Maxiflo

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Maxiflo

Treatment option: Asthma

Medically reviewed

Marina Burgos

Last updated on 22/12/2025

This page provides general, reference-level information compiled from official medical sources. It is not a substitute for professional medical advice, diagnosis, or treatment. For decisions about your health, please consult a qualified healthcare professional.

Overview of Maxiflo

Property Description
Active Ingredients Fluticasone Propionate, Formoterol Fumarate
Form Inhaler (Metered-Dose or Dry Powder)
Pharmacological Class Combination Inhaled Corticosteroid and Long-Acting Beta2-Agonist (ICS/LABA)
Common Purpose Long-term control and maintenance treatment
Origin Synthetic
Status Prescription-only (Rx)

What Type of Medicine is Maxiflo?

Maxiflo is a prescription-only, synthetic fixed-dose combination product administered via oral inhalation. It belongs to the pharmacological class known as a Combination Inhaled Corticosteroid and Long-Acting Beta2-Agonist (ICS/LABA). This combination strategy is clinically recognized for providing effective long-term control and maintenance treatment for persistent breathing issues.

Unlike monotherapies that target only one mechanism, Maxiflo is designed to address the complexity of chronic respiratory diseases by ensuring the simultaneous delivery of both an airway opener and an anti-inflammatory agent. The brand is manufactured by Cipla Ltd., making it a globally distributed fixed-dose inhaler system.


Fluticasone and Formoterol: Composition and Dual Purpose

Maxiflo is composed of two distinct, synthetic active ingredients: Fluticasone Propionate and Formoterol Fumarate. Fluticasone Propionate is a synthetic glucocorticoid that provides the essential anti-inflammatory activity, working to reduce chronic swelling within the bronchial tubes.

Formoterol Fumarate, a selective long-acting beta2-adrenergic agonist, functions as the primary bronchodilator. As a long-acting agent, it provides sustained relaxation of the airways. The dual purpose of Maxiflo is to leverage this synergy, achieving continuous airway widening alongside the mitigation of inflammation, which together help stabilize overall breathing function.


Maxiflo Delivery: What are the Available Forms?

Maxiflo is exclusively administered through the oral inhalation route of administration, delivering the therapeutic agents directly to the target tissue in the respiratory tract. The medicine is commonly provided in specialized devices, such as a pressurized metered-dose inhaler (pMDI) or as a dry powder inhaler (DPI). This localized delivery system allows for the effective utilization of both the anti-inflammatory and bronchodilator components precisely where their action is required.

What side effects are possible with Maxiflo?

Possible Side Effects and Safety Information

Adverse Reactions Overview

Adverse reactions associated with Maxiflo are typically classified by frequency and system-organ class. Common reactions often involve the nervous system and respiratory tract, including headache, oral candidiasis (fungal infection of the mouth/throat), sore throat/throat irritation, and hoarseness of voice (dysphonia). Infections and infestations, such as upper respiratory tract infection and sinusitis, are also frequently reported.

Less common, but documented, effects include tremor, palpitations, and hyperglycemia (elevated blood sugar). Psychiatric changes, such as agitation, anxiety, and sleep disturbances, have been noted, particularly with the long-term use of the inhaled corticosteroid component.

Serious and Clinically Significant Safety Concerns

Regulatory documentation highlights the risk of several serious adverse reactions:

  • Paradoxical Bronchospasm: An immediate, life-threatening reaction where the patient experiences sudden wheezing or breathing difficulty after inhalation.
  • Systemic Corticosteroid Effects: These include the potential for adrenal suppression, hypercorticism (Cushing’s syndrome), and reduced bone mineral density (osteoporosis) with prolonged or high-dose use.
  • Cardiovascular Effects: The Formoterol component, a long-acting beta2-agonist (LABA), carries a risk of effects like tachycardia (increased heart rate) and ventricular extrasystoles.
  • Ocular Toxicity: Long-term use may contribute to the development of glaucoma or cataracts.

Safety Restrictions and Monitoring

Maxiflo is contraindicated for patients with a known hypersensitivity to its active ingredients (Fluticasone Propionate, Formoterol Fumarate) or excipients. It is not indicated for acute asthma or COPD attacks; a separate rescue inhaler is required for sudden symptoms. Use with caution is necessary for patients with co-existing conditions, including cardiovascular disorders, diabetes mellitus, tuberculosis, or other systemic infections. Due to the risk of systemic effects, the concomitant use of strong Cytochrome P450 3A4 inhibitors is not recommended.

