Meftagesic

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Meftagesic

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Medically reviewed

Laura Arias

Last updated on 22/12/2025

This page provides general, reference-level information compiled from official medical sources. It is not a substitute for professional medical advice, diagnosis, or treatment. For decisions about your health, please consult a qualified healthcare professional.

Overview of Meftagesic

Meftagesic is a Fixed-Dose Combination (FDC) medicine classified primarily as an Analgesic (pain reliever) and Antipyretic (fever reducer), administered via the oral route. It is a synthetic pharmaceutical product combining two distinct, pharmacologically active ingredients to offer integrated therapeutic relief.


Quick Facts

Property Description
Active Ingredients Mefenamic Acid, Acetaminophen (Paracetamol)
Form Tablet, Oral Suspension
Pharmacological Class Analgesic, Antipyretic, Non-steroidal Anti-inflammatory Drug (NSAID)
Common Use Integrated relief of general pain and fever
Origin Synthetic small-molecule compounds

The Identity and Class of Meftagesic

This medicine is formally defined by its structure as an FDC, meaning two therapeutic compounds are presented in a single, predetermined ratio. The formulation incorporates the dual classification of its components: the preparation acts as both a primary pain and fever remedy, while the presence of Mefenamic Acid ensures the distinct properties of a Non-steroidal Anti-inflammatory Drug (NSAID) are included. This strategic combination is used to address multiple discomfort pathways simultaneously, providing integrated relief particularly for conditions where both inflammation and fever contribute significantly to discomfort.

Composition and General Therapeutic Purpose

Meftagesic contains the two active pharmaceutical ingredients (APIs): Mefenamic Acid and Acetaminophen (Paracetamol). The core therapeutic purpose is to achieve synergistic relief from general discomfort and elevated body temperature. Mefenamic Acid contributes peripheral anti-inflammatory effects, while Acetaminophen is crucial for strong central antipyretic action. This composition leverages complementary mechanisms to provide combined relief, for instance, in the management of acute musculoskeletal discomfort or during symptomatic relief of a feverish episode.

Available Forms: Tablet and Suspension

Meftagesic is available for oral administration in two primary forms: a solid tablet and a liquid oral suspension. This availability provides flexibility in use across diverse patient needs. The suspension form, often indicated by specific designations in certain trade formulations, is particularly useful for patient groups such as children, as it facilitates accurate dosage and ease of ingestion when compared to solid tablets.

What side effects are possible with Meftagesic?

Possible Side Effects and Safety Information

This section outlines the adverse reactions and safety statements officially documented for Meftagesic (a combination typically containing Mefenamic Acid and Paracetamol), based strictly on regulatory sources.

Frequency and Common Adverse Reactions

Adverse reactions are classified by how often they occur. Common side effects typically include gastrointestinal issues such as nausea, vomiting, diarrhea, abdominal pain, indigestion (heartburn), and flatulence. Other common reactions are skin rash, dizziness, and drowsiness.

System-Organ Class and Serious Risks

Regulatory documents organize adverse reactions by the major body system affected (System-Organ Class).

System-Organ Class Examples of Documented Reactions
Gastrointestinal Bleeding, Ulceration, Perforation (can be fatal), Gastritis
Cardiovascular Serious Thrombotic Events (Heart Attack, Stroke), Hypertension
Hepatobiliary Liver damage, Acute Liver Failure
Immune/Skin Severe Allergic Reactions, Stevens-Johnson Syndrome (SJS)
Renal/Urinary Impairment of renal function, Acute Renal Failure

Regulatory Restrictions and High-Risk Populations

Formal restrictions govern the use of this medicine to minimize serious risks:

  • Contraindications: Use is prohibited in patients with active peptic ulceration, a history of NSAID-induced asthma or allergies, or severe heart, liver, or kidney failure.
  • Older Adults: This population faces an increased frequency and severity of adverse reactions, particularly fatal gastrointestinal bleeding.
  • Pregnancy: Use is generally not recommended, especially late in pregnancy.
  • Dose/Duration: Regulatory guidance directs the use of the lowest effective dose for the shortest possible duration to minimize the risk of serious side effects.

