intermediate follow-up durations, typically up to six months. Studies monitored patient-reported outcomes describing perceived discomfort using validated scales like the Menopause Rating Scale (MRS).

Some meta-analyses and systematic reviews, which combine data from multiple RCTs, describe patterns of change in overall symptom scores measured during the study period. A key limitation is the heterogeneity of products available; the applicability of these results to generic or unquantified herbal supplements is not established.


Research Focused on Vasomotor Symptoms (Hot Flashes and Sweating)

Research has focused on trials assessing short-term or episodic symptom patterns linked specifically to vasomotor symptoms. Research examined how these outcomes related to physical discomfort were measured using detailed patient diaries and specific sub-scores from general menopausal indices. Studies measured and reported the frequency and intensity of these acute or disruptive episodes, and data describe patterns related to measured outcomes in the observed populations.

The evidence for this specific symptom cluster is limited by extract-specificity. There is limited information for long-term outcomes and the durability of the observed patterns beyond the immediate study period.


Evidence Gaps and Areas of Scientific Uncertainty

The primary scientific gaps relate to the limited availability of long-term data from controlled settings beyond six months, as long-term effects are not fully established. The scientific literature reports discussion that questions the consistency of evidence when systematic reviews combine data from various preparations. Comparative evidence against all alternative non-hormonal prescription options is also an area where more research is needed.

Key Studies & References

  1. Black cohosh (Cimicifuga racemosa) for menopausal symptoms: an updated review of clinical trials

Frequently Asked Questions (FAQ)

Common questions about Menofem (FAQ)


Q: How is Menofem different from other common hormone therapy drugs?

Regulatory documents and official classifications generally identify the active ingredient in Menofem, Cimicifuga racemosa, as a non-hormonal botanical agent.

This classification distinguishes the product from conventional prescription hormone therapies (HT/MHT), which use specific hormones like estrogen or progesterone.


Q: Is Menofem a type of Hormone Replacement Therapy (HRT) or Menopause Hormone Therapy (MHT)?

Menofem is not classified as a type of Hormone Replacement Therapy (HRT) or Menopause Hormone Therapy (MHT).

According to official information, it is designated as a botanical or herbal medicinal product for climacteric symptoms, reflecting its general classification as a non-hormonal treatment.


Q: How long does it usually take to feel the effects of Menofem?

Clinical research and professional overviews describe a pattern where therapeutic effects may begin after approximately two weeks of consistent use, with maximum effects often observed within eight weeks.


Q: Is Menofem ever described in combination with other types of treatment?

Official warnings state that Menofem should not be used with Estrogens (Hormone Therapy) unless specifically advised by a healthcare professional.

Official cautions also exist regarding the potential for increased liver injury risk when combining the product with any agent or supplement known to be hepatotoxic (potentially damaging to the liver).


Q: Is the long-term use of Menofem addressed in regulatory guidelines?

Official guidelines generally set six months as the recommended reassessment point for therapy if symptoms persist or worsen.

Long-term use beyond this initial period is often cited in scientific literature as an area where further data is needed to fully establish long-term effects.


Q: What is the general expectation for symptoms if I stop taking Menofem?

Stopping the use of Menofem may result in a return of menopausal symptoms.

Because the product is used to manage climacteric discomfort, the general expectation is that symptoms may revert to the pattern experienced prior to starting therapy.


Q: Are there different forms of Menofem available (e.g., tablet, patch, gel)?

Menofem is formulated as an oral capsule or tablet.

Official product documentation regulates this specific oral formulation of the extract. No other forms, such as transdermal patches or gels, are indicated for this product identity.


Q: Does Menofem have any known effects on cholesterol levels or heart health?

Some clinical studies have monitored patients during therapy and found no significant changes in serum metabolic parameters, which include cholesterol and lipid levels.

However, adverse event reports have rarely documented cases of bradycardia (a slow heart rate), and official information notes that certain cardiovascular conditions are referenced in the monitoring advice for the product.


Q: What is the typical duration of Menofem treatment, as described in official guidelines?

Official guidelines describe six months as the recommended reassessment point for therapy if symptoms persist or worsen.

This six-month period is the key recommended reassessment point for the continuation of therapy.


Q: Can Menofem be used by patients who take vitamins or dietary supplements?

The primary regulatory caution concerning supplements involves the potential for increased liver injury risk.

