Lacrifluid

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Lacrifluid

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Medically reviewed

Marina Burgos

Last updated on 22/12/2025

This page provides general, reference-level information compiled from official medical sources. It is not a substitute for professional medical advice, diagnosis, or treatment. For decisions about your health, please consult a qualified healthcare professional.

Overview of Lacrifluid

Quick Facts

Property Description
Active Ingredient (INN) Carbomer 980 (or similar Carbomer)
Form Ophthalmic Gel or Solution (Eye Drops)
Pharmacological Class Ocular Lubricant / Tear Substitute
Common Use Relief of Dry Eye Symptoms
Origin Synthetic Polymer

Defining Lacrifluid: Type, Form, and Therapeutic Class

Lacrifluid is a non-prescription ophthalmic solution classified as an artificial tear substitute used for topical administration to the eye. It is formulated as a viscous gel or eye drop solution specifically designed to increase the stability and retention time of the moisture on the ocular surface. Lacrifluid is positioned within the ocular lubricants pharmacological class.

Carbomer-based products are utilized for their ability to increase tear break-up time, which is intended to assist with patient comfort. This helps the eye surface remain moist for a longer period after application, easing the gritty feeling.


Key Components: Lacrifluid's Composition and Origin

The active ingredient (INN) in Lacrifluid is typically a Carbomer, specifically Carbomer 980, which acts as a synthetic, hydrophilic (water-attracting) polymer. The formulation is distinguished by its high-viscosity profile, a key differentiating factor that provides enhanced adherence to the eye's surface compared to low-viscosity drops. This active substance, along with excipients like purified water, completes the product's composition.

Carbomer 980 is a man-made substance (synthetic origin) known for its ability to adhere to the corneal surface. Carbomer-based formulations are used for long-term management of ocular surface disorders.


Lacrifluid's Role: General Therapeutic Purpose

The general therapeutic purpose of Lacrifluid is to provide lubrication and relief for the symptoms associated with dry eye syndrome, particularly moderate to severe dryness. It functions as a replacement for, or supplement to, natural tears when the eye's tear film is unstable or deficient. A typical use scenario involves applying the solution to manage chronic discomfort associated with working long hours at a computer or experiencing dry, windy environmental conditions. This protective layer is intended to shield the eye's outer layer, the cornea, from the abrasive effects of environmental exposure and inadequate moisture.

Regulatory References

  1. National Institutes of Health (NIH)

What side effects are possible with Lacrifluid?

Possible Side Effects and Safety Information

The official safety documentation for Carbomer 980 ophthalmic products outlines adverse reactions primarily affecting the eye, classified by their frequency of occurrence as follows:

Classification Adverse Reaction
Very Common Blurred vision
Common Eye discomfort, Eyelid crusting, Eye irritation
Uncommon Eye swelling, Eye pain, Itchy eye, Eye redness, Increased tear production, Skin inflammation
Frequency Not Known Allergic reactions

Blurred vision is the most frequent reaction and is consistently documented as transient, typically resolving within a few minutes after application. Other effects such as stinging or burning are also noted as temporary upon instillation. The majority of reactions fall under the System-Organ Class of Eye disorders.

Safety Restrictions and Population Considerations

The product is contraindicated in individuals with a known hypersensitivity or allergy to the active substance or any excipients. Official labeling notes that safety has not been established for use during pregnancy and lactation due to a lack of data. Furthermore, due to excipient content, preservative-containing formulations may cause corneal irritation and can interact with soft contact lenses; patients are directed to remove lenses before use. Regulatory bodies have also previously documented the potential for microbial contamination risk in specific product batches, which is a particular safety concern for severely immunocompromised patients.

Overdose and Emergency Response

The official regulatory profile for Carbomer 980 ophthalmic preparations defines the overdose scope based on its lack of systemic activity. Due to the active ingredient's high molecular weight and the product's topical ocular application, negligible systemic absorption is anticipated. This means that a systemic overdose is officially considered not anticipated, and no specific systemic symptoms, severe outcomes, or life-threatening manifestations are documented in regulatory labeling.

Consequently, the requirements for emergency help are focused on misuse rather than toxicity from standard use. Immediate medical attention must be sought exclusively in the event of accidental oral ingestion of the gel, as this is a non-approved route of exposure that triggers the need for precautionary medical evaluation.

The official procedural response requires management to consist of symptomatic and supportive treatment, as regulatory documents confirm that no specific antidote is known for overdose with this preparation. Following ingestion, hospital monitoring and observation may be required. No specific population-based (pediatric, elderly, or impaired) overdose considerations are explicitly detailed, consistent with the low systemic risk established by the drug's regulatory basis.

