Kifen

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Medically reviewed

Rosario Oropesa

Last updated on 22/12/2025

This page provides general, reference-level information compiled from official medical sources. It is not a substitute for professional medical advice, diagnosis, or treatment. For decisions about your health, please consult a qualified healthcare professional.

Overview of Kifen

Kifen is a medicinal product defined by the active ingredient Ibuprofen, a substance classified as a Non-Steroidal Anti-Inflammatory Drug (NSAID). This single active ingredient product is primarily intended for oral administration and is structurally a synthetic compound derived from propionic acid. Its function is clinically recognized for providing effective relief by simultaneously addressing pain, inflammation, and fever, making it a foundational treatment in symptom management.


Quick Facts

Property Description
Active ingredient Ibuprofen (INN)
Form Oral Solid or Liquid Preparations (Tablets, Capsules, Suspensions)
Pharmacological Class Non-Steroidal Anti-Inflammatory Drug (NSAID)
Common Use General relief of Pain, Inflammation, and Fever
Origin Synthetic Compound (Propionic acid derivative)

What Type of Medicine is Kifen?

Kifen, containing the internationally recognized active ingredient Ibuprofen, belongs to the Non-Steroidal Anti-Inflammatory Drug (NSAID) class. This grouping is supported by pharmacological studies confirming its efficacy in reducing pain (analgesic), mitigating inflammation (anti-inflammatory), and lowering elevated body temperature (antipyretic). This classification establishes its broad capability to address the body's generalized response to injury or illness. A differentiating factor for Ibuprofen preparations like Kifen is its OTC status in many jurisdictions, which facilitates ready access for general pain management, such as the temporary relief of aches associated with the common cold or fever.

Composition and Origin: Is Ibuprofen a Synthetic Compound?

The primary component in Kifen is Ibuprofen, which is a synthetic compound chemically defined as a derivative of propionic acid. This controlled manufacturing process ensures the purity and consistent pharmacological action of the product. Kifen, as a single-ingredient formulation, focuses solely on the proven effects of the NSAID. Its typical use involves managing discomfort where both pain and inflammatory swelling are present.

What side effects are possible with Kifen?

Possible Side Effects and Safety Information

Kifen, containing the Non-Steroidal Anti-Inflammatory Drug (NSAID) Ibuprofen, has a documented safety profile established by regulatory authorities. The adverse reactions are officially classified by frequency and system-organ class.

Adverse reactions classified as Uncommon in official labeling frequently involve Gastrointestinal Disorders, including dyspepsia, nausea, abdominal pain, and vomiting, alongside Nervous System Disorders like headache and dizziness.

Serious Adverse Reactions

Regulatory documentation highlights the potential for serious, potentially fatal, adverse events. These include serious Gastrointestinal (GI) Events, such as bleeding, ulceration, and perforation of the stomach or intestines. Furthermore, Ibuprofen is associated with a risk of serious Cardiovascular Thrombotic Events, including myocardial infarction and stroke, a risk that may increase with higher doses or longer duration of use.

Very Rare but documented serious effects include severe cutaneous adverse reactions (SCARs), such as Stevens-Johnson Syndrome (SJS), and severe hypersensitivity reactions (anaphylaxis).

Population-Specific Safety Notes

Official safety notes define heightened risks for specific patient groups. Older adults are documented to have a significantly increased risk for serious adverse events, particularly fatal GI bleeding and perforation. Use in pregnancy is advised to be avoided from 20 weeks gestation onward due to documented risks to the fetus, and is contraindicated in the third trimester. Concomitant use with other NSAIDs is generally restricted due to the increased risk of GI toxicity. Safety notes also state that Ibuprofen may interfere with the antiplatelet effect of low-dose aspirin.

Overdose and Emergency Response

Overdose and When to Seek Help

Official regulatory documentation on Kifen (Ibuprofen) overdose describes a spectrum of clinical manifestations, focusing on the gastrointestinal (GI) and central nervous systems (CNS). Documented symptoms often include nausea, vomiting, abdominal pain, severe headache, drowsiness, confusion, and a ringing in the ears (Tinnitus).

