Laciten

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Laciten

Method of action: Hypotensive

Treatment option: Hypertension

Medically reviewed

Laura Arias

Last updated on 22/12/2025

This page provides general, reference-level information compiled from official medical sources. It is not a substitute for professional medical advice, diagnosis, or treatment. For decisions about your health, please consult a qualified healthcare professional.

Overview of Laciten

Quick Facts

Property Description
Active ingredient Lacidipine
Form Oral film-coated tablet
Pharmacological class Calcium Channel Blocker (CCB)
Common use Management of high blood pressure
Origin Synthetic (Dihydropyridine derivative)

Laciten is a prescription-only antihypertensive agent primarily used in adults for the long-term management of high blood pressure. Its active ingredient, Lacidipine, belongs to the Calcium Channel Blocker (CCB) class of medicines. The medication is recognized in clinical practice for providing sustained, foundational support in maintaining healthy circulatory function.


What Type of Medicine is Laciten?

Laciten is a synthetic medication classified as a dihydropyridine derivative within the broader category of Calcium Channel Blockers (CCBs). The primary therapeutic indication for Lacidipine is the treatment of hypertension. The core of this medicine is the single active ingredient, Lacidipine, which defines its pharmacological identity and purpose. This classification places Laciten among agents that modulate calcium activity, a process involved in controlling muscle contraction within the cardiovascular system.


Laciten's Form and General Purpose

The medication is supplied as an oral film-coated tablet, making it suitable for routine, daily administration via the oral route. Laciten's general therapeutic purpose is to reduce peripheral vascular resistance—the opposition encountered by blood flow in the arteries. As a result, the pressure exerted by the blood against the vessel walls decreases, thereby managing essential hypertension over time. Typical use involves regular administration to achieve consistent blood pressure control throughout the day.


How is Lacidipine Different from Other CCBs?

Lacidipine is fundamentally characterized by its high vascular selectivity, meaning its primary focus is on the blood vessels rather than the heart's rhythm. This action is achieved through L-type calcium channel antagonism, leading to selective peripheral vasodilation (widening of the arteries). Lacidipine functions as an antagonist of the L-type calcium channels. This focused mechanism contrasts with other CCBs that may more significantly affect the heart's conduction system, positioning Laciten as an agent designed primarily for relaxing the arterial walls to ensure sustained blood pressure control.

What side effects are possible with Laciten?

Possible Side Effects and Safety Information

The safety profile of Lacidipine (Laciten) is organized and communicated through official regulatory classifications, detailing the frequency and nature of documented adverse reactions. These effects are grouped according to the physiological systems they affect, following international regulatory standards.

Frequency-Classified Adverse Reactions

The most frequently reported effects are generally Common (occurring in 1 to 10 users in 100), often related to the medicine's vasodilating action. These typically include headache, flushing, palpitations, and oedema (swelling), particularly of the ankles. Many common effects are noted as usually transient, tending to resolve with continued administration. Uncommon reactions (1 to 10 users in 1,000) include hypotension (low blood pressure) and syncope (fainting).

Clinically Significant and Serious Reactions

Specific clinically significant reactions are documented in official product information. The aggravation of underlying angina pectoris is an uncommon reaction that has been reported, particularly at the start of treatment. Angioedema (rapid swelling, potentially of the face and throat) is classified as a rare allergic reaction.

Safety Constraints and Special Populations

Official labeling mandates specific safety restrictions. Laciten is contraindicated in individuals with a known hypersensitivity to dihydropyridines, pre-existing aortic stenosis, or history of a myocardial infarction within the last month. Special caution is required for use in patients with hepatic impairment, as the antihypertensive effect may be increased. Furthermore, use during pregnancy and lactation is restricted to cases where the potential benefit is deemed to outweigh the risk to the neonate.

Overdose and Emergency Response

Overdose Manifestations and When to Seek Help

The official prescribing information for Laciten (Lacidipine) defines overdose primarily through its documented effects on the cardiovascular system. The anticipated clinical presentation involves signs of excessive blood vessel widening, specifically prolonged peripheral vasodilation, which predictably leads to hypotension (severely low blood pressure). Tachycardia (a fast heart rate) is also listed as an expected manifestation of an overdose. Regulatory documents note that more severe outcomes affecting the heart’s electrical system, such as bradycardia (a slow heart rate) and prolonged AV conduction (a cardiac rhythm abnormality), could theoretically occur.

