Loteprednol and tobramycin

inflammatory eye infections

Loteprednol (Loteprednol and Tobramycin (Loteprednol and tobramycin)) and Tobramycin (Loteprednol and tobramycin) ophthalmic (eye) solution or drops is used to treat inflammation or swelling in the eye that is caused by a bacterial infection.

Loteprednol (Loteprednol and Tobramycin (Loteprednol and tobramycin)) and Tobramycin (Loteprednol and tobramycin) solution is a combination of a steroid (Loteprednol (Loteprednol and Tobramycin (Loteprednol and tobramycin))) and an antibiotic (Tobramycin (Loteprednol and tobramycin)). Loteprednol (Loteprednol and Tobramycin (Loteprednol and tobramycin)) reduces swelling and inflammation. Tobramycin (Loteprednol and tobramycin) works by killing the bacteria or preventing it from growing.

Loteprednol (Loteprednol and Tobramycin (Loteprednol and tobramycin)) and Tobramycin (Loteprednol and tobramycin) is available only with your doctor's prescription.

• Loteprednol and tobramycin drops may cause blurred vision. Use Loteprednol and tobramycin drops with caution. Do not drive or perform other possibly unsafe tasks if you cannot see clearly.
• If your symptoms do not get better after 2 days or if they get worse, contact your health care provider.
• Soft contact lenses may absorb a chemical in Loteprednol and tobramycin drops. Do not wear contact lenses while you are using Loteprednol and tobramycin drops.
• Tell your doctor or dentist that you take Loteprednol and tobramycin drops before you receive any medical or dental care, emergency care, or surgery.
• Loteprednol and tobramycin drops only works against bacteria; it does not treat viral infections (eg, the common cold).
• Be sure to use Loteprednol and tobramycin drops for the full course of treatment. If you do not, the medicine may not clear up your infection completely. The bacteria could also become less sensitive to this or other medicines. This could make the infection harder to treat in the future.
• Long-term or repeated use of Loteprednol and tobramycin drops may cause a second infection. Tell your doctor if signs of a second infection occur. Your medicine may need to be changed to treat this.
• Lab tests, including eye exams, may be performed while you use Loteprednol and tobramycin drops. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.
• PREGNANCY and BREAST-FEEDING: If you think you may be pregnant, contact your doctor. You will need to discuss the benefits and risks of using Loteprednol and tobramycin drops while you are pregnant. It is not known if Loteprednol and tobramycin drops is found in breast milk. If you are or will be breast-feeding while you use Loteprednol and tobramycin drops, check with your doctor. Discuss any possible risks to your baby.

Usual Adult Dose for Uveitis

1 to 2 drops instilled in conjunctival sac of affected eye(s) every 4 to 6 hours

During the initial 24 to 48 hours of treatment, the frequency may be increased to every 1 to 2 hours. As clinical signs improve, the frequency may be decreased gradually. Therapy should not be stopped prematurely.

Approved

Indication: For steroid-responsive inflammatory ocular conditions for which a corticosteroid is indicated and where superficial bacterial ocular infection or a risk of bacterial ocular infection exists.

Usual Adult Dose for Iritis

1 to 2 drops instilled in conjunctival sac of affected eye(s) every 4 to 6 hours

During the initial 24 to 48 hours of treatment, the frequency may be increased to every 1 to 2 hours. As clinical signs improve, the frequency may be decreased gradually. Therapy should not be stopped prematurely.

Approved

Indication: For steroid-responsive inflammatory ocular conditions for which a corticosteroid is indicated and where superficial bacterial ocular infection or a risk of bacterial ocular infection exists.

Usual Adult Dose for Bacterial Conjunctivitis

1 to 2 drops instilled in conjunctival sac of affected eye(s) every 4 to 6 hours

During the initial 24 to 48 hours of treatment, the frequency may be increased to every 1 to 2 hours. As clinical signs improve, the frequency may be decreased gradually. Therapy should not be stopped prematurely.

Approved

Indication: For steroid-responsive inflammatory ocular conditions for which a corticosteroid is indicated and where superficial bacterial ocular infection or a risk of bacterial ocular infection exists.

Usual Adult Dose for Keratitis

1 to 2 drops instilled in conjunctival sac of affected eye(s) every 4 to 6 hours

During the initial 24 to 48 hours of treatment, the frequency may be increased to every 1 to 2 hours. As clinical signs improve, the frequency may be decreased gradually. Therapy should not be stopped prematurely.

Approved

Indication: For steroid-responsive inflammatory ocular conditions for which a corticosteroid is indicated and where superficial bacterial ocular infection or a risk of bacterial ocular infection exists.

Usual Adult Dose for Cyclitis

1 to 2 drops instilled in conjunctival sac of affected eye(s) every 4 to 6 hours

During the initial 24 to 48 hours of treatment, the frequency may be increased to every 1 to 2 hours. As clinical signs improve, the frequency may be decreased gradually. Therapy should not be stopped prematurely.

Approved

Indication: For steroid-responsive inflammatory ocular conditions for which a corticosteroid is indicated and where superficial bacterial ocular infection or a risk of bacterial ocular infection exists.