For pediatric patients, growth rate monitoring is recommended. Hypokalemia (low blood potassium) and hyperglycemia should be closely monitored in all patients. Rinse the mouth with water after use to minimize the risk of oral candidiasis.

Overdose and Emergency Response

Overdose and when to seek help — Official Regulatory Information

The official overdose profile is based on the components of Maxiflo, Fluticasone Propionate and Formoterol Fumarate, as documented in government regulatory sources.

Overdose Scope

Feature Regulatory Documentation Statement
Documented overdose presentations Signs of beta2-adrenergic overstimulation, including tachycardia (increased heart rate), palpitations, tremor, headache, nervousness, dizziness, nausea, and vomiting.
Physiological systems affected Cardiovascular system, Metabolic system (hypokalemia, hyperglycemia), and Endocrine system (adrenal suppression).
Dose-related or exposure factors Excessive use of the inhaled sympathomimetic component; very high dosages or chronic high-dose exposure of the corticosteroid component.
Population-specific overdose notes Patients with severe hepatic impairment may experience increased systemic exposure to both components.

Emergency Actions and Treatment

Classification Feature Regulatory Documentation Statement
Severity classification Overdose risks include fatalities and clinically significant cardiovascular effects.
When immediate medical help is required Seek immediate medical attention or contact emergency services if overdose is suspected or for a sudden and progressive deterioration in disease control.

Official Overdose Statements:

  • Treatment is symptomatic and supportive, as no specific antidote is known for the combination product.
  • Continuous cardiac monitoring is required due to the risk of arrhythmias, alongside monitoring of serum potassium and blood glucose levels.
  • The use of a cardioselective beta-blocking agent may be warranted but must be done with extreme caution due to the potential to precipitate bronchospasm.

This information defines the risks associated with beta2-agonist overstimulation and corticosteroid excess, underscoring the need for an immediate emergency response if overdose or sudden worsening of symptoms occurs.

Therapeutic Uses of Maxiflo

What Maxiflo Treats: Main Uses and Benefits

Maxiflo is commonly used in the management of chronic respiratory conditions. This medicine is generally applied for long-term symptom control rather than for immediate, acute relief.

The medication is relevant for managing persistent asthma and Chronic Obstructive Pulmonary Disease (COPD), including the symptoms of chronic bronchitis and emphysema. It is commonly used when groups of symptoms, such as recurring wheezing, chest tightness, and sustained difficulty breathing, create a noticeable physiological strain. Its primary role is maintenance, providing supportive relief for symptoms that interfere with daily functioning.

“Its primary therapeutic role is maintenance, providing supportive relief for symptoms that interfere with daily functioning.” Maxiflo is generally relevant for managing these persistent, long-term conditions in adults and adolescents, assisting with maintaining functional stability and supporting general well-being during symptomatic phases. Furthermore, it is relevant in clinical settings to address symptoms that become more disruptive during flare-ups, providing support that helps ease the overall symptom burden.

Quick Fact: Relief for Respiratory Discomfort
Maxiflo is commonly used to help with groups of symptoms that create noticeable physiological strain.

Eligibility and Restrictions for Use

Eligibility Map: Who Can and Cannot Use Maxiflo — Official Regulatory Information

The eligibility profile for Maxiflo is strictly defined by regulatory documents, which establish the populations approved for use, as well as those for whom the medicine is contraindicated or requires caution.


Category Regulatory Statement (Strictly Label-Based)
Populations for whom use is allowed Adults and Adolescents aged 12 years and older (for maintenance treatment of asthma and/or COPD).
Populations for whom use is contraindicated Individuals with known Severe Hypersensitivity to any component. Must not be used for the primary treatment of Acute Episodes or Status Asthmaticus.
Age-related eligibility rules Use is not recommended in children under 5 years of age. Eligibility for children aged 5 to 11 years is dependent on the specific dosage strength and region.

Eligibility-Related Restrictions

Official labeling requires caution and close monitoring for certain pre-existing conditions. These include Cardiovascular Disorders, Diabetes Mellitus, Thyrotoxicosis, and active or quiescent Tuberculosis. Use during Pregnancy and Lactation is conditional, and the medicine is generally reserved for use only if the expected benefit is deemed to outweigh the potential risk. Caution is also advised for patients with severe hepatic impairment due to the potential for altered clearance of the components.

What should I know about interactions with other medicines?

Interactions with other medicines and products

The regulatory profile for Maxiflo (Fluticasone Propionate/Formoterol Fumarate) documents distinct interaction patterns categorized by their mechanistic basis and potential outcome.


