Lisette

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Lisette

Medically reviewed

Marina Burgos

Last updated on 22/12/2025

This page provides general, reference-level information compiled from official medical sources. It is not a substitute for professional medical advice, diagnosis, or treatment. For decisions about your health, please consult a qualified healthcare professional.

Overview of Lisette

Quick Facts

Property Description
Active Ingredients Ethinyl Estradiol, Chlormadinone Acetate
Form Tablet (oral, film-coated)
Pharmacological Class Hormonal Contraceptives, Combined (CHC)
Common Use Contraception
Origin Synthetic (derived steroid hormones)

Defining Lisette: Identity and Differentiating Features

Lisette is a synthetic, prescription-only medication categorized as a Combined Oral Contraceptive (COC), which belongs to the high-level pharmacological group of Hormonal Contraceptives, Combined (CHC). Its primary general therapeutic purpose is contraception, functioning as a reliable, systemic method for the prevention of pregnancy in women. The medication is a combination product, containing both an estrogen and a progestin component, a characteristic that differentiates it from single-hormone contraceptive options. This therapeutic approach is established in pharmacological research.


Compositional Profile: Ethinyl Estradiol and Chlormadinone Acetate

The medicine's active core is composed of the synthetic estrogen Ethinyl Estradiol and the synthetic progestin Chlormadinone Acetate. This specific combination forms a monophasic treatment, presented in the dosage form of a film-coated tablet for oral route of administration. The progestin component, Chlormadinone Acetate, is structurally a progesterone derivative and provides Lisette with a key differentiating feature: its recognized antiandrogenic properties. This specific characteristic is clinically recognized as a potential factor for certain patient considerations within the broader class of combined oral contraceptives.

Regulatory References

  1. Combined Hormonal Contraceptives (CHCs)
  2. MedlinePlus
  3. Hormonal Contraceptives

What side effects are possible with Lisette?

Possible Side Effects and Safety Information

The safety profile of Lisette (Ethinyl Estradiol/Chlormadinone Acetate) is formally classified by regulatory authorities based on the affected organ system and frequency of occurrence. The majority of documented adverse reactions are classified as common or very common and are related to the reproductive and central nervous systems.

Frequency and System-Organ Classifications

Classification Type Documented Effects
Common / Very Common Headache or migraine, nausea, breast discomfort or pain, weight increase, and menstrual irregularities (including breakthrough bleeding and spotting). These effects are frequently observed during the initial months of use and often decrease over time.
Other Documented Reactions Mood changes, depression, decreased libido, abdominal pain, and skin reactions like chloasma (skin discoloration) and acne.

Serious Adverse Reactions and Restrictions

Regulatory documents highlight the increased risk of thromboembolic events (blood clots), which are considered rare but clinically serious. These include Venous Thromboembolism (VTE), Pulmonary Embolism, and Arterial Thromboembolism (ATE) (e.g., stroke or myocardial infarction). The risk of VTE is highest during the first year of treatment. Other serious documented risks involve the association with liver tumors (benign or malignant) and the development of high blood pressure.

Safety restrictions define when Lisette should not be used. Use is restricted in individuals with a history of or predisposition for thrombotic disorders, severe hepatic disease, liver tumors, or known/suspected breast cancer. Furthermore, the medication is contraindicated in women over 35 years of age who smoke due to a significantly increased risk of serious cardiovascular events.

Overdose and Emergency Response

Overdose and when to seek help — Official Regulatory Information for Lisette

This section describes the officially documented overdose profile for Lisette, consistent with regulatory information for combined hormonal contraceptives.

Element Official Regulatory Statement
Documented Overdose Presentations Nausea and vomiting; headache; breast tenderness; drowsiness; emotional changes; heavy vaginal bleeding (withdrawal bleeding, typically 2 to 7 days post-overdose).
Severity Classification Overdose is typically classified as having low acute toxicity and is not usually associated with immediate life-threatening outcomes.
Antidote Status No specific antidote is known for an overdose of this medication.
Emergency Actions Required Seek immediate medical help right away for assessment and monitoring; contact Poison Control or local emergency services; transport the medicine container for provider reference.

Resulting Overdose Structure

The official prescribing information defines the Lisette overdose profile by noting that acute exposure is generally not severe, with manifestations primarily related to high hormone levels affecting the gastrointestinal, central nervous, and reproductive systems. When overdose is suspected, the regulatory documents mandate seeking immediate medical attention. The required medical response is limited to providing symptomatic and supportive treatment, including monitoring of vital signs and potential use of activated charcoal, as there is no documented chemical antidote available.

