Levsin Drops

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Levsin Drops

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Medically reviewed

Marina Burgos

Last updated on 10/01/2026

This page provides general, reference-level information compiled from official medical sources. It is not a substitute for professional medical advice, diagnosis, or treatment. For decisions about your health, please consult a qualified healthcare professional.

Overview of Levsin Drops

Property Description
Active ingredient Hyoscyamine sulfate
Form Oral solution (liquid drops)
Pharmacological class Anticholinergic, Antispasmodic
Common use Relief of spasms and overactive gut motility
Origin Derived from naturally occurring belladonna alkaloids

What Type of Medicine is Levsin Drops?

Levsin Drops is a single-ingredient, prescription-only medication classified as an anticholinergic and antispasmodic agent. Its pharmacological classification as a belladonna alkaloid derivative is integral to its function, as it exerts a parasympatholytic effect by inhibiting certain nervous system signals responsible for involuntary muscle contractions and glandular secretions. The active component, Hyoscyamine sulfate, is chemically synthesized from naturally occurring belladonna alkaloids. This specific Hyoscyamine formulation is clinically recognized for its targeted efficacy in managing symptoms related to increased digestive movement and spasm.


What is the Active Ingredient and Why is it a Liquid Drop Formulation?

The sole active ingredient in Levsin Drops is Hyoscyamine sulfate, presented as an oral solution (liquid drops) suspended in an aqueous-based vehicle suitable for ingestion. This liquid drop formulation is a key characteristic of the product, providing a flexible method for administration that is often necessary for patients who require precise volumetric adjustments or who have difficulty swallowing tablets. This form ensures the active substance is readily available for absorption.


What is the General Purpose of Antispasmodic Levsin Drops?

The general purpose of Levsin Drops is to provide symptomatic relief by calming an overactive gastrointestinal system. Its core function is the reduction of smooth muscle spasm throughout the digestive tract. By temporarily blocking the action of acetylcholine at muscarinic receptors, the drug effectively achieves a slowing down of excessive digestive motility and a concurrent reduction of gastric secretion. The overall benefit is the relief of discomfort caused by uncontrolled muscle activity and cramping in the abdominal area, making it a valuable option for the management of symptoms related to functional bowel disorders.

Regulatory References

  1. Hyoscyamine MedlinePlus Drug Information
  2. Hyoscyamine Sulfate DailyMed Label

What side effects are possible with Levsin Drops?

Possible Side Effects and Safety Information

The safety profile for Levsin Drops (Hyoscyamine sulfate) is primarily characterized by adverse reactions that are extensions of its classification as an anticholinergic agent. The severity and appearance of effects are generally related to the dose and individual sensitivity, as frequency categories are not explicitly assigned to most reactions in the US regulatory labeling.


Adverse Reactions by System-Organ Class

Adverse effects are documented across multiple physiological systems. Common anticholinergic effects listed in official documents include dryness of the mouth, constipation, blurred vision (mydriasis), urinary retention, and tachycardia (increased heart rate). Other documented effects affect the Nervous System (drowsiness, dizziness, nervousness, headache), Skin (decreased sweating, urticaria), and the Genitourinary system (impotence, urinary hesitancy).


Serious Safety Considerations

Regulatory documents highlight the risk of specific, clinically significant adverse reactions. These include the potential for psychosis, confusion, and hallucinations, particularly in sensitive individuals. Central Nervous System symptoms of this nature are documented to typically resolve shortly after discontinuation. A critical safety note concerns the risk of heat prostration or fever due to the drug's effect of decreasing sweat gland activity, especially in high environmental temperatures. Diarrhea in certain patients, such as those with an ileostomy or colostomy, may be an indication of incomplete intestinal obstruction, making continued use inappropriate.


Population and Duration Safety Notes

Specific populations may be more susceptible to adverse effects. Older adults are documented as being particularly vulnerable to anticholinergic effects like confusion and urinary retention. In pediatric patients, there is an increased risk of elevated body temperature when the drug is used in hot environments. For prolonged use, regulatory information notes the potential for decreased salivary flow, which may lead to dental complications. The drug is known to be excreted in human milk.

Overdose and Emergency Response

Overdose and When to Seek Help

Overdose of Levsin Drops (Hyoscyamine sulfate) is associated with an escalation of the drug’s anticholinergic effects, as documented in official regulatory labeling.

