Кординик

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Кординик

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Method of action: Antianginal, Cardiac Therapy

Treatment option: Seizure Prophylaxis

Medically reviewed

Marina Burgos

Last updated on 10/01/2026

This page provides general, reference-level information compiled from official medical sources. It is not a substitute for professional medical advice, diagnosis, or treatment. For decisions about your health, please consult a qualified healthcare professional.

Overview of Кординик

Quick Facts

Property Description
Active ingredient Nicorandil (INN)
Form Film-coated tablets
Pharmacological class Antianginal Agent and Vasodilator
General purpose Relief of Angina Pectoris symptoms
Origin Synthetic organic compound

What is Кординик: Definition and Classification

Кординик is a prescription-only medication whose active ingredient is Nicorandil (INN), which is classified as both an Antianginal Agent and a potent Vasodilator. It is generally utilized for the long-term management of Stable Angina Pectoris in adults.

The Nicorandil compound is recognized for its unique dual-action drug mechanism, acting both as an Adenosine triphosphate-sensitive potassium (KATP) channel opener and a Nitric Oxide (NO) donor. Other popular brands containing this same formulation include Ikorel and Dancor.

Composition, Origin, and Dosage Form

The core of Кординик is the active ingredient Nicorandil, which is a synthetic organic compound derived structurally from Nicotinamide. The medication is formulated as a single active ingredient product and is intended for the oral route of administration.

Кординик is supplied in the standardized dosage form of film-coated tablets. This choice of form ensures precise dosage control and stability of the active Nicorandil substance, combining it with necessary pharmaceutical excipients for controlled delivery.

What is the General Therapeutic Purpose?

The general purpose of Кординик is to provide symptomatic relief from Angina Pectoris by enhancing the balance of oxygen supply to the heart muscle. By relaxing the smooth vascular muscles through its vasodilator action, the drug effectively increases coronary circulation.

This dual mechanism is clinically recognized for its ability to lower the heart’s overall workload by reducing resistance in the arterial dilation and venodilation systems. This physiological action leads to a predictable reduction in the severity and frequency of chest pain episodes, which is the general therapeutic purpose of the medication.

What side effects are possible with Кординик?

Possible side effects and safety information

The safety profile of Кординик (Nicorandil) is organized by regulatory agencies into frequency categories based on system-organ classes. The most common adverse reaction documented in official sources is headache, classified as Very Common (occurring in 1 in 10 patients or more), which is often reported particularly in the first days of treatment.

Frequency and System Categories

Side effects classified as Common (1 in 100 to less than 1 in 10) include dizziness and nausea/vomiting (Nervous and Gastrointestinal disorders, respectively), as well as cutaneous vasodilation (flushing) and increased heart rate (Vascular and Cardiac disorders). A decrease in blood pressure is officially documented as Uncommon.

Serious Adverse Reactions and Restrictions

Of clinical significance is the potential for ulcerations, which are classified as Rare or Very Rare. These include gastrointestinal ulcers (mouth, tongue, large and small intestine) and ocular ulcers (corneal and conjunctival), which can occur at any time, including years after treatment initiation. Regulatory documents note that these ulcers are often resistant to standard treatment and may necessitate withdrawal of the medication. Advanced ulcerations carry a risk of serious adverse reactions such as perforation or fistula formation.

Use of Nicorandil is absolutely restricted in patients with conditions like severe hypotension, cardiogenic shock, and acute pulmonary oedema. Furthermore, concomitant use with Phosphodiesterase 5 Inhibitors (e.g., sildenafil) is contraindicated due to the high risk of a serious fall in blood pressure. The medication is not recommended in the paediatric population.

Overdose and Emergency Response

Overdose and when to seek help

An acute overdosage of Кординик is officially documented in regulatory information to result in clinical manifestations directly related to its potent vasodilatory effect. The expected presentations include marked peripheral vasodilation, a significant fall in blood pressure (hypotension), and a compensatory rise in heart rate known as reflex tachycardia.