Therapeutic Uses of Lisette

What Lisette Treats: Main Uses and Benefits

The therapeutic application of Lisette (Ethinyl Estradiol/Chlormadinone Acetate) is defined by its ability to serve as a generally effective, systemic contraceptive while simultaneously addressing specific, hormone-sensitive clinical concerns. Clinical evaluation indicates the medication is relevant when patients require both effective contraception and additional support for symptom management related to hormonal processes.

Its use is focused on the systemic prevention of pregnancy, which generally provides patients with the key benefit of reproductive predictability and supports family planning. Beyond this, Lisette is commonly used for the systemic management of mild-to-moderate papulopustular acne vulgaris, and it plays a role in easing the discomfort of painful menstrual periods (dysmenorrhea).

Lisette's specific hormonal composition is applied in addressing androgen-dependent symptoms, including excessive oiliness (seborrhea) and unwanted hair growth (hirsutism). This therapeutic action supports a reduction in visible manifestations and contributes to easing the overall symptom load.

“The use of this medication in appropriate clinical scenarios may assist with maintaining functional stability during symptomatic periods.”


Quick Fact: Relief for Androgen-Related Symptoms

Property Description
Primary Domain Contraceptive Health
Secondary Benefit Management of Mild-to-Moderate Acne
Symptom Relief Dysmenorrhea, Seborrhea, Hirsutism
Key Patient Benefit Supports Reproductive Predictability and Symptom Load Easing

Eligibility and Restrictions for Use

Lisette: Official Eligibility and Non-Eligibility Rules

Lisette (Ethinyl Estradiol/Chlormadinone Acetate) is officially approved for use by females of reproductive potential after they have reached menarche. Eligibility is strictly governed by medical criteria focused on minimizing the risk of serious vascular events and excluding hormone-sensitive conditions.


Contraindications (Must Not Use)

Use is absolutely contraindicated in patients with a current or history of thromboembolic disorders (e.g., DVT, PE, stroke, heart attack). This restriction also applies to women over 35 years of age who smoke and those with migraine with aura at any age. The medicine is prohibited in the presence of known or suspected breast cancer, active liver disease or tumors, and is contraindicated during pregnancy.


Restricted and Conditional Use

The medicine is not recommended for women who are breastfeeding or for non-breastfeeding women less than four weeks postpartum. Use requires strict medical supervision in patients with well-controlled hypertension or diabetes, where monitoring of blood pressure and glucose is required. The regulatory label states that use is not established in the geriatric population.

What should I know about interactions with other medicines?

Interactions with other medicines and products

Lisette’s official interaction profile is structured around changes in hormone exposure and absolute prohibitions, as defined in government regulatory documents. Co-administration is contraindicated with certain Hepatitis C combination therapies (such as regimens containing ombitasvir/paritaprevir/ritonavir pm dasabuvir) due to a formally documented risk of ALT (liver enzyme) elevations.

The efficacy of the contraceptive is susceptible to pharmacokinetic interaction from substances that induce hepatic enzymes, primarily CYP3A4. Strong enzyme inducers, including certain anticonvulsants and the herbal product St. John's Wort, may decrease the plasma concentrations of both Ethinyl Estradiol and Chlormadinone Acetate, resulting in reduced contraceptive effectiveness. Conversely, the co-administration of CYP3A inhibitors can increase the systemic exposure of the Ethinyl Estradiol component, which is associated with an elevated risk of hormone-related adverse reactions.

The drug itself can act as a perpetrator of interaction by increasing the plasma concentrations of certain co-administered medications that are CYP1A2 substrates (e.g., Tizanidine). A separate pharmacodynamic interaction involves the estrogen component increasing serum binding globulins, potentially requiring an increase in the dosage of co-administered replacement thyroid hormones or cortisol therapy. Furthermore, a timing-based procedural constraint applies: if severe vomiting or diarrhea occurs within three to four hours of administration, the active ingredients may not be fully absorbed, requiring adherence to the established missed pill rules.

Mechanism of Action

Targeting Central Inhibitory Receptors

Lisette’s mechanism of action involves functioning as a Positive Allosteric Modulator (PAM) at two key inhibitory receptors within the central nervous system ( CNS): Glycine Receptors ( GlyR) and GABA A receptors ( GABA A R). Binding to allosteric sites on these receptors increases their sensitivity to the native inhibitory neurotransmitters, Glycine and GABA. This heightened receptor activity leads to a prolonged inward flux of chloride ions ( Cl^-) across the neuronal membrane. The subsequent increase in intracellular negativity results in cellular hyperpolarization, which decreases the overall excitability of the nerve cell.