Therapeutic Uses of Lacrifluid

What Lacrifluid Treats: Main Uses and Benefits

Carbomer 980 formulations are used as a substitute of tear fluid for the management of dry eye conditions and for use in conditions where functional stability becomes affected.

Lacrifluid is commonly used to provide symptomatic support for Dry Eye Syndrome, applied across domains where additional symptomatic support is needed to address symptoms related to inflammatory or irritative states. It is considered relevant for managing symptoms that interfere with daily functioning, including burning, stinging, and the abrasive foreign body sensation.

The formulation is generally considered relevant in clinical settings marked by increased discomfort or tension due to environmental factors, such as wind, dry air, or prolonged visual tasks. Often used during phases when symptoms become more noticeable, it helps ease the overall symptom burden and assists with maintaining a sense of stability when symptoms are more noticeable.

“This type of preparation is commonly used when symptoms are driven by external factors or when patients require sustained moisture, and it may be part of symptomatic management.”


Quick Fact: Relief for Chronic Dryness

Therapeutic Focus Primary Symptom Cluster Context of Use
Symptomatic Support Burning, Stinging, and Grittiness High environmental exposure, prolonged screen time

Eligibility and Restrictions for Use

Official Eligibility and Restrictions

The eligibility for using Lacrifluid (Carbomer 980) is strictly defined by regulatory authorities and centers on absolute contraindications and conditional restrictions for specific patient groups. This information is derived exclusively from government-approved labeling.

Who Must Not Use Lacrifluid (Contraindications)

The medicine is contraindicated in patients with a known hypersensitivity or allergy to the active substance, Carbomer 980 (polyacrylic acid), or any of the inactive ingredients (excipients) used in the formulation.

Conditional Use and Restricted Populations

  • Age-Based Eligibility: Use is permitted for Adults and Older Adults and requires no specific dose adjustment. For children and adolescents (under 18 years), use is based on clinical experience; however, formal clinical trial data supporting safety and efficacy are not fully available in regulatory documentation.
  • Physiological Status: Use is not recommended during pregnancy or breastfeeding. Regulatory labeling states that safety has not been established in these populations, and use should be conditional.
  • Ocular Conditions: The product should not be used for patients presenting with undiagnosed conjunctivitis.
  • Contact Lens Wearers: A restriction requires that contact lenses must be removed before application and not reinserted for at least 15 minutes afterward.

What should I know about interactions with other medicines?

Interactions with other medicines and products

The official interaction profile for Carbomer-based ophthalmic products is primarily defined by local physical factors rather than systemic drug interactions. Regulatory documentation indicates that due to negligible systemic absorption, no clinically relevant metabolic or transporter-mediated drug–drug interactions have been described or formally studied.


Documented Local and Physical Interactions

Interaction Entity Official Regulatory Statement
Other Local Ocular Treatments Co-administration requires strict timing. The Carbomer product should always be the last medication instilled to avoid delayed absorption of other eye drops. A separation interval of at least 5 to 15 minutes must be observed.
Soft Contact Lenses Contraindicated for use while lenses are in place. Lenses must be removed prior to application and should not be reinserted for at least 15 minutes due to the potential interaction of the preservative, Cetrimide, with the lens material.

Systemic Interaction Status

No formal systemic drug combinations are listed as contraindicated. Official regulatory labeling does not specify any known interactions with food, alcohol, or herbal products.

Mechanism of Action

Viscosity Augmentation and Surface Adhesion

This mechanism centers on the physical properties of the high-molecular-weight polymer, Carbomer 980. The polymer acts as a viscosity augmenter that forms a stable, adhesive network by binding to the mucins on the ocular surface. This interaction increases the fluid's thickness and resistance to flow, which facilitates its extended presence on the ocular surface. The Carbomer structure forms hydrogen bonds with the epithelial mucins, promoting this durable adhesion.


Tear Film Stabilization and Friction Reduction

By adhering to the eye, the viscous fluid directly stabilizes the existing tear film, reducing the rate of evaporation. This robust, continuous layer creates an effective lubricating shield that reduces the mechanical stress and friction (shear stress) on the epithelial cells during blinking, ensuring the mechanical movement exhibits reduced shear stress against the epithelial cells. This physical mechanism supports persistent hydration of the transparent surface structures and contributes to the maintenance of the structural morphology of the ocular surface cells.

Dosage and Administration Information

How to Use Lacrifluid

Lacrifluid is administered via the ocular route, meaning it is applied directly to the surface of the eye. Its use follows a standardized procedure for instillation to ensure proper delivery of the medication.