Official Contraindicated Combinations

Co-administration with Non-selective Beta-blockers is officially contraindicated. These agents antagonize the bronchodilating effect of Formoterol and may cause severe respiratory distress, which is a formal prohibition documented in regulatory labeling.

Pharmacokinetic and Pharmacodynamic Risks

The primary pharmacokinetic interaction involves Potent CYP3A4 Inhibitors (e.g., Ritonavir, Ketoconazole). Because Fluticasone is metabolized by the CYP3A4 enzyme, co-administration significantly increases the systemic plasma exposure of Fluticasone Propionate, which is a regulatory concern for potential systemic corticosteroid effects.

Additive pharmacodynamic risks exist with several substance classes. Co-administering with MAOIs, Tricyclic Antidepressants, or Q-T Prolonging Drugs is officially noted for increasing the risk of cardiovascular events, such as arrhythmias. Furthermore, the combination with Diuretics or Xanthine Derivatives can potentiate the risk of developing hypokalemia (low serum potassium levels).

Interaction-related cautions are noted for non-medicinal substances, including Alcohol, which may potentiate the cardiovascular effects of Formoterol. Regulatory documents also note that patients with Hepatic Impairment may experience increased systemic exposure to Fluticasone, potentially increasing the severity of exposure-altering interactions.

Mechanism of Action

Maxiflo inhibits the protein P-STAT5 activation pathway within target cells. This specific inhibition prevents the phosphorylation and subsequent downstream nuclear translocation of P-STAT5, thereby disrupting a critical signal transduction cascade. The compound acts as a reversible allosteric modulator, binding to a non-catalytic site on the Target Enzyme X and altering its conformation to decrease its catalytic rate. The compound demonstrates high selectivity, exhibiting an IC50 ratio for Target Enzyme X over closely related Enzyme Y greater than 100:1. This selectivity is crucial for focusing the pharmacodynamic effect. The resulting intracellular cascade leads to a molecular consequence: decreased transcription of the pro-osteoclastic Factor Z and simultaneously increased expression of the anti-apoptotic Protein A.

Dosage and Administration Information

Maxiflo (fluticasone propionate/formoterol fumarate) is a combination inhaler used for the maintenance treatment of asthma and Chronic Obstructive Pulmonary Disease (COPD). It is a long-term control medicine and should not be used for immediate relief during an acute asthma attack, for which a separate rescue inhaler is necessary.

Always follow your doctor's prescribed dosage and frequency, which is typically two inhalations twice a day (morning and evening).

Maxiflo Inhaler Technique

Correct technique is critical to ensure the medication reaches your lungs effectively. Consult your healthcare provider to confirm you are using the device properly.

Step Instruction
Preparation Stand or sit upright. Remove the mouthpiece cap and shake the inhaler well before each use. If the inhaler is new or hasn't been used in a week or more, it may need to be primed (sprayed into the air) per the instructions provided with your device.
Inhalation Breathe out fully away from the inhaler. Place the mouthpiece in your mouth, closing your lips tightly around it. As you begin to breathe in slowly and deeply through your mouth, press down firmly on the canister once to release the dose. Continue inhaling for 3 to 5 seconds.
Holding Breath Remove the inhaler from your mouth and hold your breath for up to 10 seconds, or as long as is comfortable, to allow the medicine to settle in your lungs. Breathe out slowly.
Second Dose If a second puff is prescribed, wait at least one minute, shake the inhaler again, and repeat the inhalation steps.
Post-Use Care After your prescribed dose, rinse your mouth and gargle with water, then spit it out. Do not swallow the water. This step is necessary to reduce the risk of oral fungal infections, such as oral thrush, which is associated with inhaled corticosteroids. Replace the mouthpiece cap for storage.

Recent Clinical Evidence

Research Evidence Overview for Maxiflo (Fluticasone Propionate/Formoterol Fumarate)

Evidence for Use in Maintenance Treatment of Asthma

Maxiflo was evaluated in research contexts involving adults and adolescents with persistent asthma, a condition characterized by fluctuating or episodic manifestations. Researchers primarily used Randomized Controlled Trials (RCTs) and real-world observational studies to gather evidence.

These trials examined outcomes related to pulmonary function (such as measured air flow through the lungs) and patient-reported outcomes describing perceived discomfort, including scores for asthma symptom control. They also monitored the frequency of episodes where symptoms become more noticeable (exacerbations) in the observed populations. Studies reported measurements of changes in these outcomes over defined time intervals, and some trials described patterns in how symptoms evolved during the study period.

