×
Components:
Estradiol, Medroxyprogesterone
Method of action:
Antiplasmic, Endocrine Therapy, Estrogen-Progestational
Available in countries
See all
close
Medically reviewed by Oliinyk Elizabeth Ivanovna, Pharmacy. Last updated on 2019.12.15

Name of the medicinal product

Kilios

Qualitative and quantitative composition

Estradiol; Medroxyprogesterone

Therapeutic indications

The information provided in Therapeutic indications of Kilios is based on data of another medicine with exactly the same composition as the Kilios of the medicine (Estradiol, Medroxyprogesterone). Be careful and be sure to specify the information on the section Therapeutic indications in the instructions to the drug Kilios directly from the package or from the pharmacist at the pharmacy.
more... close
<1)

The experience of treating women older than 65 years is limited.

Dosage (Posology) and method of administration

The information provided in Dosage (Posology) and method of administration of Kilios is based on data of another medicine with exactly the same composition as the Kilios of the medicine (Estradiol, Medroxyprogesterone). Be careful and be sure to specify the information on the section Dosage (Posology) and method of administration in the instructions to the drug Kilios directly from the package or from the pharmacist at the pharmacy.
more... close

Kilios is a continuous combined HRT regimen in which estrogen and progestagen are given every day without interruption.

Posology

One tablet each day orally without a tablet-free interval.) should be used.

Contraindications

The information provided in Contraindications of Kilios is based on data of another medicine with exactly the same composition as the Kilios of the medicine (Estradiol, Medroxyprogesterone). Be careful and be sure to specify the information on the section Contraindications in the instructions to the drug Kilios directly from the package or from the pharmacist at the pharmacy.
more... close

- Porphyria

Special warnings and precautions for use

The information provided in Special warnings and precautions for use of Kilios is based on data of another medicine with exactly the same composition as the Kilios of the medicine (Estradiol, Medroxyprogesterone). Be careful and be sure to specify the information on the section Special warnings and precautions for use in the instructions to the drug Kilios directly from the package or from the pharmacist at the pharmacy.
more... close

For the treatment of postmenopausal symptoms, HRT should only be initiated for symptoms that adversely affect quality of life. In all cases, a careful appraisal of the risks and benefits should be undertaken at least annually and HRT should only be continued as long as the benefit outweighs the risk.

Evidence regarding the risks associated with HRT in the treatment of premature menopause is limited. Due to the low level of absolute risk in younger women, however, the balance of benefits and risks for these women may be more favourable than in older women.

Medical examination/follow-up

Before initiating or reinstituting HRT, a complete personal and family medical history should be taken. Physical (including pelvic and breast) examination should be guided by this and by the contraindications and warnings for use.

During treatment, periodic check-ups are recommended of a frequency and nature adapted to the individual woman. Women should be advised what changes in their breasts should be reported to their doctor or nurse (see 'Breast cancer' below). Investigations, including appropriate imaging tools, e.g. mammography, should be carried out in accordance with currently accepted screening practices, modified to the clinical needs of the individual.

Conditions which need supervision

If any of the following conditions are present, have occurred previously and/or have been aggravated during pregnancy or previous hormone treatment, the patient should be closely supervised. It should be taken into account that these conditions may recur or be aggravated during treatment with Kilios, in particular:

- Leiomyoma (uterine fibroids) or endometriosis

- A history of or risk factors for thromboembolic disorders (see below)

- Risk factors for estrogen dependent tumours, e.g. 1st degree heredity for breast cancer

- Hypertension

- Liver disorders (e.g. liver adenoma)

- Diabetes mellitus with or without vascular involvement

- Cholelithiasis

- Migraine or (severe) headache

- Systemic lupus erythematosus

- A history of endometrial hyperplasia (see below)

- Epilepsy

- Asthma

- Otosclerosis

- Hereditary angiodema

Reasons for immediate withdrawal of therapy:

Therapy should be discontinued in case a contra-indication is discovered and in the following situations:

- Jaundice or deterioration of liver function

- Significant increase in blood pressure

- New onset of migraine-type headache

- Pregnancy

Endometrial hyperplasia and carcinoma

In women with an intact uterus the risk of endometrial hyperplasia and carcinoma is increased when estrogens are administered alone for prolonged periods. The reported increase in endometrial cancer risk among estrogen-only users varies from 2- to 12-fold greater compared with non-users, depending on the duration of treatment and estrogen dose. After stopping treatment risk may remain elevated for at least 10 years.

- The addition of a progestagen cyclically for at least 12 days per month/28 day or continuous combined oestrogen-progestagen therapy in non-hysterectomised women prevents the excess risk associated with oestrogen-only HRT.

- Break-through bleeding and spotting may occur during the first months of treatment. If break-through bleeding or spotting appears after some time of therapy, or continues after treatment has been discontinued, the reason should be investigated, which may include endometrial biopsy to exclude endometrial malignancy.

Breast cancer

The overall evidence suggests an increased risk of breast cancer in women taking combined oestrogen-progestagen and possibly also oestrogen-only HRT, that is dependent on the duration of taking HRT.

Combined oestrogen-progestagen therapy

- The randomised placebo-controlled trial (the Women's Health Initiative study (WHI), and epidemiological studies are consistent in finding an increased risk of breast cancer in women taking combined oestrogen-progestagen for HRT that becomes apparent after about 3 years.

Oestrogen-only therapy

- The WHI trial found no increase in the risk of breast cancer in hysterectomised women using oestrogen-only HRT. Observational studies have mostly reported a small increase in risk of having breast cancer diagnosed that is substantially lower than that found in users of oestrogen-progestagen combinations.

The excess risk becomes apparent within a few years of use but returns to baseline within a few (at most five) years after stopping treatment.

HRT, especially estrogen-progestagen combined treatment, increases the density of mammographic images which may adversely affect the radiological detection of breast cancer.

Ovarian cancer

Ovarian cancer is much rarer than breast cancer. Epidemiological evidence from a large meta-analysis suggests a slightly increased risk in women taking oestrogen-only or combined oestrogen-progestagen HRT, which becomes apparent within 5 years of use and diminishes over time after stopping. Some other studies, including the WHI trial, suggest that use of combined HRTs may be associated with a similar or slightly smaller risk.

Venous thromboembolism

- HRT is associated with a 1.3-3 fold risk of developing venous thromboembolism (VTE), i.e. deep vein thrombosis or pulmonary embolism. The occurrence of such an event is more likely in the first year of HRT than later.

- Patients with a history of VTE or known thrombophilic states have an increased risk of VTE and HRT may add to this risk. HRT is therefore contraindicated in these patients.

- Generally recognised risk factors for VTE include, use of oestrogens, older age, major surgery, prolonged immobilisation, obesity (BMI > 30 kg/m2), pregnancy/postpartum period, systemic lupus erythematosus (SLE), and cancer. There is no consensus about the possible role of varicose veins in VTE.

- As in all postoperative patients, prophylactic measures need to be considered to prevent VTE following surgery. If prolonged immobilisation is to follow elective surgery temporarily stopping HRT 4 to 6 weeks earlier is recommended. Treatment should not be restarted until the woman is completely mobilised.

- In women with no personal history of VTE but with a first degree relative with a history of thrombosis at young age, screening may be offered after careful counselling regarding its limitations (only a proportion of thrombophilic defects are identified by screening).

If a thrombophilic defect is identified which segregates with thrombosis in family members or if the defect is 'severe' (e.g, antithrombin, protein S, or protein C deficiencies or a combination of defects) HRT is contraindicated.

- Women already on chronic anticoagulant treatment require careful consideration of the benefit-risk of use of HRT.

