Components:
Medically reviewed by Kovalenko Svetlana Olegovna, PharmD. Last updated on 26.06.2023
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Top 20 medicines with the same components:
A synthetic naphthoquinone without the isoprenoid side chain and biological activity, but can be converted to active vitamin K2, menaquinone, after alkylation in vivo. [PubChem]
Oral
Vitamin K deficiency
Adult: 10 mg every 6 hr.
Oral
Severe hypoprothrombinaemia
Adult: 10 mg 3-4 times daily.
Intravenous
Vitamin K deficiency
Adult: 0.03 mcg/kg/day.
Child: Infants: 1-5 mcg/kg/day.
Intramuscular
Severe hypoprothrombinaemia
Adult: 2.5-10 mg daily.
Oral
Vitamin K deficiency
Adult: 10 mg every 6 hr.
Oral
Severe hypoprothrombinaemia
Adult: 10 mg 3-4 times daily.
Intravenous
Vitamin K deficiency
Adult: 0.03 mcg/kg/day.
Child: Infants: 1-5 mcg/kg/day.
Intramuscular
Severe hypoprothrombinaemia
Adult: 2.5-10 mg daily.
- Vitamin K is contraindicated in those hypersensitive to any component of a vitamin K-containing product.
- Contraindicated in patients with severe hepatic disease.
- Contraindicated in women in the last few weeks of pregnancy.
Broad-Spectrum Antibiotics-Broad-spectrum antibiotics may sterilize the bowel and decrease the vitamin K contribution to the body by the intestinal microflora. Cephalosporins-Cephalosporins containing side chains of N-methylthiotetrazole (cefmenoxime, cefoperazone, cefotetan, cefamandole, latamoxef) or methylthiadiazole (cefazolin) can cause vitamin K deficiency and hypoprothrombinemia. These cephalosporins are inhibitors of hepatic vitamin K epoxide reductase. Cholestyramine-Concomitant intake of cholestyramine and vitamin K may reduce the absorption of vitamin K. Colestipol-Concomitant intake of colestipol and vitamin K may reduce the absorption of vitamin K. Mineral Oil-Concomitant intake of mineral oil and vitamin K may reduce the absorption of vitamin K. Orlistat-Orlistat may decrease the absorption of vitamin K. Salicylates-Salicylates in large doses may inhibit vitamin K epoxide reductase resulting in vitamin K deficiency. Warfarin-Vitamin K can antagonize the effect of warfarin
A too rapid injection causes occasional hypersensitivity reactions in susceptible patients with circulation problems to shock The contained sulfite may lead to hypersensitivity reactions, especially in asthmatics with nausea, diarrhea, respiratory disorders, acute asthma attack, loss of consciousness or shock