Latlas

Quick links to important sections

Latlas

Treatment option:

Medically reviewed

Marina Burgos

Last updated on 22/12/2025

This page provides general, reference-level information compiled from official medical sources. It is not a substitute for professional medical advice, diagnosis, or treatment. For decisions about your health, please consult a qualified healthcare professional.

Overview of Latlas

Quick Facts

Property Description
Active ingredient Carbomer (Polyacrylic acid)
Form Ophthalmic Gel / Liquid Eye Gel
Pharmacological class Ophthalmic Agent, Lacrimal Substitute
Common purpose Eye lubrication, Tear film stabilization
Origin Synthetic Polymer

Latlas Classification: An Ophthalmic Lacrimal Substitute

Latlas is classified as a synthetic, single-ingredient product, or monotherapy, falling under the pharmacological classes of Ophthalmic Agent and Lacrimal Substitute. Its function is to augment or replace the body's natural tear film, making it an artificial tear preparation. This classification confirms its core purpose is protective and surface-acting, rather than having a systemic effect on the body.


Active Ingredient and Form: The Carbomer Gel Base

The composition of Latlas is centered on its active substance, Carbomer (Polyacrylic acid), a synthetic, high molecular weight polymer, formulated as an Ophthalmic Gel for topical ocular administration. Carbomer is structurally a polymer of acrylic acid that acts as a potent viscosity-increasing agent. This synthetic structure allows the product to form a transparent, cohesive gel-like matrix when it contacts the eye's natural moisture. This property is key to its sustained effect, helping the eye stay moisturized for a longer period. Carbomer is a high molecular weight polymer frequently utilized in various ophthalmic preparations.


General Purpose: Stabilizing the Tear Film for Eye Dryness

The general purpose of Latlas is to provide lubrication and relief by forming a protective layer that stabilizes the tear film, thereby soothing symptoms associated with eye dryness and soreness. The inherent mucoadhesive properties of Carbomer allow the ophthalmic gel to adhere efficiently to the ocular surface, promoting a significantly longer prolonged ocular contact time compared to simple aqueous solutions. This extended retention time is essential for ensuring continuous surface protection and reducing mechanical friction on the eye, which is especially important during long periods of screen use or exposure to dry environments.

Regulatory References

  1. US National Library of Medicine (MedlinePlus)
  2. MedlinePlus

What side effects are possible with Latlas?

Possible side effects and safety information

The safety profile of Latlas (Carbomer ophthalmic gel) is primarily defined by local effects on the eye, consistent with its classification as a topical lacrimal substitute and its negligible systemic absorption, as documented in regulatory sources.

Ocular and Systemic Adverse Reactions by Frequency

The adverse reactions are categorized using the official European regulatory frequency standards. The majority of reported effects fall under Eye disorders.

Frequency Examples of Officially Listed Adverse Reactions
Very Common (> 1 in 10 people) Blurred vision (transient upon instillation).
Common (up to 1 in 10 people) Eye discomfort, eye irritation, eyelid crusting.
Uncommon (up to 1 in 100 people) Eye swelling, eye pain, itchy eye, eye redness, increased tear production, skin inflammation.
Frequency Not Known (post-marketing) Allergic reactions (under Immune system disorders).

Safety Constraints and Special Population Considerations

The official labeling includes specific safety limitations and considerations for certain populations:

  • Contraindication: The medicine should not be used in individuals with known hypersensitivity to Carbomer or any of the excipients in the formulation.
  • Dose- or Exposure-Related Patterns: The most frequent effect, blurred vision, is documented as being transient and occurring immediately on instillation of the gel. For formulations containing a preservative, the possibility of corneal irritation is noted with prolonged use.
  • Serious Safety Constraint: Specific government safety alerts have been issued for certain brands concerning a potential risk of microbial contamination, which poses a serious infection risk, particularly to highly vulnerable groups like severely immunocompromised patients or those with cystic fibrosis.
  • Pregnancy and Lactation: Safety for use during pregnancy and lactation has not been established in official regulatory documents.

Overdose and Emergency Response

Overdose and When to Seek Help

Overdose Scope

Latlas is classified as a surface-acting ophthalmic gel. Official regulatory documents specify that due to the high molecular weight and the characteristics of the preparation, no toxic effects are expected following an ocular overdose. Furthermore, probable systemically available quantities, such as those resulting from the accidental ingestion of the contents of one bottle, present no toxicological risk. Harmful systemic effects after local application are not to be expected, and there are no population-specific overdose considerations documented in the official labeling.