If VTE develops after initiating therapy, the drug should be discontinued. Patients should be told to contact their doctors immediately when they are aware of a potential thromboembolic symptom (e.g., painful swelling of a leg, sudden pain in the chest, dyspnea).

Coronary artery disease (CAD)

- There is no evidence from randomised controlled trials of protection against myocardial infarction in women with or without existing CAD who received combined oestrogen-progestagen or oestrogen-only HRT.

Combined oestrogen-progestagen therapy

The relative risk of CAD during use of combined oestrogen+progestagen HRT is slightly increased. As the baseline absolute risk of CAD is strongly dependent on age, the number of extra cases of CAD due to oestrogen+progestagen use is very low in healthy women close to menopause, but will rise with more advanced age.

Oestrogen-only

Randomised controlled data found no increased risk of CAD in hysterectomised women using oestrogen-only therapy.

Ischaemic stroke

- Combined oestrogen-progestagen and oestrogen-only therapy are associated with an up to 1.5-fold increase in risk of ischaemic stroke. The relative risk does not change with age or time since menopause. However, as the baseline risk of stroke is strongly age-dependent, the overall risk of stroke in women who use HRT will increase with age.

Other conditions

- Estrogens may cause fluid retention and, therefore, patients with cardiac or renal dysfunction should be carefully observed.

- Women with pre-existing hypertriglyceridaemia should be followed closely during oestrogen replacement or hormone replacement therapy, since rare cases of large increases of plasma triglycerides leading to pancreatitis have been reported with estrogen therapy in this condition.

- Estrogens increase thyroid binding globulin (TBG), leading to increased circulating total thyroid hormone, as measured by protein-bound iodine (PBI), T4 levels (by column or by radio-immunoassay) or T3 levels (by radio-immunoassay). T3 resin uptake is decreased, reflecting the elevated TBG. Free T4 and free T3 concentrations are unaltered. Other binding proteins may be elevated in serum, i.e. corticoid binding globulin (CBG), sex-hormone-binding globulin (SHBG) leading to increased circulating corticosteroids and sex steroids, respectively. Free or biological active hormone concentrations are unchanged. Other plasma proteins may be increased (angiotensinogen/renin substrate, alpha-1-antitrypsin, ceruloplasmin).

- Chloasma may occasionally occur, especially in women with a history of chloasma gravidarum. Women with a tendency to chloasma should minimise exposure to the sun or ultraviolet radiation whilst taking HRT.

- HRT use does not improve cognitive function. There is some evidence of increased risk of probable dementia in women who start using continuous combined or oestrogen-only HRT after the age of 65.

Patients with rare hereditary problems of galactose intolerance, the Lapp lactase deficiency or glucose-galactose malabsorption should not take this medicine.

Effects on ability to drive and use machines

The information provided in Effects on ability to drive and use machines of Kilios is based on data of another medicine with exactly the same composition as the Kilios of the medicine (Estradiol, Medroxyprogesterone). Be careful and be sure to specify the information on the section Effects on ability to drive and use machines in the instructions to the drug Kilios directly from the package or from the pharmacist at the pharmacy.
more... close

Kilios has no influence on the ability to drive and use machines.

Undesirable effects

The information provided in Undesirable effects of Kilios is based on data of another medicine with exactly the same composition as the Kilios of the medicine (Estradiol, Medroxyprogesterone). Be careful and be sure to specify the information on the section Undesirable effects in the instructions to the drug Kilios directly from the package or from the pharmacist at the pharmacy.
more... close

The most frequently reported undesirable effect during Kilios treatment in clinical trials was breast tenderness, which occurred in 10.6% of users.

Undesirable effects according to system organ class associated with HRT treatment are presented in the table below.