Modulation of Central Motor and Nociceptive Signaling

This enhancement of inhibitory tone directly influences specific descending neural pathways, including those regulating skeletal muscle control and nociception (the transmission of potentially painful stimuli). Suppression of motor neuron excitability, particularly in the spinal cord, modifies the neural activity that drives excessive involuntary muscle contractions. Furthermore, the modulation of nociceptive pathways alters the transmission intensity of these signals toward higher CNS centers. The resulting change in neural signal output leads to observable physiological consequences, specifically decreased muscle tone and modification of nociceptive signal intensity.

Dosage and Administration Information

The administration of Lisette (Ethinyl Estradiol 35 mug / Chlormadinone Acetate 2 mg) is governed by a structured, cyclic regimen.

Administration Scope

The medicine is taken via the oral route as a film-coated tablet containing the fixed hormonal dose. The official pattern is the 21/7 day schedule, which requires taking one active tablet daily for 21 consecutive days, followed immediately by a 7-day tablet-free interval. A new 28-day course commences after the tablet-free period ends, regardless of whether bleeding has ceased.

Procedural Instructions

For consistent use, guidance emphasizes that the tablet must be ingested at approximately the same time every day. Tablets are to be taken with some liquid as needed. The typical starting regimen recommends beginning administration on Day 1 of the menstrual cycle, though starting on Days 2–5 is permissible provided a supplemental barrier method is used for the first seven days of active tablet intake.

Specific procedures are established for missed doses:

  • If a tablet is missed by less than 12 hours, it should be taken immediately, and contraceptive protection is maintained.
  • If a tablet is missed by more than 12 hours, specific instructions must be followed, as the hormonal pattern and resulting protection may be reduced.

Course Duration

Lisette is intended for long-term administration when used for contraception. However, for the management of androgen-related symptoms, the instruction specifies a limited duration of treatment, generally requiring discontinuation 3 to 4 cycles after the symptoms have satisfactorily resolved.

Recent Clinical Evidence

Research Evidence / Overview of Studies for Lisette

This section provides an overview of the types of clinical studies that have been conducted for Lisette (Ethinyl Estradiol/Chlormadinone Acetate), describing what researchers explored and which patient groups were included, based on information from official regulatory and peer-reviewed sources.


Evidence for Use in Systemic Prevention of Pregnancy (Contraception)

The evidence base consists of large, prospective, open-label trials and post-marketing surveillance studies. These studies were used in research exploring how the medicine was evaluated over multiple menstrual cycles in healthy adult and adolescent women. Researchers monitored outcomes such as the Pearl Index (a calculated measure of unintended pregnancies) and assessed the suppression of ovarian activity. Findings describe patterns observed in the studies related to the outcomes measured. Since placebo-controlled trials are unethical for contraception, the research is evaluated against historical reference rates.


Evidence for Use in Mild-to-Moderate Acne Vulgaris

Research has extensively evaluated Lisette in Randomized Controlled Trials (RCTs), applied in studies examining symptoms common to acne. Some trials compared the medicine against a placebo, while others compared it against active hormonal treatments. Studies explored outcomes related to inflammatory and irritative states, specifically measuring the reduction in total acne lesion counts and using standardized tools like the Investigator’s Global Assessment (IGA) scores. Findings describe patterns observed in the studies, where patient groups reported changes measured during the short-term study period, typically lasting about six cycles (six months).


Evidence Gaps and Areas of Research Uncertainty

Evidence quality varies across studies; while high-quality RCTs support the evaluation for acne, data for secondary uses like dysmenorrhea (painful periods) and hirsutism (unwanted hair growth) are often derived from smaller sample sizes or as secondary endpoints. Follow-up durations were limited in many comparative trials, meaning that data for the persistence of observed changes beyond the initial six months are still emerging. Research does not determine whether an individual with complex health factors was included or evaluated similarly to the core study populations.

Frequently Asked Questions (FAQ)

Common questions about Lisette (FAQ)


Q: Does Lisette require any special lab tests before starting it?

Official medical guidance indicates that a comprehensive physical examination is appropriate before starting this type of medication. This may include checks of blood pressure and relevant laboratory tests, such as those related to blood clotting or lipids (fats in the blood). The need for specific pre-treatment lab tests is typically evaluated by a healthcare provider based on a person's individual health history and established risk factors.


Q: Is Lisette a new drug or has it been around for a long time?

The specific combination of active components in Lisette has been utilized in medicine for several decades. For example, the progestin component, Chlormadinone Acetate, was initially developed in the 1960s. Although regulatory statuses vary by country, the combination product has a long history of international use and is currently approved in many countries, particularly throughout Europe.


Q: Can Lisette affect my ability to drive or operate machinery?

Official product information generally states that the medicine has no or a negligible influence on the ability to drive or use machinery. However, documented side effects include headaches and, uncommonly, dizziness or visual disturbances. Regulatory information indicates that if these effects occur, caution is necessary when driving or operating equipment.


Q: Are there any common foods or drinks that should be avoided while taking Lisette?

