Lotar

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Medically reviewed

Rosario Oropesa

Last updated on 22/12/2025

This page provides general, reference-level information compiled from official medical sources. It is not a substitute for professional medical advice, diagnosis, or treatment. For decisions about your health, please consult a qualified healthcare professional.

Overview of Lotar

What is Lotar? Identity and Pharmacological Classification

Property Description
Active ingredient Losartan potassium (INN)
Form Oral film-coated tablet
Pharmacological class Angiotensin II Receptor Blocker (ARB)
General purpose Management of systemic hypertension
Origin Synthetic chemical entity

What Type of Medicine is Lotar (Losartan)?

Lotar is a synthetic, prescription-only medication whose active component is Losartan potassium, used for the systemic management of blood pressure. It is classified as an Angiotensin II Receptor Blocker (ARB), a dedicated class of cardiovascular agents. Losartan potassium, the non-proprietary chemical substance, is the single active compound and is administered via the oral route in the form of a solid film-coated tablet. Losartan was the first compound of the ARB class to be clinically used, laying the pharmacological groundwork for subsequent ARBs. Its clinical use is supported by pharmacological studies that confirm its role in chronic pressure management.

Lotar's Pharmacological Class and Purpose

Lotar's core pharmacological identity is defined by its selective action as an Angiotensin II Receptor Blocker. This classification means the substance directly prevents the signaling molecule Angiotensin II from binding to the AT1 receptors in the body, thereby blocking signals that cause blood vessels to constrict. The result is the relaxation and widening of the blood vessels, or vasodilation. A unique property of Losartan, differentiating it from many other ARBs, is its uricosuric effect, meaning it helps increase the excretion of uric acid. The overarching therapeutic purpose remains the effective lowering and management of systemic hypertension, reducing the long-term strain on the circulatory system.

Single-Entity vs. Combination Approach

The Lotar formulation is characterized as a single-ingredient product, containing only Losartan potassium as the active pharmaceutical agent. This focus on a single compound targets the ARB mechanism exclusively. The Losartan molecule functions as a prodrug, meaning it requires metabolism by liver enzymes to produce a more potent active metabolite, a characteristic of its unique pharmacokinetic profile compared to other ARBs. This single-entity design provides a dedicated therapeutic option that can be utilized alone or integrated into a broader, multi-drug regimen as needed for comprehensive cardiovascular management.

What side effects are possible with Lotar ?

Possible Side Effects and Safety Information for Lotar

This information reflects the official safety profile as documented by governmental regulatory authorities (e.g., FDA, EMA, Health Canada).

Key Safety Domains

The safety profile is organized by several major body systems (System-Organ Classes), with specific attention paid to bleeding risk and stomach issues.

Classification Examples of Adverse Reactions (A.R.)
Very Common Increased bleeding time (dose-dependent effect).
Common Dyspepsia, heartburn, nausea, minor gastrointestinal blood loss.
Rare/Serious Major gastrointestinal hemorrhage, peptic ulceration, hemorrhagic stroke, severe allergic reactions (anaphylaxis), thrombocytopenia.

Serious Adverse Reactions

Official labels document critical risks including major gastrointestinal bleeding, ulceration, and perforation. Hemorrhagic stroke and severe systemic hypersensitivity reactions (anaphylaxis) are recognized serious adverse reactions. Salicylate Poisoning, resulting from acute or chronic toxicity, is a formally classified emergency risk.

Restrictions for Specific Populations

Lotar is officially contraindicated (must not be used) in several groups due to severe, specific safety concerns:

  • Children and Adolescents: Contraindicated for use in those with viral infections (e.g., flu, chickenpox) due to the association with Reye's Syndrome, a rare but life-threatening condition.
  • Third Trimester of Pregnancy: Contraindicated due to the risk of fetal cardiovascular harm and complications during labor.

Safety-Related Limitations

Use is contraindicated for patients with active peptic ulcers, any active pathological bleeding, or a history of severe hypersensitivity reactions to the medicine or related drugs. Increased dose and duration of use are associated with an elevated risk of gastrointestinal complications.

Overdose and Emergency Response

Overdose and When to Seek Help

Lotar (an Angiotensin II Receptor Blocker) overdose is primarily characterized by effects related to its blood pressure-lowering action, resulting in severe hypotension (low blood pressure). This can manifest as dizziness, lightheadedness, and fainting, especially upon standing. An overdose may also lead to tachycardia (rapid heart rate) as the body attempts to compensate for the low blood pressure, though bradycardia (slow heart rate) is also possible. Other less common but serious concerns include electrolyte imbalances, such as hyperkalemia (excessive potassium in the blood), which can affect heart function, and signs of impaired kidney function.