Documented Manifestations

Overdosage may present with signs including CNS stimulation, headache, dizziness, nausea, vomiting, excessive dryness of the mouth, and difficulty in swallowing. Ocular and skin manifestations such as blurred vision, dilated pupils, and hot, dry skin are also officially listed in prescribing information.

Severe Outcomes and Complications

Severe outcomes cited in regulatory information include tachycardia and CNS excitement demanding attention. The progression of the drug's curare-like effect may lead to the life-threatening complication of respiratory muscle paralysis. High fever is also documented and poses a risk of heat prostration. Infants and young children are noted in regulatory documents to be especially susceptible to these toxic effects.

Required Emergency Actions

In the event of a suspected overdose, regulatory guidance requires individuals to seek emergency medical attention immediately or contact the Poison Help line. Official management procedures include immediate stomach lavage. In cases of respiratory muscle paralysis, artificial respiration must be instituted and maintained. The use of Physostigmine injection is cited in the labeling as a specific therapeutic intervention for acute overdose.

Therapeutic Uses of Levsin Drops

Main Uses of Levsin Drops

Levsin Drops contain hyoscyamine sulfate, an anticholinergic medication used to manage various conditions affecting the gastrointestinal tract and other organ systems. The medication works by decreasing the secretion of gastric acid and slowing the natural movements of the digestive tract through the inhibition of acetylcholine.

Gastrointestinal Disorders

The primary application of Levsin Drops is the treatment of functional gastrointestinal disorders. It is frequently utilized as adjunctive therapy for the following conditions:

  • Irritable Bowel Syndrome (IBS): Helps manage symptoms such as abdominal pain, cramping, and bloating.
  • Peptic Ulcer Disease: Used in combination with other medications to control gastric acid secretion.
  • Neurogenic Bowel Disturbances: Assists in regulating bowel motility in patients with underlying neurological conditions.
  • Acute Enterocolitis: Provides symptomatic relief for intestinal inflammation and associated cramping.

Other Medical Applications

Beyond the digestive system, Levsin Drops are utilized for their antispasmodic and antisecretory properties in other clinical scenarios:

  • Bladder Spasms: Used to treat overactive bladder symptoms and urinary incontinence by relaxing the smooth muscles of the bladder wall.
  • Biliary and Renal Colic: Helps alleviate the intense pain associated with gallbladder or kidney stones by reducing spasms in the bile ducts or ureters.
  • Pancreatitis: Employed to reduce pancreatic secretions during acute episodes.
  • Rhinitis: Occasionally used to reduce excessive nasal secretions associated with the common cold or allergies.

Primary Benefits

The clinical benefits of Levsin Drops center on its ability to provide rapid relief from smooth muscle spasms and excessive secretions. By targeting the autonomic nervous system, the medication helps restore comfort and functional stability to the affected organ systems. Its liquid formulation allows for precise adjustments in management, particularly for pediatric patients or individuals who have difficulty swallowing solid oral dosage forms.

Regulatory References

  1. NIH DailyMed Label for HYOSCYAMINE SULFATE

Eligibility and Restrictions for Use

Who Can and Cannot Use Levsin Drops?

The eligibility for Levsin Drops (Hyoscyamine sulfate) is strictly defined by regulatory documents, which establish specific populations for whom the medicine is either permitted, restricted, or absolutely prohibited.

Absolute Contraindications

Use is prohibited for patients diagnosed with glaucoma; myasthenia gravis; myocardial ischemia; obstructive diseases of the urinary or gastrointestinal tracts (e.g., paralytic ileus, severe ulcerative colitis, or bladder neck obstruction); toxic megacolon; or unstable cardiovascular status in acute hemorrhage.

Age-Specific Eligibility

Age Group Regulatory Status
Adults and Adolescents (12+ years) Eligible for standard use.
Pediatric (Under 12 years) Not recommended; infants are especially susceptible to toxic effects.
Geriatric (Older Adults) Use requires caution and careful dose selection due to increased risk of toxic reactions and greater frequency of reduced organ function.

Conditional Use Restrictions

Levsin Drops should only be used with caution in patients who have renal disease, hyperthyroidism, autonomic neuropathy, or specific cardiovascular conditions such as coronary heart disease, congestive heart failure, or hypertension. For pregnancy, the drug is Category C, meaning use is conditional and only permitted if the potential benefit justifies the risk. The drug is excreted in human milk, warranting caution during lactation.

What should I know about interactions with other medicines?

