Lotel

Lotel etabonate is indicated for the treatment of steroid responsive inflammatory conditions of the palpebral and bulbar conjunctiva, cornea and anterior segment of the globe such as allergic conjunctivitis, acne rosacea, superficial punctate keratitis, herpes zoster keratitis, iritis, cyclitis, selected infective conjunctivitides, when the inherent hazard of steroid use is accepted to obtain an advisable diminution in edema and inflammation.

Lotel etabonate is less effective than prednisolone acetate 1% in two 28-day controlled clinical studies in acute anterior uveitis, where 72% of patients treated with Lotel etabonate experienced resolution of anterior chamber cells, compared to 87% of patients treated with prednisolone acetate 1%. The incidence of patients with clinically significant increases in IOP (≥10 mmHg) was 1% with Lotel etabonate and 6% with prednisolone acetate 1%. Lotel etabonate should not be used in patients who require a more potent corticosteroid for this indication.

Lotel etabonate is also indicated for the treatment of post-operative inflammation following ocular surgery.

Lotel is used to treat eye pain, redness, and swelling caused by certain eye problems or eye surgery. It is also used to temporarily treat itching of the eye caused by a condition known as seasonal allergic conjunctivitis. Lotel belongs to the group of medicines known as corticosteroids (steroids or cortisone-like medicines).

Lotel is available only with your doctor's prescription.

Usual Adult Dose for Seasonal Allergic Conjunctivitis

0.2% suspension: 1 drop instilled into the affected eye(s) four times per day

Comments:

-Shake well before using.

Use: Temporary relief of the signs and symptoms of seasonal allergic conjunctivitis

Usual Adult Dose for Acne Rosacea

0.5% suspension:1 to 2 drops instilled into the conjunctival sac of the affected eye four times per day

Comments:

-Shake well before using.

-During the initial treatment within the first week, the dosing may be increased, up to 1 drop every hour, if needed.

-Care should be taken not to discontinue therapy prematurely.

-If signs and symptoms fail to improve after two days, the patient should be re-evaluated.

Use: Treatment of steroid responsive inflammatory conditions of the palpebral and bulbar conjunctiva, cornea and anterior segment of the globe such as allergic conjunctivitis, acne rosacea, superficial punctate keratitis, herpes zoster keratitis, iritis, cyclitis, selected infective conjunctivitis, when the inherent hazard of steroid use is accepted to obtain an advisable diminution in edema and inflammation

Usual Adult Dose for Iritis

0.5% suspension:1 to 2 drops instilled into the conjunctival sac of the affected eye four times per day

Comments:

-Shake well before using.

-During the initial treatment within the first week, the dosing may be increased, up to 1 drop every hour, if needed.

-Care should be taken not to discontinue therapy prematurely.

-If signs and symptoms fail to improve after two days, the patient should be re-evaluated.

Use: Treatment of steroid responsive inflammatory conditions of the palpebral and bulbar conjunctiva, cornea and anterior segment of the globe such as allergic conjunctivitis, acne rosacea, superficial punctate keratitis, herpes zoster keratitis, iritis, cyclitis, selected infective conjunctivitis, when the inherent hazard of steroid use is accepted to obtain an advisable diminution in edema and inflammation

Usual Adult Dose for Keratitis

0.5% suspension:1 to 2 drops instilled into the conjunctival sac of the affected eye four times per day

Comments:

-Shake well before using.

-During the initial treatment within the first week, the dosing may be increased, up to 1 drop every hour, if needed.

-Care should be taken not to discontinue therapy prematurely.

-If signs and symptoms fail to improve after two days, the patient should be re-evaluated.

Use: Treatment of steroid responsive inflammatory conditions of the palpebral and bulbar conjunctiva, cornea and anterior segment of the globe such as allergic conjunctivitis, acne rosacea, superficial punctate keratitis, herpes zoster keratitis, iritis, cyclitis, selected infective conjunctivitis, when the inherent hazard of steroid use is accepted to obtain an advisable diminution in edema and inflammation

Usual Adult Dose for Conjunctivitis

0.5% suspension:1 to 2 drops instilled into the conjunctival sac of the affected eye four times per day

Comments:

-Shake well before using.

-During the initial treatment within the first week, the dosing may be increased, up to 1 drop every hour, if needed.

-Care should be taken not to discontinue therapy prematurely.

-If signs and symptoms fail to improve after two days, the patient should be re-evaluated.

Use: Treatment of steroid responsive inflammatory conditions of the palpebral and bulbar conjunctiva, cornea and anterior segment of the globe such as allergic conjunctivitis, acne rosacea, superficial punctate keratitis, herpes zoster keratitis, iritis, cyclitis, selected infective conjunctivitis, when the inherent hazard of steroid use is accepted to obtain an advisable diminution in edema and inflammation

Usual Adult Dose for Cyclitis

0.5% suspension:1 to 2 drops instilled into the conjunctival sac of the affected eye four times per day

Comments:

-Shake well before using.

-During the initial treatment within the first week, the dosing may be increased, up to 1 drop every hour, if needed.