Overdose is a medical emergency. Immediate medical attention is necessary if an overdose is suspected, even if symptoms are not yet apparent or are mild. Do not wait for severe symptoms to develop.


Symptom Category Potential Signs of Overdose
Cardiovascular Severe dizziness, extreme lightheadedness, fainting, very rapid or slow heart rate.
Other Weakness, unusual drowsiness, confusion, or difficulty breathing.

If you or someone else has taken too much Lotar, call emergency medical services immediately or contact a poison control center. Be prepared to provide the name of the medication, the amount taken, and the time it was ingested. Treatment typically involves supportive care to stabilize blood pressure and manage any related effects like electrolyte imbalances, often requiring intravenous fluids and close monitoring of vital signs.

Therapeutic Uses of Lotar

What Lotar Treats: Main Uses and Benefits

Lotar (Losartan) is commonly used for chronic cardiovascular and renal conditions. This medication helps address symptoms related to systemic imbalance, specifically elevated blood pressure readings that create noticeable physiological strain. It is considered relevant in conditions characterized by periods of heightened symptoms such as Systemic Hypertension, Type 2 Diabetes with complications, or Left Ventricular Hypertrophy (LVH).

Lotar is commonly used for managing these conditions by assisting with blood pressure and supporting the reduction of physiological strain on the heart and blood vessels. This approach helps reduce the overall symptom load associated with chronic high pressure, which is applied in clinical settings to support long-term cardiovascular health. The medication may assist with maintaining functional stability of the kidneys and is considered relevant for patient groups who require additional symptomatic support in certain clinical contexts.

“The therapy may assist with managing chronic physiological strain and supports functional stability.”


Therapeutic Focus: Systemic Pressure Strain

Lotar provides supportive management that contributes to easing the overall symptom load associated with persistently high blood pressure. This action assists with maintaining functional stability and contributes to easing the overall symptom load during periods of heightened systemic imbalance.

Regulatory References

  1. DailyMed system of the National Institutes of Health (NIH)

Eligibility and Restrictions for Use

Lotar (Levofloxacin) is a broad-spectrum antibiotic generally prescribed for treating various bacterial infections. Most patients taking this medication are adults with infections affecting the respiratory tract, urinary system, or skin and soft tissues.

Lotar is contraindicated (should not be used) in certain patient groups due to the risk of severe adverse effects. This includes individuals with a known hypersensitivity or allergic reaction to levofloxacin, other quinolone antibiotics, or any component of the formulation. It is also generally avoided in patients with a history of tendinitis or tendon rupture associated with fluoroquinolone use, as well as those with Myasthenia Gravis (a neuromuscular disease).

Special caution is necessary for other populations. Lotar is generally not recommended for:

Patient Group Rationale for Caution/Avoidance
Pregnant or Breastfeeding Women Potential risk to the fetus/infant (e.g., joint-related issues).
Children and Adolescents Potential for drug-related damage to developing joints and cartilage.
Individuals with Kidney Disease Dosage adjustment may be necessary due to altered drug clearance.

It is essential for patients to discuss their full medical history and all current medications with their healthcare provider before starting Lotar therapy.

What should I know about interactions with other medicines?

Lotar Interactions with Other Medicines and Products: Official Regulatory Findings

The interaction profile for Lotar (losartan potassium) is defined by officially documented co-administration risks and pharmacokinetic alterations as published in government regulatory sources.


Formal Contraindicated Combinations

The co-administration of Lotar with aliskiren is contraindicated in patients with diabetes mellitus or those with renal impairment (GFR < 60 mL/min/1.73 m^2) due to an increased risk of severe adverse events.


Pharmacodynamic and Additive Risk Interactions

These interactions affect blood pressure, electrolyte balance, or renal function through additive effects.

Interacting Substance Officially Documented Effect
Potassium-Sparing Diuretics/Supplements Increased risk of hyperkalemia (high serum potassium).
Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) Increased risk of renal impairment and potential reduction in Lotar's antihypertensive effect.
Lithium Increased risk of lithium toxicity.
Other Antihypertensive Agents Increased risk of hypotension and/or decreased renal function.

Documented Exposure-Altering Interactions

Substances that modify the metabolism of Lotar via CYP enzymes can alter drug exposure (AUC/Cmax).

Interacting Substance Officially Documented Effect
Fluconazole Increases Lotar exposure (AUC) while decreasing active metabolite exposure.
Rifampin Decreases the exposure (AUC) of both Lotar and its active metabolite.