The regulatory profile confirms that severe overexposure may lead to life-threatening situations if the resulting hypotension is profound and sustained. Therefore, it is mandatory to seek immediate medical attention for any suspected overdose.


Officially Documented Management

The prescribing information states that no specific antidote is documented for Nicorandil overdosage, meaning treatment is strictly supportive. Key procedural actions mandated by regulators include the immediate monitoring of cardiac function and the use of general supportive measures.

If initial measures fail to stabilize the patient, the treatment involves increasing the circulating plasma volume by substitution of fluid (infusion). For life-threatening scenarios involving refractory low blood pressure, the administration of vasopressors must be considered. Regulatory texts note that there is no experience of massive overdosage in humans.

Therapeutic Uses of Кординик

Relief for Chronic Stable Angina Pectoris

The antianginal agent Кординик may be part of symptomatic management for long-term care of stable angina pectoris, a condition presenting with symptoms related to physical discomfort in the chest, such as pressure or tightness. The therapy is relevant in clinical settings that involve acute or disruptive symptom patterns not managed by other supportive measures. The therapy contributes to easing the symptoms linked to organ-specific functional stress (recurring pain and pressure).


Reduction in Frequency of Angina Episodes

Кординик is applied in addressing symptoms in conditions involving recurrent or episodic manifestations of chest discomfort. This medication may be part of symptomatic management as a maintenance treatment aimed at managing discomfort during periods of exertion.

“The primary goal of this therapy is to provide symptomatic support, assisting patients in managing the frequent and predictable nature of their chest discomfort.”

This prophylactic use assists with maintaining functional stability and provides supportive relief when symptoms interfere with routine activities.

Quick Fact: Symptomatic Support
Main Clinical Context Maintenance treatment for chronic stable angina pectoris
Primary Symptom Focus Recurrent chest pain and exertion-induced tightness
Core Patient Benefit Contributes to easing the overall symptom burden

Eligibility and Restrictions for Use

The official regulatory profile for Кординик (Nicorandil) defines precise population eligibility rules based on age, physiological status, and concurrent medication use.

Contraindicated Populations

Use is absolutely contraindicated in individuals with:

  • Severe Hypotension or any form of shock (including cardiogenic shock).
  • Left Ventricular Dysfunction with low filling pressure or cardiac decompensation.
  • Hypovolaemia (volume depletion) or Acute Pulmonary Oedema.
  • Concurrent use of Phosphodiesterase 5 (PDE5) inhibitors (e.g., sildenafil, tadalafil) or Soluble Guanylate Cyclase (sGC) stimulators due to risk of severe, synergistic blood pressure reduction.

Age and Physiological Status

Population Group Regulatory Status
Adults (18+ years) Allowed for the symptomatic treatment of stable angina pectoris.
Children & Adolescents Not Recommended. Safety and efficacy have not been established in this age group.
Pregnancy Not Recommended. Use is generally avoided due to limited human data.
Breastfeeding Not Recommended. Unknown if Nicorandil is excreted into human milk.

Eligibility-Related Restrictions

Caution is formally advised for patients with specific conditions, including Glaucoma, Glucose-6-Phosphate Dehydrogenase (G6PD) deficiency, or Diverticular Disease. No special dosage adjustments are typically mandated for mild-to-moderate renal or hepatic impairment, but caution is recommended, especially if hyperkalaemia risk exists.

What should I know about interactions with other medicines?

Interactions with other medicines and products

Contraindicated Combinations

Co-administration of Кординик (Nicorandil) is strictly contraindicated with specific classes of medicinal products due to the risk of severe, life-threatening hypotension resulting from a synergistic pharmacodynamic effect. These prohibited combinations include Phosphodiesterase 5 Inhibitors (e.g., Sildenafil, Tadalafil, Vardenafil) and Soluble Guanylate Cyclase (sGC) Stimulators (e.g., Riociguat).