Patients on prolonged therapy may require regular monitoring for liver and kidney function, blood disorders, and the development of severe skin reactions or persistent diarrhea, which typically requires immediate suspension of treatment.

Overdose and Emergency Response

Overdose and When to Seek Help

The official regulatory guidance states that immediate medical attention or contacting emergency services is required for any known or suspected overdose of this medicine. Due to the Acetaminophen component, a severe, life-threatening outcome such as Acute Liver Failure may be delayed, meaning symptoms of organ damage may not appear until 48 to 72 hours after ingestion.

Documented Overdose Manifestations Overdose may initially present with non-specific signs including Nausea, Vomiting, Abdominal Pain, and Diaphoresis (sweating). More severe manifestations documented in regulatory labeling include signs of Central Nervous System (CNS) toxicity, such as Convulsions (Seizures), Confusion, and an Altered Conscious Level, primarily associated with the Mefenamic Acid component. Other documented outcomes include Acute Renal Failure and severe Gastrointestinal (GI) Bleeding.

Antidote and Required Monitoring Management involves prompt action because the specific antidote for Acetaminophen toxicity, N-acetylcysteine (NAC), is most effective when administered quickly. For Mefenamic Acid toxicity, no specific antidote is known. Due to these risks, regulatory bodies mandate hospital monitoring and necessary laboratory tests (e.g., liver enzyme levels) to assess the risk of toxicity. Individuals with chronic alcohol use are noted to have an increased risk for severe hepatic injury.

Therapeutic Uses of Meftagesic

What Meftagesic Treats: Main Uses and Benefits

Meftagesic is generally used in situations involving certain distressing symptoms. The therapeutic scope is guided by the established symptomatic uses of its active components, which are relevant for easing pain and inflammation. It is applied when groups of symptoms appear suddenly or fluctuate, requiring temporary assistance in stabilization.


Symptom Relief Domains

This medicine is commonly used to address the dual symptoms related to physical discomfort and systemic imbalance (fever) simultaneously. It is relevant for managing symptoms that interfere with daily comfort across several domains, including acute headaches, dental pain, pain from sprains and muscle aches, and severe cramping pain associated with primary dysmenorrhea.

A key therapeutic role is supporting patients during episodes of heightened discomfort. It contributes to easing the overall symptom load, supporting general well-being during symptomatic phases. The combination is relevant for easing symptoms that create noticeable physiological strain, and may assist with maintaining functional stability when symptoms are more noticeable.

Quick Fact: Relief for Acute Discomfort
Meftagesic is a relevant option for managing symptoms in conditions associated with acute or disruptive episodes.

Eligibility and Restrictions for Use

Who Can and Cannot Use Meftagesic?

The eligibility for Meftagesic, a fixed-dose combination containing an NSAID (Mefenamic Acid) and Acetaminophen, is strictly defined by regulatory guidelines. Use is generally restricted to adults and adolescents 14 years and older for the officially approved indications, with use in younger children not being established by the FDA for these purposes.


Absolute Contraindications

The medicine must not be used by specific populations, as formally stated in regulatory labeling:

  • Patients with a history of NSAID-related allergy (e.g., asthma, urticaria) or active gastrointestinal ulceration or chronic inflammation.
  • Individuals with severe renal failure, severe heart failure, or those undergoing Coronary Artery Bypass Graft (CABG) surgery for peri-operative pain.
  • Women who are in the third trimester of pregnancy (after 30 weeks gestation).

Restricted and Conditional Use

Certain groups require restricted use or close monitoring. Use is not recommended for breastfeeding women or those actively attempting to conceive. Older adults must use the lowest effective dose for the shortest duration due to increased risks. Additionally, due to the Acetaminophen component, patients consuming three or more alcoholic drinks daily are prohibited from use, and concurrent use of any other Acetaminophen-containing product is forbidden.

What should I know about interactions with other medicines?

Interactions with other medicines and products

Official regulatory documentation structures the interaction profile of this medicine based on the combined effects of Mefenamic Acid (NSAID) and Acetaminophen. Certain combinations are classified as contraindicated due to the risk of severe adverse effects.