Organ system class

Common ADRs, >1/100 <10

Uncommon ADRs, >1/1000 <1/100

Rare ADRs, >1/10 000 <1/1 000

Adverse events reported post marketing with frequency not known (cannot be estimated from the available data)

Neoplasms benign, malignant and unspecified (incl cysts and polyps)

Benign breast neoplasm, benign endometrial neoplasm

Uterine fibroids

Immune system disorders

Hypersensitivity reaction

Exacerbation of hereditary angioedema

Metabolism and nutrition disorders

Oedema, weight increase, weight decrease

Increased appetite, hypercholesterolemia1

Psychiatric disorders

Depression, nervousness, lethargy

Anxiety, insomnia, apathy, emotional lability, impaired concentration, changes in mood or libido, euphoria1, agitation1

Nervous system disorders

Headache, dizziness

Migraine, paraesthesia, tremor1

Eye disorders

Visual impairment, dry eye1

Contact lense intolerance

Cardiac disorders

Palpitations

Vascular disorders

Hot flushes

Hypertension1, superficial phlebitis1, purpura1

Venous thromboembolism (i.e. deep leg or pelvic venous thrombosis and pulmonary embolism)2

Cerebral ischaemic events

Respiratory, thoracic and mediastinal disorders

Dyspnoea1, rhinitis1

Gastrointestinal disorders

Nausea, vomiting, stomach cramps, flatulence

Constipation, dyspepsia1, diarrhoea1, rectal disorder1

Abdominal pain, bloating (abdominal distension)

Hepatobiliary disorders

Alterations in liver function and biliary flow

Cholestatic jaundice

Skin and subcutaneous tissue disorders

Acne, alopecia, dry skin, nail disorder1, skin nodule1, hirsuitism1, erythema nodosum, urticaria

Rash

Eczema

Musculoskeletal and connective tissue disorders

Joint disorders, muscle cramps

Renal and urinary disorders

Increased urinary frequency/urgency, urinary incontinence1, cystitis1, urine discoloration1, haematuria1

Reproductive system and breast disorders

Breast pain/tension, unscheduled vaginal bleeding or spotting, vaginal discharge, disorder of vulva/vagina, menstrual disorder

Breast enlargement, breast tenderness, endometrial hyperplasia, uterine disorder1

Dysmenorrhea, pre-menstrual like syndrome

General disorders and administration site conditions

Increased sweating

Fatigue, abnormal laboratory test1, asthenia1, fever1, flu syndrome1, malaise1

1) Have been reported in single cases in clinical trials.4

Other adverse reactions have been reported in association with estrogen/progestagen treatment:

- Myocardial infarction

- Gall bladder disease

- Skin and subcutaneous disorders: chloasma, erythema multiforme

- Probable dementia over the age of 65

- Pancreatitis

Breast cancer risk

- An up to 2-fold increased risk of having breast cancer diagnosed is reported in women taking combined oestrogen-progestagen therapy for more than 5 years.

- Any increased risk in users of oestrogen-only therapy is substantially lower than that seen in users of oestrogen-progestagen combinations.

- The level of risk is dependent on the duration of use.

- Results of the largest randomised placebo-controlled trial (WHI-study) and largest epidemiological study (MWS) are presented.

Million Women study- Estimated additional risk of breast cancer after 5 years' use

Age range

(years)

Additional cases per 1000 never-users of HRT over a 5 year period*

Risk ratio & 95%CI#

Additional cases per 1000 HRT users over 5 years (95%CI)

Oestrogen only HRT

50-65

9-12

1.2

1-2 (0-3)

Combined oestrogen-progestagen

50-65

9-12

1.7

6 (5-7)

#Overall risk ratio. The risk ratio is not constant but will increase with increasing duration on use.

Note: Since the background incidence of breast cancer differs by EU country, the number of additional cases of breast cancer will also change proportionately.

