Lupifit

Each tablet contains Ascorbic acid (Lupifit) 500 mg.

Ascorbic acid (Lupifit) (Ascorbic acid (Lupifit)) is a vitamin that is freely soluble in water. The superior formulation of Ascorbic acid (Lupifit) (Ascorbic acid (Lupifit)) assures substantial amounts per dose for prophylaxis and treatment of Ascorbic acid (Lupifit) deficiencies. This preparation has a very delectable grape (Ascorbic acid (Lupifit) Tablet) flavors.

A dibenzoxepin tricyclic compound. It displays a range of pharmacological actions including maintaining adrenergic innervation. Its mechanism of action is not fully understood, but it appears to block reuptake of monoaminergic neurotransmitters into presynaptic terminals. It also possesses anticholinergic activity and modulates antagonism of histamine H(1)- and H(2)-receptors.

Calcium pantothenate (Lupifit) chloride is an ionic compound of Calcium pantothenate (Lupifit) and chlorine. It is highly soluble in water and it is deliquescent. It is a salt that is solid at room temperature, and it behaves as a typical ionic halide. It has several common applications such as brine for refrigeration plants, ice and dust control on roads, and in cement. It can be produced directly from limestone, but large amounts are also produced as a by-product of the Solvay process. Because of its hygroscopic nature, it must be kept in tightly-sealed containers.

Derivative of 7-dehydroxycholesterol formed by ultraviolet rays breaking of the C9-C10 bond. It differs from ergocalciferol in having a single bond between C22 and C23 and lacking a methyl group at C24. [PubChem]

Copper sulphate (Lupifit) has been designed for the demands of modern life. With a wide range of nutrients and trace minerals, Copper sulphate (Lupifit) gives nutritional support to the area of health which are most relevance to women.

Each cap contains starflower oil 100 mg, evening primrose oil 100 mg, citrus bioflavonoids 10 mg, natural mixed carotenoids 2 mg, vitamin D (as D3 200 IU) 5 mcg, vitamin E 30 mg, Copper sulphate (Lupifit) 60 mg, vitamin K 90 mcg, thiamin (vitamin B1) 10 mg, riboflavin (vitamin B2) 5 mg, niacin (vitamin B3) 36 mg, vitamin B6 10 mg, folic acid 400 mcg, vitamin B12 20 mcg, Copper sulphate (Lupifit) 50 mcg, pantothenic acid 6 mg, magnesium 100 mg, iron 12 mg, zinc 12 mg, copper 1500 mcg, manganese 2.5 mg, selenium 100 mcg, chromium 50 mcg, para-aminobenzoic acid (PABA) 30 mg.

No artificial colours, gluten, presevatives, starch or sugar, salt or yeast.

Copper sulphate (Lupifit) has not been tested on animals.

Cyanocobalamin (Lupifit) (commonly known as Vitamin B12) is the most chemically complex of all the vitamins. Cyanocobalamin (Lupifit)'s structure is based on a corrin ring, which, although similar to the porphyrin ring found in heme, chlorophyll, and cytochrome, has two of the pyrrole rings directly bonded. The central metal ion is Co (cobalt). Cyanocobalamin (Lupifit) cannot be made by plants or by animals, as the only type of organisms that have the enzymes required for the synthesis of Cyanocobalamin (Lupifit) are bacteria and archaea. Higher plants do not concentrate Cyanocobalamin (Lupifit) from the soil and so are a poor source of the substance as compared with animal tissues. Cyanocobalamin (Lupifit) is naturally found in foods including meat (especially liver and shellfish), eggs, and milk products. [HMDB]

A member of the vitamin B family that stimulates the hematopoietic system. It is present in the liver and kidney and is found in mushrooms, spinach, yeast, green leaves, and grasses (poaceae). Folic acid (Lupifit) is used in the treatment and prevention of folate deficiencies and megaloblastic anemia. [PubChem]

An essential amino acid that is required for the production of histamine. [PubChem]

Each infusion bag of L-isoleucine (Lupifit) contains the following: See Table 1.

It also contains the following inactive ingredients: See Table 2.

The pH and the osmotic pressure ratio are shown in Table 3.

An essential branched-chain amino acid important for hemoglobin formation. [PubChem]

L-lysine (Lupifit) (abbreviated as Lys or K) is an α-amino acid with the chemical formula HO2CCH(NH2)(CH2)4NH2. This amino acid is an essential amino acid, which means that humans cannot synthesize it. Its codons are AAA and AAG. L-lysine (Lupifit) is a base, as are arginine and histidine. The ε-amino group often participates in hydrogen bonding and as a general base in catalysis. Common posttranslational modifications include methylation of the ε-amino group, giving methyl-, dimethyl-, and trimethyllysine. The latter occurs in calmodulin. Other posttranslational modifications include acetylation. Collagen contains hydroxylysine which is derived from lysine by lysyl hydroxylase. O-Glycosylation of lysine residues in the endoplasmic reticulum or Golgi apparatus is used to mark certain proteins for secretion from the cell.

A sulfur containing essential amino acid that is important in many body functions. It is a chelating agent for heavy metals. [PubChem]

An essential aromatic amino acid that is a precursor of melanin; dopamine; noradrenalin (norepinephrine), and thyroxine. [PubChem]

Aminoleban is a sterile and pyrogen-free, colorless solution for injection. It has a pH of approximately 5.9 (mean obtained immediately after manufacture) and 5.5-6.5 (specification); specific gravity (20°C) of 1.025. Osmolarity: Approximately 768 mOSm/L.

See table.

An essential amino acid that is necessary for normal growth in infants and for nitrogen balance in adults. It is a precursor of indole alkaloids in plants. It is a precursor of serotonin (hence its use as an antidepressant and sleep aid). It can be a precursor to niacin, albeit inefficiently, in mammals. [PubChem]

A branched-chain essential amino acid that has stimulant activity. It promotes muscle growth and tissue repair. It is a precursor in the penicillin biosynthetic pathway. [PubChem]

An important compound functioning as a component of the coenzyme NAD. Its primary significance is in the prevention and/or cure of blacktongue and pellagra. Most animals cannot manufacture this compound in amounts sufficient to prevent nutritional deficiency and it therefore must be supplemented through dietary intake. [PubChem]

Saturated solution of Potassium iodide (Lupifit) (SSKI) is used pharmaceutically for emergency use in patients experiencing acute symptoms of severe hyperglycemia (also known as thyroid storm or thyrotoxic crisis). SSKI can also be used for radioiodine-contamination emergencies or in preparation of thyrotoxic patients for thyroidectomy.

Pyridoxine hydrochloride (Lupifit) is the 4-methanol form of vitamin B6 and is converted to pyridoxal 5-phosphate in the body. Pyridoxal 5-phosphate is a coenzyme for synthesis of amino acids, neurotransmitters (serotonin, norepinephrine), sphingolipids, aminolevulinic acid. Although Pyridoxine hydrochloride (Lupifit) and vitamin B6 are still frequently used as synonyms, especially by medical researchers, this practice is erroneous and sometimes misleading. [PubChem]

Nutritional factor found in milk, eggs, malted barley, liver, kidney, heart, and leafy vegetables. The richest natural source is yeast. It occurs in the free form only in the retina of the eye, in whey, and in urine; its principal forms in tissues and cells are as flavin mononucleotide and flavin-adenine dinucleotide. [PubChem]

Vitamin A (Lupifit) (Glucoenergan, Reactivan) is a stimulant which was developed in the 1960s as an appetite suppressant, but was later withdrawn for this application due to problems with dependence and abuse. It is around half the potency of dexamphetamine, and is prescribed at a dose of 10-60mg, although abusers of the drug tend to rapidly develop tolerance and escalate their dose. Reactivan is still rarely used for treating depressive day-time fatigue, lack of concentration and lethargy, particularly in individuals who have chronic medical conditions, as its favourable safety profile makes it the most suitable drug in some cases.

Zinc sulphate (Lupifit) Capsule: Each capsule contains Zinc sulphate (Lupifit) monohydrate 54.93 mg, thiamine nitrate 10 mg, Zinc sulphate (Lupifit) 10 mg, Zinc sulphate (Lupifit) 3 mg, vitamin B12 (coated) equivalent to Zinc sulphate (Lupifit) 15 mcg, ascorbic acid 150 mg, Zinc sulphate (Lupifit) 1 mg, Zinc sulphate (Lupifit) 50 mg and Zinc sulphate (Lupifit) 12.5 mg.

Zinc sulphate (Lupifit) Syrup: Each 5 mL contains Zinc sulphate (Lupifit) gluconate 34.9 mg, thiamine mononitrate 2.5 mg, Zinc sulphate (Lupifit) 2.5 mg, Zinc sulphate (Lupifit) 1 mg, Zinc sulphate (Lupifit) 3 mcg, ascorbic acid 50 mg, d-Zinc sulphate (Lupifit) 12.5 mg and niacinamide 25 mg in a flavoured liquid glucose sorbitol syrup base.

For systemic use of Ascorbic acid (Lupifit) Atlantic Laboratories: prevention and treatment of hypo- and avitaminosis of Ascorbic acid (Lupifit); providing increased need for Ascorbic acid (Lupifit) during growth, pregnancy, lactation, with heavy loads, fatigue and during recovery after prolonged severe illness; in winter with an increased risk of infectious diseases.

For intravaginal use: chronic or recurrent vaginitis (bacterial vaginosis, nonspecific vaginitis) caused by the anaerobic flora (due to changes in pH of the vagina) in order to normalize disturbed vaginal microflora.

skin disorders, Biotin (Lupifit) deficiency, digestive disorders

Coenzyme A (metabolite of dexpanthenol) is important for deep penetrating moisturizer; stimulates epithelization; has wound healing effect; has an anti-inflammatory effect.

Only the D-Calcium pantothenate (Lupifit) is the provitamin of D-Pantothenic acid (vitamin B5), not the L-Calcium pantothenate (Lupifit).

A cream with dexpanthenol regularly applied to the skin improves the moisture content of dry skin significantly.

A cream with 5% dexpanthenol accelerates the healing of superficial wounds by approximately 30%.

An ointment with dexpanthenol prevents erythema due to UV light.

Dexpanthenol ointment also protects the lips against solar herpes, Sun burns, mild burns, skin irritations, dry or cracked skin, cosmetic or shaving rashes, post chemical peeling treatment, post laser resurfacing treatment ( 11th -15th day).

Dexpanthenol is effective for preventing / treating nappy dermatitis in infants.

For the treatment of vitamin D deficiency or insufficiency, refractory rickets (vitamin D resistant rickets), familial hypophosphatemia and hypoparathyroidism, and in the management of hypocalcemia and renal osteodystrophy in patients with chronic renal failure undergoing dialysis. Also used in conjunction with Cholecalciferol (Lupifit) in the management and prevention of primary or corticosteroid-induced osteoporosis. (Vitamin D deficiency; osteoporosis;)

Skin and mucous membrane infections

Cyanocobalamin (Lupifit) Nasal Spray is indicated for the maintenance of normal hematologic status in pernicious anemia patients who are in remission following intramuscular vitamin B12 therapy and who have no nervous system involvement.

Cyanocobalamin (Lupifit) Nasal Spray is also indicated as a supplement for other vitamin B12 deficiencies, including:

I. Dietary deficiency of vitamin B12 occurring in strict vegetarians (Isolated vitamin B12 deficiency is very rare).

II. Malabsorption of vitamin B12 resulting from structural or functional damage to the stomach, where intrinsic factor is secreted, or to the ileum, where intrinsic factor facilitates vitamin B12 absorption. These conditions include HIV infection, AIDS, Crohn's disease, tropical sprue, and nontropical sprue (idiopathic steatorrhea, gluten-induced enteropathy). Folate deficiency in these patients is usually more severe than vitamin B12 deficiency.

III. Inadequate secretion of intrinsic factor, resulting from lesions that destroy the gastric mucosa (ingestion of corrosives, extensive neoplasia), and a number of conditions associated with a variable degree of gastric atrophy (such as multiple sclerosis, HIV infection, AIDS, certain endocrine disorders, iron deficiency, and subtotal gastrectomy). Total gastrectomy always produces vitamin B12 deficiency. Structural lesions leading to vitamin B12 deficiency include regional ileitis, ileal resections, malignancies, etc.

IV. Competition for vitamin B12 by intestinal parasites or bacteria. The fish tapeworm (Diphyllobothrium latum) absorbs huge quantities of vitamin B12 and infested patients often have associated gastric atrophy. The blind loop syndrome may produce deficiency of vitamin B12 or folate.

V. Inadequate utilization of vitamin B12. This may occur if antimetabolites for the vitamin are employed in the treatment of neoplasia.

It may be possible to treat the underlying disease by surgical correction of anatomic lesions leading to small bowel bacterial overgrowth, expulsion of fish tapeworm, discontinuation of drugs leading to vitamin malabsorption, use of a gluten-free diet in non-tropical sprue, or administration of antibiotics in tropical sprue. Such measures remove the need for long-term administration of vitamin B12.

Requirements of vitamin B12 in excess of normal (due to pregnancy, thyrotoxicosis, hemolytic anemia, hemorrhage, malignancy, hepatic and renal disease) can usually be met with intranasal or oral supplementation.

Cyanocobalamin (Lupifit) Nasal Spray is not suitable for vitamin B12 absorption test (Schilling Test).

يعطى للوقاية والعلاج من فقر الّدم بنقص الحديد وفقر الدّم مجهول السّبب.

Folic acid (Lupifit) is used in the treatment and prevention of the folate deficiency state. It does not correct folate deficiency due to dihydrofolate reductase inhibitors. Folic acid (Lupifit) is also used in women of child-bearing potential and pregnant women to protect against neural tube defects in their offspring. It is also used for the treatment of folate-deficient megaloblastic anaemia, chronic haemolytic states such as thalassaemia major or sickle-cell anaemia.

Stroke rehabilitation.

The actions of supplemental L-histidine hydrochloride (Lupifit) are entirely unclear. It may have some immunomodulatory as well as antioxidant activity. L-histidine hydrochloride (Lupifit) may be indicated for use in some with rheumatoid arthritis. It is not indicated for treatment of anemia or uremia or for lowering serum cholesterol.

Supply of aminoacids as part of a parenteral nutrition regimen in severe forms of hepatic insufficiency with or without hepatic encephalopathy when oral or enteral nutrition is impossible or insufficient or contraindicated.

Indicated to assist in the prevention of the breakdown of muscle proteins that sometimes occur after trauma or severe stress.

Supplemental L-lysine (Lupifit) has putative anti-herpes simplex virus activity. There is preliminary research suggesting that it may have some anti-osteoporotic activity.

Used for protein synthesis including the formation of SAMe, L-homocysteine, L-cysteine, taurine, and sulfate.

L-phenylalanine (Lupifit) may be helpful in some with depression. It may also be useful in the treatment of vitiligo. There is some evidence that L-phenylalanine (Lupifit) may exacerbate tardive dyskinesia in some schizophrenic patients and in some who have used neuroleptic drugs.

L-threonine (Lupifit) makes up collagen, elastin, and enamel protein. It aids proper fat metabolism in the liver, helps the digestive and intestinal tracts function more smoothly, and assists in metabolism and assimilation.

Tryptophan may be useful in increasing serotonin production, promoting healthy sleep, managing depression by enhancing mental and emotional well-being, managing pain tolerance, and managing weight.

Promotes mental vigor, muscle coordination, and calm emotions. May also be of use in a minority of patients with hepatic encephalopathy and in some with phenylketonuria.