Required Emergency Response

Immediate medical attention is necessary if an overdose is suspected or if severe manifestations of cardiovascular instability, such as profound hypotension, develop. Management procedures mandated by regulatory authorities require the prompt initiation of standard general measures and appropriate supportive and therapeutic measures. Due to the critical nature of the potential cardiovascular effects, continuous monitoring cardiac function is a stringent requirement during management. This need is emphasized by the explicit regulatory statement that no specific antidote is known for Lacidipine overdose, meaning treatment must rely entirely on supportive intervention and continuous observation.

Therapeutic Uses of Laciten

What Laciten Treats: Main Uses and Benefits

Laciten is used for the long-term management of essential high blood pressure (hypertension) in adults, where its primary indication is the treatment of hypertension. This medication addresses the typically asymptomatic state of systemic arterial pressure overload and contributes to lowering the pressure against blood vessel walls.

It is relevant for managing the chronic systemic strain associated with this risk factor, including situations of isolated systolic hypertension or hypertension with co-morbidities like Type 2 Diabetes Mellitus. Consistent use helps reduce the strain on the arteries and heart.

“Laciten is applied to ease the overall symptomatic load by helping to maintain a sense of circulatory stability.”

Laciten is relevant for patients requiring sustained support for the management of cardiovascular risk factors, including older adults, and may assist with **reducing the risk of conditions associated with heightened symptoms in the cardiovascular domain.


Quick Fact: Support for Managing High Blood Pressure

Property Description
Primary Indication Essential High Blood Pressure (Hypertension)
Clinical Context Long-term risk factor management, sustained control
Benefit Supports the easing of systemic strain from high blood pressure
Relevant Groups Adults, older adults, patients with concurrent Type 2 Diabetes Mellitus

Eligibility and Restrictions for Use

Who Can and Cannot Use Laciten?

This section describes the population eligibility rules for Laciten (Lacidipine) as documented in official government regulatory information, defining who may use the medicine and who is prohibited from use.


Approved Populations and Age Restrictions

Laciten is approved for use in adults (ages 18 and over) for the treatment of hypertension. Older adults may use the medicine without requiring a dose modification based on age alone. The medicine is not recommended for use in children and adolescents (under 18 years) because safety and efficacy in this age group have not been established by regulatory authorities.


Absolute Contraindications

Laciten must not be used by patients with:

  • Known hypersensitivity to Lacidipine or any excipients.
  • Severe aortic stenosis.
  • A history of myocardial infarction within the last month.
  • Current or developing cardiogenic shock.
  • Rare hereditary problems such as galactose intolerance (due to excipients).

Conditional Use and Restrictions

Use requires special caution in patients with impaired liver function (hepatic impairment) or those with poor cardiac reserve. While the medicine is primarily metabolized by the liver, no dose modification is required for patients with renal impairment (kidney disease). Use during pregnancy and breastfeeding is restricted and only permitted when the potential benefits for the mother are judged to outweigh the possible risk to the child.

What should I know about interactions with other medicines?

Interactions with other medicines and products

Official regulatory information for Laciten (Lacidipine) highlights several areas of potential interaction, primarily rooted in its metabolic pathway and pharmacodynamic effects.


Pharmacokinetic Interactions (Drug Exposure)

Laciten is metabolized by the CYP3A4 enzyme. Co-administration with strong CYP3A4 inhibitors (such as ketoconazole or itraconazole) is expected to increase the plasma concentration of Laciten. Conversely, co-administration with strong CYP3A4 inducers (such as rifampicin, phenytoin, or phenobarbital) may decrease Laciten's plasma levels. Cimetidine may also increase Laciten plasma concentration.

Pharmacodynamic Interactions

Co-administration with other antihypertensive agents (e.g., diuretics or beta-blockers) may result in an additive hypotensive effect.

Caution is advised with concomitant use of medicines known to prolong the QT interval.