Documented Interaction Restrictions

  • Other Acetaminophen-containing products are strictly prohibited due to the risk of exceeding the safe daily dose and causing severe liver damage.
  • Co-administration with other Non-steroidal Anti-inflammatory Drugs (NSAIDs) is generally avoided due to the additive risk of serious gastrointestinal events, including bleeding and ulceration.
  • Use with Alcohol (three or more drinks per day) is documented to increase the risk of severe liver damage associated with the Acetaminophen component.

Exposure and Clearance Alterations

Interacting Substance Officially Documented Outcome
**Oral Anticoagulants** (e.g., Warfarin) Enhancement of anticoagulant effect, increasing bleeding risk (requires monitoring).
**Antihypertensives** (ACE Inhibitors, Diuretics) Reduction of their blood pressure lowering or diuretic effect; increased risk of renal impairment.
**Lithium** or **Methotrexate** Reduced renal clearance, potentially leading to elevated plasma concentrations.
**Magnesium Hydroxide Antacids** Significantly increases the rate and extent of Mefenamic Acid absorption.

This profile also notes that Elderly or volume-depleted patients are at an increased risk of renal impairment when the NSAID component is co-administered with Antihypertensives, as described in official prescribing information.

Mechanism of Action

Meftagesic employs a dual mechanism, combining two active ingredients to affect both the local generation and the central processing of nociceptive signals.

Peripheral Inflammatory Mediator Inhibition

This domain outlines the action of Mefenamic Acid, which functions as a non-selective inhibitor of Cyclooxygenase (COX) enzymes in peripheral tissues. By blocking the enzymes, the drug inhibits the biosynthesis of Prostaglandins, which are chemical mediators that modulate the excitability of nociceptive afferents and contribute to local inflammatory responses. This mechanism targets the initial, upstream molecular steps that influence peripheral nociceptive signaling.

Central Nociceptive and Thermoregulatory Modulation

This domain covers the action of Acetaminophen, which primarily acts within the Central Nervous System (CNS). It influences the central thermoregulatory pathway by weakly inhibiting central COX activity, leading to a downward adjustment of the hypothalamic thermoregulatory set point. Additionally, it exerts an analgesic effect through its metabolite, AM404, which activates TRPV1 channels and modulates CB1 receptors, modulating the transmission of nociceptive signals centrally.

Dosage and Administration Information

How to Use Meftagesic: Official Administration Guidelines

Meftagesic, a combination medicine containing Mefenamic Acid and Acetaminophen (Paracetamol), is administered according to a strict, short-term protocol. This section details the guidance on how the medicine is administered.


Administration Scope

Instruction Detail
Route of administration Oral (Taken by mouth).
Dosing schedule (Adults) Initial dose of 500 mg, followed by a maintenance dose of 250 mg (Mefenamic Acid component dosing basis).
Timing in relation to meals Must be taken with food, milk, or water to minimize gastrointestinal effects.
Age-group administration rules The standard adult dosing regimen is for use in patients 14 years of age and older.

Usage Protocol and Constraints

Classification Detail
Frequency pattern As-needed (PRN) for acute symptoms, administered every 6 hours (q6h).
Duration constraints The duration of use is limited and usually does not exceed 7 days (one week).
Special conditions The lowest effective dose must be used for the shortest duration; for primary dysmenorrhea, treatment should commence at the onset of bleeding and associated symptoms.

Resulting Procedural Structure

The official usage dictates a short course of therapy that begins with a higher loading dose to initiate relief, followed by subsequent maintenance doses taken every six hours. This protocol standardizes the procedural delivery of the medication, ensuring its use is confined to the temporary management of acute episodes.

Recent Clinical Evidence

Research Evidence / Overview of Studies

Meftagesic is a combination product typically containing Mefenamic Acid and Paracetamol (Acetaminophen). In some formulations, Dicyclomine is used instead of Paracetamol.