Regulatory sources indicate that severe overdose carries a risk of life-threatening systemic outcomes, such as Acute Renal Failure, Metabolic Acidosis, Convulsions (seizures), and serious GI events including bleeding, ulceration, or perforation. Due to these potential complications, the official labeling mandates that individuals must seek immediate medical attention and contact the Poison Control Center or Emergency Services upon any suspected overdose, with no delay, even if initial symptoms are mild or absent.

Management is described as symptomatic and supportive, as no specific antidote is known. Supportive measures include the use of Activated Charcoal to reduce absorption. Population-specific regulatory notes highlight that elderly patients are at an increased risk for serious gastrointestinal complications, and dehydrated children and adolescents face a heightened risk of renal impairment during overdose.

Therapeutic Uses of Kifen

What Kifen Treats: Main Uses and Benefits

Kifen is commonly used to help manage a range of symptoms related to physical discomfort and systemic imbalance. This medication is applied across domains where additional symptomatic support is needed, primarily addressing pain, inflammation, and fever. Kifen is relevant for easing discomfort in conditions presenting with systemic or localized symptomatic burden.

The primary therapeutic benefit is its ability to moderate the intensity of distressing manifestations. It is commonly used to help with symptoms of headache, toothache, muscle aches, sprains, strains, menstrual cramps, and to ease discomfort associated with colds and flu. This supportive relief helps maintain a sense of stability when symptoms are more noticeable.

“Applied in scenarios where additional management of discomfort is required, Kifen helps address symptom clusters that may become intense or disruptive.”

The medication is relevant in conditions characterized by periods of heightened symptoms, such as the chronic stiffness of arthritis or acute episodes of fever and generalized body aches. By assisting with the overall symptom load, it contributes to improved comfort during symptomatic periods.


Quick Fact: Relief for Inflammation

Symptom Domain General Relief Provided Common Contexts
Inflammatory States Reduction of swelling, tenderness, and stiffness Arthritis, sprains, musculoskeletal injuries
Acute Pain Easing of sudden, disruptive discomfort Headaches, toothaches, menstrual cramps
Fever Reduction of elevated body temperature Colds, influenza, systemic illness

Regulatory References

  1. NIH MedlinePlus Drug Information

Eligibility and Restrictions for Use

Official Eligibility and Contraindications

Kifen (which may contain an NSAID component like aceclofenac) is subject to strict regulatory rules defining the eligible patient population. The medicine is contraindicated in several specific groups to prevent serious health risks.

Eligibility Classification Population / Condition
Contraindicated Patients with severe liver disease or severe renal impairment/kidney failure.
Contraindicated Patients with a known history of gastrointestinal bleeding or active/recurrent stomach ulcers.
Contraindicated Patients with known hypersensitivity or allergy to the drug's components or other non-steroidal anti-inflammatory drugs (NSAIDs).
Contraindicated Use during the third trimester of pregnancy due to risks to the fetus.
Use Restricted Patients with heart disease, uncontrolled hypertension, or heart failure (use should be avoided or monitored closely).
Not Established Use in pediatric patients (children under 18 years of age).
Caution Advised Patients over 65 years of age (increased risk of side effects); patients with mild to moderate liver or kidney issues.
Not Recommended Patients who are breastfeeding.

Consult a healthcare professional for a complete individual eligibility assessment. Do not use this medicine right before or after coronary artery bypass graft (CABG) surgery.

What should I know about interactions with other medicines?

Interactions with other medicines and products

The interaction profile of Kifen (Ibuprofen) is structured around potential pharmacokinetic and pharmacodynamic conflicts as documented by regulatory authorities, requiring strict adherence to specific constraints and prohibitions.

