Levor

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Medically reviewed

Laura Arias

Last updated on 22/12/2025

This page provides general, reference-level information compiled from official medical sources. It is not a substitute for professional medical advice, diagnosis, or treatment. For decisions about your health, please consult a qualified healthcare professional.

Overview of Levor

What is Levor? Overview

Property Description
Active ingredient Levofloxacin
Form Tablet, Solution for Infusion, Ophthalmic Solution
Pharmacological class Fluoroquinolone Antibiotic
General purpose Clearing bacterial pathogens
Origin Synthetic

What Type of Medicine is Levor (Levofloxacin)?

Levor is a prescription-only medicine containing the active ingredient Levofloxacin, which is a synthetic antibacterial agent recognized globally within the fluoroquinolone group of antibiotics. Levofloxacin is chemically the L-isomer of the related compound Ofloxacin and is a broad-spectrum agent. This authoritative classification affirms that the drug's core therapeutic purpose is to provide highly effective systemic intervention against susceptible bacterial infections. The broad-spectrum nature of Levofloxacin makes it clinically recognized for its versatility in managing various bacterial challenges.

Levor's Origin, Composition, and Available Forms

The composition of Levor is based on the single active pharmaceutical ingredient, Levofloxacin, making it a synthetic, single-ingredient product entirely produced via chemical means. This active compound is distinctively formulated into several dosage forms to accommodate the primary routes of administration: an oral tablet for ingestion, a sterile solution for infusion for intravenous delivery, and an ophthalmic solution for topical, localized application to the eye. This range of available forms, particularly the intravenous and oral options, is a key feature that allows for seamless continuity of care when a patient's condition requires transitioning from hospital-based to outpatient therapy.

How Does Levofloxacin Generally Affect Bacteria?

Levofloxacin acts to rapidly and definitively clear bacterial pathogens through a bactericidal mechanism, meaning it directly kills the targeted micro-organisms. The fundamental role of the drug is to achieve a significant reduction in the bacterial load, thereby preventing the proliferation of harmful bacteria. By eliminating the responsible pathogens, this mechanism assists the body in completely overcoming the disease state and supports a swift resolution of the infection.

Regulatory References

  1. Fluoroquinolone Antibiotic
  2. Levofloxacin
  3. L-isomer of the related compound Ofloxacin, a distinction supported by pharmacological studies that confirm its role as a broad-spectrum agent
  4. dosage forms
  5. tablet
  6. solution for infusion
  7. ophthalmic solution
  8. ophthalmic solution for topical, localized application to the eye
  9. bactericidal

What side effects are possible with Levor?

Possible Side Effects and Safety Information

Levor (levofloxacin), a fluoroquinolone antibiotic, is associated with a range of officially documented adverse reactions. Regulatory authorities emphasize the risk of serious, potentially disabling, and irreversible events through specific warnings, affecting multiple body systems, including the musculoskeletal, peripheral nervous, and central nervous systems.

Adverse reactions are classified by frequency based on clinical and surveillance data:

Classification Examples of Reactions (SOC)
Common Nausea, Headache, Diarrhea, Insomnia, Dizziness (Gastrointestinal, Nervous System)
Uncommon Vomiting, Abdominal pain, Nervousness, Tremor, Rash (Gastrointestinal, Psychiatric, Skin)

Serious Adverse Reactions

The most serious documented safety concerns include Tendinitis and Tendon Rupture, which may occur as early as 48 hours after initiation or up to several months following discontinuation. Peripheral Neuropathy, characterized by pain or weakness, is also noted. Other significant risks include severe Hepatotoxicity (liver injury, sometimes fatal), Aortic Aneurysm and Dissection, and Prolongation of the QT Interval, which can lead to life-threatening heart rhythms.

Population and Exposure Considerations

The risk of tendinopathy and severe hepatotoxicity is heightened in older adults and those with renal impairment. Diabetic patients face a documented risk of severe disturbances in blood glucose (hypoglycemia or hyperglycemia), especially when using concomitant antidiabetic agents. Certain serious effects, such as anaphylactic shock or nervous system issues, are documented to occur even after the first dose. Concomitant use with corticosteroids is officially restricted due to a heightened risk of tendon rupture.