-Care should be taken not to discontinue therapy prematurely.

-If signs and symptoms fail to improve after two days, the patient should be re-evaluated.

Use: Treatment of steroid responsive inflammatory conditions of the palpebral and bulbar conjunctiva, cornea and anterior segment of the globe such as allergic conjunctivitis, acne rosacea, superficial punctate keratitis, herpes zoster keratitis, iritis, cyclitis, selected infective conjunctivitis, when the inherent hazard of steroid use is accepted to obtain an advisable diminution in edema and inflammation

Usual Adult Dose for Postoperative Ocular Inflammation

0.5% ointment: A small amount (approximately 0.5 inch ribbon) should be applied into the conjunctival sac(s) four times per day beginning 24 hours after surgery and continuing throughout the first 2 weeks of the post-operative period

0.5% gel/0.5% suspension: 1 to 2 drops should be applied into the conjunctival sac of the affected eye four times per day beginning 24 hours after surgery and continuing throughout the first 2 weeks of the post-operative period

Comments:

-0.5% gel: Invert closed bottle and shake once to fill tip before instilling drops.

-0.5% suspension: Shake well before using.

Use: Treatment of post-operative inflammation following ocular surgery

Renal Dose Adjustments

Data not available

Liver Dose Adjustments

Data not available

Precautions

Safety and efficacy have not been established in patients younger than 18 years.

Consult WARNINGS section for additional precautions.

Dialysis

Data not available

Other Comments

Storage requirements:

-Do not freeze

-Store the container in an upright position

See also:
What is the most important information I should know about Lotel?

Lotel etabonate, as with other ophthalmic corticosteroids, is contraindicated in most viral diseases of the cornea and conjunctiva including epithelial herpes simplex keratitis (dendritic keratitis), vaccinia, and varicella, and also in mycobacterial infection of the eye and fungal diseases of ocular structures. Lotel etabonate is also contraindicated in individuals with known or suspected hypersensitivity to any of the ingredients of this preparation and to other corticosteroids.

Use Lotel ointment as directed by your doctor. Check the label on the medicine for exact dosing instructions.

• Lotel ointment is only for the eye. Do not get it in your nose or mouth.
• Wash your hands before using Lotel ointment.
• To use Lotel ointment in the eye, first, wash your hands. Using your index finger, pull the lower eyelid away from your eye to form a pouch. Squeeze a thin strip of ointment into the pouch. After using Lotel ointment, gently close your eyes for 1 to 2 minutes. Wash your hands to remove any medicine that may be on them. Wipe the applicator tip with a clean, dry tissue.
• Do not wear contact lenses while you are using Lotel ointment. Take care of your contact lenses as directed by the manufacturer. Check with your doctor before you use them.
• To prevent germs from contaminating your medicine, do not touch the applicator tip to any surface, including the eye. Keep the container tightly closed.
• If you miss a dose of Lotel ointment, use it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not use 2 doses at once.

Ask your health care provider any questions you may have about how to use Lotel ointment.

Lotel is used in the treatment of inflammatory and allergic conditions of the superficial layers of the eye, such as allergic conjunctivitis (allergic itching and redness of the whites of the eye, with tearing), conjunctivitis that occurs as part of acne rosacea (persistent redness over the areas of the face and nose), superficial punctate keratitis (inflammation of cornea), iritis (Inflammation of the interior eye structures), cyclitis (inflammation of cilliary body of the eye). It is also used in the treatment of postoperative inflammation of the eye after the eye surgery.

See also:
What are the possible side effects of Lotel?

Applies to Lotel ophthalmic: ophthalmic gel/jelly, ophthalmic ointment, ophthalmic suspension

In addition to its needed effects, some unwanted effects may be caused by Lotel ophthalmic. In the event that any of these side effects do occur, they may require medical attention.

Major Side Effects

You should check with your doctor immediately if any of these side effects occur when taking Lotel ophthalmic:

More common:

• Blurred vision or other change in vision
• redness or swelling of the eye
• sensitivity of the eyes to light
• swelling of the membrane covering the white part of the eye

• Discharge from the eye
• eye discomfort, irritation, or pain
• redness of the eyelid or inner lining of the eyelid
• tiny bumps on the inner lining of the eyelid

• Blindness
• delayed wound healing
• loss of vision
• nausea or vomiting

Minor Side Effects

Some of the side effects that can occur with Lotel ophthalmic may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. If any of the following side effects continue, are bothersome or if you have any questions about them, check with your health care professional:

More common:

• Burning when medicine is applied
• dry eyes
• feeling of something in the eye
• headache
• itching
• runny nose
• sore throat
• tearing or watery eye

Lotel (as Lotel Etabonate) is a topical corticoid antiinflammatory. It is used in ophthalmic solution for the treatment of steroid responsive inflammatory conditions of the eye such as allergic conjunctivitis, uveitis, acne rosacea, superficial punctate keratitis, herpes zoster keratitis, iritis, cyclitis, and selected infective conjunctivitides. As a nasal spray, is used for the treatment and management of seasonal allergic rhinitis.