Macrogol

Each sachet (10.167 g) also contains saccharin sodium 0.017 g and orange-grapefruit flavour 0.15 g.

Oral

Chronic constipation

Adult: As an aqueous solution containing 105 g/l of the Macrogol: 125 ml up to tid for a max of 2 wk.

Child: As an aqueous solution containing 105 g/l of the Macrogol: 2-6 yr, 62.5 ml daily. 7-11 yr, 125 ml daily. Max: 250 ml.

Oral

Faecal impaction

Adult: As an aqueous solution containing 105 g/l of the Macrogol: 8 doses of 125 mL within 6 hr for a max of 3 days. Not >2 doses per hr in patients with impaired CV function.

Child: As an aqueous solution containing 105 g/l of the Macrogol: 2-4 yr, initially, 2 doses of 62.5 ml over 12 hr, escalating over 7 days to a max of 8 doses within 12 hr. 5-11 yr, initially, 4 doses of 62.5 ml over 12 hr, escalating over 7 days to a max of 12 doses within 12 hr.

Oral

Bowel evacuation

Adult: As Macrogol 4000 or 3350 mixed with electrolytes: 200-300 ml of an aqueous solution containing about 59, 60 or 105 g/l of the Macrogol, repeated every 10-15 min until the rectal effluent is clear. Max: 3-4 litres.

Child: 25-40 ml/kg/hr of an aqueous solution containing about 59, 60 or 105 g/l of the Macrogol.

Macrogol is a laxative solution that increases the amount of water in the intestinal tract to stimulate bowel movements.

Macrogol is used as a laxative to treat occasional constipation or irregular bowel movements.

Macrogol may also be used for purposes not listed in this medication guide.

Adult : PO Bowel evacuation As Macrogol 4,000 or 3,350 mixed w/ electrolytes: As soln containing about 59, 60 or 105 g/L of the Macrogol: 200-300 mL repeated every 10-15 mins till the rectal effluent is clear. Max: 3-4 L. Chronic constipationAs soln containing 105 g/L of Macrogol: 125 mL 1-3 times/day. Max duration: 2 wk. Faecal impaction As soln containing 105 g/L of Macrogol: 8 doses of 125 mL w/in 6 hr. Max duration: 3 days.

See also:
What is the most important information I should know about Macrogol?

Macrogol 3350 is contraindicated in patients with known or suspected bowel obstruction and patients known to be allergic to polyethylene glycol.

Use: Labeled Indications

Constipation, occasional: Treatment of occasional constipation

Off Label Uses

Bowel preparation before colonoscopy

Based on the Consensus Document on Bowel Preparation Before Colonoscopy from The American Society of Colon and Rectal Surgeons (ASCRS), The American Society for Gastrointestinal and Endoscopy (ASGE), and The Society of American Gastrointestinal and Endoscopic Surgeons (SAGES), Macrogol in combination with bisacodyl delayed-release tablets or magnesium citrate is effective and recommended for bowel preparation before colonoscopy.

See also:
What other drugs will affect Macrogol?

Macrogol may interfere with the absorption of other drugs if administered simultaneously. Generally, it is better to take Macrogol at least 2 hrs apart from other drugs.

See also:
What are the possible side effects of Macrogol?

Applies to Macrogol: powder packets for oral solution, powder for oral solution

Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Cramps; gas; more frequent bowel movements; nausea; stomach pain or bloating.

Seek medical attention right away if any of these SEVERE side effects occur while taking Macrogol (the active ingredient contained in Macrogol)

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); bleeding from the rectum or rectal pain; diarrhea; severe or persistent nausea, bloating, cramping, or stomach pain.