Pharmacodynamic Interactions

The blood pressure lowering effect of Кординик may be potentiated when co-administered with other agents that reduce blood pressure. Caution is advised with Antihypertensive Agents, general Vasodilators, and Tricyclic Antidepressants. Additionally, co-administration with Non-Steroidal Anti-Inflammatory Drugs (NSAIDs), including Acetylsalicylic acid, or Corticosteroids is associated with an increased risk for serious gastrointestinal complications, such as ulceration, perforation, and haemorrhage. Caution is also necessary when used with products that may increase potassium levels, such as ACE inhibitors and Angiotensin Receptor Blockers (ARBs), particularly in patients with renal impairment.


Other Documented Interactions

Official regulatory sources indicate that the metabolism of Nicorandil is not significantly affected by co-administration with tested enzyme modulators, such as the CYP inhibitor Cimetidine or the CYP3A4 inducer Rifampicin. The official label notes that alcohol may increase the blood pressure lowering effect and associated symptoms like dizziness. Administration is independent of food intake.

Mechanism of Action

How Кординик Works

The action of Кординик stems from its active ingredient, Nicorandil, which uses a unique dual-action mechanism to modulate cardiovascular processes by acting on specific molecular targets that regulate vascular tone and mitochondrial function.

mathbfKmathbfATP Channel Opening and Afterload Reduction

The primary mechanism involves the direct activation of adenosine triphosphate-sensitive potassium ( K ATP) channels in arterial smooth muscle cells. This interaction causes the cell membrane to hyperpolarize, which results in the closure of voltage-gated calcium channels. By reducing the influx of calcium ions, this cascade promotes the relaxation of resistance arteries, leading to a decrease in the systemic pressure the heart works against, known as afterload. The same mechanism on mitochondrial K ATP channels also modulates mitochondrial function under ischemic conditions.

Nitric Oxide Donation and Preload Reduction

The second, complementary mechanism involves Nicorandil acting as a Nitric Oxide (NO) donor. The released NO stimulates the enzyme soluble Guanylate Cyclase, which subsequently increases the concentration of the signaling molecule cGMP inside the smooth muscle cell. This NO-cGMP pathway induces relaxation in both arterial and venous smooth muscle. The significant dilation of capacitance veins helps reduce the volume and pressure returning to the heart, effectively lowering preload. The reduction in both preload and afterload simultaneously reduces the cardiac workload and enhances coronary blood flow.

Dosage and Administration Information

How to Use Кординик: Official Administration Guidelines

Кординик is structured for oral administration as a part of a long-term treatment plan. The medication is supplied in the form of film-coated tablets in 10 mg and 20 mg strengths. All usage instructions, including dosing and administration, are established by government regulatory bodies.


Standard Dosing and Frequency

The standard adult regimen for Nicorandil begins with a starting dose of 10 mg administered twice daily (bid). Doses are typically taken in the morning and evening. An alternative starting dose of 5 mg twice daily may be used for patients who are susceptible to headache, aiming to improve early tolerability. The dose is subject to upward titration based on patient response and clinical need, with the usual maintenance dose ranging from 10 mg to 20 mg twice daily. The maximum dose officially recommended is up to 40 mg twice daily.


Administration Requirements

Procedural Instruction Requirement
Route of Administration Oral
Timing Relative to Food Independent of food intake (with or without food)
Preparation Tablets must be swallowed whole with liquid; they must not be crushed or chewed.
Special Handling Must remain in the original blister packaging until the moment of administration due to the tablet's moisture sensitivity.

Population-Specific Use

For older adults, prescribers typically utilize the lowest effective dose. Dosage adjustment is not generally required for patients with hepatic or renal impairment. Nicorandil is not recommended for use in children and adolescents, as its safety and efficacy have not been formally established in the pediatric population.

