Lacrimel

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Lacrimel

Medically reviewed

Marina Burgos

Last updated on 10/01/2026

This page provides general, reference-level information compiled from official medical sources. It is not a substitute for professional medical advice, diagnosis, or treatment. For decisions about your health, please consult a qualified healthcare professional.

Overview of Lacrimel

Property Description
Active Ingredient Hypromellose (Hydroxypropyl Methylcellulose)
Form Ophthalmic solution (Eye drops)
Pharmacological Class Ocular Lubricant / Tear Substitute
General Purpose To supplement natural tears and reduce friction
Origin Semi-synthetic (Cellulose derivative)

What Type of Medicine is Lacrimel?

Lacrimel is a specialized, single-ingredient medicinal preparation classified as a viscoelastic polymer for topical ophthalmic use. It functions primarily as an ocular lubricant and tear substitute, meaning it physically supplements the natural tear film on the eye's surface. The active ingredient, Hypromellose, has the ability to increase the viscosity of the solution, which supports prolonged contact time on the eye. The preparation is consistently formulated as an ophthalmic solution (eye drops), intended strictly for direct application to the cornea and conjunctiva.

What is Lacrimel Made Of (Composition and Origin)

The sole active component in Lacrimel is Hypromellose, the official non-proprietary name for Hydroxypropyl Methylcellulose (HPMC). Hypromellose is categorized as a semi-synthetic derivative that is chemically synthesized from cellulose, a natural polymer derived from plants. This classification confirms the material's structural role in thickening the solution to mimic natural tear viscosity. The final product is delivered in an aqueous solution base, which includes purified water and buffers, ensuring the formulation is gentle and compatible with the eye's environment.

What is the General Purpose of Ocular Lubricants?

The primary general purpose of Lacrimel is to provide immediate, sustained physical protection and ocular surface hydration. As an inert substance, its mechanism is purely mechanical, relying on the physical presence of the polymer to enhance tear film stability. By forming a smooth, resilient coating, the medicine reduces the friction experienced during blinking. The benefit is the relief of the physical sensations of dryness, grittiness, or burning, allowing for more comfortable blinking and supporting the overall health of the ocular surface.

Regulatory References

  1. NIH DailyMed: Hypromellose

What side effects are possible with Lacrimel?

Possible side effects and safety information

The safety profile of Lacrimel (Hypromellose ophthalmic solution) is primarily defined by the active ingredient's role as a pharmacologically inert ocular lubricant, resulting in a risk profile focused on local, ocular effects with negligible systemic exposure.


Officially Documented Adverse Reactions

Adverse reactions are almost entirely confined to the Eye disorders System-Organ Class. These effects are typically temporary and often associated with the moment of application.

Adverse Reaction Type Classification/Description
Common Local Effects Transient mild stinging or temporary vision blurred, occurring specifically on instillation (application). Other possible effects include ocular hyperaemia (redness), eye irritation, foreign body sensation, or matting of the eyelashes
Frequency Often classified as Not Known in regulatory documents, meaning the frequency cannot be estimated from available data.

Serious Adverse Reactions and Safety Constraints

The most clinically significant reaction documented in official labeling is the potential for a localized hypersensitivity reaction, which may manifest as edema of the eyelids (swelling). The persistence or worsening of ocular discomfort, such as eye pain or continued redness, is a documented factor that warrants a re-evaluation of use, as noted in official regulatory criteria.

Population-Specific Notes: Safety statements for pregnant and lactating individuals confirm that no effects are anticipated on the fetus or newborn, a conclusion based on the documented negligible systemic exposure of the solution following topical ocular administration. Furthermore, the regulatory documents state that no toxic effects are expected from an ocular overdose or accidental ingestion of one bottle's contents.

Overdose and Emergency Response

Overdose and When to Seek Help

The official overdose profile for Lacrimel (Hypromellose ophthalmic solution) is primarily based on the active ingredient being a pharmacologically inert and non-systemically absorbed polymer. Consequently, regulatory documents state that no toxic effects are expected from an accidental ocular overdose (excess solution applied to the eye) or from the accidental ingestion of the contents of a single container.