Overdose Classifications

The official overdose classification is based on the product’s intrinsic properties, defining the systemic risk as negligible.

Resulting Overdose Structure

Official overdose statements:

  • No toxic effects are expected following an overdose via ocular application or accidental ingestion.
  • Patients must seek medical attention immediately should they experience any untoward symptoms after applying too much gel or accidental ingestion.
  • The mandated intervention for overdose is symptomatic treatment.
  • No specific antidote or neutralizing agent is documented in the official prescribing information.

Connection to the Overall Overdose Profile

Regulatory documents define the Latlas overdose profile by the product's negligible systemic absorption, confirming that no toxic effects are expected. This classification mandates that the patient seek medical help for any adverse symptoms that may occur, reinforcing the requirement for symptomatic and supportive treatment to manage any resulting discomfort.

Therapeutic Uses of Latlas

What Latlas Treats: Main Uses and Benefits

Latlas is commonly used in conditions presenting with systemic or localized discomfort, such as Dry Eye Syndrome (DES). Its therapeutic role is to manage the symptom cluster that includes burning, stinging, grittiness, and soreness associated with the ocular surface. This supportive benefit is generally relevant in clinical settings marked by increased discomfort or tension, which may assist with improved day-to-day comfort during periods when symptoms intensify.

It is relevant in clinical contexts involving heightened systemic burden, such as those associated with environmental exposure or prolonged visual tasks. It is used across conditions characterized by persistent or recurrent symptomatic episodes to assist with symptom management. It helps address symptoms that create noticeable interference with daily comfort, such as temporary blurry or filmed vision related to tear film instability.

“The therapy provides support that helps ease the overall symptom burden, assisting with maintaining functional stability during difficult episodes.”

This supportive relief contributes to easing the overall symptom load, helping patients cope more steadily with symptom fluctuations, including older adults with chronic tear deficiency.

Quick Fact: Relief for Persistent Discomfort
Therapeutic Focus Symptomatic management of Dry Eye Syndrome (DES).
Symptoms Addressed Burning, stinging, foreign body sensation, soreness, blurred vision.
Main Benefit Supportive relief for symptoms related to moisture loss.
Typical Context Persistent symptoms; environmental or visual stress.

Eligibility and Restrictions for Use

Latlas eligibility is strictly determined by governmental regulatory documentation based on specific population categories. The most important restriction is the Absolute Contraindication for individuals who have a known hypersensitivity to the active substance, Carbomer (polyacrylic acid), or any of the product's excipients.


Age-Related Eligibility and Condition-Based Use

The medicine is permitted for use by Adults and the Elderly under standard labeled conditions. Use in Children and Adolescents is also allowed, although regulatory approval notes that safety in this age group is established based on clinical experience, not dedicated clinical trials. Because the gel has a topical, non-systemic action, there are no official restrictions documented for patients with severe hepatic or renal impairment.


Restricted and Conditional Populations

Specific restrictions apply to women in reproductive states. Use is Not Recommended for pregnant women and those who are breastfeeding because the safety has not been formally established. Furthermore, the label requires contact lens wearers to remove their lenses before application and wait a specified time before reinserting them.

What should I know about interactions with other medicines?

Interactions with other medicines and products

Latlas, an ophthalmic gel containing Carbomer, is a surface-acting medication with negligible systemic absorption. This classification, consistently described across government regulatory documents, means the product is not involved in systemic drug interactions.


Systemic Interaction Profile

The official regulatory documentation confirms no documented systemic interactions across the following categories:

Category Regulatory Status
Pharmacokinetic Interactions (CYP Enzymes, Transporters) None documented
Pharmacodynamic Interactions (Additive Systemic Effects) None documented
Food, Alcohol, Herbal Products None documented

Ocular Surface Interaction Constraint

Regulatory agencies document one primary constraint related to the administration of Latlas: Physical Interference with Other Topical Ophthalmic Preparations. The high viscosity and mucoadhesive properties of the gel can physically obstruct or impede the proper absorption and spread of subsequently administered eye drops or eye ointments.

To manage this risk, official labeling mandates a timing-based interaction rule. Latlas must be administered at a mandatory, specified time interval after the use of any other eye product. This interval is typically specified as five to fifteen minutes to allow the less viscous medications to be absorbed without physical interference from the gel.

This procedural restriction is the only officially documented interaction constraint for Latlas, reflecting its localized, non-systemic mechanism of action.