Recent Clinical Evidence

Research evidence / Overview of Studies for Кординик


Evidence for Symptom Management in Stable Angina Pectoris

Research exploring Кординик in chronic stable angina has been primarily conducted through short-term randomized controlled trials (RCTs). These studies were designed to evaluate the medicine’s research role in exploring symptomatic changes, which are outcomes related to physical discomfort such as chest pain and tightness. Other studies also assessed activity level by monitoring patients during standardized exercise tests to see how symptoms evolved.

These trials reported measurements showing findings describe patterns observed in the studies related to self-reported angina frequency compared to placebo. When compared against other established anti-anginal medications, however, findings were mixed when measured outcomes were compared against those of other established anti-anginal medications. What remains uncertain is the durability of these symptomatic patterns over many years, as follow-up durations were limited in many of the trials focusing only on symptom relief.


Evidence for Long-Term Cardiovascular Outcomes

The investigation explores the long-term patterns related to major cardiovascular events and is largely based on one large, multi-center, randomized, placebo-controlled trial. This research was specifically designed to explore outcomes related to the combined occurrence of coronary heart disease (CHD) death, non-fatal heart attack (MI), or unplanned hospital visits for cardiac chest pain. This large study was conducted in a specific group of high-risk adults with established CHD who were already taking other standard therapies.

This research highlights changes measured during the study period, indicating that patterns observed in the overall primary endpoint reflected the component related to hospital admissions. Importantly, the separate analysis of the secondary outcome of CHD death or non-fatal MI did not show a measurement difference between the study groups that met the trial's criteria, meaning the data for those specific events remain uncertain.


Gaps and Uncertainties in the Research Evidence

The prognostic data, which relates to major cardiovascular events, relies heavily on findings from a single, large trial. Furthermore, the primary outcome measurements in that study reflected the component related to hospital admissions, and the data for the key events of cardiac death or non-fatal heart attack are still emerging and remain uncertain. The long-term study was conducted some time ago, meaning that comparative evidence is lacking for current clinical practice standards with modern, intensified preventive treatments.

Key Studies & References The role of nicorandil in the management of stable angina pectoris (Review of Symptomatic Evidence).

Frequently Asked Questions (FAQ)

Common questions about Кординик (FAQ)


Q: Is Кординик the same kind of medicine as [similar drug name]? What's the main difference?

Official information describes the active ingredient, Nicorandil, as a dual-action agent. It works by opening certain potassium channels and by acting as a Nitric Oxide (NO) donor. This dual mechanism is what differentiates its action from typical single-action treatments used for stable angina, such as standard nitrates.


Q: Does Кординик contain [common ingredient, e.g., aspirin, gluten, lactose]?

Official product information, which includes the list of ingredients (excipients), states the specific compounds used in the tablet formulation. This list confirms the presence or absence of common substances like lactose, gluten, or specific allergens in the final medicine.


Q: How quickly should someone start feeling the expected effect of Кординик?

According to official drug studies, the medicine is absorbed rapidly after being taken orally. It typically reaches its maximal concentration in the blood within 30 to 60 minutes. The rapid absorption profile is consistent with the drug’s prescribed long-term management regimen.


Q: Is Кординик known to cause weight gain or weight loss?

Official safety documents indicate that weight gain is not a reported side effect. However, weight loss has been documented in rare cases linked to severe gastrointestinal ulcerations, a potential adverse reaction listed in the regulatory documents.


Q: How does Кординик affect the liver or kidneys?

Official pharmacokinetic studies indicate that the drug is primarily processed and eliminated by the kidneys. Regulatory documents state that no clinically important changes in the drug's profile are generally expected in patients with mild-to-moderate chronic liver or kidney disease. While rare, there have been documented reports of liver disorders, such as hepatitis, associated with the medicine.


Q: Are there specific tests a doctor should do before prescribing Кординик?

Clinical studies supporting the use of the medicine for stable angina required participants to have a confirmed diagnosis, often verified through specialized tests like an angiogram or a positive exercise test. This process reflects the necessity of a thorough medical assessment to confirm the diagnosis before treatment is initiated.