Interactions with other medicines and products

The official regulatory profile for Levsin Drops focuses on two primary interaction patterns: additive pharmacological effects and physical interference with drug absorption. These patterns establish constraints for co-administration with other substances.

Pharmacodynamic Reinforcement

Co-administration with other medications that exhibit antimuscarinic or anticholinergic effects may result in additive adverse effects due to a synergistic cholinergic blockade. Officially listed categories and specific substances for this type of interaction include:

  • Other Antimuscarinics, Phenothiazines, Monoamine Oxidase (MAO) Inhibitors, Tricyclic Antidepressants, and some Antihistamines.
  • Amantadine and Haloperidol.

Absorption and Timing Requirements

  • Antacids: Co-administration with antacids may interfere with the absorption of Hyoscyamine sulfate. The regulatory label specifies a timing separation requirement: Levsin Drops should be administered before meals, and antacids after meals.
  • Other Oral Medications: Due to the drug’s effect of decreasing gastrointestinal motility, the absorption of other concurrently administered oral medications may be reduced.
  • Alcohol: Consumption of alcohol may increase the documented side effects of drowsiness and dizziness.

Population-Specific Caution

Regulatory documents include a caution related to drug excretion: the risk of toxic reactions may be greater in individuals with impaired renal function, a factor associated with the drug being substantially excreted by the kidney.

Mechanism of Action

The mechanism of action for Levsin Drops focuses on blocking signals within the autonomic nervous system that drive smooth muscle contraction and glandular secretion.

Non-Selective Receptor Blockade

The active ingredient, hyoscyamine, is a non-selective competitive antagonist of peripheral muscarinic acetylcholine receptors (M1–M5). By binding to these receptors, hyoscyamine prevents the excitatory neurotransmitter acetylcholine (ACh) from activating its targets. This action blocks signal transmission through the affected pathways of the peripheral cholinergic system.

Suppression of Smooth Muscle Cascades

Blocking the muscarinic receptors on visceral organs reduces the signal strength originating from cholinergic nerve signals. This sequence results in decreased contraction of smooth muscle in the affected viscera, including the gastrointestinal (GI) and genitourinary tracts. This action reduces the physiological output of contractility and propulsive movement.

Inhibition of Exocrine Secretion

The same receptor antagonism on glandular cells, such as those in the salivary, gastric, and sweat glands, suppresses their function. This results in a decrease in the secretory function of exocrine glands, such as salivary, gastric, and bronchial glands. This action represents a direct physiological consequence of the drug's mechanism on cholinergic-regulated glands.

Dosage and Administration Information

How to Use Levsin Drops

Levsin Drops, which is an oral solution containing 0.125 mg of Hyoscyamine sulfate per mL, is designated strictly for oral administration. The usage pattern is based on symptom presence and is administered as needed (PRN), adhering to specific dose ranges and maximum limits.


Official Administration and Measurement

Administration requires the use of the calibrated dropper provided with the product to ensure accurate volumetric measurement of the dose. The labeling indicates that the dose is typically scheduled to be taken 30 to 60 minutes before meals and at bedtime to align with periods of gastrointestinal activity.


Standard Dosing and Frequency

Usage frequency mandates a minimum interval of four hours between doses. The total amount administered in a 24-hour period must not exceed the specified maximums, which vary by age group.

Population Dosing Range (Per Dose) Maximum Daily Dose (24 Hours)
Adults 12 Years and older 0.25 mL to 2 mL 12 mL (1.5 mg) or 6 mL (0.75 mg) depending on formulation
Children 2 to <12 Years 0.25 mL to 1 mL 6 mL (0.75 mg)

Use in Pediatric Populations

Dosage for infants and children under 2 years of age is determined by the patient’s body weight (kilograms), requiring consultation of the specific drops-per-weight tables detailed in the prescribing information. This weight-based requirement ensures adherence to the necessary dosage precision for this younger population.

Recent Clinical Evidence

Research Evidence / Overview of Studies for Levsin Drops


Evidence for use in Abdominal Cramps and Spasms

Research has examined the use of Levsin Drops in conditions characterized by fluctuating or episodic manifestations, particularly those involving the digestive system. Studies in this area often focus on outcomes related to patient-reported experiences and the body's digestive function. Research explored how the compound was observed to relate to outcomes reflecting systemic or functional imbalance in the gastrointestinal (GI) tract, which are relevant to the presence of abdominal cramps and spasms.