Phase 1: Efficacy Studies in Pain and Fever

The primary component, Mefenamic Acid, is a non-steroidal anti-inflammatory drug (NSAID) whose effectiveness has been extensively studied for the management of mild to moderate pain, particularly menstrual pain (dysmenorrhea). Studies have shown an association between its use and a reduction in pain intensity.

Paracetamol, an analgesic and antipyretic, is commonly included to address fever and increase the overall pain relief threshold, targeting pain signals within the central nervous system. The combination of Mefenamic Acid and Paracetamol is commonly evaluated for conditions such as headache, dental pain, and musculoskeletal aches.

  • Combination Efficacy: Research suggests fixed-dose combination products, like those containing an NSAID and an analgesic, may provide a comprehensive approach to pain management by influencing both inflammation and the body's pain response.

Phase 2: Safety Profile and Adverse Events

Observed safety profiles in clinical settings reflect the known risks associated with its components, Mefenamic Acid and Paracetamol.

Component Risk Observed Safety Concerns
Mefenamic Acid (NSAID) Potential for gastrointestinal adverse events (ulceration, bleeding) and cardiovascular thrombotic events.
Paracetamol (Acetaminophen) Risk of liver toxicity, particularly with long-term use or doses exceeding the maximum recommended limit.

Reported side effects in trials were most commonly gastrointestinal discomfort, headache, and dizziness. Patients with pre-existing conditions like severe liver, kidney, or heart disease were often excluded from trials due to elevated risk factors. Monitoring of kidney and liver function is standard in clinical practice, especially if the treatment duration is prolonged.

Key Studies & References

  1. The efficacy and safety of paracetamol for pain relief: an overview of systematic reviews
  2. Fixed-Dose Combination of NSAIDs and Spasmolytic Agents in the Treatment of Different Types of Pain—A Practical Review

Frequently Asked Questions (FAQ)

Common questions about Meftagesic (FAQ)


Q: How long do the effects of Meftagesic usually last?

Official product information, based on the component Mefenamic Acid, describes the elimination half-life as approximately two hours. The half-life refers to the time it takes for half of the drug to be cleared from the body.


Q: Are there any major food or drink restrictions while taking Meftagesic?

Official guidelines state the medicine is required to be administered with food, milk, or water to help minimize potential gastrointestinal effects. Regulatory documents also caution against the daily consumption of three or more alcoholic drinks, as this is described as increasing the risk of severe liver damage associated with the Acetaminophen component.


Q: What are the most common side effects reported for Meftagesic?

Regulatory documents state that common adverse reactions typically include gastrointestinal issues such as diarrhea, nausea, vomiting, abdominal pain, indigestion (heartburn), and flatulence. Other common reactions noted are dizziness and drowsiness.


Q: Are there known interactions between Meftagesic and common cold medicines?

The regulatory documents strictly forbid co-administration with any other products containing Acetaminophen (Paracetamol) or other Non-steroidal Anti-inflammatory Drugs (NSAIDs). Because these ingredients are often found in common cold remedies, authoritative sources underscore the importance of full disclosure of all medications to a healthcare professional.


Q: How does Meftagesic work to reduce inflammation?

The Mefenamic Acid component works by inhibiting certain enzymes in the body called Cyclooxygenase (COX) enzymes. By blocking these enzymes, the drug prevents the production of Prostaglandins, which are chemical substances that contribute to local inflammation and pain responses.


Q: Is Meftagesic considered a narcotic or opioid?

According to regulatory documents, this medicine is formally classified as a Non-steroidal Anti-inflammatory Drug (NSAID) and an analgesic (pain reliever) and antipyretic (fever reducer). It is not classified as a narcotic or opioid.


Q: Does taking Meftagesic cause drowsiness or affect driving?

Regulatory documents list both drowsiness and dizziness as common side effects associated with the use of this medicine. Authoritative medical sources note that these effects can potentially affect a person's ability to drive or safely operate machinery.


Q: Is it possible to become dependent on Meftagesic?

Official labeling documents and the medicine’s classification as an NSAID/analgesic do not list a risk of dependence or misuse as a required warning for the product.


Q: Are there specific age limits for who can use Meftagesic?