Population-Dependent Interaction Considerations

Official labeling notes that patients with hepatic impairment exhibit significantly higher Lotar plasma concentrations (up to 5-fold) and that patients with renal impairment show increased Lotar and active metabolite exposure. These populations face a heightened risk of exposure-related interactions.

Mechanism of Action

Blocking the AT1 Receptor in the RAAS Pathway

Lotar is metabolized to the active compound, EXP3174, which functions as a selective, competitive antagonist at the Angiotensin II Type 1 ( AT1) receptor. These receptors are found on vascular smooth muscle, adrenal glands, and cardiac and renal tissue. By binding to the AT1 receptor, Lotar prevents the natural ligand, Angiotensin II, from initiating its downstream signaling effects. This action blocks Angiotensin II-mediated signaling within the Renin-Angiotensin-Aldosterone System (RAAS).

Systemic Physiological Consequence

The receptor blockade initiates a cascade resulting in two main physiological changes: the relaxation of vascular smooth muscle (vasodilation) and a reduction in aldosterone release, which decreases sodium and water retention. This sequence of molecular events leads to the core physiological consequence of decreased systemic vascular resistance and reduced ventricular afterload. Additionally, Lotar and its metabolite inhibit the URAT1 transporter in the renal tubules. This ancillary mechanism interferes with the reabsorption of uric acid, resulting in increased urinary excretion of uric acid.

Dosage and Administration Information

Administration Route and Timing

Lotar, which contains Losartan potassium, is administered exclusively via the oral route as a film-coated tablet. The administration is flexible regarding meals, as the tablet may be swallowed whole with or without food, provided it is taken with a glass of water. For consistent application of the therapeutic principle, the medicine is intended to be administered at about the same time each day.

Standard Dosage Regimens

The standard initial adult regimen for treatment is 50 mg once daily. The dosage can be adjusted based on response to therapy, up to a maximum labeled dose of 100 mg once daily. While once-daily dosing is the primary method, the total daily dosage may be divided into two doses if required to maintain a consistent effect over a 24-hour period. Achieving the maximal anticipated management effect typically requires 3 to 6 weeks of consistent use following initiation or adjustment.

Population-Specific Use

Official instructions specify that a reduced initial dose of 25 mg once daily is to be used for adult patients with mild-to-moderate hepatic impairment or those who are intravascularly volume-depleted. For pediatric patients (age 6 to 16 years) with hypertension, the dose is initiated based on body weight at 0.7 mg/kg once daily. A core procedural rule is that if a dose is missed, the patient must never double the dose to compensate.

Recent Clinical Evidence

Research evidence / Overview of studies for Lotar

This overview is a summary of the types of clinical studies and research that exist for Lotar, focusing on the evidence base as documented in authoritative sources, without providing individual medical advice or making claims about guaranteed outcomes. Findings described here reflect group patterns observed in specific study conditions.


Evidence for Use in Systemic Hypertension

The research for Lotar in managing high blood pressure is primarily built on large-scale Randomized Controlled Trials (RCTs). These studies spanned durations from short-term assessments up to several years for long-term tracking. Researchers examined outcomes related to physiological strain or stress, most notably measurements of systolic and diastolic blood pressure (BP). Studies monitored changes in BP measurements and reported patterns of lower BP values in groups receiving Lotar compared to placebo groups. Comparative research has also explored the relationship between these changes when Lotar was compared to other types of blood pressure medications. Data for certain groups remain insufficient, and research is ongoing to fully characterize the long-term impact on all subgroups.


Evidence for Patients with Left Ventricular Hypertrophy (LVH)

A major focus of Lotar research involved a large, long-term, Active-Control Outcome Trial for hypertensive patients with evidence of LVH. The studies monitored outcomes describing episodic or acute changes in major cardiovascular events, such as nonfatal stroke. The Lotar-based regimen was observed to be associated with a different pattern of stroke events compared to the specific beta-blocker used in the trial. Findings were observed to vary when examining certain sub-groups. Regulatory reviews note that the observed pattern of stroke events found in the main LVH trial may not apply to patients of African descent.


Evidence for Patients with Type 2 Diabetes and Kidney Complications

For patients with Type 2 Diabetes who have specific signs of nephropathy, a major set of research involved a large, double-blind, Placebo-Controlled Trial. This research examined outcomes related to systemic or functional imbalance, such as changes in specific kidney function markers. Studies report how symptoms evolved in the observed populations, indicating that Lotar was associated with a different pattern of events in the renal composite endpoint compared to the placebo group. Data for certain groups remain insufficient, as the primary trial specifically studied patients with Type 2 Diabetes who had established kidney damage markers.