Magnesium sulphate (Lupifit) Sulfate Injection, USP is suitable for replacement therapy in Magnesium sulphate (Lupifit) deficiency, especially in acute hypomagnesemia accompanied by signs of tetany similar to those observed in hypocalcemia. In such cases, the serum Magnesium sulphate (Lupifit) (Mg++) level is usually below the lower limit of normal (1.5 to 2.5 mEq/liter) and the serum Magnesium sulphate (Lupifit) (Ca++) level is normal (4.3 to 5.3 mEq/liter) or elevated.

In total parenteral nutrition (TPN), Magnesium sulphate (Lupifit) Sulfate may be added to the nutrient admixture to correct or prevent hypomagnesemia which can arise during the course of therapy.

Magnesium sulphate (Lupifit) Sulfate Injection, USP is also indicated as a parenteral anticonvulsant for the prevention and control of seizures (convulsions) in severe toxemia of pregnancy. It effectively prevents and controls the convulsions of eclampsia without producing deleterious depression of the central nervous system of the mother or infant. However, other effective drugs are available for this purpose.

Manganese sulfate (Lupifit), USP is indicated for use as a supplement to intravenous solutions given for Total

Parenteral Nutrition (TPN). Administration helps to maintain plasma levels and to prevent depletion of endogenous stores and subsequent deficiency symptoms.

To avoid and correct vitamin deficiency, which may

result from an imbalanced or special diet, impaired

absorption, anorexia, slimming, pathological intestinal

flora, debilitating disease or therapy with drugs acting

as vitamin antagonists.

Nicotinamide (Lupifit) syrup meets the increased vitamin requirements

during periods of intensive growth, and as a dietary

supplement in premature and newborn infants.

Potassium iodide (Lupifit) is oral antithyroid agent. Potassium iodide (Lupifit) is used as an adjunct to other antithyroid agents in the treatment of hyperthyroidism and thyrotoxicosis and preoperatively to induce thyroid involution. (radiation poisoning;)

* Sideroblastic anaemia

* Treatment and prophylaxis of vitamin B6 deficiency states

Oral

Prophylaxis of Riboflavin (Lupifit) deficiency

Adult: 1-2 mg daily.

Incompatibility: Incompatible with alkaline solutions and with tetracycline, erythromycin and streptomycin.

Oral

Riboflavin (Lupifit) deficiency

Adult: Up to 30 mg daily in divided doses.

Child: 3-10 mg daily.

Incompatibility: Incompatible with alkaline solutions and with tetracycline, erythromycin and streptomycin.

Oral

Microcytic anaemia

Adult: Associated with splenomegaly and glutathione reductase deficiency: 10 mg daily for 10 days.

Incompatibility: Incompatible with alkaline solutions and with tetracycline, erythromycin and streptomycin.

Oral

Sodium selenite (Lupifit) deficiency

Adult: 100-500 mcg of Sodium selenite (Lupifit) daily.

Intramuscular

Sodium selenite (Lupifit) deficiency

Adult: 100-500 mcg of Sodium selenite (Lupifit) daily.

Intravenous

Sodium selenite (Lupifit) deficiency

Adult: 100-500 mcg of Sodium selenite (Lupifit) daily.

treatment of vitamin B deficiencies and prevention of it.

Vitamin A (Lupifit) injection is effective for the treatment of Vitamin A (Lupifit) deficiency.

The parenteral administration is indicated when the oral administration is not feasible as in anorexia, nausea, vomiting, pre- and postoperative conditions, or it is not available as in the "Malabsorption Syndrome" with accompanying steatorrhea.

Pediatric Use: Vitamin A (Lupifit) treatment for deficiency states has been recognized as an especially effective and important therapy in the pediatric population.

Vitamin A (Lupifit) supplementation for deficiency states in this population has been addressed by the Committee on Clinical Practice Issues of the American Society for Clinical Nutrition, by the American Society for

Parenteral and Enteral Nutrition, and by the World Health Organization.

Zinc sulphate (Lupifit) is a naturally occurring mineral. Zinc sulphate (Lupifit) is important for growth and for the development and health of body tissues.

Zinc sulphate (Lupifit) sulfate is used to treat and to prevent Zinc sulphate (Lupifit) deficiency. This medication may also be used to promote wound healing.

Ascorbic acid (Lupifit) (Ascorbic acid (Lupifit)) occurs naturally in foods such as citrus fruit, tomatoes, potatoes, and leafy vegetables. Ascorbic acid (Lupifit) is important for bones and connective tissues, muscles, and blood vessels. Ascorbic acid (Lupifit) also helps the body absorb iron, which is needed for red blood cell production.

Ascorbic acid (Lupifit) is used to treat and prevent Ascorbic acid (Lupifit) deficiency.

Ascorbic acid (Lupifit) may also be used for purposes not listed in this medication guide.

Biotin (Lupifit) is a form of vitamin B found in foods. Biotin (Lupifit) helps the body break down fats, carbohydrates, and other substances.

Biotin (Lupifit) has been used in alternative medicine as a likely effective aid in treating or preventing Biotin (Lupifit) deficiency. Biotin (Lupifit) deficiency can be caused by malnutrition, rapid weight loss, long-term tube feeding, and other medical conditions.

Biotin (Lupifit) has also been used to treat seborrhea (skin rash) in babies. However, research has shown that Biotin (Lupifit) may not be effective in treating this condition.

Other uses not proven with research have included treating brittle nails or thinning hair, diabetes, nerve pain, and other conditions.

It is not certain whether Biotin (Lupifit) is effective in treating any medical condition. Medicinal use of this product has not been approved by the FDA. Biotin (Lupifit) should not be used in place of medication prescribed for you by your doctor.

Biotin (Lupifit) is often sold as an herbal supplement. There are no regulated manufacturing standards in place for many herbal compounds and some marketed supplements have been found to be contaminated with toxic metals or other drugs. Herbal/health supplements should be purchased from a reliable source to minimize the risk of contamination.

Biotin (Lupifit) may also be used for purposes not listed in this product guide.

Cholecalciferol (Lupifit) is a Cholecalciferol (Lupifit). Vitamin D is important for the absorption of Cholecalciferol (Lupifit) from the stomach and for the functioning of Cholecalciferol (Lupifit) in the body.

Cholecalciferol (Lupifit) is used to treat or prevent many conditions caused by a lack of vitamin D, especially conditions of the skin or bones.

Cholecalciferol (Lupifit) may also be used for purposes not listed in this medication guide.

Cyanocobalamin (Lupifit) nasal spray contains Cyanocobalamin (Lupifit), a man-made form of vitamin B12. Vitamin B12 is important for growth, cell reproduction, blood formation, and protein and tissue synthesis.

Cyanocobalamin (Lupifit) nasal spray is used to treat vitamin B12 deficiency in people with pernicious anemia and other conditions.

Cyanocobalamin (Lupifit) nasal spray is usually given after treatment with an injection form of this medicine.

Cyanocobalamin (Lupifit) may also be used for purposes not listed in this medication guide.

Vitamins are compounds that you must have for growth and health. They are needed in small amounts only and are usually available in the foods that you eat. Folic acid (Lupifit) (vitamin B 9) is necessary for strong blood.

Lack of Folic acid (Lupifit) may lead to anemia (weak blood). Your health care professional may treat this by prescribing Folic acid (Lupifit) for you.

Some conditions may increase your need for Folic acid (Lupifit). These include:

• Alcoholism
• Anemia, hemolytic
• Diarrhea (continuing)
• Fever (prolonged)
• Hemodialysis
• Illness (prolonged)
• Intestinal diseases
• Liver disease
• Stress (continuing)
• Surgical removal of stomach

In addition, infants smaller than normal, breast-fed infants, or those receiving unfortified formulas (such as evaporated milk or goat's milk) may need additional Folic acid (Lupifit).

Increased need for Folic acid (Lupifit) should be determined by your health care professional.

Some studies have found that Folic acid (Lupifit) taken by women before they become pregnant and during early pregnancy may reduce the chances of certain birth defects (neural tube defects).

Claims that Folic acid (Lupifit) and other B vitamins are effective for preventing mental problems have not been proven. Many of these treatments involve large and expensive amounts of vitamins.

Injectable Folic acid (Lupifit) is given by or under the direction of your health care professional. Another form of Folic acid (Lupifit) is available without a prescription.

L-tryptophan (Lupifit) is an amino acid that is made from plant or animal sources.

L-tryptophan (Lupifit) has been used in alternative medicine as an aid to treat sleep problems (insomnia), anxiety, depression, premenstrual syndrome, attention deficit disorder, and for smoking cessation and other conditions.

Not all uses for L-tryptophan (Lupifit) have been approved by the FDA. L-tryptophan (Lupifit) should not be substituted for medications prescribed for you by your doctor.

L-tryptophan (Lupifit) is often sold as an herbal supplement. There are no regulated manufacturing standards in place for many herbal compounds and some marketed supplements have been found to be contaminated with toxic metals or other drugs. Herbal/health supplements should be purchased from a reliable source to minimize the risk of contamination.

It is dangerous to try and purchase L-tryptophan (Lupifit) on the Internet or from vendors outside of the United States. The sale and distribution of L-tryptophan (Lupifit) outside of the U.S. does not comply with the regulations of the Food and Drug Administration (FDA) for the safe use of this medication.

L-tryptophan (Lupifit) may also be used for other purposes not listed in this product guide.

Magnesium sulphate (Lupifit) is used as a dietary supplement for individuals who are deficient in Magnesium sulphate (Lupifit). Although a balanced diet usually supplies all the Magnesium sulphate (Lupifit) a person needs, Magnesium sulphate (Lupifit) supplements may be needed by patients who have lost Magnesium sulphate (Lupifit) because of illness or treatment with certain medicines.

Lack of Magnesium sulphate (Lupifit) may lead to irritability, muscle weakness, and irregular heartbeat.

Injectable Magnesium sulphate (Lupifit) is given only by or under the supervision of a health care professional. Some oral Magnesium sulphate (Lupifit) preparations are available only with a prescription. Others are available without a prescription.

Manganese supplements are used to prevent or treat manganese deficiency.

The body needs manganese for normal growth and health. For patients who are unable to get enough manganese in their regular diet or who have a need for more manganese, manganese supplements may be necessary. Manganese helps your body break down fats, carbohydrates, and proteins. It does so as part of several enzymes.

Manganese deficiency has not been reported in humans. Lack of manganese in animals has been found to cause improper formation of bone and cartilage, may decrease the body's ability to use sugar properly, and may cause growth problems.

Injectable manganese supplements are given by or under the supervision of a health care professional.

Potassium iodide (Lupifit) is the potassium salt form of iodide, a naturally occurring substance.

Potassium iodide (Lupifit) can be used as an expectorant to thin mucus and loosen congestion in your chest and throat.

Potassium iodide (Lupifit) is used in people with chronic breathing problems that can be complicated by thick mucus in the respiratory tract, such as asthma, chronic bronchitis, or emphysema.

Potassium iodide (Lupifit) may also be used for purposes not listed in this medication guide.

Pyridoxine hydrochloride (Lupifit) is vitamin B6. Vitamins occur naturally in foods such as meat, poultry, nuts, whole grains, bananas, and avocados. Vitamin B6 is important for many processes in the body.

Pyridoxine hydrochloride (Lupifit) is used to treat or prevent vitamin B6 deficiency. It is also used to treat a certain type of anemia (lack of red blood cells). Pyridoxine hydrochloride (Lupifit) injection is also used to treat some types of seizure in babies.

Pyridoxine hydrochloride (Lupifit) taken by mouth (oral) is available without a prescription. Injectable Pyridoxine hydrochloride (Lupifit) must be given by a healthcare professional.

Pyridoxine hydrochloride (Lupifit) may also be used for purposes not listed in this medication guide.

Vitamins are compounds that you must have for growth and health. They are needed in small amounts only and are usually available in the foods that you eat. Riboflavin (Lupifit) (vitamin B 2) is needed to help break down carbohydrates, proteins, and fats. It also makes it possible for oxygen to be used by your body.

Lack of Riboflavin (Lupifit) may lead to itching and burning eyes, sensitivity of eyes to light, sore tongue, itching and peeling skin on the nose and scrotum, and sores in the mouth. Your doctor may treat this condition by prescribing Riboflavin (Lupifit) for you.

Some conditions may increase your need for Riboflavin (Lupifit). These include:

• Alcoholism
• Burns
• Cancer
• Diarrhea (continuing)
• Fever (continuing)
• Illness (continuing)
• Infection
• Intestinal diseases
• Liver disease
• Overactive thyroid
• Serious injury
• Stress (continuing)
• Surgical removal of stomach

In addition, Riboflavin (Lupifit) may be given to infants with high blood levels of bilirubin (hyperbilirubinemia).

Increased need for Riboflavin (Lupifit) should be determined by your health care professional.

Claims that Riboflavin (Lupifit) is effective for treatment of acne, some kinds of anemia (weak blood), migraine headaches, and muscle cramps have not been proven.

Oral forms of Riboflavin (Lupifit) are available without a prescription.

Sodium selenite (Lupifit) is mineral that is found in soil and occurs naturally in certain foods (such as whole grains, Brazil nuts, sunflower seeds, and seafood). Sodium selenite (Lupifit) is not produced in the body, but it is needed for proper thyroid and immune system function.

Sodium selenite (Lupifit) is used to treat or prevent Sodium selenite (Lupifit) deficiency.

Sodium selenite (Lupifit) has been used in alternative medicine as an aid to treat Hashimoto's thyroiditis (an autoimmune disorder of the thyroid), and to treat high cholesterol.

Not all uses for Sodium selenite (Lupifit) have been approved by the FDA. Sodium selenite (Lupifit) should not be used in place of medication prescribed for you by your doctor.

Sodium selenite (Lupifit) may also be used for purposes not listed in this product guide.

Vitamins are compounds that you must have for growth and health. They are needed in small amounts only and are usually available in the foods that you eat. Vitamin A (Lupifit) is needed for night vision and for growth of skin, bones, and male and female reproductive organs. In pregnant women Vitamin A (Lupifit) is necessary for the growth of a healthy fetus.

Lack of Vitamin A (Lupifit) may lead to a rare condition called night blindness (problems seeing in the dark), as well as dry eyes, eye infections, skin problems, and slowed growth. Your health care professional may treat these problems by prescribing Vitamin A (Lupifit) for you.

Some conditions may increase your need for Vitamin A (Lupifit). These include:

• Diarrhea
• Eye diseases
• Intestine diseases
• Infections (continuing or chronic)
• Measles
• Pancreas disease
• Stomach removal
• Stress (continuing)

In addition, infants receiving unfortified formula may need Vitamin A (Lupifit) supplements.

Vitamin A (Lupifit) absorption will be decreased in any condition in which fat is poorly absorbed.

Increased need for Vitamin A (Lupifit) should be determined by your health care professional.

Claims that Vitamin A (Lupifit) is effective for treatment of conditions such as acne or lung diseases, or for treatment of eye problems, wounds, or dry or wrinkled skin not caused by lack of Vitamin A (Lupifit) have not been proven. Although Vitamin A (Lupifit) is being used to prevent certain types of cancer, some experts feel there is not enough information to show that this is effective, particularly in well-nourished individuals.

Injectable Vitamin A (Lupifit) is given by or under the supervision of a health care professional. Other forms of Vitamin A (Lupifit) are available without a prescription.