The findings generally describe patterns observed in studies where Levsin Drops was evaluated in settings evaluating daily-life functioning. Specifically, the data show patterns related to short-term changes in patient-reported experiences. What remains uncertain is the precise extent of change observed compared to other treatment approaches, as comparative evidence is lacking in some areas.


Evidence for use in Peptic Ulcer Disease (Adjunctive Therapy)

Levsin Drops was studied for use as a supplementary treatment in peptic ulcer disease. Research examined its use as an add-on therapy, focusing on the study of outcomes related to systemic or functional imbalance. Studies in this area contribute to the broader evidence landscape by examining how Levsin Drops was observed when used alongside other therapies.

Research available does not confirm whether Levsin Drops contributes to the healing process of ulcers or prevents them from recurring. The findings relate to the patient-reported outcomes describing perceived discomfort while used in addition to main treatments. Certainty remains low regarding its independent healing contribution, as the research examined its use only alongside primary treatments.


Long-term studies and follow-up

Research has explored what happens over time with the use of this type of medication. This section reports on what studies have explored regarding long-term outcomes, focusing on the durability of observed patterns in patient experience. For many anticholinergic medications like Levsin, long-term effects are not fully established because follow-up durations were limited. Data regarding long-term patient-reported outcomes or potential changes in side effect profiles are still emerging.


Evidence in special populations

The research examined whether the effects of Levsin Drops differ across specific patient groups. For older adults, evidence suggests that this class of medication was observed in research requiring additional analysis. Findings from some studies reported observations of confusion or dizziness in this age group, and the evidence highlights that data are still emerging when Levsin Drops is considered for older adults.

For children, Levsin Drops was evaluated in specific formulations. However, the evidence quality varies across studies, and data for certain groups of children remain insufficient. Safety and performance for use in children have not been fully established in available clinical studies.


What is still uncertain about Levsin Drops

One key area of uncertainty is research that compares outcomes with Levsin Drops to outcomes observed with newer or alternative treatments. Comparative evidence is lacking for many direct comparisons. Furthermore, the results apply only to the populations studied, meaning applicability to individuals with unusual combinations of symptoms is not guaranteed.

Key Studies & References

  1. Efficacy of antispasmodic agents for the treatment of Irritable Bowel Syndrome: systematic review and meta-analysis
  2. Hyoscyamine Sulfate Tablets and Drops (Levsin) Package Insert / Prescribing Information (Indications and Adjunctive Use)
  3. Hyoscyamine Pregnancy and Lactation Use (General Anticholinergic Class Information)

Frequently Asked Questions (FAQ)

Common questions about Levsin Drops (FAQ)

Q: How quickly does Levsin Drops usually start working?

A: The active ingredient is described as being rapidly and completely absorbed after oral use. Official guidance indicates that the onset of action is generally expected to occur within 20 to 30 minutes after taking the drops.

Q: How long do the effects of Levsin Drops typically last?

A: The duration of effect is related to the drug's half-life, which is reported to be 2 to 3.5 hours. Official documents suggest that dosing is typically scheduled every four hours or as needed, based on the duration of therapeutic effect.

Q: Are there common signs that Levsin Drops is working?

A: The intended clinical effect of this medicine is the reduction of spasms and excessive movement (hypermotility) in the gastrointestinal tract. The drug's intended action is associated with the resulting relief of symptoms such as cramps or abdominal discomfort.

Q: Can Levsin Drops be taken with food?

A: Official guidance recommends that the medicine typically be taken 30 to 60 minutes before meals and at bedtime. This specific timing is suggested to align with the drug's function and maximize its intended effect on gut activity.

Q: What if I miss a use of Levsin Drops?

A: The standard advice is that the medicine may be used as soon as remembered, unless it is almost time for the next scheduled use. In that case, the missed amount is typically skipped, and the regular schedule continued, as directed by official patient information.

Q: How is the absorption of Levsin Drops in the body described?

A: According to regulatory documents, the active ingredient is described as being rapidly and fully absorbed from the gastrointestinal tract shortly after oral administration.

Q: Is it safe to drive or operate machinery while using Levsin Drops?

A: Regulatory documents state that this medicine may cause side effects such as drowsiness, dizziness, or blurred vision. Because of these potential effects, caution is recommended with activities that require mental alertness, such as driving or operating machinery, until an individual knows how the drug affects them.

Q: Are there any warnings about sunlight exposure while using Levsin Drops?