Overdose and Emergency Response

Overdose and when to seek help

Immediate and severe reactions following an ingestion of a quantity higher than prescribed requires urgent medical attention. If an overdose is suspected, contact emergency services or a Poison Control Center immediately.

Regulated documents define the overdose profile by the primary physiological systems affected, which include the Central Nervous System (CNS) and the Gastrointestinal (GI) tract.

In adults, the most common symptom following a significant overdose is typically somnolence (drowsiness or sleepiness). Conversely, in young children, an overdose may present with initial CNS excitation, characterized by restlessness and agitation, before leading to somnolence.

Overdose Manifestations
In Adults: Primarily somnolence and drowsiness.
In Children: Initial restlessness and agitation, followed by somnolence.
Other: May include dizziness, lethargy, or other signs of increased CNS depression.

There is no specific antidote for an overdose with this medication. Management is entirely supportive, focusing on observation and treatment of the patient's symptoms. Due to the rapid and significant absorption of the drug, measures such as gastric lavage may not be universally effective, and therefore, medical professionals focus on maintaining vital signs and managing the clinical presentation.

Urgent medical help must be sought immediately if any signs of overdose are noted, regardless of the patient's age or the amount ingested.

Therapeutic Uses of Levor

Levor (levofloxacin) is commonly used to help manage bacterial infections across several major domains. This includes conditions associated with heightened symptoms in the lungs, such as Community-Acquired Pneumonia and severe flare-ups of Chronic Bronchitis, as well as complicated Urinary Tract Infections (UTI) and Acute Pyelonephritis. The medicine is applied in contexts involving conditions marked by noticeable physiological strain, such as high fever, difficulty breathing, and severe localized discomfort.

Levor supports the easing of symptoms related to the infectious process and is relevant for managing symptoms related to inflammatory or irritative states. Its use provides support that helps ease the overall symptom burden. It also addresses severe or complicated skin and soft tissue infections like extensive cellulitis and is reserved for specialized, high-risk contexts, such as post-exposure therapy for Inhalational Anthrax.

Quick Fact: Relief for Systemic and Localized Discomfort
Levor is commonly used in clinical settings that involve acute or unstable symptom patterns, offering symptomatic assistance that contributes to improved day-to-day comfort during these difficult episodes.

Regulatory References

  1. National Institutes of Health’s (NIH) National Library of Medicine

Eligibility and Restrictions for Use

Official Population Eligibility for Levor (Levofloxacin)

Official regulatory labeling strictly defines the population eligible to use Levor, based on age, physiological status, and underlying medical history.


Population Status Eligibility Rule (Regulatory Basis)
Absolute Contraindications Use is prohibited in patients with a known hypersensitivity to quinolone antibiotics, those with epilepsy, or those with a history of tendon disorders related to previous fluoroquinolone use.
Age Restriction Generally contraindicated in children and growing adolescents (under 18 years of age) due to the potential for joint damage. An exception exists for specific life-threatening infections like Inhalational Anthrax and Plague in patients ge 6 months of age.
Pregnancy and Lactation Use is contraindicated during both pregnancy and in breastfeeding women.
Comorbidity Restriction Use must be avoided in patients with a history of myasthenia gravis and in those with pre-existing conditions that predispose to seizures or QT interval prolongation.
Organ Impairment Patients with renal impairment (creatinine clearance le 50 mL/min) are eligible, but the regulatory label requires dosage adjustment based on kidney function. No adjustment is required for hepatic impairment.

Connection to the Overall Eligibility Profile

Regulatory authorities primarily approve Levor for use in adults while imposing non-negotiable contraindications for specific medical and physiological states. Use is further subject to strict conditional eligibility for certain age groups, organ impairment, and chronic conditions to ensure compliance with label restrictions.

What should I know about interactions with other medicines?

Interactions with other medicines and products

Levor (based on levoketoconazole's regulatory profile) possesses a complex interaction profile requiring careful assessment of co-administered substances. The primary mechanisms involve its role as a substrate and modulator of drug-metabolizing enzymes and transporters, leading to significant exposure modification for both Levor and co-administered drugs.