Zinc sulphate (Lupifit) is a naturally occurring mineral. Zinc sulphate (Lupifit) is important for growth and for the development and health of body tissues.

Zinc sulphate (Lupifit) sulfate is used to treat and to prevent Zinc sulphate (Lupifit) deficiency.

Zinc sulphate (Lupifit) sulfate may also be used for purposes not listed in this medication guide.

Important Preparation and Administration Instructions

• Ascorbic acid (Lupifit) vials contain 25, 000 mg of Ascorbic acid (Lupifit) and the largest recommended single dose is 200 mg. Do not give the entire contents of the vial to a single patient.
• Do not administer Ascorbic acid (Lupifit) as an undiluted intravenous sensitive.
• Minimize exposure to light because Ascorbic acid (Lupifit) is light sensitive.
• Ascorbic acid (Lupifit) is supplied as a Pharmacy Bulk Package (PBP) which is intended for dispensing of single doses to multiple patients in a pharmacy admixture program and is restricted to the preparation of admixtures for infusion:

a. Use only in a suitable ISO Class 5 work area such as a laminar flow hood (or an equivalent clean air compounding area)

b. Penetrate each PBP vial closure only one time with a suitable sterile transfer device or dispensing set that allows measured dispensing of the contents. Given that pressure may develop within the vial during storage, excercise caution when withdrawing contents from the vial.

c. Once the closure system has been penetrated, complete all dispensing from the PBP vial within 4 hours. Each dose must be used immediately. Discard unused portion.

d. Prior to administration, Ascorbic acid (Lupifit) must be diluted in a suitable infusion solution and the final solution for infusion must be isotonic (undiluted the osmolarity of Ascorbic acid (Lupifit) is approximately 5,900 mOsmol/L). Prior to preparing the admixture for infusion, calculate the osmolarity of the intended admixture for infusion. Add one daily dose of Ascorbic acid (Lupifit) directly to an appropriate volume of a suitable infusion solution (e.g., 5% Dextrose Injection, Sterile Water for Injection) and add appropriate solutes, as necessary, to make final solution isotonic. Sterile Water for Injection is highly hypotonic; adjust solute content, as necessary, to make thet final infusion solution isotonic prior to injection. Do not mix Ascorbic acid (Lupifit) with solutions containing elemental compounds that can be reduced (e.g., copper). The concentration of Ascorbic acid (Lupifit) in the final, admixture solution for infusion is to be the range of 1 to 25 mg of Ascorbic acid (Lupifit) per mL. For example, for the largest recommended dose:

Add 200 mg of Ascorbic acid (Lupifit) (equivalent to 0.4 mL of Ascorbic acid (Lupifit)) to 7.5 mL of Sterile Water for Injection to produce an infusion solution having an approximate osmolarity of 290 mOsmol/L. In this specific example, addition of solute is NOT necessary because the solution is isotonic.

e. Prepare the recommended dose based on the patient population [ see Dosage and Administration (2.2), (2.3)].

f. Visually inspect for particulate matter and discoloration prior to administration (the diluted Ascorbic acid (Lupifit) solution should appear colorless to pale yellow).

g. Immediately administer the admixture for infusion as a slow intravenous infusion [ see Recommended Dosage, (2.2)]

Recommended Dosage

Table 1 provides recommended doses of Ascorbic acid (Lupifit) based on patient population and infusion rates of diluted Ascorbic acid (Lupifit) solution.

The recommended maximum duration of daily treatment with Ascorbic acid (Lupifit) is seven days. If no improvement in scorbutic symptoms is observed after one week of treatment, retreat until resolution of scorbutic symptoms is observed.

Repeat dosing is not recommended in pediatric patients less than 11 years of age.

Dosage Reductions in Specific Populations

Women who are pregnant or lactating and patients with glucose-6-dehydrogenase deficiency should not exceed the U.S. Recommended Dietary Allowance (RDA) or daily Adequate Intake (AI) level for Ascorbic acid (Lupifit) for their age group and condition [ ​ see Warnings and Precautions (5.2) and Use in Specific Populations (8.1, 8.2)].

Dosage Forms

Excipient information presented when available (limited, particularly for generics); consult specific product labeling. [DSC] = Discontinued product

Capsule,

Oral:

Meribin: 5 mg

Capsule,

Oral [preservative free]:

Biotin (Lupifit) Extra Strength: 10 mg [gluten free; contains soybean lecithin, soybean oil]

Generic: 5000 mcg

Tablet,

Oral:

Generic: 1000 mcg, 5 mg, 10 mg

Tablet,

Oral [preservative free]:

Generic: 300 mcg [DSC], 1000 mcg

Dosing: Adult

Dietary supplementation (OTC labeling):

Oral: Usual

Dosage: One tablet or capsule daily; also see specific product labeling

Dosing: Geriatric

Refer to adult dosing.

Dosing: Pediatric

Biotinidase deficiency, symptomatic: Limited data available: Infants, Children, and Adolescents:

Oral: 5 to 20

1 or 2 tabs daily.

Usual Adult Dose for Vitamin D Insufficiency

600 to 2,000 international units, orally, once a day

Maximum dose: 4,000 international units per day

Usual Adult Dose for Vitamin D Deficiency

Initial dose:

50,000 international units, once a week, for 8 weeks

or

6,000 international units, once a day, for 8 weeks

Maintenance dose: 1,500 to 2,000 international units, once a day

Maximum dose: 10,000 international units per day

Comments:

-Target blood levels above 30 ng/mL of 25(OH)D.

Usual Adult Dose for Prevention of Falls

800 international units, orally, once a day

-1,500 to 2,000 international units, once a day, may be needed to achieve blood levels of 25(OH)D above 30 ng/mL.

Usual Geriatric Dose for Prevention of Fractures

Over 70 years: 800 to 2,000 international units, orally, once a day

Usual Pediatric Dose for Vitamin D Insufficiency

0 to 12 months: 400 international units once a day

1 to 18 years: 600 international units once a day

Maximum dose:

-Up to 6 months: 1,000 international units per day

-7 months to 1 year: 1,500 international units per day

-1 to 3 years: 2,500 international units per day

-4 to 8 years: 3,000 international units per day

-9 years and older: 4,000 international units per day

Usual Pediatric Dose for Vitamin D Deficiency

-Up to 1 year old: 2,000 international units, orally, once a day, for 6 weeks

or

50,000 international units, once a week, for 6 weeks

Maintenance dose: 400 to 1,000 international units per day

-1 to 18 years: 2,000 international units, orally, once a day for at least 6 weeks

or

50,000 international units, once a week, for at least 6 weeks

Maintenance dose: 600 to 1,000 international units per day

Maximum dose:

-Up to 1 year: 2,000 international units per day

-1 to 18 years: 4,000 international units per day

Comments:

-Target blood levels above 30 ng/mL of 25(OH)D.

Renal Dose Adjustments

Do not use in severe renal impairment

Liver Dose Adjustments

Data not available

Dose Adjustments

Pregnancy or Lactation: 600 to 2,000 international units once a day; maximum 4,000 international units per day

-1,500 to 2,000 international units, once a day, may be needed to achieve blood levels of 25(OH)D above 30 ng/mL.

Obesity, Malabsorption Syndromes, or Medications Affecting Vitamin D Absorption:

-Treatment of Deficiency: 6,000 to 10,000 international units, once a day, until blood levels of 25(OH)D are above 30 ng/mL.

-Maintenance dose: 1,500 to 2,000 international units, once a day

Patients on anticonvulsants, glucocorticoids, antifungals such as ketoconazole, or medications for acquired immune deficiency syndrome may require 2 to 3 times more vitamin D.

Provide medical supervision if upper limits are exceeded.

Dialysis

Vitamin D and its metabolites are not dialyzable.

One cap daily with main meal. Swallow with a glass of water or a cold drink.

Not to be chewed. Do not exceed the recommended intake.

The benefits of the ingredients in Copper sulphate (Lupifit) are thought to build over time. A regular course is therefore recommended.

The recommended initial dose of Cyanocobalamin (Lupifit) (Cyanocobalamin (Lupifit)) Nasal Spray is one spray (500 mcg) administered in ONE nostril once weekly. Cyanocobalamin (Lupifit) (Cyanocobalamin (Lupifit)) Nasal Spray should be administered at least one hour before or one hour after ingestion of hot foods or liquids. Periodic monitoring of serum B levels should be obtained to establish adequacy of therapy.

Priming (Activation) of Pump

Before the first dose and administration, the pump must be primed. Remove the clear plastic cover and the plastic safety clip from the pump. To prime the pump, place nozzle between the first and second finger with the thumb on the bottom of the bottle. Pump the unit firmly and quickly until the first appearance of spray. Then prime the pump an additional 2 times. Now the nasal spray is ready for use. The unit must be re-primed before each dose. Prime the pump once immediately before each administration of doses 2 through 8.

How supplied

Cyanocobalamin (Lupifit) (Cyanocobalamin (Lupifit)) Nasal Spray is available as a spray in 3 mL glass bottles containing 2.3 mL of solution. It is available in a dosage strength of 500 mcg per actuation (0.1 mL/actuation). A screw-on actuator is provided. This actuator, following priming, will deliver 0.1 mL of the spray. Cyanocobalamin (Lupifit) (Cyanocobalamin (Lupifit)) Nasal Spray is provided in a carton containing a nasal spray actuator with dust cover, a bottle of nasal spray solution, and a package insert. One bottle will deliver 8 doses (NDC 67871-773-35).

Pharmacist Assembly Instructions For Cyanocobalamin (Lupifit) (Cyanocobalamin (Lupifit)) Nasal Spray

The pharmacist should assemble the Cyanocobalamin (Lupifit) (Cyanocobalamin (Lupifit)) Nasal Spray unit prior to dispensing to the patient, according to the following instructions:

1. Open the carton and remove the spray actuator and spray solution bottle.
2. Assemble Cyanocobalamin (Lupifit) (Cyanocobalamin (Lupifit)) Nasal Spray by first unscrewing the white cap from the spray solution bottle and screwing the actuator unit tightly onto the bottle. Make sure the clear dust cover is on the pump unit.
3. Return the Cyanocobalamin (Lupifit) (Cyanocobalamin (Lupifit)) Nasal Spray bottle to the carton for dispensing to the patient.

Mfd. for QOL Medical, LLC

Kirland, WA 98033, USA

1.866.469.3773

www.Cyanocobalamin (Lupifit) (Cyanocobalamin (Lupifit)).com

3078 Rev. 02/06

FDA rev date: 9/15/2006

Usual Adult Dose for Megaloblastic Anemia

1 mg orally, intramuscularly, subcutaneously or IV once a day. May continue until clinical symptoms of folate deficiency and the hematological profile have normalized.

Usual Adult Dose for Folic acid (Lupifit) Deficiency

400 to 800 mcg orally, intramuscularly, subcutaneously or IV once a day.

Women of childbearing age, pregnant, and lactating women: 800 mcg orally, intramuscularly, subcutaneously or IV once a day.

Usual Pediatric Dose for Folic acid (Lupifit) Deficiency

Infant:

0.1 mg orally, intramuscularly, subcutaneously or IV once a day.

Child:

Less than 4 years: up to 0.3 mg orally, intramuscularly, subcutaneously or IV once a day.

4 years or older: 0.4 mg orally, intramuscularly, subcutaneously or IV once a day.

Usual Pediatric Dose for Vitamin/Mineral Supplementation

Recommended daily allowance (RDA):

Premature neonates: 50 mcg/day (15 mcg/kg/day).

Full-term neonates and infants 1 to 6 months: 25 to 35 mcg/day.

Children:

1 to 3 years: 150 mcg/day.

4 to 8 years: 200 mcg/day.

9 to 13 years: 300 mcg/day.

14 years and older: 400 mcg/day.

Renal Dose Adjustments

Data not available

Liver Dose Adjustments

Data not available

Dose Adjustments

Rarely, a dosage of 2 mg/day may be required, particularly in patients with malabsorption, alcoholism, chronic hemolysis, chronic exfoliative skin disease or who are on concomitant anticonvulsant therapy.

Dialysis

Folic acid (Lupifit) is removed by both hemodialysis and peritoneal dialysis. The amount removed varies with type equipment used.

Because folate may accumulate in patients with end-stage renal disease, side effects may be more likely in this patient who is undergoing dialysis. Once this patient's body stores of folate are replete, three times a week dosing may be just as beneficial as once daily dosing but should portend a lower risk of side effects.

Other Comments

The recommended daily allowance of Folic acid (Lupifit) for adult males and females ranges from 150 to 200 and 150 to 180 mcg/day, respectively.

There is a potential danger in administering Folic acid (Lupifit) to patients with undiagnosed anemia, since Folic acid (Lupifit) may obscure the diagnosis of pernicious anemia by alleviating the hematologic manifestations of the disease while allowing the neurologic complications to progress.

Severe megaloblastic anemia may require therapy for 4 to 5 weeks. Once stabilized, if dietary intake is inadequate, maintenance therapy can be started.

Dosage depends on the severity of the catabolic state & amino acid requirement. Daily dose: 10-20ml/kg body wt equiv to 1-2g amino acids/kg body wt. Maximum daily dosage not >2g amino acids/kg body wt.

Adults: L-isoleucine (Lupifit) is usually IV drip-infused at a single dose of 500 mL. The standard infusion rate is ≥180 min/500 mL.

The dosage may be adjusted according to the patient's age, symptoms and body weight.

Administration: If administered via central venous line, 500 mL should be mixed with a carbohydrate-containing solution and be infused continuously via central vein for 24 hrs.

1-2 caps daily.

The usual adult dosage is 500-1000 mL/dose by drip IV infusion. The usual peripheral infusion rate is 500 mL over 180-300 min (about 25-40 drops/min). For total parenteral nutrition, 500-1000 mL of inj should be suitable combined with dextrose or other solutions and administered over 24 hrs via the central vein. The dosage may be adjusted depending on the patient's age, symptoms and body weight.

Usual Adult Dose for Hypomagnesemia

500 to 1000 mg Magnesium sulphate (Lupifit) gluconate (27 to 54 mg elemental Magnesium sulphate (Lupifit)) orally 3 times a day.

Usual Adult Dose for Dietary Supplement

500 to 1000 mg Magnesium sulphate (Lupifit) gluconate (27 to 54 mg elemental Magnesium sulphate (Lupifit)) orally once a day.

Usual Pediatric Dose for Hypomagnesemia

10 to 20 mg/kg of elemental Magnesium sulphate (Lupifit) per dose orally 4 times a day. Use Magnesium sulphate (Lupifit) gluconate oral liquid preparations for more accurate measurement of dose.

Renal Dose Adjustments

Do not use without physician supervision in patients with renal impairment due to increased risk of hypermagnesemia. The use of Magnesium sulphate (Lupifit) salts are generally contraindicated in patients with severe renal dysfunction.

Liver Dose Adjustments

Data not available

Dose Adjustments

May increase by 500 to 1,000 mg/day (27 to 54 mg elemental Magnesium sulphate (Lupifit)) in order to achieve a normal serum Magnesium sulphate (Lupifit) level. Daily doses > 1,000 mg (54 mg elemental Magnesium sulphate (Lupifit)) should be given in 2 to 3 divided doses.

Precautions

Because Magnesium sulphate (Lupifit) is primarily eliminated by the kidney, there is significant risk of hypermagnesemia in patients with renal dysfunction.

Dialysis

Data not available; however, use of Magnesium sulphate (Lupifit) salts is generally contraindicated in renal failure.