Q: Is there a generic version of Кординик available?

Yes, the active ingredient, Nicorandil, is marketed under various trade names in different countries. Regulatory agencies, such as the EMA, have documentation that refers to the drug alongside other generic or brand alternatives containing the same active substance.


Q: What are some common reasons people stop taking Кординик?

Regulatory surveillance studies have documented that the most frequently reported reasons for discontinuation of the medicine in practice (excluding a change in underlying condition) are experiencing headache, the medicine being reported as 'not effective', and dizziness.


Q: Are there any vitamins or supplements that interact with Кординик?

Official safety warnings indicate a caution regarding supplements that may increase potassium levels in the blood. Since the drug itself can contribute to this effect, the co-administration of potassium supplements is noted as a factor that may increase the risk of elevated potassium levels (Hyperkalaemia).


Q: Why do some people say Кординик gave them stomach issues?

Official regulatory information lists gastrointestinal issues, including nausea and vomiting, as common side effects. Furthermore, the medicine is officially associated with a rare potential for gastrointestinal ulcerations in the mouth, stomach, or intestines, which are documented to occur at any time during treatment.


Q: Can I take Кординик if I have diabetes?

Official documents do not list diabetes as an absolute restriction on use. However, the medicine carries a risk of contributing to Hyperkalaemia (elevated potassium levels). As diabetes can involve other related health risks, the drug's potential to affect electrolyte balance is a factor that is noted in official cautions.


Q: Does Кординик affect fertility in men or women?

According to the official regulatory safety documents, there is no evidence available to suggest that the medicine reduces fertility in either men or women.


Q: Is there a maximum time someone can take Кординик according to official guidelines?

Official guidance describes the medicine as being structured for the long-term treatment of stable angina pectoris, without a specific, mandatory stop date. The primary long-term clinical trial supporting its cardiovascular profile followed patients for an average duration of over a year and a half.


Q: Can I drink coffee or caffeine while taking Кординик?

Official drug safety sources have documented a warning that the excessive intake of caffeine from sources such as coffee, tea, and certain canned drinks should be managed during treatment.


Q: Can people with asthma or other respiratory issues use Кординик?

Asthma is not listed as a condition that would absolutely restrict the use of the medicine. However, official regulatory documents do list bronchitis and dyspnoea (shortness of breath) as possible side effects associated with the use of this medicine.


Q: How is the official information about Кординик kept up-to-date?

Regulatory bodies (such as the EMA and MHRA) monitor the medicine’s safety profile after approval through post-marketing surveillance. If new or serious risks are identified, these agencies issue official Drug Safety Updates and require revisions to the official labels (SmPCs) to reflect the new safety data.


Q: Does the brand or generic version of Кординик work differently?

In many regions, generic versions of the active ingredient (Nicorandil) must meet strict regulatory standards. For a generic to be approved, it must demonstrate bioequivalence, which confirms that it is expected to work in the same way and deliver the same amount of the active substance to the body.

How should Кординик be stored and disposed of?

How to Store and Dispose of Кординик (Nicorandil)

Official regulatory documents define specific, mandatory conditions for storing Кординик tablets to maintain product stability and safety.

Mandatory Storage and Stability

The product must be stored within the temperature range specified on the package, which may be mathbf2 C to mathbf8 C or not exceeding mathbf25 C. Tablets must be protected from environmental factors by being stored in a dry and dark place, ideally in the original container.

The labeled shelf-life is two years, and the medicine must not be used after the expiration date.

Safety and Disposal

It is a mandatory requirement that Кординик must be kept out of the sight and reach of children.

Disposal of any unused or expired tablets must be carried out according to local pharmaceutical waste regulations and should not involve household waste or wastewater unless explicitly permitted.

Attention! Always consult to a doctor or pharmacist before using pills or medicines.

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