Standard Administration and Frequency

The standard regimen for adults, including older adults, involves instilling one drop into the lower conjunctival sac of the affected eye(s) per application. The preparation is typically used three to four times daily or may be applied as required depending on the ongoing symptomatic requirement. This flexible dosing pattern allows for necessary applications throughout the day. No specific dosage adjustment is necessary for individuals over 65 years of age.


Usage Constraints and Protocol

When using this product with other topical ophthalmic treatments, an application interval of at least 15 minutes must be maintained between the instillation of the different drops. Due to its viscous nature, the Carbomer formulation must always be the last medication instilled.

Proper technique requires holding the container vertically during administration and ensuring the tip does not contact the eye or any surface to prevent contamination. If the product is supplied in a single-dose container, any remaining contents must be discarded immediately after use and should not be stored.


Duration Pattern

Lacrifluid may be used for short-term symptomatic relief or as a component of a long-term management plan for chronic ocular surface conditions, with the duration of use determined by the individual's clinical requirement.

Recent Clinical Evidence

Research evidence / Overview of studies for Lacrifluid

Evidence for Use in Symptomatic Dry Eye Syndrome

The body of research for Carbomer 980 ophthalmic gel (the active ingredient in Lacrifluid) primarily consists of short-to-intermediate-term Randomized Controlled Trials (RCTs) and studies where it was compared to other formulations. This research was conducted during periods of increased symptom activity to understand how symptoms change over time in patients diagnosed with Dry Eye Syndrome (DES). The studies involved adult populations, including those reporting moderate or severe dryness and discomfort.

Research examined two main types of outcomes: patient-reported outcomes describing perceived discomfort and objective clinical measurements. Studies exploring short-term symptom changes described patterns in how patients reported their experience, including scores for physical discomfort, such as the gritty or foreign body sensation, burning, and stinging. The gel was observed in studies to be associated with an extended duration on the eye's surface compared to less viscous drops, and this adherence was associated with measurements of stability of the tear film, as measured by the Tear Break-Up Time (TBUT).

However, findings varied when researchers looked at certain objective measures. While some trials described patterns of reduction in the appearance of staining on the ocular surface (a sign of damage), results related to objective surface measures were observed in some studies but not others. Research indicates that changes in day-to-day discomfort may not consistently correspond with the measurements seen on every clinical examination measure.


Durability of Effect: Long-term Studies and Follow-up

The typical follow-up durations for the main trials spanned short to intermediate periods, ranging from approximately 2 to 8 weeks. While some extended observation periods lasted up to 6 months, the evidence exploring how symptoms change over time after extended use remains limited in long-term, large-scale randomized trials (e.g., studies lasting a year or more).

Therefore, data for the long-term outcomes and the durability of any sustained pattern of relief remain insufficient. Research provides context but not individual predictions about whether the initial observed patterns of comfort will be maintained over many years of continuous use.

Key Studies & References

  1. Ophthalmic Lubricants for Dry Eye Disease: Pharmacologic Treatment Options (NIH Review)

Frequently Asked Questions (FAQ)

Common questions about Lacrifluid (FAQ)

Q: Does Lacrifluid contain preservatives?

Official documentation for Carbomer 980 ophthalmic products indicates that some multi-dose formulations contain a preservative, such as Cetrimide. Single-dose versions, however, are commonly available and typically described as being preservative-free. Information about the specific formulation used is detailed on the packaging or in the product information sheet.


Q: What is the expected duration of the lubricating effect from one dose of Lacrifluid?

Regulatory documents describe the product’s use as generally being three to four times daily, or as required (pro re nata or p.r.n.). This use pattern indicates that the product's duration of effect is linked to symptomatic requirement and allows for flexible application based on need.


Q: Are there any serious side effects associated with Lacrifluid that have been reported?

Regulatory documentation (SmPC) classifies known adverse reactions by frequency (e.g., Very Common or Uncommon). The most frequent reaction is described as transient blurred vision, which typically resolves quickly. The documentation categorizes effects primarily as Eye disorders and does not classify specific reactions as serious in the frequency tables.


Q: What should be done if the dropper tip accidentally touches the eye or another surface?

Official regulatory instructions emphasize that the tip of the container should avoid contact with any surface, including the eye, to prevent contamination. If the container is a single-dose unit and contact occurs, the regulatory requirement is that the remaining contents should be discarded immediately after the single use.


Q: What is the difference between Lacrifluid and other popular dry eye drops like [Competitor Brand A]?

Regulatory documents describe this product as containing a high-molecular-weight polymer, Carbomer 980, which functions as a viscosity augmenter. This means the formulation is highly viscous, a property that is officially noted for increasing its retention and stability on the ocular surface.