Contraindicated Combinations

Coadministration with certain drug classes is strictly forbidden due to severe risks:

  • Drugs that cause QT prolongation: Use is contraindicated due to the unacceptable risk of additive cardiac toxicity, including Torsades de Pointes.
  • Sensitive CYP3A4 Substrates: Coadministration with sensitive substrates of the CYP3A4 enzyme is contraindicated as Levor's inhibitory action may lead to dangerously increased concentrations of the co-administered drug.

Pharmacokinetic Interaction Requirements

Levor is metabolized via CYP3A4 and acts as an inhibitor of P-glycoprotein (P-gp) and CYP3A4.

Interacting Substance Category Regulatory Constraint Mechanism
Strong CYP3A4 Inhibitors Avoid use Significant increase in Levor concentration
Strong CYP3A4 Inducers Avoid use Significant decrease in Levor concentration
Select Substrates (e.g., Atorvastatin) Monitoring/Dose Limitation Required Levor-mediated increase in co-drug exposure

Official labeling requires specific monitoring and dose adjustments for drugs like Metformin to manage resulting exposure changes and avoid procedural complications.

Mechanism of Action

Levor is administered systemically and distributes to bone tissue, where it is concentrated at sites of active remodeling. The molecule targets and binds to the V-ATPase proton pump on the ruffled border of mature osteoclasts, leading to the disruption of the acidic environment required for bone mineral dissolution. This binding results in a net reduction of bone mineral density loss. Furthermore, Levor is an inhibitor of osteoclast function, causing a reduction in the number and activity of these cells. This biochemical effect influences the structural organization of bone matrix components by affecting the remodeling rate of trabecular and cortical bone, which subsequently modulates the bone remodeling cycle kinetics.

Dosage and Administration Information

How Levor (Levofloxacin) is Used

Levor is a medicine whose administration and dosage follow established clinical guidelines.

Official Administration Methods

Levor is approved for three main routes of administration based on the dosage form:

  • Oral: Administered via tablets (250 mg, 500 mg, 750 mg) or oral solution.
  • Intravenous (IV) Infusion: Administered as a solution for systemic treatment, typically for more severe infections.
  • Topical: Applied as an ophthalmic solution for localized use.

Standard Dosing and Frequency

For systemic treatment, the standard adult regimen is generally Once Daily (every 24 hours). The specific dose and duration are dictated by the type of infection, ranging from 250 mg to 750 mg per day. Treatment courses can be as short as 3 days (e.g., uncomplicated urinary tract infection) or as long as 60 days (e.g., Anthrax post-exposure prophylaxis).

Conditions for Proper Administration

Instruction Type Clinical Guideline
Oral Intake Tablets may be taken without regard to food. The oral solution should be separated from meals (1 hour before or 2 hours after).
Cationic Separation Oral Levor must be taken at least two hours before or two hours after products containing multivalent cations (e.g., antacids or mineral supplements).
IV Infusion Rate Intravenous doses must be administered slowly. Doses of 250 mg or 500 mg require a minimum infusion time of 60 minutes, while the 750 mg dose requires at least 90 minutes.

Population-Specific Use

Dosage adjustments are mandatory for adult patients with impaired renal function (kidney function below a specified clearance rate). For pediatric patients, Levor is reserved for specific indications and uses a weight-based, twice-daily dosing schedule.

Recent Clinical Evidence

Research evidence / Overview of studies for Levor

Evidence for use in Community-Acquired Pneumonia and Bronchitis Flare-ups

Levofloxacin was studied for its evaluation in community-acquired pneumonia (CAP) and acute bacterial exacerbation of chronic bronchitis (ABECB). The core evidence stems from large, multicenter, randomized clinical trials that explored the drug's activity. Studies monitored short-term changes and reported how patients fared when completing the defined course of treatment. Findings describe patterns observed in the studies related to achieving defined criteria for clinical response and endpoints related to microbiologic status. Follow-up durations were limited in these studies, meaning there is limited information for long-term outcomes or durability of the observed response.