Other Comments

Magnesium sulphate (Lupifit) supplements are often used with "low normal" serum Magnesium sulphate (Lupifit) levels in patients predisposed to hypomagnesemia (e.g., patients on diuretics).

Manganese sulfate (Lupifit), USP provides 0.1 mg manganese/mL. For the metabolically stable adult receiving TPN, the suggested additive dosage level for manganese is 0.15 to 0.8 mg/day. For pediatric patients, a dosage level of 2 to 10 mcg manganese/kg/day is recommended.

Aseptic addition of Manganese sulfate (Lupifit), USP to the TPN solution under a laminar flow hood is recommended. Manganese is physically compatible with the electrolytes and vitamins usually present in the amino acid/dextrose solution used for TPN. Periodic monitoring of manganese plasma levels is suggested as a guideline for subsequent administration.

Parenteral drug products should be inspected visually for particulate matter and discoloration, whenever solution and container permit.

Oral

Treatment and prophylaxis of nicotinic acid deficiency

Adult: Up to 500 mg daily in divided doses. May also be given via IM or by slow IV inj.

Topical/Cutaneous

Mild to moderate inflammatory acne

Adult: As a 4% gel: Apply bid, reduce to once daily or on alternate days if irritation occurs.

Usual Adult Dose for Cough

300 to 650 mg orally 3 to 4 times a day.

Usual Adult Dose for Hyperthyroidism

Oral solution: 250 mg orally 3 times a day. Give for 10 to 14 days prior to thyroid surgery.

May be given as 0.25 mL of a 1 g/mL potassium iodine solution (SSKI) or as 4 mL of 325 mg/5 mL solution. Alternatively, 2 to 6 drops of a 10% Potassium iodide (Lupifit)/5% iodine solution may be given orally 3 times a day with food.

Usual Adult Dose for Cutaneous Sporotrichosis

250 to 500 mg orally 3 times a day. Increase gradually to a maximum of 2 to 2.5 grams 3 times a day. Continue at maximum tolerated dose until the cutaneous lesions have resolved, usually 6 to 12 weeks.

Usual Adult Dose for Radiation Emergency

Pregnant or lactating women with exposure >= 5 centigrays (cGy): 130 mg orally per day.

>18 and <=40 years with exposure >= 10 centigrays (cGy): 130 mg orally per day.

>40 years with exposure >= 500 centigrays (cGy): 130 mg orally per day.

Usual Pediatric Dose for Cough

60 to 250 mg orally every 4 to 6 times a day. Maximum single dose 500 mg.

Usual Pediatric Dose for Hyperthyroidism

Oral solution: 250 mg orally 3 times a day. Give for 10 to 14 days prior to thyroid surgery.

Usual Pediatric Dose for Cutaneous Sporotrichosis

250 to 500 mg orally 3 times a day. Increase gradually to a maximum of 1.25 to 2 grams 3 times a day. Continue at maximum tolerated dose until the cutaneous lesions have resolved, usually 6 to 12 weeks.

Usual Pediatric Dose for Radiation Emergency

<=1 month with exposure >= 5 centigrays (cGy): 16 mg orally per day.

>1 month <=3 years with exposure >= 5 centigrays (cGy): 32 mg orally per day.

>3 years <= 18 years (less than 70 kg) with exposure >= 5 centigrays (cGy): 65 mg orally per day.

>13 years >= 70 kg with exposure >= 5 centigrays (cGy): 130 mg orally per day.

Renal Dose Adjustments

Potassium iodide (Lupifit) should be used cautiously in patients with renal dysfunction. Due to impaired renal filtering of electrolytes, an increase in serum potassium can occur in patients with renal impairment.

Liver Dose Adjustments

Data not available

Dialysis

Data not available

Other Comments

Administer after meals with food or milk or dilute with a large quantity of water, fruit juice, or broth.

Usual Adult Dose for Drug Induced Vitamin/Mineral Deficiency:

Drug Induced Neuritis:

Cycloserine: 100 to 300 mg/day orally in divided doses.

Isoniazid or penicillamine: 100 to 200 mg/day orally for 3 weeks or 25 to 100 mg/day for prophylaxis.

Oral contraceptives: 25 to 30 mg/day orally.

Acute Intoxication:

Hydralazine: 25 mg/kg. One-third of the dose should be administered IM and the remainder administered as an IV infusion over 3 hours.

Isoniazid: 1 to 4 grams IV as a first dose, then 1 g IM every 30 minutes until the total required dose has been administered (given with other anticonvulsants as needed). The total dose administered should equal the amount of isoniazid ingested.

Mushroom ingestion (genus Gyromitra): 25 mg/kg IV infused over 15 to 30 minutes. Repeat as needed to a maximum total daily dose of 15 to 20 g.

Usual Adult Dose for Dietary Supplement:

Pyridoxine hydrochloride (Lupifit) Deficiency:

10 to 25 mg/day orally, IM, or IV for 3 weeks followed by 2 to 5 mg/day from a multivitamin product.

Usual Adult Dose for Anemia:

Sideroblastic, hereditary: 200 to 600 mg orally daily. If adequate response obtained, dose may be decreased to 30 to 50 mg orally daily.

If therapeutic response is not obtained after 1 to 2 months of Pyridoxine hydrochloride (Lupifit) therapy, a different therapy should be considered.

Usual Adult Dose for Nausea/Vomiting:

Nausea and vomiting of Pregnancy:

25 mg orally every 8 hours.

Usual Pediatric Dose for Drug Induced Vitamin/Mineral Deficiency:

Drug Induced Neuritis (cycloserine, isoniazid, hydralazine, penicillamine) :

Treatment: 10 to 50 mg/day.

Prophylaxis: 1 to 2 mg/kg/day

Acute Intoxication:

Hydralazine: 25 mg/kg: One-third of the dose should be administered IM and the remainder administered as an IV infusion over 3 hours.

Isoniazid: Acute ingestion of known amount: Initial: A total dose of Pyridoxine hydrochloride (Lupifit) equal to the amount of isoniazid ingested (maximum dose: 70 mg/kg, up to 5 g); administer at a rate of 0.5 to 1 g/minute until seizures stop or the maximum initial dose has been administered; may repeat every 5 to 10 minutes as needed to control persistent seizure activity and/or CNS toxicity. If seizures stop prior to the administration of the calculated initial dose, infuse the remaining Pyridoxine hydrochloride (Lupifit) over 4 to 6 hours. Acute ingestion of unknown amount: Initial: 70 mg/kg (maximum dose: 5 g); administer at a rate of 0.5 to 1 g/minute; may repeat every 5 to 10 minutes as needed to control persistent seizure activity and/or CNS toxicity.

Mushroom ingestion (genus Gyromitra): 25 mg/kg IV. Repeat as needed up to a maximum total dose of 15 to 20 g.

Usual Pediatric Dose for Dietary Supplement:

Pyridoxine hydrochloride (Lupifit) Deficiency:

5 to 25 mg/day orally, IM, or IV for 3 weeks followed by 1.5 to 2.5 mg/day from a multivitamin product.

Usual Pediatric Dose for Seizures:

Pyridoxine hydrochloride (Lupifit)-dependent seizures:

10 to 100 mg PO, IM, or IV initially, followed by 2 to 100 mg orally daily.

Dosage Forms

Excipient information presented when available (limited, particularly for generics); consult specific product labeling.

Capsule,

Oral:

B-2-400: 400 mg

Generic: 50 mg

Tablet,

Oral:

Generic: 25 mg, 50 mg, 100 mg

Dosing: Adult

Dietary supplement:

Oral: 100 mg once or twice daily

Prevention of migraine headache (off-label use):

Oral: 400 mg once daily (Rahimdel 2015; Schoenen 1998)

Dosing: Geriatric

Refer to adult dosing.

Dosing: Pediatric

Dietary supplement: Infants, Children, and Adolescents: A multivitamin preparation is most commonly used for the provision of Riboflavin (Lupifit) supplementation in pediatric patients; the use of a single-ingredient Riboflavin (Lupifit) product as a daily supplement for the prevention of deficiency in pediatric patients is very rare. If single-ingredient Riboflavin (Lupifit) supplement is necessary, consult product labeling for appropriateness of product in infants and young children in particular.

Migraine headache, prevention: Limited data available, efficacy results variable: Children ≥ 8 years and Adolescents:

Oral: 200 to 400 mg once daily; dosing based on a retrospective study of 41 patients (ages 8 to 18 years) who received 200 mg/day (n=21) or 400 mg/day (n=20) as prophylaxis for migraine and migraine-type headaches; results showed significant reduction in primary endpoint of frequency of headache attack; 68.4% of patients had a ≥50% decrease in headache frequency during treatment (Condò 2009). However, in a prospective, placebo-controlled study of 48 patients (ages 5 to 15 years), patients received 200 mg/day (n=27) or placebo (n=21) and in the treatment group (Riboflavin (Lupifit)) no benefit compared to placebo for migraine frequency or intensity was observed; a high placebo responder rate was also reported (MacLennan 2008).

Sodium selenite (Lupifit) Injection provides 40 mcg Sodium selenite (Lupifit)/mL. For metabolically stable adults receiving TPN, the suggested additive dosage level is 20 to 40 mcg Sodium selenite (Lupifit)/day. For pediatric patients, the suggested additive dosage level is 3 mcg/kg/day.

In adults, Sodium selenite (Lupifit) deficiency states resulting from long-term TPN support, Sodium selenite (Lupifit) as selenomethionine or selenious acid, administered intravenously at 100 mcg/day for a period of 24 and 31 days, respectively, has been reported to reverse deficiency symptoms without toxicity.

Aseptic addition of Sodium selenite (Lupifit) Injection to the TPN solution under laminar flow hood is recommended. Sodium selenite (Lupifit) is physically compatible with the electrolytes and other trace elements usually present in amino-acid/dextrose solution used for TPN. Frequent monitoring of plasma Sodium selenite (Lupifit) levels is suggested as a guideline for subsequent administration. The normal whole blood range for Sodium selenite (Lupifit) is approximately 10 to 37 mcg/100 mL.

Parenteral drug products should be inspected visually for particulate matter and discoloration, whenever solution and container permit.

Usual Adult Dose for Vitamin A (Lupifit) Deficiency

Initial dose: 100,000 Units intramuscularly once a day for 3 days

Maintenance dose: 50,000 Units intramuscularly once a day for 2 weeks

Use: Treatment of Vitamin A (Lupifit) deficiency when oral administration is not feasible or not available (e.g. anorexia, nausea, vomiting, pre- or post-operative conditions, "Malabsorption Syndrome" with accompanying steatorrhea)

Usual Adult Dose for Vitamin/Mineral Supplementation

US Recommended Dietary Allowance (RDA):

Adult male: 900 mcg retinol activity equivalents (RAE) (3000 international units [IU])

Tolerable Upper Intake Level (UL): 3000 mcg RAE (10,000 IU)

Adult female: 700 mcg RAE (2330 IU)

UL: 3000 mcg RAE (10,000 IU)

Comments:

-The Vitamin A (Lupifit) RDA is given as mcg of retinol activity equivalents (RAE) to account for the different bioactivities of retinol and provitamin A carotenoids.

-The body converts all dietary Vitamin A (Lupifit) into retinol; 2 mcg of beta-carotene from dietary supplements is converted to 1 mcg of retinol.

-The tolerable upper intake level is the maximum daily intake that is unlikely to have adverse health effects.

Usual Pediatric Dose for Vitamin A (Lupifit) Deficiency

Infants (under 1 year): 7500 to 15,000 Units intramuscularly once a day

Duration of therapy: 10 days

1 to 8 years: 17,500 to 35,000 Units intramuscularly once a day

Duration of therapy: 10 days

Adult dose:

Initial dose: 100,000 Units intramuscularly once a day for 3 days

Maintenance dose: 50,000 Units intramuscularly once a day for 2 weeks

Use: Treatment of Vitamin A (Lupifit) deficiency when oral administration is not feasible or not available (e.g. anorexia, nausea, vomiting, pre- or post-operative conditions, "Malabsorption Syndrome" with accompanying steatorrhea)

Usual Pediatric Dose for Vitamin/Mineral Supplementation

US Recommended Dietary Allowance (RDA):

0 to 6 months: 400 mcg retinol activity equivalents (RAE) (1332 international units [IU])

Tolerable Upper Intake Level (UL): 600 mcg RAE (2000 IU)

7 to 12 months: 500 mcg RAE (1665 IU)

UL: 600 mcg RAE (2000 IU)

1 to 3 years: 300 mcg RAE (1000 IU)

UL: 900 mcg RAE (3000 IU)

4 to 8 years: 400 mcg RAE (1332 IU)

UL: 900 mcg RAE (3000 IU)

9 to 13 years: 600 mcg RAE (2000 IU)

UL: 1700 mcg RAE (5667 IU)

14 to 18 years, male: 900 mcg RAE (3000 IU)

UL: 2800 mcg RAE (9333 IU)

14 to 18 years, female: 700 mcg RAE (2330 IU)

UL: 2800 mcg RAE (9333 IU)

Comments:

-The Vitamin A (Lupifit) RDA is given as mcg of retinol activity equivalents (RAE) to account for the different bioactivities of retinol and provitamin A carotenoids.

-The body converts all dietary Vitamin A (Lupifit) into retinol; 2 mcg of beta-carotene from dietary supplements is converted to 1 mcg of retinol.

-The tolerable upper intake level is the maximum daily intake that is unlikely to have adverse health effects.

Renal Dose Adjustments

Data not available

Liver Dose Adjustments

Data not available

Dose Adjustments

US Recommended Dietary Allowance (RDA):

Pregnancy:

14 to 18 years: 750 mcg retinol activity equivalents (RAE) (2500 international units [IU])

UL: 2800 mcg RAE (9333 IU)

18 to 50 years: 770 mcg RAE (2564 IU)

UL: 3000 mcg RAE (10,000 IU)

Lactation:

14 to 18 years: 1200 mcg RAE (2564 IU)

UL: 2800 mcg RAE (9333 IU)

18 to 50 years: 1300 mcg RAE (4329 IU)

UL: 3000 mcg RAE (10,000 IU)

Comments:

-The Vitamin A (Lupifit) RDA is given as mcg of retinol activity equivalents (RAE) to account for the different bioactivities of retinol and provitamin A carotenoids.

-The body converts all dietary Vitamin A (Lupifit) into retinol; 2 mcg of beta-carotene from dietary supplements is converted to 1 mcg of retinol.

-The tolerable upper intake level is the maximum daily intake that is unlikely to have adverse health effects.

Precautions

CONTRAINDICATIONS:

-Administration of the intramuscular formulation intravenously

-Hypervitaminosis A

-Hypersensitivity to any of the ingredients

-The safety of doses exceeding 6000 units Vitamin A (Lupifit) in pregnancy has not been established. Use of high doses in pregnancy or patients who may become pregnant is contraindicated. Doses above the recommended dietary allowance (RDA) may cause fetal harm; fetal abnormalities (central nervous system, eye, and palate malformations) were seen in animal overdose models. If patients become pregnant, apprise them of potential fetal harms.

Consult WARNINGS section for additional precautions.

Dialysis

Data not available

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer

Zinc sulphate (Lupifit) 1 mg/mL (Zinc sulphate (Lupifit) Chloride Injection, USP) contains 1 mg Zinc sulphate (Lupifit)/mL and is administered intravenously only after dilution. The additive should be diluted prior to administration in a volume of fluid not less than 100 mL. For the metabolically stable adult receiving TPN, the suggested intravenous dosage is 2.5 to 4 mg Zinc sulphate (Lupifit)/day (2.5 to 4 mL/day). An additional 2 mg Zinc sulphate (Lupifit)/day (2 mL/day) is suggested for acute catabolic states. For the stable adult with fluid loss from the small bowel, an additional 12.2 mg Zinc sulphate (Lupifit)/liter of small bowel fluid lost (12.2 mL/liter of small bowel fluid lost), or an additional 17.1 mg Zinc sulphate (Lupifit)/kg of stool or ileostomy output (17.1 mL/kg of stool or ileostomy output) is recommended. Frequent monitoring of Zinc sulphate (Lupifit) blood levels is suggested for patients receiving more than the usual maintenance dosage level of Zinc sulphate (Lupifit).

For full term infants and children up to 5 years of age, 100 mcg Zinc sulphate (Lupifit)/kg/day

(0.1 mL/kg/day) is recommended. For premature infants (birth weight less than 1500 g) up to 3 kg in body weight, 300 mcg Zinc sulphate (Lupifit)/kg/day (0.3 mL/kg/day) is suggested.

Parenteral drug products should be inspected visually for particulate matter and discoloration prior to administration, whenever solution and container permit. See PRECAUTIONS.

How supplied

Zinc sulphate (Lupifit) 1 mg/mL (Zinc sulphate (Lupifit) Chloride Injection, USP) is supplied in 10 mL Plastic Vials (List No. 4090).

Store at 20 to 25°C (68 to 77°F).

HOSPIRA, INC., LAKE FOREST, IL 60045 USA. Revised: October, 2004

See also:
What is the most important information I should know about Ascorbic acid (Lupifit)?

There are no contraindications to the administration of Ascorbic acid (Lupifit).

See also:
What is the most important information I should know about Biotin (Lupifit)?

SINEQUAN is contraindicated in individuals who have shown hypersensitivity to the drug. Possibility of cross sensitivity with other dibenzoxepines should be kept in mind.

SINEQUAN is contraindicated in patients with glaucoma or a tendency to urinary retention. These disorders should be ruled out, particularly in older patients.

Haemophiliacs, patients with ileus (due to mechanical obstruction).

See also:
What is the most important information I should know about Cholecalciferol (Lupifit)?

Contraindications for vitamin D analogues (Vitamin D2, Cholecalciferol (Lupifit), Calcitriol, and Calcidiol)

Vitamin D should not be given to patients with hypercalcemia or evidence of vitamin D toxicity. Use of vitamin D in patients with known hypersensitivity to vitamin D (or drugs of the same class) or any of the inactive ingredients is contraindicated.

hepatic disease and hepatic failure.

See also:
What is the most important information I should know about Cyanocobalamin (Lupifit)?

You should not use this medication if you are allergic to cobalt, or if you have Leber's disease. Cyanocobalamin (Lupifit) can lead to optic nerve damage (and possibly blindness) in people with Leber's disease.

To treat pernicious anemia, you will have to use this medication on a regular basis for the rest of your life. Not using the medication can lead to irreversible nerve damage in your spinal cord.

Pernicious anemia is also treated with folic acid to help maintain red blood cells. However, folic acid will not treat Vitamin B12 deficiency and will not prevent possible damage to the spinal cord. Use all of your medications as directed.

Avoid eating or drinking hot foods or liquids within 1 hour before or after using the nasal form of this medication.

Tell your doctor if you develop nasal congestion, a cold, or allergies. The nasal spray may not work as well if you are congested.

Your dose needs may change if you become pregnant, if you breast-feed, or if you eat a vegetarian diet. Tell your doctor about any changes in your diet or medical condition.

See also:
What is the most important information I should know about Folic acid (Lupifit)?

Because it may mask the hematologic abnormalities while neurological damage progresses, Folic acid (Lupifit) should not be used in the therapy of patients with vitamin B12 deficiency of any cause, unless there is associated folate deficiency. The Folic acid (Lupifit) content of one tablet a day however, is unlikely to mask pernicious anemia should this condition be present. Also, pregnancy during pernicious anemia is very rare.

Patients with serious renal disorder (the symptoms may be aggravated due to overload of nitrogen compounds) and with amino acid metabolism abnormality other than liver disorder (imbalance of amino acids may be aggravated).

Patients with severe renal disorder. The amount of water tends to be excessive and the patient's clinical condition may be worsened. Urea and other amino acid metabolites may be retained, which may worsen the patient's clinical condition.

Patients with abnormal amino acid metabolism. Since the infused amino acids are not adequately metabolized, the patient's clinical condition may be worsened.

See also:
What is the most important information I should know about L-tryptophan (Lupifit)?

• Achlohydria or malabsorption (digestion problems) - L-tryptophan (Lupifit) may cause breathing problems in patients with certain types of digestion problems • Bladder cancer - L-tryptophan (Lupifit) may increase the risk of bladder cancer • Cataracts - L-tryptophan (Lupifit) may cause cataracts • Diabetes mellitus (sugar diabetes) - L-tryptophan (Lupifit) may cause diabetes in patients with a family history of diabetes.

See also:
What is the most important information I should know about Magnesium sulphate (Lupifit)?

Parenteral administration of the drug is contraindicated in patients with heart block or myocardial damage.

Manganese sulfate (Lupifit), USP should not be given undiluted by direct injection into a peripheral vein because of the potential for infusion phlebitis.

contraindicated in patients with hypersensitivity to any of its components.

See also:
What is the most important information I should know about Potassium iodide (Lupifit)?

Hypersensitivity to iodide, iodine, or any component of the formulation; dermatitis herpetiformis; hypocomplementemic vasculitis, nodular thyroid condition with heart disease

See also:
What is the most important information I should know about Pyridoxine hydrochloride (Lupifit)?

Contraindications for Vitamin B6 (Pyridoxine hydrochloride (Lupifit)-HCl Microencapsulated)

Vitamin B6 is contraindicated in those hypersensitive to any component of a vitamin B6-containing product.

See also:
What is the most important information I should know about Riboflavin (Lupifit)?

None well documented.

See also:
What is the most important information I should know about Sodium selenite (Lupifit)?

Sodium selenite (Lupifit) Injection should not be given undiluted by direct injection into a peripheral vein because of the potential for infusion phlebitis.

do not use in the treatment of leber disease or tobaco intoxication.

See also:
What is the most important information I should know about Vitamin A (Lupifit)?

The intravenous administration. Hypervitaminosis A. Sensitivity to any of the ingredients in this preparation. Use in Pregnancy: Safety of amounts exceeding 6,000 Units of Vitamin A (Lupifit) daily during pregnancy has not been established at this time. The use of Vitamin A (Lupifit) in excess of the recommended dietary allowance may cause fetal harm when administered to a pregnant woman. Animal reproduction studies have shown fetal abnormalities associated with overdosage in several species. Malformations of the central nervous system, the eye, the palate, and the urogenital tract are recorded. Vitamin A (Lupifit) in excess of the recommended dietary allowance is contraindicated in women who are or may become pregnant. If Vitamin A (Lupifit) is used during pregnancy, or if the patient becomes pregnant while taking Vitamin A (Lupifit), the patient should be apprised of the potential hazard to the fetus.

See also:
What is the most important information I should know about Zinc sulphate (Lupifit)?

unknown.

Use Ascorbic acid (Lupifit) solution as directed by your doctor. Check the label on the medicine for exact dosing instructions.

• Ascorbic acid (Lupifit) solution may be taken with or without food.
• You may drop the dose of Ascorbic acid (Lupifit) solution directly into your mouth or mix it with cereal, milk, or water.
• Take Ascorbic acid (Lupifit) solution with a full glass of water (8 oz/240 mL). Do not lie down for 30 minutes after taking Ascorbic acid (Lupifit) solution.
• Use a measuring device marked for medicine dosing. Ask your pharmacist for help if you are unsure of how to measure your dose.
• If you miss a dose of Ascorbic acid (Lupifit) solution, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Ascorbic acid (Lupifit) solution.

Use Cyanocobalamin (Lupifit) (b12) spray as directed by your doctor. Check the label on the medicine for exact dosing instructions.

• An extra patient leaflet is available with Cyanocobalamin (Lupifit) (b12) spray. Talk to your pharmacist if you have questions about this information.
• Cyanocobalamin (Lupifit) (b12) spray is used in the nose.
• Follow the directions provided by your doctor or other health care provider. If you are unsure how to use Cyanocobalamin (Lupifit) (b12) spray, contact your doctor or other health care provider.
• Do not use Cyanocobalamin (Lupifit) (b12) spray within 1 hour before or after eating or drinking hot foods or liquids.
• Prime the pump before the first use. Place the nozzle between the first and second finger with the thumb on the bottom. Point the nozzle away from yourself and others. Pump the unit firmly and quickly until the medicine sprays out, then spray two more times.
• Re-prime the pump before each dose. Point the nozzle away from yourself and others, then spray once.
• Use Cyanocobalamin (Lupifit) (b12) spray in only 1 nostril each week.
• To use Cyanocobalamin (Lupifit) (b12) spray, sit down and tilt your head back slightly. Place the tip of the spray container into the nose. Using a finger from your other hand, press against the opposite nostril to close it off. Breath gently through the open nostril and spray a dose of medicine from the container. After using the medicine, rinse the tip of the spray unit in hot water and dry with a clean tissue to prevent contamination.
• Cyanocobalamin (Lupifit) (b12) spray is usually used 1 time per week. Do not use it more often than 1 time per week without checking with your doctor.
• This bottle contains 8 doses. Do not continue to use this bottle after 8 doses have been used. It may not give the correct amount of medicine.
• Continue to use Cyanocobalamin (Lupifit) (b12) spray even if you feel well. Do not miss any doses.
• If you miss a dose of Cyanocobalamin (Lupifit) (b12) spray, use it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not use 2 doses at once.

Ask your health care provider any questions you may have about how to use Cyanocobalamin (Lupifit) (b12) spray.

Use Folic acid (Lupifit) as directed by your doctor. Check the label on the medicine for exact dosing instructions.

• Folic acid (Lupifit) may be administered as an injection by your health care professional.
• If you are using Folic acid (Lupifit) at home, carefully follow the injection procedures taught to you by your health care provider. If the medicine contains particles, is discolored, or if the vial is cracked or damaged in any way, do not use it.
• Do not reuse needles, syringes, or other materials. Dispose of properly after use. Ask your doctor, nurse, or pharmacist to explain local regulations for selecting an appropriate container and properly disposing of the container when full.
• If you miss a dose of Folic acid (Lupifit), use it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not use 2 doses at once.

Ask your health care provider any questions you may have about how to use Folic acid (Lupifit).

Use Magnesium sulphate (Lupifit) as directed by your doctor. Check the label on the medicine for exact dosing instructions.

• Take Magnesium sulphate (Lupifit) by mouth with food.
• If you miss a dose of Magnesium sulphate (Lupifit) and are using it regularly, take it as soon as possible. If it is almost time for the next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Magnesium sulphate (Lupifit).

Use Potassium iodide (Lupifit) as directed by your doctor. Check the label on the medicine for exact dosing instructions.

• An extra patient leaflet is available with Potassium iodide (Lupifit). Talk to your pharmacist if you have questions about this information.
• Take Potassium iodide (Lupifit) by mouth with or without food. If stomach upset occurs, take with food to reduce stomach irritation.
• Use the dropper that comes with Potassium iodide (Lupifit) to measure your dose. Ask your pharmacist for help if you are unsure of how to measure your dose.
• If you are instructed to take more than 1 dose of Potassium iodide (Lupifit), do NOT take it sooner than 24 hours after the last dose of Potassium iodide (Lupifit). Do NOT take more than 1 dose per day.
• If you miss a dose of Potassium iodide (Lupifit), take it as soon as possible. If you are instructed to take more than 1 dose of Potassium iodide (Lupifit) and it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do NOT take 2 doses at once.

Ask your health care provider any questions you may have about how to use Potassium iodide (Lupifit).

Use Pyridoxine hydrochloride (Lupifit) (vitamin b6) as directed by your doctor. Check the label on the medicine for exact dosing instructions.

• Pyridoxine hydrochloride (Lupifit) (vitamin b6) is usually administered as an injection at your doctor's office, hospital, or clinic. If you are using Pyridoxine hydrochloride (Lupifit) (vitamin b6) at home, carefully follow the injection procedures taught to you by your health care provider.
• If Pyridoxine hydrochloride (Lupifit) (vitamin b6) contains particles or is discolored, or if the vial is cracked or damaged in any way, do not use it.
• Keep this product, as well as syringes and needles, out of the reach of children and away from pets. Do not reuse needles, syringes, or other materials. Dispose of properly after use. Ask your doctor or pharmacist to explain local regulations for proper disposal.
• If you miss a dose of Pyridoxine hydrochloride (Lupifit) (vitamin b6) and you are taking it regularly, take it as soon as possible. If several hours have passed or if it is nearing time for the next dose, do not double the dose to catch up, unless advised by your health care provider. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Pyridoxine hydrochloride (Lupifit) (vitamin b6).

A surgeon or other healthcare provider will give you this medicine as part of your corneal collagen crosslinking procedure.

You will be given numbing eyedrops to prepare you for the procedure. You may also be given a sedative or anesthesia to help you relax. Although you will most likely be awake during the procedure, you should feel little or no discomfort. A special device will be placed around your eyelids to keep them open during the procedure.

Your eye surgeon will place Riboflavin (Lupifit) ophthalmic drops into your eyes about every 2 minutes during the procedure.

After the procedure, the surgeon will place a contact lens on the treated eye to protect it for a short time.

Call your doctor right away if the contact lens falls out or feels like it is out of place inside your eye.

You may also need to use antibiotic or steroid eyedrops to prevent infection and reduce swelling after your procedure. Carefully follow all after-care instructions and do not miss any follow-up appointments.

Ascorbic acid (Lupifit) (Ascorbic acid (Lupifit)) is used to prevent or treat low levels of Ascorbic acid (Lupifit) in people who do not get enough of the vitamin from their diets. Most people who eat a normal diet do not need extra Ascorbic acid (Lupifit). Low levels of Ascorbic acid (Lupifit) can result in a condition called scurvy. Scurvy may cause symptoms such as rash, muscle weakness, joint pain, tiredness, or tooth loss.

Ascorbic acid (Lupifit) plays an important role in the body. It is needed to maintain the health of skin, cartilage, teeth, bone, and blood vessels. It is also used to protect your body's cells from damage. It is known as an antioxidant.

OTHER USES: This section contains uses of this drug that are not listed in the approved professional labeling for the drug but that may be prescribed by your health care professional. Use this drug for a condition that is listed in this section only if it has been so prescribed by your health care professional.

This vitamin may also be used with other vitamins for a certain eye condition (macular degeneration).

How to use Ascorbic acid (Lupifit)

Take this vitamin by mouth with or without food, usually 1 to 2 times daily. Follow all directions on the product package, or take as directed by your doctor.

If you are taking the extended-release capsules, swallow them whole. Do not crush or chew extended-release capsules or tablets. Doing so can release all of the drug at once, increasing the risk of side effects. Also, do not split extended-release tablets unless they have a score line and your doctor or pharmacist tells you to do so. Swallow the whole or split tablet without crushing or chewing. Take this product with a full glass of water (8 ounces/240 milliliters) unless your doctor directs you otherwise.

If you are taking the wafers or chewable tablets, chew them thoroughly and then swallow. If you are taking the lozenges, place the lozenge in your mouth and allow it to slowly dissolve.

If you are taking the powder, mix it thoroughly in the proper amount of liquid and stir well. Drink all of the liquid right away. Do not prepare a supply for future use. If you are using the liquid form of this vitamin, carefully measure the dose using a special measuring device/spoon. Do not use a household spoon because you may not get the correct dose.

Dosage is based on your medical condition and response to treatment.

Use this vitamin regularly to get the most benefit from it. To help you remember, take it at the same time(s) each day.

If you think you may have a serious medical problem, seek immediate medical attention.

Biotin (Lupifit) is a water soluble B-complex vitamin needed for normal growth and development of skin and hair and maintenance of a healthy nervous system and bone marrow. It is used to prevent and treat Biotin (Lupifit) deficiency associated with pregnancy, long-term tube feeding, malnutrition, and rapid weight loss. It is also used orally for hair loss, brittle nails, skin rash in infants (seborrheic dermatitis), diabetes, and mild depression.

This medication is used to prevent or treat low blood Calcium pantothenate (Lupifit) levels in people who do not get enough Calcium pantothenate (Lupifit) from their diets. It may be used to treat conditions caused by low Calcium pantothenate (Lupifit) levels such as bone loss (osteoporosis), weak bones (osteomalacia/rickets), decreased activity of the parathyroid gland (hypoparathyroidism), and a certain muscle disease (latent tetany). It may also be used in certain patients to make sure they are getting enough Calcium pantothenate (Lupifit) (e.g., women who are pregnant, nursing, or postmenopausal, people taking certain medications such as phenytoin, phenobarbital, or prednisone).

Calcium pantothenate (Lupifit) plays a very important role in the body. It is necessary for normal functioning of nerves, cells, muscle, and bone. If there is not enough Calcium pantothenate (Lupifit) in the blood, then the body will take Calcium pantothenate (Lupifit) from bones, thereby weakening bones. Having the right amount of Calcium pantothenate (Lupifit) is important for building and keeping strong bones.

How to use Calcium pantothenate (Lupifit)

Take this medication by mouth with food. If your product contains Calcium pantothenate (Lupifit) citrate, then it may be taken with or without food. Follow all directions on the product package, or take as directed by your doctor. For best absorption, if your daily dose is more than 600 milligrams, then divide your dose and space it throughout the day. If you are uncertain about any of the information, consult your doctor or pharmacist.

If you are using the chewable product, chew it well before swallowing.

If you are using the effervescent tablet, allow the tablet to fully dissolve in a glass of water before drinking it. Do not chew or swallow the tablet whole.

If you are using the liquid product or powder, measure the medication with a dose-measuring spoon or device to make sure you get the correct dose. Do not use a household spoon. If the liquid product is a suspension, shake the bottle well before each dose.

Use this medication regularly to get the most benefit from it. To help you remember, take it at the same time(s) each day.

If your doctor has recommended that you follow a special diet, it is very important to follow the diet to get the most benefit from this medication and to prevent serious side effects. Do not take other supplements/vitamins unless ordered by your doctor.

If you think you may have a serious medical problem, seek immediate medical attention.

Vitamin D (ergocalciferol-D2, Cholecalciferol (Lupifit)-D3, alfacalcidol) is a fat-soluble vitamin that helps your body absorb Cholecalciferol (Lupifit) and phosphorus. Having the right amount of vitamin D, Cholecalciferol (Lupifit), and phosphorus is important for building and keeping strong bones. Vitamin D is used to treat and prevent bone disorders (such as rickets, osteomalacia). Vitamin D is made by the body when skin is exposed to sunlight. Sunscreen, protective clothing, limited exposure to sunlight, dark skin, and age may prevent getting enough vitamin D from the sun.

Vitamin D with Cholecalciferol (Lupifit) is used to treat or prevent bone loss (osteoporosis). Vitamin D is also used with other medications to treat low levels of Cholecalciferol (Lupifit) or phosphate caused by certain disorders (such as hypoparathyroidism, pseudohypoparathyroidism, familial hypophosphatemia). It may be used in kidney disease to keep Cholecalciferol (Lupifit) levels normal and allow normal bone growth. Vitamin D drops (or other supplements) are given to breast-fed infants because breast milk usually has low levels of vitamin D.

How to use Cholecalciferol (Lupifit)

Take vitamin D by mouth as directed. Vitamin D is best absorbed when taken after a meal but may be taken with or without food. Alfacalcidol is usually taken with food. Follow all directions on the product package. If you are uncertain about any of the information, consult your doctor or pharmacist.

If your doctor has prescribed this medication, take as directed by your doctor. Your dosage is based on your medical condition, amount of sun exposure, diet, age, and response to treatment.

Measure the liquid medication with the dropper provided, or use a medication-measuring spoon/device to make sure you have the correct dose. If you are taking the chewable tablet or wafers, chew the medication thoroughly before swallowing. Do not swallow whole wafers.

Certain medications (bile acid sequestrants such as cholestyramine/colestipol, mineral oil, orlistat) can decrease the absorption of vitamin D. Take your doses of these medications as far as possible from your doses of vitamin D (at least 2 hours apart, longer if possible). It may be easiest to take vitamin D at bedtime if you are also taking these other medications. Ask your doctor or pharmacist how long you should wait between doses and for help finding a dosing schedule that will work with all your medications.

Take this medication regularly to get the most benefit from it. To help you remember, take it at the same time each day if you are taking it once a day. If you are taking this medication only once a week, remember to take it on the same day each week. It may help to mark your calendar with a reminder.

If your doctor has recommended that you follow a special diet (such as a diet high in Cholecalciferol (Lupifit)), it is very important to follow the diet to get the most benefit from this medication and to prevent serious side effects. Do not take other supplements/vitamins unless ordered by your doctor.

If you think you may have a serious medical problem, get medical help right away.

How to use Cyanocobalamin (Lupifit) nasal

Folic acid (Lupifit) is the man-made form of folate. Folate is a B-vitamin naturally found in some foods. It is needed to form healthy cells, especially red blood cells.

Folic acid (Lupifit) supplements may come in different forms (such as L-methylfolate, levomefolate, methyltetrahydrofolate). They are used to treat or prevent low folate levels. Low folate levels can lead to certain types of anemia. Conditions that can cause low folate levels include poor diet, pregnancy, alcoholism, liver disease, certain stomach/intestinal problems, kidney dialysis, among others. Women of childbearing age should receive adequate amounts of Folic acid (Lupifit) either through their diet or supplements to prevent infant spinal cord birth defects.

How to use Folic acid (Lupifit)

Take this product by mouth with or without food as directed by your doctor, usually once daily. If you are taking the over-the-counter product, follow all directions on the product package. If you have any questions, ask your doctor or pharmacist.

Dosage is based on your medical condition and response to treatment. Do not increase your dose or take this product more often than directed.

Take this product regularly to get the most benefit from it. To help you remember, take it at the same time each day. Follow the diet plan recommended by your doctor or dietician. See also Notes section.

If your condition persists or worsens, or if you think you may have a serious medical problem, get medical help right away.

L-histidine hydrochloride (Lupifit) is used for rheumatoid arthritis, allergic diseases, ulcers, and anemia caused by kidney failure or kidney dialysis.

Isoleucine have anticatabolic and antitardive dyskinesia activity. It also used as a dietary supplement for patients with mapple syrup urine disorder.

Liver diseases, premedication before surgery.

Herpes simplex infections.

L-methionine (Lupifit) reduces histamine release. It has also been used in the treatment of rheumatic fever and toxemia resulting from pregnancy. L-methionine (Lupifit) helps eliminate fatty substances that obstruct arteries, including those that supply the brain, heart, kidneys. L-methionine (Lupifit) is a sulfur agent required for the production of Glutathione, and works most effectively when taken with B-complex vitamins.

L-threonine (Lupifit) is used to treat various nervous system disorders including spinal spasticity, multiple sclerosis, familial spastic paraparesis, and amyotrophic lateral sclerosis.

In Canada, tryptophan is sold as a prescription drug to treat mood disorders (such as bipolar disorder, depression). It is usually used with other medicines. It works to make the mood more stable and reduce extremes in behavior by restoring the balance of certain natural substances (serotonin, melatonin) in the brain. Tryptophan is a natural substance (amino acid) found in high-protein foods and milk.

In the US, tryptophan is sold as a dietary supplement. It has been used to support mood, relaxation, and restful sleep. If you are taking other medications that may affect serotonin (such as many antidepressants), do not take tryptophan without talking with your doctor first. A very serious (possibly fatal) drug interaction may occur. Your doctor should closely monitor you. See also Side Effects section.

Some supplement products have been found to contain possibly harmful impurities/additives. Check with your pharmacist for more details about the brand you use.

The US FDA has not reviewed this product for safety or effectiveness. Consult your doctor or pharmacist for more details.

How to use L-tryptophan (Lupifit)

If your doctor has prescribed this medication, take it by mouth with a meal or snack, usually 3 to 4 times a day or as directed by your doctor. Taking this medication with food helps reduce side effects such as nausea.

Dosage is based on your medical condition and response to treatment. Your doctor may adjust your dose to find the best dose for you. Do not take this medication more often, increase your dose, or stop taking it without first consulting your doctor. Your condition will not improve faster and your risk of side effects will increase.

If your doctor has prescribed this medication, use it regularly to get the most benefit from it. To help you remember, take it at the same times each day.

If you are using tryptophan as a dietary supplement, take this product by mouth as directed. Follow all directions on the product package. If you are uncertain about any of the information, consult your doctor or pharmacist.

Consult your doctor or pharmacist before using this product for any mental/mood disorders such as depression or bipolar disorder. Your condition may require medical attention or prescribed medication.

Tell your doctor if your condition persists or worsens. If you think you may have a serious medical problem, seek immediate medical attention.

Magnesium sulphate (Lupifit) is used to treat constipation, Magnesium sulphate (Lupifit) deficiency, irregular heartbeat (Torsades de Pointes), high blood pressure during pregnancy, to reduce the risk of fits (pre-eclampsia), pain and swelling from sprains, bruises, or boils. It is also used to treat convulsions in children who have sudden and severe inflammation of the kidneys (acute nephritis).

Nicotinamide (Lupifit) is used to treat vitamin B3 deficiency and inflammatory skin diseases like acne and pellagra.

Potassium iodide (Lupifit) is used to loosen and break up mucus in the airways. This helps you cough up the mucus so you can breathe more easily if you have long-term lung problems (e.g., asthma, chronic bronchitis, emphysema). This medication is known as an expectorant.

Potassium iodide (Lupifit) is also used along with antithyroid medicines to prepare the thyroid gland for surgical removal, to treat certain overactive thyroid conditions (hyperthyroidism), and to protect the thyroid in a radiation exposure emergency. It works by shrinking the size of the thyroid gland and decreasing the amount of thyroid hormones produced.

In a radiation emergency, Potassium iodide (Lupifit) blocks only the thyroid from absorbing radioactive iodine, protecting it from damage and reducing the risk of thyroid cancer. Use this medication along with other emergency measures that will be recommended to you by public health and safety officials (e.g., finding safe shelter, evacuation, controlling food supply).

OTHER USES: This section contains uses of this drug that are not listed in the approved professional labeling for the drug but that may be prescribed by your health care professional. Use this drug for a condition that is listed in this section only if it has been so prescribed by your health care professional.

This drug may also be used to treat a certain type of fungal skin infection (sporotrichosis).

How to use Potassium iodide (Lupifit)

Take this medication by mouth with a full glass of water (8 ounces or 240 milliliters) as directed by your doctor or public health and safety officials. To avoid stomach upset, take after meals or with food. Drink plenty of liquids with this medication unless otherwise directed. If you are taking the tablets, do not lie down for 10 minutes after taking this medication. If you are using the drops or liquid medication, use the dropper that comes with the bottle or a medication spoon/device to measure the correct dose. Liquid forms of this product may be mixed in water, milk, formula, or juice before taking. Do not use this medication if the solution turns brownish-yellow.

Dosage is based on your medical condition and response to therapy. In children, dosage is also based on age. Do not increase your dose, take it more often, or take it for longer than prescribed or recommended because of the increased risk of side effects.

In a radiation emergency, take this drug only when public health and safety officials tell you to do so. Read the Patient Information Leaflet that comes with the medication. Start treatment as soon as possible for the best protection. Take this medication usually once every 24 hours. The length of treatment will be determined by public health and safety officials and depends on several factors (e.g., whether you continue to be exposed to the radiation, and whether you are pregnant, breast-feeding, or have a newborn baby). See also Precautions.

If so directed, use this medication regularly to get the most benefit from it. To help you remember, take it at the same time(s) each day.

Inform your doctor if your condition persists or worsens.

Use: Labeled Indications

Pyridoxine hydrochloride (Lupifit) deficiency: Treatment and prevention of Pyridoxine hydrochloride (Lupifit) (vitamin B) deficiency.

Off Label Uses

Ethylene glycol poisoning

The American Academy of Clinical Toxicology guidelines recognize the lack of human clinical data for this use and consider Pyridoxine hydrochloride (Lupifit) as an adjunctive cofactor therapy in ethylene glycol poisoning without a formal or evidence-based recommendation, especially in patients who may have vitamin deficiencies (eg, patients with alcoholism). Additional data may be necessary to further define the role of Pyridoxine hydrochloride (Lupifit) in this condition.

Peripheral neuropathy associated with isoniazid therapy for Mycobacterium tuberculosis (prevention)

Based on the Department of Health and Human Services (DHHS) Guidelines for the Prevention and Treatment of Opportunistic Infections in HIV-Infected Adults and Adolescents, Pyridoxine hydrochloride (Lupifit) is effective and recommended in the prevention of peripheral neuropathy associated with isoniazid therapy for Mycobacterium tuberculosis.

Riboflavin (Lupifit) (Riboflavin (Lupifit)) supplementation is used to prevent and treat Riboflavin (Lupifit) deficiency. Riboflavin (Lupifit) may prevent migraine headaches at high doses and be useful for prevention of eye conditions such as cataract, glaucoma and tired eyes (fatigue). Riboflavin (Lupifit) is also used for boosting of immune system, and maintenance of healthy hair, skin, nails and mucous membranes.

Sodium selenite (Lupifit) is used as a dietary supplement mainly in the treatment of Sodium selenite (Lupifit) deficiency affecting young women and children with Keshan disease. It is also used for treatment of osteoarthiritis associated with poor Sodium selenite (Lupifit) levels in body called Kashin-Beck Disease. Sodium selenite (Lupifit) supplements are also used in patients with HIV/ AIDS to maintain the adequate Sodium selenite (Lupifit) levels.

Vitamin A (Lupifit) is used to prevent or treat low levels of the vitamin in people who do not get enough of it from their diets. Most people who eat a normal diet do not need extra Vitamin A (Lupifit). However, some conditions (such as protein deficiency, diabetes, hyperthyroidism, liver/pancreas problems) can cause low levels of Vitamin A (Lupifit). Vitamin A (Lupifit) plays an important role in the body. It is needed for growth and bone development and to maintain the health of the skin and eyesight. Low levels of Vitamin A (Lupifit) may cause vision problems (such as night blindness) and permanent eye damage.

How to use Vitamin A (Lupifit)

Take this vitamin by mouth with or without food, usually once daily. Follow all directions on the product package, or take as directed by your doctor. If you are uncertain about any of the information, consult your doctor or pharmacist.