Renal Dose Adjustments

Data not available

Liver Dose Adjustments

Data not available

Precautions

Loteprednol (Loteprednol and Tobramycin (Loteprednol and tobramycin))-Tobramycin (Loteprednol and tobramycin) ophthalmic is contraindicated in most viral diseases of the cornea and conjunctiva including epithelial herpes simplex keratitis (dendritic keratitis), vaccinia, and varicella, and also in mycobacterial infection of the eye and fungal diseases of ocular structures.

Caution is recommended when used with glaucoma. Intraocular pressure should be monitored if used for 10 days or longer.

Patients should be examined (e.g., slit lamp biomicroscopy and, if appropriate, fluorescein staining) prior to initial and renewed prescription orders. No more than 20 mL should be prescribed initially and the prescription should not be refilled without further evaluation.

In acute purulent eye conditions, Loteprednol (Loteprednol and Tobramycin (Loteprednol and tobramycin))-Tobramycin (Loteprednol and tobramycin) ophthalmic may mask infection or enhance existing infection. Patients should be reevaluated if signs and symptoms do not improve after 2 days.

Extreme caution is recommended when treating patients with history of herpes simplex. Ocular steroid use may prolong the course and exacerbate the severity of many ocular viral infections.

If hypersensitivity occurs with Loteprednol (Loteprednol and Tobramycin (Loteprednol and tobramycin))-Tobramycin (Loteprednol and tobramycin) ophthalmic, use should be discontinued and appropriate therapy started.

Safety and effectiveness have not been established in pediatric patients (less than 18 years of age).

Dialysis

Data not available

Other Comments

Fungus invasion should be considered with any persistent corneal ulceration. Fungal cultures are recommended when appropriate.

Soft contact lenses should not be worn during use of Loteprednol (Loteprednol and Tobramycin (Loteprednol and tobramycin))-Tobramycin (Loteprednol and tobramycin) ophthalmic.

Patients should be instructed to avoid allowing the dropper tip to contact the eye, eyelid, fingers, or any other surface.

Use Loteprednol and tobramycin drops as directed by your doctor. Check the label on the medicine for exact dosing instructions.

• Loteprednol and tobramycin drops is to be used as eye drops. It is not to be injected into the eye.
• Shake well before each use.
• To use Loteprednol and tobramycin drops in the eye, first, wash your hands. Tilt your head back. Using your index finger, pull the lower eyelid away from the eye to form a pouch. Drop the medicine into the pouch and gently close your eyes. Immediately use your finger to apply pressure to the inside corner of the eyelid for 1 to 2 minutes. Do not blink. Remove excess medicine around your eye with a clean, dry tissue, being careful not to touch your eye. Wash your hands to remove any medicine that may be on them.
• To prevent germs from contaminating your medicine, do not touch the applicator tip to any surface, including the eye. Keep the container tightly closed.
• To clear up your infection completely, use Loteprednol and tobramycin drops for the full course of treatment. Keep using it even if you feel better in a few days.
• Loteprednol and tobramycin drops is usually used for a maximum of 2 weeks. If it is used for longer than 10 days, eye exams may be required.
• If you miss a dose of Loteprednol and tobramycin drops, use it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not use 2 doses at once.

Ask your health care provider any questions you may have about how to use Loteprednol and tobramycin drops.

See also:
What are the possible side effects of Loteprednol and tobramycin?

Applies to Loteprednol (Loteprednol and Tobramycin (Loteprednol and tobramycin)) / Tobramycin (Loteprednol and tobramycin) ophthalmic: ophthalmic suspension

In addition to its needed effects, some unwanted effects may be caused by Loteprednol (Loteprednol and Tobramycin (Loteprednol and tobramycin)) / Tobramycin (Loteprednol and tobramycin) ophthalmic. In the event that any of these side effects do occur, they may require medical attention.

Major Side Effects

You should check with your doctor immediately if any of these side effects occur when taking Loteprednol (Loteprednol and Tobramycin (Loteprednol and tobramycin)) / Tobramycin (Loteprednol and tobramycin) ophthalmic:

More common:

• Blurred vision
• change in vision
• feeling like something is in the eye
• increased intraocular pressure
• loss of vision
• pain or irritation of the clear front part of the eye
• sensitivity of the eyes to light

• Blurred vision or seeing blue-green halos around objects
• decreased vision
• difficulty seeing at night
• discharge from the eye
• dry eyes
• eyelid burning, redness, itching, pain, or tenderness
• fast heartbeat
• fever
• hives
• hoarseness
• irritation and swelling of the eye
• itching
• joint pain
• lid itching and swelling
• pain in the eye
• rash
• redness of the eyelid
• redness of the skin
• shortness of breath
• stiffness or swelling
• swelling of the eyelids, face, lips, hands, or feet
• tightness in the chest
• troubled breathing or swallowing
• wheezing

• Redness of the eye
• tearing

Minor Side Effects

Some of the side effects that can occur with Loteprednol (Loteprednol and Tobramycin (Loteprednol and tobramycin)) / Tobramycin (Loteprednol and tobramycin) ophthalmic may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. If any of the following side effects continue, are bothersome or if you have any questions about them, check with your health care professional:

More common:

• Burning of the eye
• headache
• increased sensitivity of the eyes to light
• stinging of the eye