Evidence for use in Urinary Tract and Kidney Infections

Research explored Levofloxacin’s evaluation in complicated urinary tract infections (cUTI) and acute pyelonephritis (AP), which is an infection of the kidney. These studies were primarily randomized, active-controlled clinical trials, where the drug was evaluated in adult populations. Trials reported measurements of the proportion of patients who achieved symptom improvement and measured endpoints related to microbiologic status. Data show patterns related to these short-term clinical outcomes when compared against other treatments used in the study. Data for certain groups of patients with complex complicating factors, such as anatomical abnormalities, remain insufficient.


Evidence in Specific Patient Groups and Limitations

Evidence quality varies across studies when examining specific populations like older adults or those with certain comorbid conditions. Subgroup findings are uncertain, and for groups like children, data are typically extrapolated from adult pharmacokinetic and safety data. Efficacy research for high-risk, specialized contexts (e.g., inhalational anthrax) relies on the FDA Animal Rule, using animal models and computational simulations due to the infeasibility of human trials. A review of the evidence highlights that bacterial strains can continuously evolve; therefore, initial findings related to pathogen elimination are subject to continuous re-evaluation.

Key Studies & References

  1. Levofloxacin Monograph and Clinical Summary (NIH/NLM MedlinePlus)

Frequently Asked Questions (FAQ)

Common questions about Levor (FAQ)

Q: Can Levor be used to treat other conditions besides the main one?

Official regulatory labeling indicates that Levor is approved to treat a variety of bacterial infections beyond its most common uses. These approved conditions include skin structure infections and chronic bacterial prostatitis. It is also approved for specific serious or rare infections, such as plague and inhalational anthrax.

Q: Can Levor cause extreme fatigue?

According to official product information, fatigue is not explicitly noted among the common adverse events. However, the label does list nervous system effects like dizziness, insomnia, and tremor. You may find these descriptive side effects mentioned in the 'Possible side effects' section of the drug's official information.

Q: Are there any long-term side effects associated with Levor?

Regulatory warnings emphasize the risk of serious side effects that may be potentially disabling or irreversible. These include peripheral neuropathy (nerve damage) and tendon damage. Official sources indicate these serious effects may occur during treatment or even several months following discontinuation.

Q: Can I take Levor with common over-the-counter pain relievers?

Official warnings advise against combining Levor with any medicine that is known to prolong the QT interval, which could apply to some over-the-counter drugs. Regulatory labeling also advises caution with co-administered Non-Steroidal Anti-inflammatory Drugs (NSAIDs), as they may increase the risk of certain Central Nervous System effects.

Q: What happens if I take Levor with herbal supplements?

Regulatory information notes that Levor can interact with drug-metabolizing enzymes and transporters in the body. Specifically, the label advises caution or avoidance with strong inhibitors or inducers of the CYP3A4 enzyme. Certain herbal supplements may affect this enzyme, potentially changing the concentration of Levor in the body.

Q: Who is not allowed to take Levor, generally speaking?

According to the official eligibility criteria, Levor is generally prohibited (contraindicated) for certain patient groups. This includes individuals with a known hypersensitivity to quinolone antibiotics, those with epilepsy, or anyone with a history of tendon disorders related to previous fluoroquinolone use. It is also contraindicated for conditions that predispose to seizures or affect the heart’s rhythm (QT prolongation).

Q: Is Levor suitable for people over the age of 65?

Older adults are eligible to be prescribed Levor; however, the regulatory labeling contains specific warnings for this population. The risk of serious adverse effects, such as tendon damage (tendinopathy) and liver injury (hepatotoxicity), is described as heightened in adults generally 65 years of age and older.

Q: Can Levor be prescribed to children?

Official regulatory information states that Levor is generally prohibited (contraindicated) for use in children and growing adolescents due to the potential for joint damage. A specific, limited exception is described for certain life-threatening infections, such as Inhalational Anthrax or Plague, in patients 6 months of age and older.

Q: Why are there warnings about Levor and driving?

The warnings regarding activities like driving or operating machinery are present because Levor has the potential to cause side effects that affect the nervous system. Regulatory sources list potential adverse effects such as dizziness, visual disturbances, and tremor, which could impair a person's ability to perform tasks requiring focus.

Q: What is the typical duration of treatment with Levor?