* Taken from baseline incidence rates in developed countries

US WHI studies - additional risk of breast cancer after 5 years' use

Age range

(years)

Incidence per 1000 women in placebo arm over 5 years

Risk ratio & 95%CI

Additional cases per 1000 HRT users over 5 years (95%CI)

CEE oestrogen-only

50-79

21

0.8 (0.7 - 1.0)

-4 (-6 - 0)*

CEE+MPA oestrogen & progestagen‡

50-79

17

1.2 (1.0 - 1.5)

+4 (0 - 9)

* WHI study in women with no uterus, which did not show an increase in risk of breast cancer

‡When the analysis was restricted to women who had not used HRT prior to the study there was no increased risk apparent during the first 5 years of treatment: after 5 years the risk was higher than in non-users.

Endometrial cancer risk

Postmenopausal women with a uterus

The endometrial cancer risk is about 5 in every 1000 women with a uterus not using HRT. In women with a uterus, use of oestrogen-only HRT is not recommended because it increases the risk of endometrial cancer.

Depending on the duration of oestrogen-only use and oestrogen dose, the increase in risk of endometrial cancer in epidemiology studies varied from between 5 and 55 extra cases diagnosed in every 1000 women between the ages of 50 and 65.

Adding a progestagen to oestrogen-only therapy for at least 12 days per cycle can prevent this increased risk. In the Million Women Study the use of five years of combined (sequential or continuous) HRT did not increase risk of endometrial cancer (RR of 1.0 (0.8-1.2)).

Ovarian cancer risk

Use of oestrogen-only or combined oestrogen-progestagen HRT has been associated with a slightly increased risk of having ovarian cancer diagnosed. A meta-analysis from 52 epidemiological studies reported an increased risk of ovarian cancer in women currently using HRT compared to women who have never used HRT (RR 1.43, 95% CI 1.31-1.56). For women aged 50 to 54 years taking 5 years of HRT, this results in about 1 extra case per 2000 users. In women aged 50 to 54 who are not taking HRT, about 2 women in 2000 will be diagnosed with ovarian cancer over a 5-year period.

Risk of venous thromboembolism

HRT is associated with a 1.3-3-fold increased relative risk of developing venous thromboembolism (VTE), i.e. deep vein thrombosis or pulmonary embolism. The occurrence of such an event is more likely in the first year of using HRT. Results of the WHI studies are presented:

WHI Studies - Additional risk of VTE over 5 years' use

Age range (years)

Incidence per 1000 women in placebo arm over 5 years

Risk ratio and 95%CI

Additional cases per 1000 HRT users

Oral oestrogen-only*

50-59

7

1.2 (0.6-2.4)

1 (-3 - 10)

Oral combined oestrogen-progestagen

50-59

4

2.3 (1.2 - 4.3)

5 (1 - 13)

* Study in women with no uterus

Risk of coronary artery disease

- The risk of coronary artery disease is slightly increased in users of combined oestrogen-progestagen HRT over the age of 60.

Risk of ischaemic stroke

- The use of oestrogen-only and oestrogen + progestagen therapy is associated with an up to 1.5 fold increased relative risk of ischaemic stroke.

WHI studies combined - Additional risk of ischaemic stroke* over 5 years' use

Age range (years)

Incidence per 1000 women in placebo arm over 5 years

Risk ratio and 95%CI

Additional cases per 1000 HRT users over 5 years

50-59

8

1.3 (1.1 1.6)

3 (1-5)

* no differentiation was made between ischaemic and haemorrhagic stroke.

Reporting of suspected adverse reactions

Reporting suspected adverse reactions after authorisation of the medicinal product is important. It allows continued monitoring of the benefit/risk balance of the medicinal product. Healthcare professionals are asked to report any suspected adverse reactions via Yellow Card Scheme at: www.mhra.gov.uk/yellowcard.

