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Components:
Pancreatin
Method of action:
Amylolytic, Enzymes, Lipolytic, Proteolytic, Replenishing Deficiency Of Pancreatic Enzymes
Medically reviewed by Fedorchenko Olga Valeryevna, Pharmacy-Provisor. Last updated on 2019.12.09

Pharmacokinetic properties

The information provided in Pharmacokinetic properties of Kreon is based on data of another medicine with exactly the same composition as the Kreon of the medicine (Pancreatin). Be careful and be sure to specify the information on the section Pharmacokinetic properties in the instructions to the drug Kreon directly from the package or from the pharmacist at the pharmacy.
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Absorption

The enzymes are present in the form of pH-sensitive enteric-coated minitablets, which are filled into hard gelatin capsules. The minitablets, which are released from the capsule into the stomach, are enteric coated to resist inactivation at low pH. Once released, the minitablets are distributed into the stomach and pass into the duodenum where the enteric coating begins to dissolve and the enzymes are released when the pH reaches 5.5. Duodenal availability studies in adults indicate that following oral administration of Kreon HL capsules, measurable levels of enzymes are present in the duodenum. Pancreatin is not absorbed from the gastro-intestinal tract in appreciable amounts.

Metabolism

Once they have accomplished their digestive function, the enzymes may be digested in the intestine.

Elimination

The constituents may be partially absorbed and subsequently excreted in the urine. Any undigested enzymes are excreted in the faeces.

Special populations

Paediatrics

The pharmacokinetics of pancreatin in paediatric subjects have not been investigated.

Elderly

The pharmacokinetics of pancreatin in elderly subjects have not been investigated.

Renal impairment

The pharmacokinetics of pancreatin in renally impaired subjects have not been investigated.

Hepatic impairment

The pharmacokinetics of pancreatin in hepatically impaired subjects have not been investigated.

Pharmacotherapeutic group

The information provided in Pharmacotherapeutic group of Kreon is based on data of another medicine with exactly the same composition as the Kreon of the medicine (Pancreatin). Be careful and be sure to specify the information on the section Pharmacotherapeutic group in the instructions to the drug Kreon directly from the package or from the pharmacist at the pharmacy.
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Enzyme preparations, ATC code: A09AA02.

Preclinical safety data

The information provided in Preclinical safety data of Kreon is based on data of another medicine with exactly the same composition as the Kreon of the medicine (Pancreatin). Be careful and be sure to specify the information on the section Preclinical safety data in the instructions to the drug Kreon directly from the package or from the pharmacist at the pharmacy.
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No relevant information additional to that contained elsewhere in the Summary of Product Characteristics.

Incompatibilities

The information provided in Incompatibilities of Kreon is based on data of another medicine with exactly the same composition as the Kreon of the medicine (Pancreatin). Be careful and be sure to specify the information on the section Incompatibilities in the instructions to the drug Kreon directly from the package or from the pharmacist at the pharmacy.
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None stated.

Special precautions for disposal and other handling

The information provided in Special precautions for disposal and other handling of Kreon is based on data of another medicine with exactly the same composition as the Kreon of the medicine (Pancreatin). Be careful and be sure to specify the information on the section Special precautions for disposal and other handling in the instructions to the drug Kreon directly from the package or from the pharmacist at the pharmacy.
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Not applicable.

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