Contraindicated Combinations and High-Risk Additive Effects

Co-administration with other Non-Steroidal Anti-Inflammatory Drugs (NSAIDs), including COX-2 selective inhibitors, is contraindicated due to an increased risk of serious adverse events. The combination with high-dose Acetylsalicylic acid (above 75 mg daily) is also restricted. Ibuprofen enhances the effects of anticoagulants (e.g., Warfarin) and increases the additive risk of gastrointestinal bleeding when combined with oral corticosteroids or antiplatelet agents.

Interference with Clearance and Efficacy

Ibuprofen may decrease the renal clearance of substances like Lithium, leading to increased plasma concentrations and potential toxicity. It also inhibits the tubular secretion of Methotrexate, which results in elevated and prolonged serum levels. Furthermore, Ibuprofen may diminish the therapeutic effect of antihypertensives (e.g., ACE inhibitors) and diuretics.

Administration Timing and Substance Constraints

A specific timing separation is required when co-administering with low-dose Acetylsalicylic acid used for cardioprotection; regulatory documents advise taking Ibuprofen at least 8 hours before or 30 minutes after the aspirin dose. The risk of stomach bleeding is increased with concurrent use of alcohol. Caution regarding nephrotoxicity is noted for patients with renal or cardiac impairment when combined with diuretics.

Mechanism of Action

How Kifen Works

Modulation of Receptor-Mediated Signaling

Kifen engages mechanisms that regulate specific receptor- or enzyme-mediated signaling pathways where excitatory transmitters dominate. This modification of early molecular steps decreases the net effect of mediator accumulation, resulting in a reduction of pathway output.


Engagement with Key Regulatory Pathways

The drug acts within domains involving specific signaling enzymes to modulate key molecular cascades. By initiating or suppressing signaling sequences, Kifen supports the maintenance of an adjusted pathway state and initiates downstream physiological changes.


Influence on Downstream Cascade Feedback

This compound is relevant in systems where targeted pathway adjustment is required, influencing processes driven by distinct signaling patterns. Kifen engages mechanisms that influence feedback regulation within the pathways to modulate the activity of regulatory mechanisms and shift the pathway's operational set-point.

Dosage and Administration Information

Kifen, which contains the active ingredient ibuprofen, is officially designated for administration primarily via the oral route, commonly available in solid forms (tablets, capsules) and liquid suspensions. The intravenous route is reserved for use in specific institutional settings for infusion, typically in acute conditions or for specialized neonatal use.


Dosing Schedules and Frequency

The medicine follows defined regulatory dosing ranges. For self-care use, the standard single adult dose is 200 mg to 400 mg. Doses are scheduled at intervals of 4 to 6 hours as needed. The maximum daily intake for non-prescription use is 1200 mg. Under professional guidance, particularly for chronic inflammatory conditions, the total daily dose may range up to 3200 mg, administered in divided doses.


Administration Context and Duration

Oral administration requires swallowing the dose with a full glass of water. To minimize potential gastrointestinal irritation, official instructions recommend administration with food or milk. Use for acute symptoms should not exceed a short-term limit, typically 10 days for pain or 3 days for fever, unless a longer regimen is prescribed.


Population-Specific Rules

Dosing for pediatric patients over six months of age is weight-based, calculated in milligrams per kilogram (mg/kg) to ensure appropriate use. For older adults and patients with known reduced kidney or liver function, official usage guidelines emphasize utilizing the lowest effective dose for the shortest necessary duration.

Recent Clinical Evidence

Research evidence / Overview of Studies for Kifen

The evidence base for Kifen (Ibuprofen) is founded primarily on Randomized Controlled Trials (RCTs) and comprehensive meta-analyses that synthesize findings across many studies. This body of research describes how Kifen was studied, the types of outcomes that were measured, and the identified research gaps.


Evidence for Short-Term Pain and Symptom Relief

Research focusing on short-term changes in physical discomfort and fever often evaluates episodic symptom patterns.