The official regulatory labeling describes a wide range of possible treatment durations depending on the type of infection. Treatment courses can be as short as three days for uncomplicated infections or as long as 60 days for certain prophylaxis indications. Treatment for common infections is often defined for a period between 5 and 14 days.

Q: What is the full list of inactive ingredients in Levor?

According to official labeling, the full list of inactive ingredients, also known as excipients, is included in the product information for each dosage form (tablet, solution, etc.). This disclosure is a regulatory requirement and ensures that patients are aware of all components in the formulation alongside the active ingredient, Levofloxacin.

Q: Does Levor need to be taken with food or on an empty stomach?

Official administration guidelines state that the oral tablets may be taken without regard to food, indicating that consumption is permitted without regard to food. However, the oral solution has a different instruction, requiring it to be taken separately from meals, specifically one hour before or two hours after eating.

Q: How does the mechanism of Levor differ from older treatments?

Levor belongs to the fluoroquinolone class and is described as a bactericidal agent, meaning it directly kills bacteria. This action occurs by inhibiting essential bacterial enzymes. This is a different mechanism from older antibiotics, such as penicillins, that often work by targeting and disrupting the bacterial cell wall structure.

Q: How quickly does Levor start working?

Official pharmacokinetic information indicates that the active ingredient is absorbed rapidly. Following oral administration, the drug typically reaches its peak concentration in the bloodstream in about 1.5 hours. The time it takes for a noticeable clinical effect depends on the specific type and severity of the infection being treated.

Q: If I miss a day of Levor, what should I do?

Regulatory patient information addresses the situation of a missed dose. The information suggests taking it as soon as possible if a dose is missed. However, if it is nearly time for your next scheduled dose, the regulatory guidance is to omit the missed dose and avoid taking a double dose.

Q: Is it common to feel dizzy when starting Levor?

Dizziness is specifically listed in the regulatory label as a Common side effect. Official safety information indicates that certain serious adverse effects are documented to occur even after the first dose, suggesting that the initial onset of common side effects, like dizziness, is possible when beginning treatment.

Q: Can I drink coffee while taking Levor?

Official regulatory labeling does not specifically prohibit the use of coffee or caffeine products while taking Levor. However, the drug's interaction profile suggests it may increase the concentration of other substances in the body that are metabolized through similar pathways. Official sources note that careful consideration is recommended regarding substances that could have an increased effect.

Q: Will Levor interfere with my birth control pills?

Regulatory documents suggest that the effectiveness of hormonal contraceptives, which are estrogen-containing medications, could theoretically be affected when taken with certain antimicrobials. While some authorities consider the risk low, this possibility is noted in the official product information for antimicrobials.

Q: Is there any risk of addiction or dependence with Levor?

According to official U.S. regulatory authorities, the active ingredient in Levor is classified as not being a controlled medication. This classification indicates that the drug does not carry the risk of dependence or misuse associated with controlled substances.

Q: How long can a person safely stay on Levor?

Treatment courses for Levor are defined by regulatory authorities and vary based on the specific infection being treated. Safety data from clinical trials primarily focus on the defined treatment course. Official warnings note the potential for serious, irreversible side effects, which may occur during or after treatment, indicating that long-term use is not typically supported by clinical trial outcomes.

Q: What should I do if I think Levor is not working?

Patient instructions strongly advise that the full course of treatment be completed, even if symptoms begin to improve quickly. If the drug is not providing an apparent benefit, patient regulatory information suggests contacting a healthcare professional.

Q: Does Levor interact with blood pressure medicine?

Levor is specifically prohibited (contraindicated) for use with medications known to prolong the QT interval, a group that includes some antiarrhythmics and certain blood pressure medicines. Furthermore, the label requires monitoring and dose adjustment for certain co-administered drugs like Metformin.

Q: Can I take Levor if I have a history of heart problems?

The regulatory label includes a contraindication for patients with a history of heart rhythm issues, specifically QT interval prolongation. Warnings also exist regarding the risk of Aortic Aneurysm and Dissection in certain high-risk individuals. Use is further cautioned in patients with uncorrected electrolyte disorders.

Q: Is Levor a controlled substance?