Regulatory documents indicate that the medicine is approved for use in patients 14 years of age and older. Safety and effectiveness in pediatric patients younger than 14 years old have generally not been established for the approved indications.


Q: What should I do if I miss a scheduled time for Meftagesic?

Authoritative medical source instructions direct that if a dose is missed, patients should take it as soon as possible. However, if it is almost time for the next scheduled dose, the instructions direct patients to skip the missed dose and continue with the regular schedule. Regulatory guidance specifies that doses should not be doubled.


Q: Can Meftagesic be taken with supplements or vitamins?

Authoritative medical sources underscore the regulatory requirement that patients disclose all products being taken to their healthcare professional, including vitamins, nutritional supplements, and herbal products. Full disclosure is important for monitoring potential interactions.


Q: Are there long-term health concerns associated with taking Meftagesic?

Regulatory labels state that the risk of serious side effects, including cardiovascular events (such as heart attack or stroke) and serious gastrointestinal events (such as bleeding or ulceration), may increase with the duration of use. Therefore, the medicine is generally limited to short-term treatment.


Q: Is it normal to feel a bit dizzy after taking Meftagesic?

Dizziness is officially documented as one of the common adverse reactions associated with the use of this medicine. This documentation indicates that dizziness is a frequently observed potential effect.


Q: What does the research say about Meftagesic for chronic pain conditions?

The regulatory indications for this medicine are for the short-term relief of acute pain and primary dysmenorrhea. The label cautions that risks increase with the duration of use, which restricts its use in the management of long-term or chronic conditions.


Q: What are the regulations regarding Meftagesic use in children?

Regulatory documents indicate that the medicine is approved for patients 14 years of age and older. Safety and effectiveness in pediatric patients younger than 14 years old have generally not been established for the approved indications.


Q: What are the most serious, but rare, potential side effects of Meftagesic?

The documented serious risks include fatal cardiovascular thrombotic events (like heart attack or stroke), severe gastrointestinal events (including bleeding and ulceration), acute liver failure, and severe skin reactions like Stevens-Johnson Syndrome. Regulatory guidance directs that the lowest effective dose be used for the shortest possible duration to minimize these risks.


Q: Are there any lifestyle factors that affect how Meftagesic works?

Regulatory guidance states the medicine is required to be taken in relation to meals (with food, milk, or water). It also cautions against daily consumption of three or more alcoholic drinks due to the increased risk of liver damage associated with the Acetaminophen component.


Q: Can I take Meftagesic if I am fasting for a period of time?

Official administration guidelines state that the medicine is required to be administered with food, milk, or water to minimize potential irritation to the stomach and intestines. This is a condition of use described in regulatory documentation.


Q: Why is it described as a short-term use medication?

The medication is restricted to short-term use because official regulatory guidance requires using the lowest effective dose for the shortest duration possible. This measure is taken to minimize the potential risk of serious side effects, particularly cardiovascular and gastrointestinal events, which are linked to prolonged use.


Q: Does Meftagesic interact with herbal supplements like St. John's Wort?

Authoritative medical sources underscore the regulatory requirement that patients disclose all herbal products and supplements being taken to their healthcare professional. This is because certain herbs, such as St. John's Wort, are known to affect how the body processes some prescription medicines, which could alter the drug's effects.

How should Meftagesic be stored and disposed of?

Storage and Disposal Information

This section outlines the official requirements for storing and disposing of Meftagesic (Mefenamic Acid and Paracetamol combination), based on regulatory documents.

Storage Condition Requirement
Temperature Store below 30°C.
Protection Keep away from light and moisture.
Child Safety Keep out of the reach of children and pets.

The drug's stability profile requires protection from excessive heat and environmental factors to maintain its quality over the three-year shelf-life. For oral liquid formulations, the container should be kept tightly closed. While general guidance suggests an in-use period of six months after opening for oral liquids, product-specific labeling should be consulted. Unused or expired medication should be disposed of via drug take-back programs or by following specific national and local guidelines for pharmaceutical waste.

Attention! Always consult to a doctor or pharmacist before using pills or medicines.

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