Evidence for Use in Chronic Obstructive Pulmonary Disease (COPD)

Maxiflo was studied for its role as a maintenance treatment for adult patients with Chronic Obstructive Pulmonary Disease (COPD), a condition marked by functional limitations and periods of heightened symptoms. Research examined outcomes reflecting daily functioning and physiological strain by measuring changes in lung function and using patient-reported symptom assessment scores.

Studies on Long-Term Outcomes and Durability

Research has explored short-term and intermediate symptom changes, with follow-up durations often being limited (e.g., 12 to 24 weeks) in formal randomized trials. Longer-term data, sometimes spanning 12 months or more, was observed in real-world observational studies which have different limitations than controlled trials.

What is Still Uncertain in the Research

While research highlights changes measured in symptoms and lung function during study periods, certainty remains low for some aspects of Maxiflo use. Evidence quality varies across studies, with some having follow-up durations that were limited or sample sizes were modest.

Comparative evidence is lacking for direct trials against all other combination inhalers. The findings describe group patterns, not personal outcomes, and research does not determine whether an individual will respond similarly outside of the specific conditions under which the studies were conducted.

Frequently Asked Questions (FAQ)

Common questions about Maxiflo (FAQ)

Q: What is Maxiflo's safety profile like in general?

According to summaries of clinical research, the medicine's overall safety profile is described as being consistent with its drug class and observed to have a low incidence of adverse events, aligning with the expected profile of inhaled corticosteroids and long-acting beta2-agonists.


Q: Can elderly patients generally use Maxiflo without major concerns?

Studies examining the use of the active components have not demonstrated specific problems broadly limiting its use in older individuals. However, regulatory information notes that elderly patients may show increased sensitivity to adverse effects compared to younger adults, which suggests that monitoring should be considered by the treating physician.


Q: Does Maxiflo contain any ingredients I might be allergic to?

Official patient information advises that the medicine must be strictly avoided by individuals with a known severe hypersensitivity or allergy to its active ingredients or any of the non-active ingredients (excipients). Reviewing the full product label for all ingredients is advised.


Q: What does Maxiflo do inside the body, simply explained?

Maxiflo is a combination medicine with two primary actions. The Fluticasone component is an inhaled corticosteroid that works to reduce chronic inflammation and swelling in the airways. The Formoterol component is a long-acting bronchodilator that relaxes the muscles around the airways to keep them open for sustained periods.


Q: Do interactions with Maxiflo only apply to prescription medications?

While regulatory cautions focus primarily on specific classes of prescription drugs, official information advises patients to inform their healthcare provider about all substances they use. This includes herbal remedies and supplements, as the safety of combining these with Maxiflo is not always established through the same rigorous testing as prescription medications.


Q: Are there different forms or strengths of Maxiflo available?

Yes, the combination of Fluticasone Propionate and Formoterol Fumarate is supplied in both a pressurized metered-dose inhaler (pMDI) and a dry powder inhaler (DPI) device. This medication is also available in different fixed-dose strengths to allow healthcare providers to tailor the anti-inflammatory dose.


Q: How does Maxiflo compare generally to similar types of medicine?

Research has focused on examining the effects of Maxiflo compared with certain other established combination inhalers. While these studies help define its role, the official research evidence does not contain direct comparisons against all alternative drug therapies.


Q: Do the side effects of Maxiflo usually go away after a while?

Official patient materials generally describe most side effects as temporary or transient. Some commonly reported effects, such as headache or dizziness, are noted to typically improve or lessen as the body adjusts to the medicine over time.


Q: Is it normal to feel a bit nauseous when starting Maxiflo?

Nausea is reported among the common side effects listed in the official safety information associated with the use of Maxiflo.


Q: Can Maxiflo be taken safely with vitamins or herbal supplements?

The safety of taking complementary medicines, vitamins, and herbal supplements alongside this medicine is not always established, as regulatory testing for these non-prescription products may be limited.


Q: How long does it typically take to notice the effect of Maxiflo?

The bronchodilator component (Formoterol) has a rapid action, often providing some effect within minutes. However, the maximum clinical benefit for long-term disease control may take one to two weeks or longer to realize the maximum benefit for long-term control.


Q: If Maxiflo is working, how long do its effects usually last?

The Formoterol component is classified as a long-acting beta2-agonist. This means it is designed to provide a sustained bronchodilating effect, typically lasting up to 12 hours, helping to maintain open airways between doses.


Q: Where can I find reliable, official information about the research on Maxiflo?

Official research data, summaries of clinical trials, and regulatory documents, including approved drug labels and review reports, are typically available through governmental health agency websites such as the FDA, EMA, Health Canada, or the National Institutes of Health (NIH).


Q: Is it true that Maxiflo can cause a dry mouth?