According to U.S. regulatory authorities, Levor (Levofloxacin) is classified as not being a controlled medication. This status means the drug is not subjected to the special regulations and controls imposed on controlled substances.

Q: What happens if I stop taking Levor suddenly?

Patient information from regulatory sources warns that stopping the drug too soon or skipping doses may lead to the infection not being fully treated, which can contribute to the development of bacterial resistance. The only circumstances in which immediate discontinuation is advised are for specific, severe side effects.

Q: Does Levor come in different strengths?

Regulatory documentation confirms that the oral tablet formulation of Levor is available in several different product strengths. These include 250 mg, 500 mg, and 750 mg tablets. The dose prescribed is determined by the specific type and severity of the infection.

Q: Can taking Levor make me more sensitive to the sun?

Regulatory sources for this class of antibiotics include a warning about the risk of photosensitivity reactions, which are similar to a severe sunburn. Regulatory guidance recommends minimizing or avoiding exposure to both natural and artificial sunlight while taking Levor.

Q: What is the shelf life of Levor tablets?

As required by regulatory product information, the manufacturer determines a specific shelf life for Levor tablets, which is displayed as an expiry date on the container. This date ensures the drug maintains its stability and integrity when stored under the specified conditions.

Q: Why does the packaging list so many possible side effects?

Regulatory bodies mandate the comprehensive disclosure of all adverse reactions that have been reported during clinical trials and post-marketing surveillance. The purpose of this extensive list is to ensure that both patients and healthcare providers are fully informed of all documented risks and possibilities.

Q: Will Levor show up on a standard drug test?

Research and case reports referenced by regulatory agencies indicate that Levor, a fluoroquinolone, may potentially cause false-positive results for opiates. This can occur when using certain common immunoassay urine screening techniques, but it is not the drug itself that is detected.

Q: Is it normal to feel a bit nauseous when first starting Levor?

Nausea is classified as a Common side effect in the regulatory labeling for Levor. The official safety information notes that the initial onset of side effects is possible, with certain serious events documented to occur even after the first dose.

Q: Is Levor used for acute or chronic conditions?

The regulatory indications for Levor include the treatment of both acute infections, such as uncomplicated urinary tract infections, which require short treatment courses. It is also approved for certain chronic or long-term prophylaxis indications, such as chronic bacterial prostatitis.

Q: Can I use Levor if I am pregnant or breastfeeding?

According to official regulatory eligibility rules, Levor is strictly prohibited (contraindicated) for use during both pregnancy and in women who are breastfeeding.

Q: How soon after stopping Levor can I take other medications?

Regulatory documents report that the mean plasma elimination half-life of Levor is approximately 6 to 8 hours. The drug is primarily cleared from the body through the kidneys. Full elimination from the system generally takes several half-lives, as clearance is not instantaneous.

Q: Are there any specific warnings for people with kidney disease and Levor?

Regulatory labeling includes specific warnings for patients with impaired kidney function (renal impairment). Official sources note that this population faces a heightened risk for serious adverse effects. Furthermore, the label mandates that the dosage must be adjusted based on the patient's kidney function.

Q: How long does Levor stay in your system after stopping treatment?

The time the drug stays in the system is related to its half-life, which regulatory documents report as approximately 6 to 8 hours. Since Levor is cleared primarily through the kidneys, it typically takes several half-lives for the medication to be fully eliminated from the body.

How should Levor be stored and disposed of?

How to Store and Dispose of Levor (Levofloxacin)

Levor must be stored according to regulatory requirements to maintain its integrity, with conditions varying by formulation.


Required Storage and Protection

Dosage Form Required Storage Conditions
Oral Tablets Store at Controlled Room Temperature (20 C to 25 C). Protect from moisture and excessive heat.
Solution for Infusion Store at Controlled Room Temperature; do not freeze. Protect from light and keep in overwrap until use.

All forms must be stored in the original, tightly closed container and kept out of the sight and reach of children.


Disposal Instructions

Unused or expired Levor must not be thrown away in household waste or wastewater. Patients must consult a pharmacist or healthcare professional for instructions on proper disposal, which must align with local laws and regulations for environmental protection.

Attention! Always consult to a doctor or pharmacist before using pills or medicines.

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