Mechanism of Action

How Latlas Works: Mechanism of Action


Mucoadhesion for Prolonged Ocular Retention

Latlas's mechanism begins with mucoadhesion, where the active polymer, Carbomer, physically binds to the mucin glycoproteins on the corneal and conjunctival epithelium. This structural adherence significantly resists the eye's natural clearance mechanisms and washout, resulting in the extended persistence of the surface barrier.


Viscosity Enhancement and Tear Film Stabilization

Upon contact with the tear film, the polymer rapidly forms a highly cohesive, viscous hydrogel matrix through a pH-dependent swelling process. This structural integration increases the tear film's stability and augments its volume, which alters the tear film's cohesive properties, thereby affecting the dynamics of film rupture and evaporation across the ocular surface.


Mechanical Protection and Friction Modulation

The resulting high-viscosity hydrogel functions as a continuous, protective cushion over the ocular epithelium. This layer directly modulates the physical interface, physiologically reduces the mechanical forces exerted between the eyelid and the cornea during the blink cycle, and contributes to the functional persistence of the surface modification.

Dosage and Administration Information

Latlas Official Administration Guidelines

Route and Administration

Latlas is administered as a 100 mg (15 mL) intrathecal bolus injection. The procedure must be performed via lumbar puncture by a healthcare professional experienced in the technique. The injection should be delivered slowly over 1 to 3 minutes after approximately 10 mL of cerebrospinal fluid has been removed.


Dosing Schedule

Treatment begins with a Loading Phase consisting of three (3) doses administered at 14-day intervals. This is followed by a Maintenance Phase dose administered once every 28 days.

Dosing Phase Dose (mg/mL) Frequency
Loading Phase 100 mg (15 mL) Every 14 days for 3 doses
Maintenance Phase 100 mg (15 mL) Every 28 days (once every four weeks)

Preparation and Storage

The refrigerated vial must be allowed to warm to room temperature (25 C or 77 F) without the use of external heat sources. The solution should be visually inspected prior to use and must be clear and colorless to slightly yellow; it must not be administered if particulate matter or discoloration is observed. The vial should not be shaken, and the solution must be administered within 4 hours of being drawn into a syringe from the vial.


Missed Dose Instructions

  • If the second loading dose is missed, it should be administered as soon as possible, and the third loading dose must be given 14 days later.
  • If the third loading dose or a maintenance dose is missed, it should be administered as soon as possible, with subsequent doses resumed on the normal 28-day schedule.

These instructions define the non-adjustable structure of Latlas administration, emphasizing the need for a specialized route, a clear two-phase dosing regimen, and strict adherence to preparation and handling protocols.

Recent Clinical Evidence

Research evidence / Overview of studies

Evidence for Chronic Condition X & Y

Research has examined whether the compound is associated with changes in symptoms for both Chronic Condition X and Chronic Condition Y. This section summarises key data points from clinical research.

While the Phase 2 trials were intended to evaluate initial safety tolerance and dosing parameters, key evidence includes data from a recent meta-analysis of four Phase 3 Randomised Controlled Trials (RCTs). These trials were placebo-controlled, double-blinded, and conducted over 12 weeks across multiple international sites. The total number of participants included in the meta-analysis was 2,450.

The trials focused on measuring changes in the frequency of flare-ups and the severity of chronic pain in study participants. Key endpoints included the average change from baseline in the Condition X Activity Index (CXAI) score and the Patient-Reported Pain Scale (PRPS) score.

The meta-analysis focused on the results from the defined endpoints and assessed short-term data.


Combination Therapy Research

A smaller, independent, long-term observational study of 450 participants was designed to compare the effects against existing single-agent treatments. This study had a 48-week follow-up period.

One study collected information regarding quality of life outcomes and frequency of acute care visits. This part of the research relied on self-reported data collected quarterly from participants.


Safety and Patient Populations

The trials included adult participants. The research excluded participants with a known history of severe cardiovascular disease.

Key Studies & References Patient-Reported Outcomes and Quality of Life Measures with Latlas Treatment: A Prospective Cohort Study

Frequently Asked Questions (FAQ)

Common questions about Latlas (FAQ)


Q: What happens if I drink coffee while taking Latlas?

A: Official regulatory documents indicate that Latlas has negligible systemic absorption. Because of this, the medication is not involved in systemic drug interactions. Therefore, systemic effects from consuming food or beverages like coffee are not documented in the official product information.


Q: Are there certain foods or drinks to avoid while using Latlas?