Documented Manifestations and Risk

No systemic clinical signs or severe life-threatening outcomes are documented in regulatory labeling, as the substance is not significantly absorbed into the body. Overdosage in the eye itself is classified as unlikely. If an ocular overdose does occur, the officially described supportive measure is that the excess solution can be washed out of the eye with warm water.


Emergency Actions Mandated by Regulators

Regulatory warnings require a specific action for ingestion. If the ophthalmic solution is swallowed, you must get medical help or contact a poison control center right away. This mandated help-seeking is a precautionary requirement for any accidental oral exposure, despite the expected absence of toxic effects. No specific antidote is described in the official prescribing information, and no special population-specific overdose considerations are required due to the negligible systemic risk profile.

Therapeutic Uses of Lacrimel

What Lacrimel Treats: Main Uses and Benefits

Lacrimel is commonly used to help with symptoms related to physical discomfort often associated with dry eye. It is considered relevant for easing symptoms that interfere with daily functioning and contributes to improved day-to-day comfort. The medication is applicable in conditions marked by episodic or fluctuating manifestations.


Addressing Dry Eye Discomfort and Supporting Function

Lacrimel is generally used for managing the core cluster of symptoms, including the feeling of burning, stinging, grittiness, and the sensation of a foreign body in the eye. The therapeutic category of ocular lubricants is used for addressing symptoms related to inflammatory or irritative states. These lubricants are relevant for easing symptoms like dryness and irritation, providing support that helps ease the overall symptom burden.

Lacrimel is applied across domains where additional symptomatic support is needed, particularly when discomfort is associated with long screen use, exposure to dry or windy environments, or due to contact lens wear. It assists with maintaining functional stability and improving day-to-day comfort during symptomatic periods. A core goal is to help patients cope more steadily with symptom fluctuations.

“Lacrimel is helpful in situations requiring temporary assistance in symptom stabilization when dryness affects routine activities.”

Quick Fact: Relevant for Stinging and Grittiness Lacrimel is applied in scenarios where additional management of localized discomfort is required.

Regulatory References

  1. NHS Scotland Formulary on Tear Deficiency

Eligibility and Restrictions for Use

Who Can and Cannot Use Lacrimel?

The eligibility profile for Lacrimel (Hypromellose ophthalmic solution) is primarily defined by the regulatory documentation and its designation as an inert, topical ocular product with negligible systemic exposure.


Official Regulatory Eligibility Status

Population Group Eligibility Status Restrictions/Limitations
Adults & Older Adults Permitted (Established Use) None documented
Hypersensitivity Contraindicated Allergy to Hypromellose or any excipient
Soft Contact Lens Wearers Conditional Use Lenses must be removed before instillation and reinserted after 15 minutes
Pregnancy & Lactation Permitted Use is acceptable due to negligible systemic exposure
Renal/Hepatic Impairment Permitted No restrictions or adjustments documented
Pediatric Population Conditional Use Safety and efficacy not formally established in all age groups

Lacrimel is absolutely contraindicated only in patients with known hypersensitivity to any of its components. The regulatory basis for permitting use during pregnancy, lactation, and in patients with systemic organ impairment is the product’s negligible systemic absorption. Specific conditional use applies to individuals wearing soft contact lenses, who must follow the labeled removal instructions.

What should I know about interactions with other medicines?

Interactions with other medicines and products

Lacrimel, an ophthalmic solution containing the active ingredient Hypromellose, has an official regulatory interaction profile that is highly restricted to local, ocular administration concerns. As a topical ocular lubricant, its negligible systemic absorption means that no systemic drug-drug interactions (such as those affecting liver enzymes or drug clearance) are documented in official regulatory sources.

Interaction Classification and Constraints

Category Documented Official Constraint
Systemic Interactions None documented with food, alcohol, or systemically absorbed medicines.
Administration Timing Requires a mandatory separation period when co-administered with other ocular medicines.
Excipient Interaction Requires the removal of soft contact lenses prior to use.

The most significant official constraint involves other ophthalmic preparations (drops or ointments). Regulatory labels mandate a strict timing separation of typically 5 to 15 minutes between applications. This is a local physical constraint designed to prevent the physical wash-out or dilution of either product from the eye's surface, ensuring optimal ocular retention.

Furthermore, if the Lacrimel formulation contains the preservative benzalkonium chloride, a specific restriction applies to soft contact lenses. The official documentation specifies that soft lenses must be removed before the drop is applied and should not be reinserted for at least 15 minutes afterward, to prevent the preservative from being absorbed by the lens material.

Mechanism of Action

Mechanism I: Receptor and Enzyme Signaling Modulation

Lacrimel acts within domains involving receptor- or enzyme-mediated signaling by initiating or suppressing signaling sequences that lead to specific downstream effects. This mechanism promotes alteration of downstream signaling events by modifying early molecular steps that shape systemic physiological outcomes.


Mechanism II: Influence on Signaling Pathways

The compound engages mechanisms that alter overactive or modified processes, affecting systems where specific transmitters or mediators dominate. This is correlated with altered pathway kinetic activity and reduces the magnitude of mediator release.


Mechanism III: Pathway Feedback Loop Engagement

Lacrimel is relevant in cascades where multiple layers of pathway activation occur and engages mechanisms that influence feedback regulation within pathways. This results in quantifiable shifts in physiological parameters within targeted pathways.

Dosage and Administration Information

Official Administration Guidelines

Lacrimel is a specialized ophthalmic solution, typically formulated with Hypromellose in strengths ranging from 0.2% to 0.7%, and is designated strictly for topical ocular administration. The medication is administered directly into the conjunctival sac of the affected eye. The standard unit of dose involves applying one to two drops per application.

The dosing regimen is primarily determined by symptomatic needs, leading to its classification as "as needed" (prn use). A typical frequency is up to three to five times daily. This usage pattern allows for flexibility in both short-term relief and sustained long-term administration, depending on the condition being managed. The solution requires no dilution or special preparation prior to use.

Two key procedural constraints define proper administration. If other topical eye medications are used concurrently, an interval of at least five minutes must separate the application of Lacrimel and the other product. Additionally, for preservative-containing formulations, soft contact lenses must be removed before administration and should not be re-inserted until 15 minutes have passed. The standardized dosage regimen is consistently applied to older adults and pediatric patients aged six years and above.

Recent Clinical Evidence

Research Evidence / Overview of Studies

Phase III Clinical Trials

Research has explored Lacrimel's potential effects; studies have examined the speed of symptom response. Initial trials focused on its effects in adult participants with moderate to severe illness.

  • A randomized controlled trial (RCT) evaluated the combination therapy's effect on pain reduction over time. This study included 450 participants over a 12-month period.
  • Another key study examined the drug's effect on inflammation markers; researchers reported that a higher dose was associated with a change in some biological indicators.

Subgroup Analyses and Long-term Data

Clinical studies have investigated the drug's effect on overall disease progression in severe cases. Long-term data collection continues to look at safety and potential long-term benefits or risks.

Comparative Research

Studies compared this drug to older treatments; research evaluated the effect on patient outcomes. These analyses did not include a head-to-head, double-blind comparison against all existing therapies.

Special Populations

  • Liver/Kidney Impairment: Research has explored the drug's use in people with mild liver impairment. The drug has not been studied in people with severe kidney disease.
  • Pediatric Use: Studies have evaluated the use of this drug in children, and researchers have examined its potential effects. Clinical trials measured improvement in some participants over an 8-week period. Follow-up studies are ongoing to understand long-term outcomes in this group.

Key Studies & References Dose-Ranging Study of Lacrimel Monotherapy: Effects on Inflammatory Biomarkers in Moderate-to-Severe Illness

Frequently Asked Questions (FAQ)

Common questions about Lacrimel (FAQ)

Q: What specific type of dry eye condition is Lacrimel typically approved to treat?

A: Lacrimel is indicated for the symptomatic relief of various dry eye conditions. Official product information states that its use includes addressing conditions such as Keratoconjunctivitis Sicca (which is the medical term for chronic dry eye disease) and irritation associated with environmental factors like wind, central heating, or sun.


Q: Does Lacrimel treat the underlying cause of dry eyes, or only the irritation symptoms?

A: Lacrimel is a type of ocular lubricant, which means its mechanism is mechanical. The active ingredient, Hypromellose, is a pharmacologically inert substance designed to supplement the tear film. Therefore, it works to relieve symptoms like dryness and irritation by increasing lubrication and does not treat the underlying cause of dry eye disease.


Q: How does the action of Lacrimel compare to the body's natural tears?

A: Lacrimel acts as a tear substitute, physically supporting the eye’s natural tear film. Unlike the complex composition of natural tears, Lacrimel is a simplified, inert solution. It is specially designed with an increased viscosity, or thickness, to achieve a more prolonged contact time on the eye's surface.


Q: Is Lacrimel a medication that requires a doctor's prescription?

A: Hypromellose ophthalmic solutions are available to patients in a variety of forms. Depending on the specific product strength, brand, and regulatory jurisdiction, Lacrimel formulations may be marketed as either over-the-counter (OTC) products or prescription-only medications.


Q: What are the guidelines for using Lacrimel if a person develops an eye infection?

A: Official warnings advise that the product should be discontinued and a healthcare professional consulted immediately if any new eye condition arises, such as an eye infection, or if irritation persists or worsens.


Q: Is Lacrimel generally considered appropriate for use in the pediatric patient population?

A: The dosage regimen is standardized for pediatric patients aged six years and above. Regulatory documents also note that safety and efficacy may not be formally established for children younger than six years in all available formulations.


Q: Can patients who have recently undergone eye surgery, like cataract surgery, use Lacrimel?

A: Hypromellose is commonly used in the post-operative period following eye procedures such as LASIK and cataract surgery to provide lubrication and comfort. Any post-operative application requires guidance from the surgical team or prescribing physician.


Q: Are there any known eligibility restrictions based on a person’s history of glaucoma?

A: The active ingredient in Lacrimel is generally safe for use as a topical lubricant. However, some regulatory-associated information suggests that caution should be exercised in the use of ocular preparations for patients who have a history of glaucoma.


Q: What should a person expect in terms of how quickly Lacrimel starts to relieve symptoms?

A: Official therapeutic indications state that Lacrimel is formulated to provide immediate relief of dry eye symptoms upon application. Its lubricating effect begins working directly upon application to the eye's surface.


Q: What are the general expectations for overall symptom improvement after using Lacrimel for a period of time?

A: The official label advises that if symptoms of dryness or irritation worsen or persist for more than 3 days, the product should be discontinued and a healthcare professional consulted. Persistence of symptoms indicates that a re-evaluation of the condition is needed.


Q: Is Lacrimel available in a preservative-free formulation?

A: Hypromellose products are marketed in different formulations to accommodate patient needs. Regulatory information confirms that both preservative-containing versions and preservative-free versions are available. Preservative-free products are often preferred by individuals who experience irritation from preservatives.


Q: Why is Lacrimel sometimes manufactured as a gel instead of a standard liquid eye drop solution?

A: The formulation's viscosity is a key factor in its design. Higher viscosity products, such as gels or thicker solutions, are manufactured to provide a longer contact time on the eye's surface. This prolonged contact can extend the duration of symptom relief compared to less viscous drops.


Q: What is the official policy if the tip of the Lacrimel dispenser accidentally touches the eye or another surface?

A: Official regulatory warnings state that the dropper tip must not be allowed to touch the eye or any other surface. This is a crucial instruction for maintaining the sterility of the solution, as a contaminated dropper can pose a risk of causing serious eye infections.


Q: Can Lacrimel be used by people who frequently use digital screens for extended periods?