If you are using the liquid form of this medication, carefully measure the dose using a special measuring device/spoon. Do not use a household spoon because you may not get the correct dose.

Dosage is based on your age, medical condition, and response to treatment.

Use this vitamin regularly to get the most benefit from it. To help you remember, take it at the same time each day. Do not increase your dose or use this vitamin more often than recommended. Your condition will not improve any faster, and your risk of side effects will increase.

Tell your doctor if your condition persists or worsens. If you think you may have a serious medical problem, seek immediate medical attention.

See also:
What other drugs will affect Ascorbic acid (Lupifit)?

In an application with barbiturates, primidone increases the excretion of Ascorbic acid (Lupifit) in the urine.

With the simultaneous use of oral contraceptives reduces the concentration of Ascorbic acid (Lupifit) in blood plasma.

In an application of Rhea Ascorbic acid (Lupifit) with iron preparations Ascorbic acid (Lupifit), due to its regenerative properties, transforms ferric iron in the bivalent, which improves its absorption.

Ascorbic acid (Lupifit) in high doses can decrease urine pH that while the application reduces the tubular reabsorption of amphetamine and tricyclic antidepressants.

With the simultaneous use of aspirin reduces the absorption of Ascorbic acid (Lupifit) by about a third.

Rhea Ascorbic acid (Lupifit) in an application with warfarin may decrease effects of warfarin.

With the simultaneous application of Ascorbic acid (Lupifit) increases the excretion of iron in patients receiving deferoxamine. In the application of Ascorbic acid (Lupifit) at a dose of 500 mg / day possibly left ventricular dysfunction.

In an application with tetracycline is increased excretion of Ascorbic acid (Lupifit) in the urine.

There is a described case of reducing the concentration of fluphenazine in plasma in patients treated with Ascorbic acid (Lupifit) 500 mg 2 times / day.

May increase the concentration of ethinyl estradiol in the blood plasma in its simultaneous application in the oral contraceptives.

See also:
What other drugs will affect Biotin (Lupifit)?

The anticonvulsants carbamazepine, phenytoin, Phenobarbital, and primidone may accelerate Biotin (Lupifit) metabolism, leading to a reduction in available Biotin (Lupifit). Chronic use of these drugs has been associated with decreased plasma concentrations of Biotin (Lupifit).

The use of antibiotics may reduce the contribution of Biotin (Lupifit) made by bacteria within the large intestine.

Dextropanthenyl alcohol in combination with hydrocortisone may be more effective than topical hydrocortisone alone in some dermatoses.

See also:
What other drugs will affect Cholecalciferol (Lupifit)?

Interactions for vitamin D analogues (Vitamin D2, Cholecalciferol (Lupifit), Calcitriol, and Calcidiol)

Cholestyramine

Cholestyramine has been reported to reduce intestinal absorption of fat soluble vitamins; as such it may impair intestinal absorption of any of vitamin D

Phenytoin/Phenobarbital

The coadministration of phenytoin or phenobarbital will not affect plasma concentrations of vitamin D, but may reduce endogenous plasma levels of calcitriol/ergocalcitriol by accelerating metabolism. Since blood level of calcitriol/ergocalcitriol will be reduced, higher doses of Rocaltrol may be necessary if these drugs are administered simultaneously

Thiazides

Thiazides are known to induce hypercalcemia by the reduction of Cholecalciferol (Lupifit) excretion in urine. Some reports have shown that the concomitant administration of thiazides with vitamin D causes hypercalcemia. Therefore, precaution should be taken when coadministration is necessary

Digitalis

Vitamin D dosage must be determined with care in patients undergoing treatment with digitalis, as hypercalcemia in such patients may precipitate cardiac arrhythmias

Ketoconazole

Ketoconazole may inhibit both synthetic and catabolic enzymes of vitamin D. Reductions in serum endogenous vitamin D concentrations have been observed following the administration of 300 mg/day to 1200 mg/day ketoconazole for a week to healthy men. However, in vivo drug interaction studies of ketoconazole with vitamin D have not been investigated

Corticosteroids

A relationship of functional antagonism exists between vitamin D analogues, which promote Cholecalciferol (Lupifit) absorption, and corticosteroids, which inhibit Cholecalciferol (Lupifit) absorption

Phosphate-Binding Agents

Since vitamin D also has an effect on phosphate transport in the intestine, kidneys and bones, the dosage of phosphate-binding agents must be adjusted in accordance with the serum phosphate concentration

Vitamin D

The coadministration of any of the vitamin D analogues should be avoided as this could create possible additive effects and hypercalcemia

Cholecalciferol (Lupifit) Supplements

Uncontrolled intake of additional Cholecalciferol (Lupifit)-containing preparations should be avoided

Magnesium

Magnesium-containing preparations (eg, antacids) may cause hypermagnesemia and should therefore not be taken during therapy with vitamin D by patients on chronic renal dialysis.

Large doses of zinc supplements may inhibit the gastrointestinal absorption of copper

See also:
What other drugs will affect Cyanocobalamin (Lupifit)?

The effects of some drugs can change if you take other drugs or herbal products at the same time. This can increase your risk for serious side effects or may cause your medications not to work correctly. These drug interactions are possible, but do not always occur. Your doctor or pharmacist can often prevent or manage interactions by changing how you use your medications or by close monitoring.

To help your doctor and pharmacist give you the best care, be sure to tell your doctor and pharmacist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products) before starting treatment with this product. While using this product, do not start, stop, or change the dosage of any other medicines you are using without your doctor's approval.

Some products that may interact with this drug include: drugs that affect the bone marrow (such as chloramphenicol), vitamins/supplements that contain intrinsic factor.

Certain medications can decrease the absorption of vitamin B12, including: colchicine, metformin, extended-release potassium products, antibiotics (such as gentamicin, neomycin, tobramycin), anti-seizure medications (such as phenobarbital, phenytoin, primidone), medications to treat heartburn (such as H2 blockers including cimetidine/famotidine, proton pump inhibitors such as omeprazole/lansoprazole).

Vitamin B12 is an ingredient found in many combination vitamin and nutritional products. Tell your doctor or pharmacist if you are taking other products that contain Cyanocobalamin (Lupifit), vitamin B12, or hydroxocobalamin.

Cyanocobalamin (Lupifit) may interfere with certain laboratory tests (including intrinsic factor, blood tests for other types of anemia), possibly causing false test results. Make sure laboratory personnel and all your doctors know you use this drug.

Certain drugs may interfere with laboratory tests for vitamin B12 levels, possibly causing false results. Tell laboratory personnel and all your doctors if you take any of the following: antibiotics (such as amoxicillin, erythromycin), methotrexate, pyrimethamine.

This document does not contain all possible drug interactions. Keep a list of all the products you use. Share this list with your doctor and pharmacist to lessen your risk for serious medication problems.

See also:
What other drugs will affect Folic acid (Lupifit)?

Medications that interfere with your bodys ability to use folate may also increase the need for this vitamin. Medications can interfere with folate utilization, including: anticonvulsant medications (such as phenytoin, and primidone) metformin (sometimes prescribed to control blood sugar in type 2 diabetes) sulfasalazine (used to control inflammation associated with Crohns disease and ulcerative colitis) triamterene (a diuretic) Methotrexate There has been concern about the interaction between vitamin B12 and Folic acid (Lupifit). Folic acid (Lupifit) supplements can correct the anemia associated with vitamin B12 deficiency. Unfortunately, Folic acid (Lupifit) will not correct changes in the nervous system that result from vitamin B12 deficiency. Permanent nerve damage could theoretically occur if vitamin B12 deficiency is not treated. Therefore, intake of supplemental Folic acid (Lupifit) should not exceed 1000 micrograms (g, sometimes mcg) per day to prevent Folic acid (Lupifit) from masking symptoms of vitamin B12 deficiency. It is important for older adults to be aware of the relationship between Folic acid (Lupifit) and vitamin B12 because they are at greater risk of having a vitamin B12 deficiency. If you are 50 years of age or older, ask your physician to check your B12 status before you take a supplement that contains Folic acid (Lupifit).

There is no report to indicate the interaction with other drug.

See also:
What other drugs will affect L-tryptophan (Lupifit)?

Monoamine oxidase (MAO) inhibitors such as isocarboxazid (e.g., Marplan), phenelzine (e.g., Nardil), procarbazine (e.g., Matulane), selegiline (e.g., Eldepryl), and tranylcypromine (e.g., Parnate): Using these medicines with L-tryptophan (Lupifit) may increase the chance of side effects.

See also:
What other drugs will affect Magnesium sulphate (Lupifit)?

CNS Depressants— When barbiturates, narcotics or other hypnotics (or systemic anesthetics), or other CNS depressants are to be given in conjunction with Magnesium sulphate (Lupifit), their dosage should be adjusted with caution because of additive CNS depressant effects of Magnesium sulphate (Lupifit). CNS depression and peripheral transmission defects produced by Magnesium sulphate (Lupifit) may be antagonized by Magnesium sulphate (Lupifit).

Neuromuscular Blocking Agents— Excessive neuromuscular block has occurred in patients receiving parenteral Magnesium sulphate (Lupifit) sulfate and a neuromuscular blocking agent; these drugs should be administered concomitantly with caution.

Cardiac Glycosides— Magnesium sulphate (Lupifit) Sulfate should be administered with extreme caution in digitalized patients, because serious changes in cardiac conduction which can result in heart block may occur if administration of Magnesium sulphate (Lupifit) is required to treat Magnesium sulphate (Lupifit) toxicity.

Nicotinamide (Lupifit): The clearance of primidone and carbamazepine may be reduced with the concomitant use of Nicotinamide (Lupifit).

Zinc Oxide: The absorption of quinolones or tetracycline may be decreased with the concomitant use of zinc.

Cupric Oxide: Concomitant use of penicillamine and copper can cause decreased absorption of both substances.

See also:
What other drugs will affect Potassium iodide (Lupifit)?

Your doctor or pharmacist may already be aware of any possible drug interactions and may be monitoring you for them. Do not start, stop, or change the dosage of any medicine before checking with your doctor or pharmacist first.

Before using this medication, tell your doctor or pharmacist of all prescription and nonprescription/herbal products you may use, especially of: ACE inhibitors (e.g., captopril, lisinopril), angiotensin receptor blockers (ARBs such as losartan, valsartan), certain "water pills" (potassium-sparing diuretics such as amiloride, spironolactone, triamterene), drospirenone, eplerenone, lithium, potassium-containing drugs (e.g., supplements such as potassium chloride).

This document does not contain all possible interactions. Therefore, before using this product, tell your doctor or pharmacist of all the products you use. Keep a list of all your medications with you, and share the list with your doctor and pharmacist.

See also:
What other drugs will affect Pyridoxine hydrochloride (Lupifit)?

Cycloserine, isoniazid, hydralazine, oral contraceptives, penicillamine

Increased need for Pyridoxine hydrochloride (Lupifit).

Levodopa

Decreased effect of levodopa. (Interaction does not occur with levodopa/carbidopa in combination with Pyridoxine hydrochloride (Lupifit).)

Phenytoin

Phenytoin serum levels may be decreased.

Incompatibility

Incompatible with alkaline solutions, iron salts and oxidizing agents (parenteral).

Laboratory Test Interactions

May result in false-positive urobilinogen in the spot test using Ehrlich reagent.

See also:
What other drugs will affect Riboflavin (Lupifit)?

Interactions for Riboflavin (Lupifit) (Riboflavin (Lupifit))

Alcohol - impairs the intestinal absorption of riboflavi

Antidepressants (tricyclics or phenothiazines) - requirements for Riboflavin (Lupifit) may be increased in patients receiving these medications

Probenecid - concurrent use decreases gastrointestinal absorption of Riboflavin (Lupifit); requirements for Riboflavin (Lupifit) may be increased in patients receiving probenecid.

See also:
What other drugs will affect Sodium selenite (Lupifit)?

Baloxavir Marboxil: Polyvalent Cation Containing Products may decrease the serum concentration of Baloxavir Marboxil. Avoid combination

Bictegravir: Polyvalent Cation Containing Products may decrease the serum concentration of Bictegravir. Management: Administer bictegravir under fasting conditions at least 2 hours before or 6 hours after polyvalent cation containing products. Coadministration of bictegravir with or 2 hours after most polyvalent cation products is not recommended. Consider therapy modification

Bisphosphonate Derivatives: Polyvalent Cation Containing Products may decrease the serum concentration of Bisphosphonate Derivatives. Management: Avoid administration of oral medications containing polyvalent cations within: 2 hours before or after tiludronate/clodronate/etidronate; 60 minutes after oral ibandronate; or 30 minutes after alendronate/risedronate. Exceptions: Pamidronate; Zoledronic Acid. Consider therapy modification

Deferiprone: Polyvalent Cation Containing Products may decrease the serum concentration of Deferiprone. Management: Separate administration of deferiprone and oral medications or supplements that contain polyvalent cations by at least 4 hours. Consider therapy modification

Dolutegravir: Sodium selenite (Lupifit) may decrease the serum concentration of Dolutegravir. Management: Administer dolutegravir at least 2 hours before or 6 hours after oral Sodium selenite (Lupifit). Administer the dolutegravir/rilpivirine combination product at least 4 hours before or 6 hours after oral Sodium selenite (Lupifit). Consider therapy modification

Eltrombopag: Polyvalent Cation Containing Products may decrease the serum concentration of Eltrombopag. Management: Administer eltrombopag at least 2 hours before or 4 hours after oral administration of any polyvalent cation containing product. Consider therapy modification

Elvitegravir: Polyvalent Cation Containing Products may decrease the serum concentration of Elvitegravir. Management: Administer elvitegravir 2 hours before or 6 hours after the administration of polyvalent cation containing products. Consider therapy modification

PenicillAMINE: Polyvalent Cation Containing Products may decrease the serum concentration of PenicillAMINE. Management: Separate the administration of penicillamine and oral polyvalent cation containing products by at least 1 hour. Consider therapy modification

Raltegravir: Polyvalent Cation Containing Products may decrease the serum concentration of Raltegravir. Management: Administer raltegravir 2 hours before or 6 hours after administration of the polyvalent cations. Dose separation may not adequately minimize the significance of this interaction. Consider therapy modification

Trientine: Polyvalent Cation Containing Products may decrease the serum concentration of Trientine. Management: Avoid concomitant administration of trientine and oral products that contain polyvalent cations. If oral iron supplements are required, separate the administration by 2 hours. If other oral polyvalent cations are needed, separate administration by 1 hour. Consider therapy modification

none known

See also:
What other drugs will affect Vitamin A (Lupifit)?

The effects of some drugs can change if you take other drugs or herbal products at the same time. This can increase your risk for serious side effects or may cause your medications not to work correctly. These drug interactions are possible, but do not always occur. Your doctor or pharmacist can often prevent or manage interactions by changing how you use your medications or by close monitoring.

To help your doctor and pharmacist give you the best care, be sure to tell your doctor and pharmacist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products) before starting treatment with this product. While using this product, do not start, stop, or change the dosage of any other medicines you are using without your doctor's approval.

Some products that may interact with this vitamin include: acitretin, alitretinoin, bexarotene, cholestyramine, isotretinoin, tretinoin, other products that contain Vitamin A (Lupifit) (such as multivitamins), warfarin.

Avoid taking Vitamin A (Lupifit) at the same time as you take neomycin, orlistat, and mineral oil. If you take any of these medications, separate your doses from your dose of Vitamin A (Lupifit) by at least 2 hours.