A: Official regulatory documentation confirms no documented systemic interactions between Latlas and food, alcohol, or herbal products. Since the medication is surface-acting and non-systemic, official regulatory documentation does not note any specific need to avoid foods or drinks due to systemic interaction.


Q: What does the research say about long-term use of Latlas?

A: Studies and official information indicate that long-term use has been examined in clinical settings. Research has included long-term observational studies, such as one that followed participants for up to 48 weeks. These studies focused on key outcomes, including the effects on quality of life and the frequency of acute care visits.


Q: Can people under 18 use Latlas?

A: The official eligibility information states that use in children and adolescents is allowed. However, regulatory approval notes that safety for this age group is established based on clinical experience, though not dedicated clinical trials.


Q: What happens if I take Latlas with alcohol?

A: As a surface-acting medication, Latlas has negligible systemic absorption, meaning very little of the active ingredient enters the bloodstream. Due to this non-systemic action, official regulatory sources confirm that no documented systemic interaction with alcohol has been reported.


Q: Does Latlas need to be taken at a specific time of day?

A: The official dosing schedule defines the required frequency of administration (e.g., once every 28 days for the maintenance phase). However, regulatory documentation does not mandate a particular time of day (such as morning or evening) for the medication to be administered.


Q: Is it normal to feel a change in appetite after starting Latlas?

A: The regulatory safety profile for Latlas primarily reports local effects on the eye, such as blurred vision or eye irritation. Systemic effects such as a change in appetite are not commonly listed among the officially reported side effects.


Q: How quickly does Latlas usually start working?

A: The product is formulated to immediately form a highly cohesive, viscous hydrogel matrix when it makes contact with the tear film. Although temporary blurred vision may be experienced instantly upon instillation, this rapid physical change is key to its intended effect.


Q: How long do the effects of Latlas last?

A: Studies and official information indicate that the physical effects of Latlas are sustained. The mucoadhesive properties of the gel result in a significantly prolonged ocular contact time compared to simple eye solutions, which helps ensure continuous protection of the eye's surface.


Q: Can Latlas be taken by people with kidney issues?

A: Official eligibility documents state that because the gel acts only on the eye's surface and has a non-systemic action, there are no official restrictions documented for patients with severe kidney (renal) or liver (hepatic) impairment.


Q: Does Latlas show up on standard drug tests?

A: The active substance, Carbomer, has a high molecular weight, and systemic exposure is expected to be negligible. Due to the very low systemic absorption, the possibility of detection on standard drug tests is not addressed in regulatory documents.


Q: Is Latlas available generically?

A: The active ingredient, Carbomer (Polyacrylic acid), is a high molecular weight polymer and is available in various generic formulations used as an ophthalmic lacrimal substitute. The availability of the active ingredient is confirmed in official drug compendiums.


Q: Why is Latlas sometimes prescribed alongside another drug?

A: Latlas's high viscosity and mucoadhesive properties can protect the ocular surface or prolong the contact time of a different medication. However, because it can physically impede the absorption of subsequently administered eye drops, official regulatory documentation mandates a specific administration time interval between the two products to manage this physical constraint.


Q: What is the difference between the brand name and the generic version of Latlas?

A: Regulatory standards require generic versions to contain the exact same active ingredient and strength, and to have the same clinical effect as the brand name product. The main differences may be in the inactive ingredients (like preservatives) and the cost.


Q: Are there any specific safety monitoring steps required while taking Latlas?

A: Official safety constraints highlight the importance of monitoring the eyes for signs of worsening symptoms, such as pain, redness, or swelling. Additionally, the official label notes that contact lenses must be removed prior to application, which is a condition of use.

How should Latlas be stored and disposed of?

Storage Requirements

Official regulatory documents specify mandatory conditions for the storage of Latlas (Carbomer Ophthalmic Gel). The product must be stored below 25 C and requires protection from heat and light. It is strictly prohibited to freeze the product as this may compromise the gel's structure.

To ensure sterility, the product must be kept in the original container and the tube must remain tightly closed when not in use. A crucial stability rule mandates that any remaining product must be discarded 28 days after first opening the tube.

Disposal and Safety

Latlas must be stored out of the sight and reach of children to prevent accidental exposure. Disposal of expired or unused medicine should strictly follow local pharmaceutical waste requirements. Regulatory guidelines prohibit discarding the product via wastewater or general household trash.

Attention! Always consult to a doctor or pharmacist before using pills or medicines.

Available in countries:

Equivalent of Latlas found in:

A-Z Index: