Lasoride

oedema, hypertension, hepatic cirrhosis with ascites

Lasoride is contraindicated in patients with anuria and in patients with a history of hypersensitivity to Furosemide (Lasoride).

Lasoride may increase the ototoxic potential of aminoglycoside antibiotics, especially in the presence of impaired renal function. Except in life-threatening situations, avoid this combination.

Lasoride should not be used concomitantly with ethacrynic acid because of the possibility of ototoxicity. Patients receiving high doses of salicylates concomitantly with Furosemide (Lasoride), as in rheumatic disease, may experience salicylate toxicity at lower doses because of competitive renal excretory sites.

Lasoride has a tendency to antagonize the skeletal muscle relaxing effect of tubocurarine and may potentiate the action of succinylcholine.

Lithium generally should not be given with diuretics because they reduce lithiums renal clearance and add a high risk of lithium toxicity.

Lasoride may add to or potentiate the therapeutic effect of other antihypertensive drugs. Potentiation occurs with ganglionic or peripheral adrenergic blocking drugs.

Lasoride may decrease arterial responsiveness to norepinephrine. However, norepinephrine may still be used effectively.

Tablets

Simultaneous administration of sucralfate and Furosemide (Lasoride) tablets may reduce the natriuretic and antihypertensive effects of Furosemide (Lasoride). Patients receiving both drugs should be observed closely to determine if the desired diuretic and/or antihypertensive effect of Furosemide (Lasoride) is achieved. The intake of Furosemide (Lasoride) and sucralfate should be separated by at least two hours.

Tablets, Injection, and

Oral Solution

One study in six subjects demonstrated that the combination of Furosemide (Lasoride) and acetylsalicylic acid temporarily reduced creatinine clearance in patients with chronic renal insufficiency. There are case reports of patients who developed increased BUN, serum creatinine and serum potassium levels, and weight gain when Furosemide (Lasoride) was used in conjunction with NSAIDs.

Literature reports indicate that coadministration of indomethacin may reduce the natriuretic and antihypertensive effects of Furosemide (Lasoride) in some patients by inhibiting prostaglandin synthesis. Indomethacin may also affect plasma renin levels, aldosterone excretion, and renin profile evaluation. Patients receiving both indomethacin and Furosemide (Lasoride) should be observed closely to determine if the desired diuretic and/or antihypertensive effect of Furosemide (Lasoride) is achieved.

nausea, diarrhoea, blurred vision, dizziness, headache, photosensitivity, hypotension, bone marrow depression (rare), hepatic dysfunction, hyperglycaemia, glycosuria, ototoxicity, hyponatraemia, idiosyncratic hypersensitivity, dry mouth, fatigue, muscle cramps, nausea, impotence, raised blood levels of glucose, urates, lipids,calcium, reduced levels of K and magnesium, raised CPK levels.

Potentially Fatal: Fluid and electrolyte imbalance, hypersens.

A benzoic-sulfonamide-furan. It is a diuretic with fast onset and short duration that is used for edema and chronic renal insufficiency.