Food and Product Constraints

Laciten should not be taken with grapefruit juice as the product's bioavailability may be altered. The consumption of alcohol is also recommended with caution, as it may enhance the drug's effects.

Population-Specific Notes

Official labeling indicates that caution should be exercised in patients with impaired liver function due to the potential for an increased antihypertensive effect.

Mechanism of Action

Selective Blockade of Vascular Calcium Channels

Laciten acts as a selective antagonist of the L-type calcium channels (Cav1.x) found primarily on vascular smooth muscle cells. This core molecular action inhibits the necessary influx of calcium ions (Ca^2+), thereby interrupting the signal sequence required for the contraction of arterial walls.


Modulation of Arterial Tone and Peripheral Resistance

The resulting relaxation of the arterial walls, known as vasodilation, is the primary physiological consequence of the blockade mechanism. This vasodilation leads to a reduction in total peripheral vascular resistance (TPR), which is the opposition to blood flow throughout the systemic circulation, and results in the modulation of systemic hemodynamic forces.


⏳ Mechanism-Driven Kinetic Constraints

The mechanism exhibits an intrinsically slow onset of activity due to the drug's requirement to slowly accumulate in the cell membrane before binding to the channel. While this prevents rapid physiological changes, the slow removal from the membrane reservoir determines the long duration of action and sustained modulation of vascular tone.

Dosage and Administration Information

How to Use Laciten

Laciten (Lacidipine) is administered as an oral film-coated tablet designed for once-daily intake as a long-term treatment regimen. The instructions for use are intended to ensure proper and consistent administration.


Dosing and Scheduling

Category Administration Guideline
Route of Administration Oral administration only.
Standard Dosing Regimen The initial dose is 2 mg once daily. The dose is typically increased to 4 mg once daily for maintenance, with a maximum daily dose of 6 mg.
Dosing Frequency Must be taken once daily, preferably in the morning.
Titration Schedule Dose adjustments should not occur sooner than 3 to 4 weeks after the previous change, allowing time for the full pharmacological effect to stabilize.
Duration of Use The medication is intended for long-term continuous treatment for hypertension management.

Administration Requirements

Laciten tablets should be swallowed whole with a drink of water, and may be taken with or without food. It is procedurally important to take the tablet at the same time each day to maintain consistent levels. The tablet must not be taken with grapefruit juice, as this can alter the drug's absorption.

Population-Specific Use

For older adults, no initial dose modification is generally required. For patients with hepatic impairment, careful monitoring and consideration of a reduced starting dose may be necessary. For those with renal impairment, no dose adjustment is required. The use of Laciten is not recommended for the pediatric population (under 18) as its safety and efficacy have not been established. If a dose is missed, standard practice is to skip the forgotten dose and take the next dose at the usual time the following day, without taking a double dose.

Recent Clinical Evidence

Research Evidence / Overview of Studies for Laciten

The evidence supporting the use of Lacidipine, the active ingredient in Laciten, was derived from clinical research, including randomized controlled trials (RCTs), comparative studies, and meta-analyses. The focus of this research is strictly on the medicine's regulatory-approved use for high blood pressure.


Evidence for Use in Essential High Blood Pressure

Lacidipine was evaluated in numerous short-term RCTs, which are used to evaluate the medicine under controlled research conditions. These studies typically enrolled adults diagnosed with mild-to-moderate essential high blood pressure. Researchers examined outcomes monitoring physiological strain, mainly focusing on the change in both Systolic Blood Pressure (SBP) and Diastolic Blood Pressure (DBP) measurements.

Short-term controlled research data reports consistent patterns of change in measured blood pressure. Studies reported measurements of SBP and DBP that were generally lower relative to the starting levels. In comparative trials, the data show patterns related to blood pressure change that are comparable to those reported for the comparator treatments. Results apply only to the populations studied, primarily adults.


Studies on Arterial Health Markers and Progression

Beyond directly measuring blood pressure, research has explored how Lacidipine was associated with certain physiological outcomes that monitor parameters relevant to the circulatory system. Some long-term comparative trials examined the progression of Carotid Intima-Media Thickness (IMT), a surrogate marker for changes in the arterial walls. These studies typically extended for periods up to four years.