Official labeling includes a warning regarding the potential for increased liver injury risk when the product is combined with any agent or supplement known to be hepatotoxic (harmful to the liver). General interactions with common, non-hepatotoxic vitamins are not typically documented.


Q: What are the official warnings about using Menofem if a patient has a history of blood clots?

Due to rare adverse event reports, including cases of venous thrombosis (blood clots), official guidance suggests caution.

Professional guidance often recommends caution when the product is used by individuals with a history of thromboembolic disorders.


Q: Is it normal to experience irregular bleeding or spotting when first starting Menofem?

Adverse event reports have listed irregular menstrual cycles or spotting and uterine bleeding as possible side effects associated with the active ingredient.

Regulatory safety information requires that any unusual or unexpected bleeding be reported to a healthcare provider for prompt evaluation.


Q: Is a change in breast tenderness expected with Menofem use?

Adverse event reports have included breast pain or tenderness and breast enlargement as potential side effects.

Regulatory guidance includes a recommendation for regular breast examinations during therapy due to the possibility of these effects.


Q: How does Menofem affect sleep patterns or night sweats?

The product is indicated for the relief of climacteric symptoms, which includes the management of night sweats.

Clinical studies have also examined the use of the extract in relation to improvements in sleep quality and insomnia in women experiencing these symptoms.


Q: Can Menofem be used by women who have gone through early or premature menopause?

The product is officially indicated for adult women who are experiencing climacteric symptoms.

Clinical trials that form the basis for the regulatory indication have generally included patients across the range of menopausal statuses, including those who are postmenopausal.


Q: What is the importance of the dose when considering Menofem?

Clinical studies have shown that some preparations of the active ingredient exhibit a dose-dependent effect.

This means that the specific, measured quantity of the active compound delivered by the dosage may influence the reported level of efficacy for menopausal symptom relief.


Q: Does Menofem impact the results of common health screenings, like mammograms?

Due to the potential for the product to have effects on breast tissue, regulatory guidance includes a recommendation for regular breast and pelvic exams during therapy.

This recommendation is related to ongoing monitoring during the course of treatment.


Q: Are there special considerations for using Menofem for patients with diabetes or high blood pressure?

While not listed as formal contraindications, official information references certain conditions in relation to monitoring.

Some clinical studies have monitored patients with pre-existing high blood pressure and tracked changes in blood pressure and serum metabolic parameters (including glucose) during the course of therapy.


Q: Can Menofem affect fertility or pregnancy outcomes (informational query)?

Menofem is contraindicated and should not be used during pregnancy or while breastfeeding.

Regulatory warnings indicate that the active ingredient may potentially act as an abortifacient and could affect a nursing infant.


Q: Do official documents mention any potential for Menofem to affect cognitive function or memory?

Clinical research informing the product monograph has explored the extract's effects on the Central Nervous System (CNS) and pathways in the brain.

This includes studying regions associated with emotional and cognitive function as part of the overall assessment of its impact on neurovegetative symptoms.


Q: Is Menofem intended for use in perimenopause or only post-menopause?

Official indications confirm that the product is intended for the relief of climacteric symptoms in both perimenopausal and postmenopausal women.


Q: Do any official documents describe Menofem's impact on bone health or osteoporosis risk?

The product is not officially indicated for the treatment of osteoporosis or bone disease.

However, research has explored the extract’s effect on bone metabolism in relevant models, as bone health is a significant concern during the menopausal transition.


Q: What are the general rules for stopping Menofem treatment?

Regulatory guidance specifies that use must be immediately discontinued if any symptoms suggesting liver injury (such as yellowing of the skin, dark urine, or severe abdominal pain) or a severe hypersensitivity reaction occur.

How should Menofem be stored and disposed of?

Storage and Disposal Requirements

Menofem tablets must be stored at a controlled room temperature, generally defined as being below 30 C. To protect the stability of the medicine, it is mandatory to store the tablets in the original outer carton and blister packaging to shield them from both light and moisture. The official labeling instructs users to not freeze the product.

Child Safety and Handling

As with all medicinal products, Menofem must be stored out of the sight and reach of children.

Disposal of Unused Medicine

Unused or expired Menofem should not be disposed of in household wastewater or general trash, unless specifically authorized by local regulations. Official disposal instructions require that any leftover product be discarded through a community or pharmacy-based drug take-back program or other system compliant with local pharmaceutical waste requirements.

Attention! Always consult to a doctor or pharmacist before using pills or medicines.

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