Klenzit-MS

Klenzit-MS Lotion is indicated for the topical treatment of acne vulgaris in patients 12 years and older.

Treating severe acne. It may also be used for other conditions as determined by your doctor.

Klenzit-MS cream is a retinoid-like compound. The exact way Klenzit-MS cream works is unknown. However, it helps the skin cells renew quicker and decreases blackhead formation.

Usual Adult Dose for Acne

Klenzit-MS

Topical 0.1% cream, 0.1% gel, 0.3% gel

Apply to the affected area once a day at bedtime after washing. A thin film should be applied, avoiding eyes, lips, angles of the nose, and mucous membranes.

Lotion: Apply a thin film of lotion to the entire face and other affected areas of the skin once daily, after washing gently with a mild soapless cleanser. Dispense a nickel size amount of lotion (3 to 4 actuations of the pump) to cover the entire face. Avoid application to the areas of skin around eyes, lips and mucous membranes.

Usual Pediatric Dose for Acne

Klenzit-MS

Topical 0.1% cream, 0.1% gel, 0.3% gel

11 years or less: Safety and efficacy have not been established.

12 to 18 years: Apply to the affected area once a day at bedtime after washing. A thin film should be applied, avoiding eyes, lips, angles of the nose, and mucous membranes.

Safety and effectiveness of the lotion formulation in pediatric patients under the age of 12 have not been established.

Renal Dose Adjustments

Data not available

Liver Dose Adjustments

Data not available

Precautions

Klenzit-MS should not be applied to skin with cuts, abrasions, eczema, or sunburn.

Patients should minimize exposure to sunlight, including sunlamps, and use sunscreens and other protection whenever prolonged exposure is unavoidable. Therapy should be discontinued if sunburn develops, and not resumed until the skin fully recovers. Patients may also have a heightened susceptibility to irritation due to weather extremes (wind or cold).

Klenzit-MS may cause erythema, dryness, scaling, burning, and itching, which usually begin the first 2 to 4 weeks of therapy but diminish with continued use. Patients who develop excessive irritation should use the medication less frequently, interrupt treatment briefly, or discontinue use totally.

Klenzit-MS therapy may render the skin more vulnerable to the irritating effects of astringents, abrasive soaps, skin cleansers, and other facial chemicals and cosmetics that contain alcohol or have a strong drying effect. Concomitant use of these agents with Klenzit-MS should be approached with caution. Products containing alpha hydroxy or glycolic acids should be avoided.

Klenzit-MS should not be used around the eyes, mouth, angles of the nose, mucous membranes, or on cut, abraded, or eczematous skin. Contact with the eye may cause an ocular reaction such as swelling, conjunctivitis, and irritation.

Wax epilation should not be performed on Klenzit-MS-treated skin.

Safety and effectiveness in pediatric patients under the age of 12 years has not been established.

Dialysis

Data not available

Other Comments

Initially, an apparent exacerbation of acne may appear within the first few weeks of treatment due to the action of Klenzit-MS topical on previously unseen lesions. Therapeutic results are typically noticed after 8 to 12 weeks of treatment.

See also:
What is the most important information I should know about Klenzit-MS?

Avoid getting this medication in your eyes, in the creases of your nose, or on your lips. If it does get into any of these areas, wash with water. Do not use Klenzit-MS topical on sunburned, windburned, dry, chapped, irritated, or broken skin. Also avoid using this medication in wounds or on areas of eczema. Wait until these conditions have healed before using Klenzit-MS topical.

Do not use skin products that contain alpha hydroxy or glycolic acid while you are also using Klenzit-MS topical.

Avoid using skin products that can cause irritation, such as harsh soaps, shampoos, or skin cleansers, hair coloring or permanent chemicals, hair removers or waxes, or skin products with alcohol, spices, astringents, or lime. Do not use other medication skin products unless your doctor has told you to.

Avoid exposure to sunlight or artificial UV rays (sunlamps or tanning beds). Klenzit-MS topical can make your skin more sensitive to sunlight and sunburn may result. Use a sunscreen (minimum SPF 15) and wear protective clothing if you must be out in the sun.

Use Klenzit-MS cream as directed by your doctor. Check the label on the medicine for exact dosing instructions.