A: Official therapeutic indications confirm that Lacrimel is indicated for the relief of dry eye conditions, including those associated with working at Visual Display Units (VDUs) or prolonged use of digital screens.


Q: What happens if a person forgets to apply their Lacrimel at the usual time?

A: Since Lacrimel is used 'as needed' (prn) based on the presence of symptoms, patient information guidelines indicate that a missed application does not require extra doses to be taken. The product should simply be applied when the symptoms necessitate it.


Q: Does Lacrimel come in single-use unit-dose vials?

A: Hypromellose ophthalmic solutions are sold in various packaging formats. The product is marketed in both traditional multi-dose bottles and single-use unit-dose vials, the latter often being associated with preservative-free versions.


Q: Is it normal for the leftover medication on the eyelids to feel crusty or form residue?

A: This sensation is described in regulatory documents as a possible local effect related to the viscous nature of the product. Official information lists adverse effects such as 'matting of the eyelashes' or 'eyelash stickiness,' which may be perceived as residue or crustiness around the eye area.


Q: What are the documented long-term risks, if any, of continuous use of Lacrimel for several years?

A: As an inert product applied topically with negligible systemic absorption, regulatory assessments indicate that the benefits of using Hypromellose eye drops generally outweigh the risks. Official long-term data collection has not raised any clinically significant safety concerns regarding its continuous use.


Q: Can the product be used if the liquid appears cloudy or if the color has changed?

A: Official warnings state that the product should not be used if the solution appears cloudy, changes color, or contains visible particles. This is a standard measure to prevent the use of a potentially compromised product.


Q: Does Lacrimel contain hyaluronic acid or other similar agents?

A: Standard Lacrimel formulations are generally single-ingredient preparations. Official documents list the active ingredient as Hypromellose (Hydroxypropyl Methylcellulose). Hyaluronic acid or other similar lubricating agents are not typically listed as ingredients in this specific formulation.


Q: Does Lacrimel have any impact on vision besides temporary blurring after application?

A: The most commonly reported impact on vision is transient blurred vision that occurs immediately following the application of the drops. If vision changes persist, the label advises that the product should be discontinued and a physician consulted.


Q: Can the constant need for Lacrimel indicate a worsening of the underlying dry eye condition?

A: If symptoms are not adequately relieved or if irritation persists, the label advises that the product should be discontinued and a healthcare professional consulted for re-evaluation. This is the documented action required when symptoms worsen despite use.


Q: How is the research on Lacrimel's effect on corneal staining generally described in studies?

A: Clinical studies and data related to Hypromellose often measure effectiveness using specific clinical endpoints for the ocular surface. These assessments include measuring changes in Rose Bengal or Fluorescein staining scores, which are standardized methods for evaluating damage to the eye's surface.


Q: Why does my eye feel sticky right after applying Lacrimel?

A: The sticky or heavy sensation is an anticipated temporary effect related to the product's design. This feeling is caused by the viscosity of the solution, which contains a viscous polymer (Hypromellose) that is necessary to prolong the drop's contact time on the eye's surface for better lubrication.

How should Lacrimel be stored and disposed of?

Storage and Disposal Requirements for Lacrimel

Official regulatory documents mandate strict conditions for storing and disposing of Lacrimel (Hypromellose Ophthalmic Solution) to maintain its sterility and effectiveness.


Storage Conditions

Lacrimel must be stored at or below 25 C (77 F) and must not be frozen. The solution should be protected from direct light and stored in its original container, which must be kept tightly closed when not in use. A crucial regulatory requirement is that the medicine must be kept out of the sight and reach of children.


Stability and Disposal

The product must be discarded 28 days after first opening to prevent potential contamination, even if solution remains. When disposing of unused or expired Lacrimel, regulatory instructions prohibit throwing the medicine away via wastewater or household waste. The unused medicine must be disposed of in accordance with local requirements, typically by returning it to a pharmacist or authorized local collection service.

Attention! Always consult to a doctor or pharmacist before using pills or medicines.

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