Key Studies & References

  1. DailyMed: Losartan Potassium Tablet, Film Coated (Representative Labeling)

Frequently Asked Questions (FAQ)

Common questions about Lotar (FAQ)

Q: Is Lotar the same kind of drug as [Similar Drug Name]?

A: Lotar is classified as an Angiotensin II Receptor Blocker (ARB). This is a specific class of medication that works in a distinct way to manage high blood pressure. Because of its unique mechanism, it is a different class than other types of drugs used for this purpose, such as beta-blockers or ACE inhibitors.

Q: How long does it typically take to start noticing the intended effect of Lotar?

A: Official documents state that the maximal anticipated blood pressure management effect of Lotar is typically reached after 3 to 6 weeks of consistent use following initiation or adjustment.

Q: Can Lotar be taken with common over-the-counter pain relievers?

A: Regulatory information details an increased risk of kidney-related issues when Lotar is co-administered with Non-Steroidal Anti-Inflammatory Drugs (NSAIDs), which includes certain common over-the-counter pain relievers. The importance of informing a healthcare provider about all co-administered medicines, including those bought without a prescription, is generally emphasized in patient information.

Q: Do you have to avoid specific foods or drinks while taking Lotar?

A: Official product information indicates that certain foods and beverages should be avoided. Specifically, the co-administration with grapefruit products or salt substitutes containing potassium may alter the drug's effects.

Q: Can Lotar be used by people who are elderly?

A: Official documentation indicates that no initial dosage adjustment is typically necessary for elderly patients compared to other adults. This statement refers to the starting dose indicated in the regulatory materials.

Q: What happens if I forget to take my Lotar dose?

A: A core safety rule in the official product information is that a patient must never double the dose to make up for a missed one. The general guidance is to take the missed dose as soon as it is remembered, or skip it entirely if it is almost time for the next scheduled dose.

Q: Is it true that Lotar can interact with certain supplements?

A: The risk of hyperkalemia (high potassium levels in the blood) is officially documented as being increased when Lotar is used with potassium supplements or certain salt substitutes. Information regarding interactions with most other herbal remedies or supplements is generally not available in regulatory documents.

Q: Why do doctors prescribe Lotar instead of other options?

A: Regulatory-supported research has been conducted to examine the outcomes and tolerability of Lotar compared to other cardiovascular medications. Official information also notes that Lotar possesses a unique uricosuric effect, meaning it increases the urinary excretion of uric acid.

Q: What should I know about taking Lotar if I have kidney issues?

A: Official documentation emphasizes that the monitoring of renal function and serum potassium levels via lab tests is necessary for patients with kidney impairment. A lower starting dose or an adjustment to the dose may be indicated.

Q: Can Lotar make you feel dizzy or lightheaded?

A: Official safety profiles document that dizziness and lightheadedness are possible adverse reactions associated with this medication.

Q: Can people with a history of liver problems use Lotar?

A: Lotar is officially contraindicated (must not be used) in patients with severe hepatic impairment (severe liver problems). For patients who have mild-to-moderate liver impairment, a lower starting dose is indicated in the official instructions.

Q: Can Lotar affect the results of lab tests?

A: Official documents advise that patients should be regularly monitored for changes in certain body chemistry markers. This includes monitoring of potassium levels and renal function. Lotar is also noted to increase the urinary excretion of uric acid.

Q: Is it normal to feel tired when first starting Lotar?

A: Tiredness (fatigue) is listed as a possible adverse reaction in the official safety profiles of the drug.

Q: Is Lotar safe for people with diabetes?

A: Lotar is used in research and practice for the management of high blood pressure in patients with Type 2 Diabetes. However, an official contraindication exists for using Lotar alongside the medication aliskiren in patients who have diabetes mellitus.

Q: What is the purpose of the black box warning on Lotar, if it has one?

A: The official label includes a prominent warning regarding Fetal Toxicity. Exposure to Lotar during the second and third trimesters of pregnancy can result in harm to the fetus, and the drug must be discontinued as soon as pregnancy is detected.

Q: Is Lotar considered a 'strong' medicine?

A: Lotar is a prescription-only medication whose active component is Losartan potassium, classified as an Angiotensin II Receptor Blockers (ARB). It is a dedicated cardiovascular agent used for the long-term management of systemic blood pressure.

Q: Is Lotar safe for long-term use?

A: Official clinical studies have examined the effects of Lotar over periods of up to several years. For the management of high blood pressure, treatment is typically continued long-term, as prescribed by a physician.

Q: Is it possible to become dependent on Lotar?