• An extra patient leaflet is available with Klenzit-MS cream. Talk to your pharmacist if you have questions about this information.
• Do not use other medicines on your skin without first discussing it with your doctor.
• Klenzit-MS cream is for external use only. Avoid contact with the eyes, lips, angles of the nose, and mucous membranes. Exposure of Klenzit-MS cream to the eye may cause swelling, redness, and irritation.
• Do not apply Klenzit-MS cream to cuts, abrasions, eczematous skin, or sunburned skin.
• Use Klenzit-MS cream in the evening before bedtime unless directed otherwise by your doctor.
• Before applying Klenzit-MS cream, clean the area to be treated with mild soap or soapless cleanser and gently dry.
• Apply a thin film of Klenzit-MS cream to the affected and surrounding area. Rub in gently. Wash your hands immediately after using Klenzit-MS cream.
• A mild sensation of warmth or slight stinging may occur shortly after using Klenzit-MS cream.
• If you miss a dose of Klenzit-MS cream, use it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not use 2 doses at once. If several applications are missed, contact your doctor or pharmacist.

Ask your health care provider any questions you may have about how to use Klenzit-MS cream.

This medication is used to treat acne. It may decrease the number and severity of acne pimples and promote quick healing of pimples that do develop. Klenzit-MS belongs to a class of medications called retinoids. It works by affecting the growth of cells and decreasing swelling and inflammation.

How to use Klenzit-MS topical

Wash your hands before applying this medication. Gently clean the affected skin with a mild or soapless cleanser and pat dry. Use your fingertips to apply a small amount of medication in a thin layer, usually once daily at bedtime, or as directed by your doctor. A gauze pad or cotton swab can be used to apply the solution.

Use this medication on the skin only. Do not apply to the inner lip area or inside the nose/mouth. Do not apply to cut, scraped, sunburned, or eczema-affected skin.

Avoid getting this medication in your eyes. If this medication gets into your eyes, flush with large amounts of water. Call your doctor if eye irritation develops. Wash your hands after using the medication to avoid accidentally getting it in your eyes.

During the first few weeks of using Klenzit-MS, your acne might appear worse because the medication is working on pimples forming inside the skin. It may take up to 8-12 weeks to notice results from this medication.

Use it regularly in order to get the most benefit from it. To help you remember, use it at the same time each day. Do not use a larger amount or use it more frequently than recommended. Your skin will not improve any faster, and it will increase the risk of developing redness, peeling and pain.

This medication is available in different strengths and forms (e.g., gel, cream, solution). The best type of medication for you to use will depend on the condition of your skin and your response to therapy. Inform your doctor if your condition persists or worsens.

See also:
What other drugs will affect Klenzit-MS?

As DIFFERIN® (Klenzit-MS gel) Gel has the potential to produce local irritation in some patients, concomitant use of other potentially irritating topical products (medicated or abrasive soaps and cleansers, soaps and cosmetics that have a strong drying effect, and products with high concentrations of alcohol, astringents, spices, or lime) should be approached with caution. Particular caution should be exercised in using preparations containing sulfur, resorcinol, or salicylic acid in combination with DIFFERIN® (Klenzit-MS gel) Gel. If these preparations have been used, it is advisable not to start therapy with DIFFERIN® (Klenzit-MS gel) Gel until the effects of such preparations in the skin have subsided.

See also:
What are the possible side effects of Klenzit-MS?

In controlled clinical trials, local cutaneous irritation was monitored in 285 acne patients who used Klenzit-MS Cream once daily for 12 weeks. The frequency and severity of erythema, scaling, dryness, pruritus and burning were assessed during these studies. The incidence of local cutaneous irritation with Klenzit-MS Cream from the controlled clinical studies is provided in the following table:

Other reported local cutaneous adverse events in patients who used Klenzit-MS Cream once daily included: sunburn (2%), skin discomfort-burning and stinging (1%) and skin irritation (1%). Events occurring in less than 1% of patients treated with Klenzit-MS Cream included: acne flare, dermatitis and contact dermatitis, eyelid edema, conjunctivitis, erythema, pruritus, skin discoloration, rash, and eczema.

Klenzit-MS is a topical retinoid primarily used in the treatment of acne and is also used (off-label) to treat keratosis pilaris as well as other skin conditions. It is currently marketed by Galderma under the trade names Differin in some countries, and Klenzit-MS in India. [Wikipedia]