A: Due to the drug's effect of decreasing sweat gland activity, official warnings describe a risk of heat prostration, fever, or heat stroke when exposed to high environmental temperatures. This risk is a documented safety consideration.

Q: Are there any long-term effects associated with Levsin Drops?

A: Regulatory documents note that prolonged use of this type of medication may cause decreased salivary flow. This reduced saliva production can contribute to the development of dental complications, such as caries (cavities) or periodontal disease.

Q: Do Levsin Drops contain sugar, alcohol, or dyes?

A: The product's official labeling lists the inactive ingredients, which typically include ethyl alcohol, sucrose, sorbitol (a type of sugar alcohol), and specific FD&C coloring agents (dyes) in the oral solution formulation.

Q: Are there any reported cases of allergic reaction to Levsin Drops?

A: Although rare, the official label includes allergic reactions or hypersensitivity (such as a rash or swelling) as a possible adverse effect that has been reported. Severe reactions are a documented serious safety consideration requiring prompt medical attention.

Q: What should I do if I experience unexpected effects after using Levsin Drops?

A: Official regulatory guidance indicates that any unexpected effects, especially those that are severe or potentially life-threatening (such as confusion, fast heartbeat, or a rash), are a serious concern and require prompt medical attention from a healthcare professional.

Q: Does official guidance mention specific medical conditions that restrict the use of Levsin Drops?

A: Yes, official documents list conditions that prohibit use (known as contraindications, e.g., glaucoma, obstructive diseases) and conditions where use requires caution (e.g., certain cardiovascular issues, renal disease, hyperthyroidism).

Q: Are Levsin Drops safe for older adults?

A: Regulatory documents advise that use in older adults requires caution because this population is more susceptible to toxic effects, including excitement, confusion, and urinary retention. A careful dose selection is noted as necessary due to a greater frequency of reduced organ function in this age group.

Q: Are there any known issues with using Levsin Drops in children?

A: Use in children requires caution due to increased susceptibility to toxic effects. Official documents note a specific risk of elevated body temperature when the medicine is used in children exposed to high environmental temperatures.

Q: Can Levsin Drops be taken at the same time as antacids?

A: Co-administration is advised against because antacids may interfere with the absorption of Levsin Drops. Regulatory guidance specifies a timing separation where Levsin Drops is administered before meals and antacids are administered after meals.

Q: Can Levsin Drops change the way other prescription medicines work?

A: Due to its effect of slowing down gut movement (decreased gastrointestinal motility), Levsin Drops may reduce the rate or extent of absorption of other oral medications taken at the same time.

Q: Can Levsin Drops be mixed with any liquids other than water?

A: The liquid formulation is administered with the calibrated dropper and is sometimes directed to be mixed with a small amount of water or other suitable liquids (like juice or formula) for easier ingestion, particularly in younger patients.

Q: How is the drop formulation different from a tablet formulation?

A: The drop formulation is an oral solution that allows for more precise volumetric dosing using the calibrated dropper and is an alternative for individuals who have difficulty swallowing tablets.

Q: Why might a doctor suggest the drop formulation instead of a tablet?

A: The liquid drop form offers flexible administration and is often suggested for patients, particularly infants and children, who require weight-based dosage adjustments or struggle with solid oral forms.

Q: Is there specific research available on Levsin Drops?

A: Studies have examined the drug's use as adjunctive therapy in the treatment of peptic ulcer and to control visceral spasm and hypermotility in functional gastrointestinal disorders (such as irritable bowel syndrome). The research focuses on symptom management and control.

How should Levsin Drops be stored and disposed of?

How to Store and Dispose of Levsin Drops

The storage and disposal of Levsin Drops (Hyoscyamine Sulfate Oral Solution) must strictly follow the requirements specified in official regulatory labeling to maintain the product's stability.

Storage Requirements

Condition Requirement
Temperature Store at controlled room temperature, 20 C to 25 C (68 F to 77 F). Do not refrigerate or freeze.
Protection Must be protected from light and moisture.
Container Keep in the original, tight, light-resistant container with a child-resistant closure.
Child Safety Keep out of the reach of children.

Disposal Instructions

Unused or expired Levsin Drops should be disposed of using a drug take-back program. If a take-back program is unavailable, the liquid must be mixed with an unappealing material, placed in a sealed bag, and discarded in household trash. This medicine is not to be flushed down a toilet or poured into a sink.

Attention! Always consult to a doctor or pharmacist before using pills or medicines.

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