Components:
Medically reviewed by Militian Inessa Mesropovna, PharmD. Last updated on 26.06.2023
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Menadione
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Broad-Spectrum Antibiotics-Broad-spectrum antibiotics may sterilize the bowel and decrease the vitamin K contribution to the body by the intestinal microflora. Cephalosporins-Cephalosporins containing side chains of N-methylthiotetrazole (cefmenoxime, cefoperazone, cefotetan, cefamandole, latamoxef) or methylthiadiazole (cefazolin) can cause vitamin K deficiency and hypoprothrombinemia. These cephalosporins are inhibitors of hepatic vitamin K epoxide reductase. Cholestyramine-Concomitant intake of cholestyramine and vitamin K may reduce the absorption of vitamin K. Colestipol-Concomitant intake of colestipol and vitamin K may reduce the absorption of vitamin K. Mineral Oil-Concomitant intake of mineral oil and vitamin K may reduce the absorption of vitamin K. Orlistat-Orlistat may decrease the absorption of vitamin K. Salicylates-Salicylates in large doses may inhibit vitamin K epoxide reductase resulting in vitamin K deficiency. Warfarin-Vitamin K can antagonize the effect of warfarin
Menadione