Official drug labels for combined oral contraceptives commonly note the potential interaction with consuming grapefruit or grapefruit juice. The reason is that grapefruit can affect how the body processes the estrogen component, potentially increasing the risk of adverse reactions. No other common foods or drinks are typically prohibited by regulatory documents.


Q: Does Lisette interact with common over-the-counter pain relievers?

The primary interaction warnings for this medication concern substances that affect certain liver enzymes (CYP3A4), which is associated with a risk of compromised contraceptive efficacy. Common over-the-counter pain relievers, such as ibuprofen or acetaminophen, are generally not listed in regulatory documents as having clinically significant interactions with the active ingredients.


Q: Is Lisette habit-forming or is there a risk of dependency?

No, Lisette is not considered a habit-forming substance. Official regulatory documents indicate that combined oral contraceptives do not have an associated risk of dependency or drug abuse potential.


Q: Is Lisette approved for use in countries outside the U.S.?

Yes, regulatory documentation confirms that this product is approved and used in many countries outside the United States. For example, it is approved within the European Union and is subject to the regulatory oversight of the European Medicines Agency (EMA) and national health agencies.


Q: Can Lisette be split or crushed to make it easier to swallow?

Official administration guidance specifies that Lisette is a film-coated tablet that should be swallowed whole with liquid. Regulatory documents do not provide instructions for splitting or crushing the tablet, and altering the form of a film-coated tablet is associated with the potential to affect its proper absorption.


Q: What should be done if someone experiences a severe skin reaction while taking Lisette?

Regulatory safety documents define the appearance of severe skin reactions as one of the medical conditions that requires immediate discontinuation of the medication. Such an event is cited as a condition requiring urgent medical evaluation.


Q: Does Lisette affect sleep patterns?

While direct sleep disturbance may not be listed, official documents cite related side effects such as mood changes, depression, and headaches or migraines. Since these are effects on the central nervous system, they could indirectly impact a person’s sleep patterns.


Q: Can people with kidney problems use Lisette?

Regulatory documents state that a history of renal disease (kidney problems) is generally associated with a recommendation for using an alternative method of contraception. This is due to the potential for increased risk of high blood pressure and other complications related to the disease's progression.


Q: Is the purpose of Lisette to cure a condition or to manage symptoms?

Official regulatory indications define Lisette's use as preventing pregnancy (contraception) and managing the symptoms of conditions like acne. It is not classified as a curative medicine.


Q: Can Lisette cause increased sensitivity to sunlight?

Yes, official documents list chloasma (skin discoloration) as a potential side effect. Regulatory information indicates that women who have a tendency toward chloasma are typically cautioned regarding exposure to the sun or ultraviolet radiation while using the medicine.


Q: Does Lisette interact with alcohol?

Regulatory labels generally do not list a direct chemical interaction between the hormones in Lisette and alcohol. However, official procedural instructions state that any severe vomiting or diarrhea occurring within three to four hours of taking the tablet may affect absorption. If this occurs, adherence to the established missed pill rules is indicated in the prescribing information.


Q: What is the definition of the side effect 'dizziness' in the context of Lisette?

Official regulatory documents list dizziness as an uncommon side effect for this medication, which is described as a feeling of lightheadedness or unsteadiness. This is documented separately from common effects like headache or migraine.


Q: Is Lisette available as a generic version?

The specific combination of active ingredients in Lisette is available under several brand names globally. Furthermore, in many regions where the patent has expired, the medication is available as a non-branded generic version.


Q: Does Lisette require a gradual decrease in dose when stopping treatment?

Official regulatory documents indicate that when discontinuing Lisette, the medication should be stopped by completing the active tablets in the current pack. Discontinuation instructions for both contraception and androgen-related symptoms do not specify the need for a gradual decrease in dose.

How should Lisette be stored and disposed of?

Storage Conditions and Container Rules

The storage of Lisette (Ethinyl Estradiol/Chlormadinone Acetate) tablets is defined by regulatory standards to preserve stability and effectiveness.

  • Temperature: The product must be stored at a temperature below 30°C and should not be refrigerated or frozen.
  • Protection: To guard against moisture and light, the medication must be kept in its original blister pack and outer carton.
  • Child Safety: Lisette must be stored out of the sight and reach of children.

Disposal Instructions

Official disposal guidance ensures environmental safety and public protection:

  • Disposal Prohibition: Do not dispose of the medicine via wastewater (e.g., sink or toilet) or through regular household trash.
  • Mandatory Procedure: Return any unused or expired blister packs to a pharmacist or an approved waste-disposal site, ensuring disposal is carried out according to local pharmaceutical waste regulations.

Attention! Always consult to a doctor or pharmacist before using pills or medicines.

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