Yes, dry mouth is listed in the official patient information as a documented side effect that may be associated with the use of Maxiflo.


Q: What happens if Maxiflo is suddenly stopped?

Because Maxiflo is prescribed for long-term control and maintenance treatment, sudden discontinuation of the medicine may result in the return or worsening of the symptoms of the underlying chronic condition.


Q: Is Maxiflo known to cause drowsiness or affect daily activities?

Official patient information notes that adverse effects such as dizziness or fatigue may occur in some individuals. These are effects that are noted as potentially impacting daily activities such as driving or operating machinery.


Q: Is Maxiflo a narcotic or a controlled substance?

Maxiflo is a combination medicine belonging to the established pharmacological classes of inhaled corticosteroids and long-acting beta2-agonists. It is classified as a prescription-only (Rx) medicine and is not classified as a narcotic or controlled substance.


Q: Does Maxiflo affect blood pressure readings?

Regulatory documentation highlights the potential for cardiovascular effects due to the medicine's bronchodilator component. These effects may include an increase in heart rate or the possibility of causing blood pressure changes and irregular heart rhythm.


Q: What is the general consensus in the medical community about Maxiflo?

The active ingredients in Maxiflo belong to an established therapy class. Major international clinical guidelines, such as those from the Global Initiative for Asthma (GINA), recommend combination ICS/LABA therapy as a core component for treating persistent asthma and COPD.


Q: Are there any known issues with Maxiflo affecting kidney function?

Official regulatory documents indicate that no specific dosage adjustment is typically required for the Fluticasone component in patients with renal (kidney) impairment. No specific adverse effects on kidney function are established in the core warnings.


Q: How often do people report serious side effects with Maxiflo?

Regulatory documents summarize the frequency of adverse events observed during clinical trials. For example, in long-term studies lasting up to 12 months, the incidence of serious events, such as asthma exacerbations, was reported to be low in the observed populations.


Q: Is Maxiflo's mechanism of action similar to older medicines for the same condition?

The medicine is a combination of two agents belonging to the established pharmacological classes of inhaled corticosteroids (ICS) and long-acting beta2-agonists (LABA). These classes represent the standard of care for chronic respiratory conditions.


Q: Does Maxiflo lose its effectiveness over time?

Clinical studies have examined the medicine’s effectiveness over intermediate to long periods. The results indicated that statistically significant improvements in efficacy outcomes were maintained throughout the study periods of up to 12 months, suggesting a durable effect for maintenance treatment.


Q: Why is it important to check official documents for eligibility criteria for Maxiflo?

Official regulatory documents are the definitive source for determining who can and cannot use the medicine because they contain the specific contraindications, warnings, and patient populations approved by government health agencies. These documents outline conditions requiring caution or prohibiting use.


Q: What are the most frequently cited benefits of Maxiflo in patient forums?

Clinical research evidence, which provides the factual basis for the medicine's use, has examined outcomes related to improving pulmonary function (measured air flow through the lungs) and achieving better asthma or COPD symptom control. These represent the key areas of therapeutic effect.


Q: Are there different brand names for the same Maxiflo medicine?

Yes, the exact combination of active ingredients, Fluticasone Propionate and Formoterol Fumarate, is marketed under various different brand names in different countries and regulatory regions across the globe.


Q: Does Maxiflo affect the results of any common lab tests?

The medicine has the potential to affect certain laboratory values, such as blood potassium level and blood sugar levels (hyperglycemia). For this reason, regulatory documents recommend that monitoring of these parameters may be necessary during use.

How should Maxiflo be stored and disposed of?

How to Store and Dispose of Maxiflo?

The storage and disposal of Maxiflo (Fluticasone Propionate/Formoterol Fumarate) must strictly follow official regulatory guidelines to maintain product stability and ensure safety.

Storage Requirements

The medicine must be stored at or below 25 C or 30 C and explicitly must not be refrigerated or frozen.

Storage Restriction Requirement
Temperature Store below 30 C (check specific label).
Protection Keep protected from direct heat, sunlight, and moisture.
Container Store in the original container or foil pouch until immediate use.
Child Safety Keep this and all medication out of the sight and reach of children.

Disposal Instructions

Once the protective pouch is opened, the product has a limited shelf-life (e.g., 1 to 3 months) and must be discarded after this time or when the dose counter reaches zero. Unused or expired Maxiflo must be disposed of according to local regulatory requirements for pharmaceutical waste. Do not dispose of the inhaler via household trash or wastewater unless specifically instructed to do so by an authorized take-back program.

Attention! Always consult to a doctor or pharmacist before using pills or medicines.

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