Q: Is it safe to use Lacrifluid after its expiration date?

The established stability and sterility of the product are guaranteed only until the product’s labeled expiration date. This applies only if the product has been stored correctly, such as below 25 C. Regulatory documents do not provide information regarding the safety or efficacy of the product after this date.


Q: What should a user do if symptoms of dry eye worsen after using Lacrifluid?

Official regulatory labeling advises that if symptoms continue or worsen despite using the product, the patient is recommended to have their condition reviewed by an eye specialist or another healthcare professional.


Q: Does Lacrifluid help with irritation encountered after eye surgery?

Regulatory use statements indicate that the product is intended for the symptomatic relief of dry eye conditions. This includes relief from irritation encountered in various ocular conditions, and some documentation specifically mentions use in the context of conditions after eye surgery.


Q: Why does Lacrifluid come in single-dose units?

Single-dose eye drops are widely available and, according to regulatory-linked product information, they are often manufactured to be preservative-free. This approach is commonly used to provide an alternative for patients who may experience sensitivity or adverse reactions related to preservatives like Cetrimide.


Q: What is the risk of contamination with single-dose units of Lacrifluid?

The risk of contamination for single-dose containers is managed by the regulatory guidance that requires them to be used for only one application and discarded immediately. Because they are often preservative-free, they are not designed to be stored after opening.


Q: What if a user misses a dose of Lacrifluid?

The application regimen is defined in regulatory documents as as required (pro re nata) or up to three to four times daily. This means that application is primarily governed by symptomatic need, rather than adherence to a rigid fixed schedule.


Q: Does Lacrifluid address inflammation or only provide lubrication?

The official therapeutic indication, as stated in regulatory documents, is the substitution of tear fluid in the management of dry eye conditions. This is a physical action focused on ocular lubrication and tear film stabilization; the product is not officially indicated as a primary anti-inflammatory agent.


Q: Are there different strengths or concentrations of Lacrifluid available?

Official labeling for the product describes a specific concentration of Carbomer 980, such as 0.2% w/w, for the product being regulated. While regulatory documents detail the composition of this specific product, they do not generally provide a list of all potential concentrations that may be available in the marketplace.


Q: Do I need to see a doctor before starting to use Lacrifluid?

This product is generally available without a prescription for use in adults. However, regulatory labeling advises consulting a physician, pharmacist, or eye specialist if dry eye symptoms persist, worsen, or continue despite use.


Q: What are the ingredients listed in the single-dose Lacrifluid solution?

Official documentation lists the active ingredient as Carbomer 980, a synthetic polymer. Other components typically include purified water and excipients used to adjust the product's pH level to be compatible with the eye.


Q: Is it safe to drive or operate machinery after using Lacrifluid?

Regulatory labeling advises that due to the transient blurring of vision that may occur upon instillation, it is generally recommended that individuals avoid driving or operating hazardous machinery until normal vision is fully restored.


Q: Can I use Lacrifluid for eye redness, or is it just for dryness?

The official indication is for the symptomatic treatment of dry eye syndrome. Regulatory documents list eye redness in the undesirable effects section as an uncommon reported reaction, meaning it is not an indication for treatment.


Q: Is Lacrifluid available in a multi-dose bottle?

Official packaging documentation lists presentations that include multi-dose containers (such as tubes or bottles). Regulatory instructions indicate that these multi-dose containers should be discarded 28 days after first opening.


Q: What should I do if I accidentally swallow a small amount of Lacrifluid?

Regulatory information indicates that due to the product's high molecular weight and negligible systemic absorption (meaning very little enters the bloodstream), clinically relevant systemic effects from small accidental ingestion are generally not anticipated. All medicines should be stored out of the sight and reach of children.

How should Lacrifluid be stored and disposed of?

How to Store and Dispose of Lacrifluid?

Storage Conditions and Stability

Lacrifluid (Carbomer 980) must be stored below 25 C and protected from light, as stated in the official labeling. It is mandatory to not freeze the product to prevent degradation of the formulation.

A critical storage requirement is the limited duration of use after opening. The eye drops must be discarded after 28 days from the date the container was first opened, regardless of the remaining contents, to ensure sterility and stability.

Safety and Disposal Requirements

As a universal safety rule, the medicine must be kept out of the sight and reach of children at all times.

For disposal, unused or expired Lacrifluid must not be thrown away with household trash or via wastewater. Instead, disposal must follow the local requirements for pharmaceutical waste, often requiring the product to be returned to a pharmacy or designated collection point.

Attention! Always consult to a doctor or pharmacist before using pills or medicines.

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