Overdose

The information provided in Overdose of Kilios is based on data of another medicine with exactly the same composition as the Kilios of the medicine (Estradiol, Medroxyprogesterone). Be careful and be sure to specify the information on the section Overdose in the instructions to the drug Kilios directly from the package or from the pharmacist at the pharmacy.
more... close

Estrogen overdose may cause nausea, headache and uterine bleeding. Numerous reports on high doses of estrogen-containing oral contraceptives ingested by young children indicate that serious harmful effects do not occur. Treatment of estrogen overdose is symptomatic. High doses of medroxyprogesterone acetate (MPA) used for cancer treatment have not resulted in serious undesirable effects.

Pharmacodynamic properties

The information provided in Pharmacodynamic properties of Kilios is based on data of another medicine with exactly the same composition as the Kilios of the medicine (Estradiol, Medroxyprogesterone). Be careful and be sure to specify the information on the section Pharmacodynamic properties in the instructions to the drug Kilios directly from the package or from the pharmacist at the pharmacy.
more... close

Pharmacotherapeutic group: Progestagens and estrogens, fixed combinations;

ATC code: G03FA12.

The active ingredient, synthetic 17β-estradiol, is chemically and biologically identical to endogenous human estradiol. It substitutes for the loss of estrogen production in menopausal women, and alleviates menopausal symptoms.

Estrogens prevent bone loss following menopause or ovariectomy.

Medroxyprogesterone acetate is a derivative of the natural progesterone, 17-alpha-hydroxy-6-methylprogesterone. Medroxyprogesterone acetate binds to progestin-specific receptors and acts on the endometrium to convert the status of the endometrium from proliferative to secretory.

As estrogens promote the growth of the endometrium, unopposed estrogens increase the risk of endometrial hyperplasia and cancer. The addition of medroxyprogesterone acetate greatly reduces the estrogen-induced risk of endometrial hyperplasia in non-hysterectomised women.

Clinical trial information

Relief of estrogen deficiency symptoms and bleeding patterns

- Relief of menopausal symptoms was achieved during the first few weeks of treatment.

- Amenorrhoea was seen in 91% of women receiving 1 mg estradiol valerate and in 80% of women receiving 2 mg estradiol valerate after 10-12 months of treatment. Irregular bleeding and/or spotting appeared in 41% of the women receiving 1 mg estradiol valerate and 51% of women receiving 2 mg estradiol valerate during the first three months of treatment and in 9% of the women receiving 1 mg estradiol valerate and in 20% of women receiving 2 mg estradiol valerate during 10-12 months of treatment.

Prevention of osteoporosis

- Estrogen deficiency at menopause is associated with an increasing bone turnover and decline in bone mass. The effect of estrogens on bone mineral density (BMD) is dose dependent. Protection appears to be effective for as long as treatment is continued. After discontinuation of HRT, bone mass is lost at a rate similar to that in untreated women.

- Evidence from the WHI trial and meta-analysed trials shows that current use of HRT, alone or in combination with a progestagen - given to predominantly healthy women - reduces the risk of hip, vertebral, and other osteoporotic fractures. HRT may also prevent fractures in women with low bone density and/or established osteoporosis, but the evidence for that is limited.

- After 4 years of treatment with Kilios combinations containing the 1 mg dose, the increase in lumbar spine bone mineral density (BMD) was 6.2 + 0.5% (mean + SD). The percentage of women who maintained or gained BMD in lumbar zone during treatment was 86.6 %.

- Kilios combinations containing the 1 mg dose also had an effect on hip BMD. The increase after 4 years was 2.9 + 0.4% (mean + SD) at femoral neck. The percentage of women who gained BMD in hip zone during treatment was 80.4 %.

- After 4 years of treatment with Kilios combinations containing the 2 mg dose, the increase in lumbar spine BMD was 7.4 + 0.4% (mean + SD). The percentage of women who gained BMD in lumbar zone during treatment was 95.8 %.

- Kilios combinations containing the 2 mg dose also had an effect on hip BMD. The increase after 4 years was 2.9 + 0.4% (mean + SD) at femoral neck. The percentage of women who gained BMD in hip zone during treatment was 72.3 %.