These findings provide limited insight into the prediction of major cardiovascular events. The primary outcomes studied here are considered surrogate endpoints, meaning they are measurable indicators that predict risk rather than being a direct clinical event like a stroke.


What is Still Uncertain about the Research

A key research gap is the limited number of extensive, long-running outcome trials comparing Lacidipine against all contemporary first-line agents for major cardiovascular event prevention. Additionally, many long-term studies relied heavily on surrogate markers like IMT. Data in crucial subgroups findings are uncertain or insufficient, such as in patients with severe underlying organ disease or in the pediatric population.

Key Studies & References

  1. NICE Guideline: Hypertension in adults: diagnosis and management (CG127) - Referencing CCB use in hypertension

Frequently Asked Questions (FAQ)

Common questions about Laciten (FAQ)


Q: Is Laciten the same kind of medicine as [similar common drug name]?

Laciten's active ingredient, Lacidipine, is classified as a dihydropyridine calcium channel blocker (CCB). While other medicines you may have heard of might also be CCBs, official information highlights Laciten’s high vascular selectivity. This feature is described as positioning the medicine to primarily modulate the tone of the blood vessels, as opposed to agents with more pronounced effects on the heart's conduction system.

Q: Is it normal to feel a bit dizzy when first starting Laciten?

The most frequently reported effects of Laciten are generally related to its action of widening the blood vessels, which can sometimes cause effects like flushing or headache. Although dizziness is not specifically listed as a common effect, regulatory information does note that hypotension (low blood pressure) can occur, which may lead to feelings of lightheadedness or dizziness. Many common effects are noted as usually transient, meaning they tend to resolve or lessen with continued administration, but individual experience can vary.

Q: How is Laciten different from a supplement I see advertised online?

Laciten is a synthetic, prescription-only medicine, meaning its use is reviewed and authorized by regulatory bodies and requires a prescription from a healthcare professional. Supplements, by contrast, are generally not subject to the same strict regulatory review as prescription drugs. Its purpose is defined by its regulatory approval as a prescription-only agent for the management of essential high blood pressure.

Q: What is the official safety classification of Laciten?

Official regulatory documents organize the safety profile by detailing the frequency of documented adverse reactions (Common, Uncommon, Rare). The labeling also specifically identifies certain conditions where the drug is contraindicated (must not be used), such as severe aortic stenosis or a myocardial infarction within the last month. The labeling also includes specific restrictions on its use during pregnancy and breastfeeding, conditional upon physician assessment.

Q: Why is Laciten often prescribed instead of other available options?

Official information characterizes the active ingredient, Lacidipine, by its high vascular selectivity. This feature positions the medicine as an agent designed primarily for relaxing the arterial walls to ensure sustained blood pressure control. The choice between antihypertensive treatments is a clinical decision made by a healthcare professional.

Q: What if I'm already taking multiple different medications—is Laciten still an option?

The concurrent use of Laciten with other medications is reviewed based on official interaction guidelines. Regulatory documents detail that Laciten is metabolized by the CYP3A4 enzyme, meaning it can interact with strong inhibitors or inducers of that enzyme. Co-administration with other antihypertensive agents is described as potentially resulting in an additive hypotensive effect.

Q: Do studies support the idea that Laciten has a consistent effect across different populations?

Clinical trials focused on essential high blood pressure report consistent patterns of change in measured blood pressure in the adult populations studied. However, regulatory information indicates that data in crucial subgroups may be uncertain or insufficient. The most comprehensive evidence is found in trials involving adults with mild-to-moderate high blood pressure.

Q: Can people with a history of heart conditions use Laciten?

Official labeling contains specific warnings and restrictions regarding certain heart conditions. For example, Laciten is contraindicated (must not be used) in patients with severe aortic stenosis or a history of a myocardial infarction within the last month. Conditional use is required for individuals with poor cardiac reserve. The official label also notes the aggravation of underlying angina pectoris as an uncommon reaction, particularly at the start of treatment.

Q: What is the difference between the active and inactive ingredients in Laciten?