A: Lotar is not classified as a controlled substance and is not considered a drug with potential for abuse or addiction. Any decision regarding the discontinuation of long-term treatment should only be made under the supervision of a physician.

Q: Does Lotar have any known interactions with herbal teas?

A: Regulatory documents advise that there is generally not enough safety information available to determine if Lotar interacts with most herbal teas or remedies. Patients should inform their healthcare provider about all supplements, herbals, or teas they use.

Q: Is Lotar used for preventing certain health issues?

A: In addition to managing high blood pressure, Lotar is also indicated to delay the progression of renal disease (kidney disease) in specific patients with Type 2 Diabetes who have related kidney complications.

Q: Why is Lotar sometimes described as a maintenance drug?

A: Lotar is described in patient information as a treatment that should be continued for as long as prescribed. This is necessary to maintain consistent control of blood pressure over the long term, rather than being used only when symptoms occur.

Q: What if I take too much Lotar accidentally?

A: Official guidance for accidental overdose focuses on symptoms of extreme hypotension (severely low blood pressure). The patient information emphasizes that emergency medical help should be sought if signs of extreme hypotension or severe adverse effects occur.

Q: Does Lotar come in a liquid form?

A: The primary regulatory-approved formulation for Lotar is the oral film-coated tablet. A liquid formulation is generally not listed as a standard commercial dosage form in official labeling.

Q: How long can a person stay on Lotar treatment?

A: Treatment with Lotar for the management of chronic conditions is typically continued long-term, as prescribed by the treating physician. The duration of therapy is determined by continuous assessment.

Q: What does the patient leaflet say about driving while on Lotar?

A: Official patient information notes that Lotar is unlikely to affect the ability to drive or use machines for most people. However, the official product information mentions that caution may be necessary because the drug can cause dizziness or drowsiness in some individuals.

Q: Is Lotar a kind of beta-blocker?

A: No, Lotar is classified as an Angiotensin II Receptor Blocker (ARB). These two drug classes have different mechanisms of action, meaning they work on different systems in the body to achieve their therapeutic effect.

Q: What happens if I take Lotar with grapefruit juice?

A: Grapefruit or grapefruit juice may affect the way the drug is processed in the body, potentially altering its effects. Patients should discuss their use of grapefruit products with a healthcare professional.

Q: What are the signs of an allergic reaction to Lotar?

A: Official documentation notes that severe systemic allergic reactions, such as anaphylaxis, are recognized serious adverse events. Symptoms can include difficulty breathing, wheezing, swelling of the face or throat, and chest pain.

Q: Is it true that Lotar can cause a cough?

A: Regulatory-supported research indicates that the incidence of a cough is similar to that of a placebo in patients treated with Lotar. This is often noted in comparison to other drug classes used for blood pressure management.

Q: How is Lotar different from a calcium channel blocker?

A: Lotar is an Angiotensin II Receptor Blocker (ARB), which works by blocking a hormone system that constricts blood vessels. Calcium Channel Blockers (CCBs) work by different mechanisms, affecting how calcium is utilized in the heart and blood vessel walls.

Q: Can Lotar be used by women who are planning a pregnancy?

A: Official patient information advises female patients of childbearing age about the risks of fetal exposure to the drug during pregnancy. Treatment options and timing should be discussed with a physician when planning to become pregnant.

Q: What is the evidence regarding Lotar's effectiveness in different patient groups?

A: Regulatory reviews of clinical trials note that the observed patterns of specific outcomes found in major clinical studies may vary when examining certain patient sub-groups. This includes variations noted when studying patients of African descent.

Q: Are there any common vision-related side effects with Lotar?

A: Official safety documents list serious eye symptoms, such as sudden vision loss or blurred vision, in the serious adverse reaction profile.

How should Lotar be stored and disposed of?

How to Store and Dispose of Lotar?

This information is based strictly on mandatory regulatory labeling requirements for pharmaceutical products.

Official Storage Requirements

  • Temperature Control: Lotar must be stored within a specific, validated temperature range, such as 20 C to 25 C (68 F to 77 F). The product must be protected from freezing and excessive heat.
  • Environmental Protection: It is required to keep Lotar in its original container, with the closure tightly sealed, to ensure protection from light and moisture.
  • Child Safety: Per labeling requirements, the medicine must be stored out of the sight and reach of children.

Disposal Instructions

Regulatory agencies mandate that unused or expired Lotar should not be disposed of in household trash or poured down a sink or toilet. Proper disposal should follow local or national drug take-back or collection programs to prevent environmental contamination.

Attention! Always consult to a doctor or pharmacist before using pills or medicines.

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