Pharmacokinetic properties

The information provided in Pharmacokinetic properties of Kilios is based on data of another medicine with exactly the same composition as the Kilios of the medicine (Estradiol, Medroxyprogesterone). Be careful and be sure to specify the information on the section Pharmacokinetic properties in the instructions to the drug Kilios directly from the package or from the pharmacist at the pharmacy.
more... close

Following oral administration estradiol valerate is absorbed from the gastrointestinal tract and rapidly hydrolysed to estradiol by esterases. In postmenopausal women aged 50-65 years the maximum concentration of estradiol in serum (Cmax) was reached within 4 to 6 hours after multiple dosing of 1 mg or 2 mg estradiol valerate. After 1 mg dose Cmax was about 166 pmol/l, trough concentration (Cmin) about 101 pmol/l and average concentration (Caverage) about 123 pmol/l. For 2 mg dose Cmax was 308 pmol/l, Cmin 171 pmol/l and Caverage 228 pmol/l. Comparable estradiol concentrations were observed in women over 65 years.

Circulating estradiol is bound to plasma proteins, mainly to sex hormone binding globulin (SHBG) and serum albumin. Estradiol undergoes extensive biotransformation. Its metabolites are excreted in the urine as glucuronide and sulfate conjugates together with a small proportion of unchanged estradiol. Besides urinary excretion, estrogen metabolites undergo an enterohepatic circulation. Only a small amount of a dose is excreted in the faeces.

The absorption of medroxyprogesterone acetate after oral administration is low due to low solubility and there is large individual variation. Medroxyprogesterone acetate undergoes virtually no first-pass metabolism. After multiple dosing of 2.5 mg or 5 mg medroxyprogesterone acetate to women aged 50-65 years, maximum concentration in serum was reached in less than 2 hours. After 2.5 mg dose Cmax was about 0.37 ng/ml, Cmin about 0.05 ng/ml and Caverage about 0.11 ng/ml. After 5 mg dose Cmax was about 0.64 ng/ml, Cmin about 0.12 ng/ml and Caverage about 0.21 ng/ml. Comparable medroxyprogesterone acetate concentrations were observed in women over 65 years.

Medroxyprogesterone acetate is over 90% bound to plasma proteins, mainly to albumin. The elimination half-life of oral medroxyprogesterone acetate is approximately 24 hours. Medroxyprogesterone acetate is extensively metabolised by hepatic hydroxylation and conjugation and excreted in the urine and the bile. Metabolism is poorly documented and the pharmacological activity of the metabolites is not known.

Pharmacotherapeutic group

The information provided in Pharmacotherapeutic group of Kilios is based on data of another medicine with exactly the same composition as the Kilios of the medicine (Estradiol, Medroxyprogesterone). Be careful and be sure to specify the information on the section Pharmacotherapeutic group in the instructions to the drug Kilios directly from the package or from the pharmacist at the pharmacy.
more... close
Progestagens and estrogens, fixed combinations

Incompatibilities

The information provided in Incompatibilities of Kilios is based on data of another medicine with exactly the same composition as the Kilios of the medicine (Estradiol, Medroxyprogesterone). Be careful and be sure to specify the information on the section Incompatibilities in the instructions to the drug Kilios directly from the package or from the pharmacist at the pharmacy.
more... close

Not applicable.

Special precautions for disposal and other handling

The information provided in Special precautions for disposal and other handling of Kilios is based on data of another medicine with exactly the same composition as the Kilios of the medicine (Estradiol, Medroxyprogesterone). Be careful and be sure to specify the information on the section Special precautions for disposal and other handling in the instructions to the drug Kilios directly from the package or from the pharmacist at the pharmacy.
more... close

No special requirements.

Site feedback

How easy to use our site?

Commentary is required, without it we won't know how to become better
The maximum length of review is 1000 symbols

Thanks!

You help us to become better