The active ingredient is Lacidipine, which is the substance responsible for the medicine's pharmacological effect (lowering blood pressure). The inactive ingredients (excipients) are necessary for the tablet’s formulation, stability, and structure. Official labeling lists all ingredients and specifically notes that patients with rare hereditary problems, such as galactose intolerance, must not use the medicine due to certain excipients.

Q: What if I miss two doses of Laciten? What do I do then?

Official regulatory guidance provides instructions for a single missed dose, which is to skip the forgotten dose and take the next dose at the usual time the following day. Guidance for missing more than one dose is not explicitly detailed in the standard product information. If you miss multiple doses, this is a matter to discuss with the prescribing professional.

Q: What is the general success rate reported in clinical trials for Laciten?

Research was primarily designed to evaluate the physiological changes under controlled conditions, focusing on the reduction of Systolic and Diastolic Blood Pressure (SBP and DBP). Research data generally reported patterns of blood pressure change that were consistent among the studied populations. However, regulatory overviews typically do not define or publish a single, quantified 'general success rate' for the patient population.

Q: How quickly should someone expect to feel the effects of Laciten?

Official sources indicate that the active substance starts its action between 30 and 50 minutes after taking the tablet. Due to its mechanism, the antihypertensive effect is gradual, and the medicine is positioned for long-term management. Dose adjustments are not typically made sooner than 3 to 4 weeks after the previous change to allow the full effect to stabilize.

Q: Can Laciten cause problems with driving or operating machinery?

According to the official patient leaflet, the medicine may cause dizziness or tiredness in some people, especially at the start of treatment. The official product information advises that if these effects are experienced, activities requiring high mental alertness, such as driving or operating heavy machinery, should be avoided.

Q: Does Laciten interact with common over-the-counter pain relievers?

Regulatory information advises patients to inform their doctor or pharmacist about all medicines being taken, which includes those bought without a prescription (over-the-counter). This is necessary to review all possible interactions to ensure all products are suitable to be used concurrently with Laciten.

Q: How long does Laciten usually stay in your system?

The length of time a medicine stays in the body is often measured by its half-life. Official pharmacological data indicates that the average terminal half-life of the active substance is between 13 and 19 hours. This long duration contributes to its ability to be taken effectively once daily.

Q: Does taking Laciten require any special monitoring or blood tests?

No routine blood tests for general use are explicitly mandated in the official labeling. However, official information emphasizes that patients with existing liver impairment may require close monitoring due to the potential for an increased antihypertensive effect.

Q: Can Laciten be split or crushed if someone has trouble swallowing pills?

Laciten is provided as an oral film-coated tablet. Regulatory guidance states that the tablet must be swallowed whole with water. The regulatory guidance that the tablet must be swallowed whole with water implies that manipulation of the dose form is not authorized.

Q: What is the risk of dependence or addiction with Laciten?

Official regulatory product information for Lacidipine does not report any risk of addiction or drug dependence. This medicine is not associated with habit-forming tendencies.

Q: Does Laciten have any known interactions with herbal supplements?

Yes, official patient information explicitly advises telling your doctor or pharmacist if you are taking any other medicines, including herbal medicines. This is necessary to review all possible interactions before starting treatment.

Q: What should a person know about stopping Laciten after taking it for a long time?

This medicine is intended for long-term continuous treatment for high blood pressure. If treatment is to be stopped, regulatory guidance indicates that the dose may need to be reduced gradually over several days. Regulatory documents indicate that abrupt discontinuation should be avoided. Any changes to the treatment plan are clinical decisions that should be discussed with the prescribing professional.

How should Laciten be stored and disposed of?

Storage and Disposal of Laciten (Lacidipine)

Laciten (lacidipine) tablets must be stored under specific regulatory conditions to maintain efficacy and stability.


Storage Requirements

The medicine must be stored below 25°C (77°F). Protection is mandatory against both light and moisture, requiring the product to be kept in the original container/package. For safety, the product must be kept out of the sight and reach of children.


Disposal Instructions

Disposal must adhere to local pharmaceutical waste regulations. Laciten must not be thrown away via household waste or disposed of through wastewater (drains or toilets). Unused or expired medication should be taken to an authorized collection point or follow specific instructions provided by local authorities.

Attention! Always consult to a doctor or pharmacist before using pills or medicines.

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