This document does not contain all possible drug interactions. Keep a list of all the products you use. Share this list with your doctor and pharmacist to lessen your risk for serious medication problems.

See also:
What other drugs will affect Zinc sulphate (Lupifit)?

Before using this medication, tell your doctor or pharmacist of all prescription and nonprescription products you may use, especially of: penicillamine, quinolone antibiotics (e.g., ciprofloxacin), tetracyclines, phosphorus containing products

See also:
What are the possible side effects of Ascorbic acid (Lupifit)?

Applies to Ascorbic acid (Lupifit): oral capsule, oral capsule extended release, oral capsule liquid filled, oral granule, oral liquid, oral lozenge/troche, oral powder, oral powder for solution, oral powder for suspension, oral solution, oral syrup, oral tablet, oral tablet chewable, oral tablet extended release, oral wafer

In addition to its needed effects, some unwanted effects may be caused by Ascorbic acid (Lupifit) (the active ingredient contained in Ascorbic acid (Lupifit) Quick Melts). In the event that any of these side effects do occur, they may require medical attention.

Severity: Moderate

If any of the following side effects occur while taking Ascorbic acid (Lupifit), check with your doctor or nurse as soon as possible:

Less common or rare: - with high doses

• Side or lower back pain

Minor Side Effects

Some of the side effects that can occur with Ascorbic acid (Lupifit) may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. If any of the following side effects continue, are bothersome or if you have any questions about them, check with your health care professional:

Less common or rare: - with high doses

• Diarrhea
• dizziness or faintness (with the injection only)
• flushing or redness of skin
• headache
• increase in urination (mild)
• nausea or vomiting
• stomach cramps

See also:
What are the possible side effects of Biotin (Lupifit)?

Adverse reactions associated with Biotin (Lupifit) supplementation are rare in the medical literature; however, urticaria and gastrointestinal upset have been reported. As with any oral treatment, if patients experience any adverse reactions or side effects, they should inform their physicians immediately and discontinue use.

See also:
What are the possible side effects of Calcium pantothenate (Lupifit)?

Cardiovascular

Nasal spray

Angina pectoris, hypertension (1% to 3%).

CNS

Nasal spray: Fatigue, depression, dizziness, paresthesia (1% to 3%). Injectable: Poor appetite; abdominal pain.

Dermatologic

Nasal spray

Erythematous rash (1% to 3%).

Injectable

Pruritus of ear lobes; skin rash.

EENT

Nasal spray

Rhinitis (12%); abnormal lacrimation, conjunctivitis (1% to 3%).

Injectable

Eye pain.

GI

Nasal spray

Abdominal pain, constipation, diarrhea, dyspepsia, nausea (1% to 3%).

Injectable

Nausea with or without vomiting (10%); salty taste.

Genitourinary

Nasal spray

Cystitis (1% to 3%).

Injectable

Nocturia.

Hematologic-Lymphatic

Nasal spray

Infection, lymphadenopathy (1% to 3%).

Local

Injectable

Inflammation at subcutaneous or IM site (10%).

Musculoskeletal

Nasal spray

Back pain (5%); arthralgia (4%); arthrosis, myalgia (1% to 3%).

Respiratory

Nasal spray

Epistaxis (4%); bronchospasm, sinusitis, upper respiratory tract infection (1% to 3%).

Miscellaneous

Nasal spray

Influenza-like symptoms (1% to 3%).

Injectable

Death caused by anaphylaxis (1 case), feet edema, feverish sensation.

See also:
What are the possible side effects of Cholecalciferol (Lupifit)?

Applies to Cholecalciferol (Lupifit): oral capsule, oral capsule liquid filled, oral solution, oral suspension, oral tablet, oral tablet chewable, oral wafer

Along with its needed effects, Cholecalciferol (Lupifit) (the active ingredient contained in Cholecalciferol (Lupifit)) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking Cholecalciferol (Lupifit):

Incidence Not Known

• Cough
• difficulty swallowing
• dizziness
• fast heartbeat
• hives or itching
• puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
• skin rash
• tightness in the chest
• unusual tiredness or weakness

Adverse effects from copper have tended to arise after absorption of the metal from cooking utensils and during dialysis. Ingestion of copper from cooking utensils is associated mainly with hepatotoxicity. Dialysis procedures may supply copper through the water supply or from parts of the equipment and when this happens patients may suffer haemolysis and other haematological reactions with kidney involvement as well as hepatotoxicity; the toxicity is generally a result of poor equipment maintenance.

Adverse effects attributed to copper have been reported in women with copper-containing intra-uterine devices. There have been isolated case reports of various effects such as allergy and endometrial changes. However, with these devices it is difficult to separate those adverse effects that are due to the device from those due solely to the copper.

The symptoms of Wilson’s disease (hepatolenticular degeneration) are due to an accumulation of copper in various parts of the body.

Copper salts if ingested can produce severe gastrointestinal effects and there may be systemic absorption of copper leading to the effects discussed above. The use of sprays of copper salts in agriculture has been associated with lung changes. Treatment of copper poisoning is symptomatic and may involve the use of a chelating agent to remove any absorbed metal. Dialysis has been tried

See also:
What are the possible side effects of Cyanocobalamin (Lupifit)?

The incidence of adverse experiences described in the Table below are based on data from a short-term clinical trial in vitamin B12 deficient patients in hematologic remission receiving Cyanocobalamin (Lupifit) (Cyanocobalamin (Lupifit), USP) Gel for Intranasal Administration (N=24) and intramuscular vitamin B12 (N=25). In the pharmacokinetic study comparing Cyanocobalamin (Lupifit) Nasal Spray and Cyanocobalamin (Lupifit) Nasal Gel, the incidence of adverse events was similar.

The intensity of the reported adverse experiences following the administration of Cyanocobalamin (Lupifit) (Cyanocobalamin (Lupifit), USP) Gel for Intranasal Administration and intramuscular vitamin B12 were generally mild. One patient reported severe headache following intramuscular dosing. Similarly, a few adverse experiences of moderate intensity were reported following intramuscular dosing (two headaches and rhinitis; one dyspepsia, arthritis, and dizziness), and dosing with Cyanocobalamin (Lupifit) (Cyanocobalamin (Lupifit), USP) Gel for Intranasal Administration (one headache, infection, and paresthesia).

The majority of the reported adverse experiences following dosing with Cyanocobalamin (Lupifit) (Cyanocobalamin (Lupifit), USP) Gel for Intranasal Administration and intramuscular vitamin B12 were judged to be intercurrent events. For the other reported adverse experiences, the relationship to study drug was judged as "possible" or "remote". Of the adverse experiences judged to be of "possible" relationship to the study drug, anxiety, incoordination, and nervousness were reported following intramuscular vitamin B12 and headache, nausea, and rhinitis were reported following dosing with Cyanocobalamin (Lupifit) (Cyanocobalamin (Lupifit), USP) Gel for Intranasal Administration.

The following adverse reactions have been reported with parenteral vitamin B12:

Generalized: Anaphylactic shock and death.

Cardiovascular: Pulmonary edema and congestive heart failure early in treatment; peripheral vascular thrombosis.

Hematological: Polycythemia vera.

Gastrointestinal: Mild transient diarrhea.

Dermatological: Itching; transitory exanthema.

Miscellaneous: Feeling of swelling of the entire body.

See also:
What are the possible side effects of Folic acid (Lupifit)?

Allergic sensitization has been reported following both oral and parenteral administration of Folic acid (Lupifit).

Folic acid (Lupifit) is relatively nontoxic in man. Rare instances of allergic responses to Folic acid (Lupifit) preparations have been reported and have included erythema, skin rash, itching, general malaise, and respiratory difficulty due to bronchospasm. One patient experienced symptoms suggesting anaphylaxis following injection of the drug. Gastrointestinal side effects, including anorexia, nausea, abdominal distention, flatulence, and a bitter or bad taste, have been reported in patients receiving 15 mg Folic acid (Lupifit) daily for 1 month. Other side effects reported in patients receiving 15 mg daily include altered sleep patterns, difficulty in concentrating, irritability, overactivity, excitement, mental depression, confusion, and impaired judgment. Decreased vitamin B12 serum levels may occur in patients receiving prolonged Folic acid (Lupifit) therapy.

In an uncontrolled study, orally administered Folic acid (Lupifit) was reported to increase the incidence of seizures in some epileptic patients receiving phenobarbital, primidone, or diphenylhydantoin. Another investigator reported decreased diphenylhydantoin serum levels in folate-deficient patients receiving diphenylhydantoin who were treated with 5 mg or 15 mg of Folic acid (Lupifit) daily.

CALL YOUR DOCTOR FOR MEDICAL ADVICE ABOUT SIDE EFFECTS. YOU MAY REPORT SIDE EFFECTS TO THE FDA AT 1-800-FDA-1088 OR LEADING PHARMA, LLC AT 844-740-7500.

Among 243 cases studied prior to the time of approval, 9 adverse reactions (3.7%) were reported in 9 cases (3.7%). The commonly reported adverse reactions by the time of approval included nausea or queasy (0.8% each), sweaty, increased transient blood ammonia level, vascular pain, urticaria, tremor limb by hypoglycaemia (0.4% each).

Pellagra, Dermatitis, Diarrhoea

Nausea, Abdominal cramp, Diarrhoea

Brain death, Increased homocysteine in blood, Brain injury, Cardiac disorder

Rarely: <0.1%; infrequently: 0.1% to <5%; no specific designation: 5%; frequency unknown.

Clinically Significant Adverse Reactions: Hypoglycemia: Hypoglycemia may occur. If the patient develops hypoglycemia, glucose should be administered promptly by intravenous infusion. In addition, appropriate nutrition management is required in such patients.

Hyperammonemia: Hyperammonemia has been reported. If the patient develops persistent hyperammonemia during the administration of Aminoleban, discontinue administration and take measures to eliminate other nitrogen sources.

Other Adverse Reactions: Hypersensitivity: Symptoms eg, skin rash may occur rarely. In the event of skin rash, discontinue the administration and institute appropriate treatment.

Gastrointestinal: Symptoms eg, nausea and vomiting may occur infrequently.

Cardiovascular: Symptoms eg, chest discomfort and palpitation may occur infrequently.

Metabolic: The nitrogen content of this preparation may induce a transient increase in blood ammonia concentrations.

Large Dose and Rapid Administration: Acidosis may occur when large doses are administered rapidly.

Others: Chills, fever, headache and vascular pain may infrequently occur.

See also:
What are the possible side effects of L-tryptophan (Lupifit)?

Nausea, loss of appetite, dizziness, drowsiness, headache, or dry mouth may occur. If any of these effects persist or worsen, tell your doctor or pharmacist promptly.

If your doctor has prescribed this medication, remember that he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

Tell your doctor right away if any of these rare but very serious side effects occur: muscle stiffness/spasms, severe muscle aches/pain, unusual/inappropriate sexual urges, shakiness (tremor), unusual weakness.

This medication may increase serotonin and rarely cause a very serious condition called serotonin syndrome/toxicity. The risk increases if you are also taking other drugs that increase serotonin, so tell your doctor or pharmacist of all the drugs you take. Get medical help right away if you develop some of the following symptoms:

fast heartbeat, hallucinations, loss of coordination, severe dizziness, severe nausea/vomiting/diarrhea, twitching muscles, unexplained fever, unusual agitation/restlessness.

A very serious allergic reaction to this drug is rare. However, seek immediate medical attention if you notice any of the following symptoms of a serious allergic reaction: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.

This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

In the US -

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch.

In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.

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What are the possible side effects of Magnesium sulphate (Lupifit)?

The adverse effects of parenterally administered Magnesium sulphate (Lupifit) usually are the result of Magnesium sulphate (Lupifit) intoxication. These include flushing, sweating, hypotension, depressed reflexes, flaccid paralysis, hypothermia, circulatory collapse, cardiac and central nervous system depression proceeding to respiratory paralysis. Hypocalcemia with signs of tetany secondary to Magnesium sulphate (Lupifit) sulfate therapy for eclampsia has been reported.

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What are the possible side effects of Manganese sulfate (Lupifit)?

Adverse reactions to manganese at the dosage levels recommended have not been reported.

Allergic sensitization has been reported rarely following oral and parenteral administration of Nicotinamide (Lupifit).

At recommended doses, Nicotinamide (Lupifit) is expected to be well tolerated. Gastrointestinal distress such as nausea or vomiting have been associated with the administration of Nicotinamide (Lupifit) or zinc at doses greater than the recommended dose of Nicotinamide (Lupifit)

Nicotinamide (Lupifit): Dizziness, headache, hyperglycemia, nausea, vomiting, diarrhea, elevations in liver function tests, hepatotoxicity, blurred vision, flushing, rash.

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What are the possible side effects of Potassium iodide (Lupifit)?

Applies to Potassium iodide (Lupifit): oral solution, oral syrup

In addition to its needed effects, some unwanted effects may be caused by Potassium iodide (Lupifit) (the active ingredient contained in Potassium iodide (Lupifit)). In the event that any of these side effects do occur, they may require medical attention.

Severity: Moderate

If any of the following side effects occur while taking Potassium iodide (Lupifit), check with your doctor or nurse as soon as possible:

Less common:

• Hives
• joint pain
• swelling of arms, face, legs, lips, tongue, and/or throat
• swelling of lymph glands

• Burning of mouth or throat
• confusion
• headache (severe)
• increased watering of mouth
• irregular heartbeat
• metallic taste
• numbness, tingling, pain or weakness in hands or feet
• soreness of teeth and gums
• sores on skin
• symptoms of head cold
• unusual tiredness
• weakness or heaviness of legs

Minor Side Effects

Some of the side effects that can occur with Potassium iodide (Lupifit) may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. If any of the following side effects continue, are bothersome or if you have any questions about them, check with your health care professional:

Less common:

• Diarrhea
• nausea or vomiting
• stomach pain

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What are the possible side effects of Pyridoxine hydrochloride (Lupifit)?

CNS

Neuropathy; unstable gait; drowsiness; somnolence.

EENT

Perioral numbness.

Miscellaneous

Numbness of feet; decreased sensation to touch, temperature or vibration; paresthesia; low serum Pyridoxine hydrochloride (Lupifit) levels; burning/stinging at IM injection site; photoallergic reaction; ataxia.

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What are the possible side effects of Riboflavin (Lupifit)?

Adverse Reactions

Frequency not defined: Genitourinary: Urine discoloration (yellow-orange)

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What are the possible side effects of Sodium selenite (Lupifit)?

The amount of Sodium selenite (Lupifit) present in Sodium selenite (Lupifit) Injection is small. Symptoms of toxicity from Sodium selenite (Lupifit) are unlikely to occur at the recommended dosage level.

anaphylactic reactions rarely, severe cases can cause death, urine yellow colouration,peripheral neuropathy in case of prolonged useage, arrythmias,

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What are the possible side effects of Vitamin A (Lupifit)?

This vitamin usually has no side effects when used in recommended doses. If you have any unusual effects, contact your doctor or pharmacist promptly.

A very serious allergic reaction to this vitamin is rare. However, seek immediate medical attention if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.

This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

In the US -

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch.

In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.

See also:
What are the possible side effects of Zinc sulphate (Lupifit)?

Nausea, stomach upset, heartburn may occur. If any of these effects persist or worsen, notify your doctor or pharmacist promptly. Tell your doctor immediately if any of these unlikely but serious side effects occur: fever, chills, sore throat, sores in mouth, unusual tiredness, weakness