Studies for Acute, Mild Pain

Research exploring how symptoms change over time focuses heavily on acute, mild to moderate pain, which includes common issues like headaches, toothaches, sprains, and general muscle aches. Research examined outcomes related to physical discomfort, which included monitoring the change in pain intensity and observing the reported frequency of supplemental pain medication use by participants. However, the majority of this evidence is limited to short follow-up durations, with most trials observing responses over defined time intervals lasting only a few hours up to one week. There is limited information for long-term outcomes regarding the repeated, daily use of Kifen for acute pain lasting beyond a week.

Studies for Fever Management

For managing fever, a condition where symptoms may vary in intensity, research examined Kifen. These Randomized Controlled Trials explored outcomes related to systemic imbalance, such as the change in elevated body temperature and the duration for which that change was observed. The studies monitored both adults and children, meaning research specifically including the pediatric population is well-represented. Findings describe patterns observed in the studies related to the timeframe of observed temperature change.


Areas of Ongoing Research and Uncertainty

The research highlights what is known—and what is still uncertain—about Kifen. While short-term evidence is well-represented and consistent for acute pain and fever, certain limitations persist:

  • Long-term effects are not fully established for continuous use, particularly at the lower doses.
  • Data for certain groups remain insufficient, with limited information for specific comorbid populations or older adult subgroups.
  • Follow-up durations were limited in many acute pain trials, focusing primarily on the immediate period after a dose.

Study results reflect the specific conditions under which they were conducted, and research provides context but not individual predictions regarding symptom change.

Key Studies & References

  1. Efficacy and safety of ibuprofen and acetaminophen in children and adults: a meta-analysis and qualitative review
  2. WHO Model List of Essential Medicines (23rd List, 2023)

Frequently Asked Questions (FAQ)

Common questions about Kifen (FAQ)


Q: How quickly does Kifen usually start working?

A: Pharmacokinetic data from official regulatory documents describes how the body processes the medicine.

This information indicates that peak serum levels—the point at which the medicine is most concentrated in the body—are generally attained one to two hours after administration, which reflects the period when the effect is typically strongest.


Q: What happens if I miss a dose of Kifen?

A: The product label describes the action to be taken: if a dose is missed, the patient information describes taking it as soon as it is remembered.

However, if it is nearly time for the next scheduled dose, the regulatory guidance describes skipping the missed dose and avoiding taking two doses at one time.


Q: Is Kifen considered a long-term treatment option?

A: Official product information emphasizes the use of this type of medicine at the lowest effective dose for the shortest duration possible.

Regulatory documents indicate that the risk of serious side effects, particularly those affecting the heart and digestive system, may increase with long-term or extended use.


Q: What does 'contraindication' mean when talking about Kifen?

A: A contraindication is a condition or circumstance that makes the use of a medicine improper or inadvisable.

Regulatory documents describe that the medicine is restricted from use when a patient has a condition that would put them at significantly increased risk of harm, such as a known allergy to Kifen or other NSAIDs.


Q: Why is Kifen not recommended for people with [Known exclusionary condition]?

A: The medicine is not recommended for certain conditions, such as severe kidney disease or active ulcers, because official warnings indicate it could worsen these pre-existing health issues.

This is due to the potential for complications like fluid retention or increased risk of internal bleeding.


Q: What is the purpose of the black box warning on Kifen's official information?

A: The Boxed Warning is the strongest safety warning regulatory agencies require for a medicine.

Its purpose is to alert users to the risk of serious cardiovascular thrombotic events (like heart attack and stroke) and serious gastrointestinal adverse events (like bleeding and ulceration).


Q: What is the difference between a common side effect and a serious side effect of Kifen?

A: Regulatory agencies classify adverse reactions by both their frequency and their severity.

Common or uncommon side effects are those that occur more often (like nausea or headache), whereas serious adverse events are rare but potentially fatal occurrences, such as severe bleeding or cardiovascular events.


Q: Are there long-term side effects associated with Kifen use?

A: Regulatory documents confirm that the risk of serious side effects increases with longer duration of use.

These serious adverse events include cardiovascular thrombotic events and gastrointestinal complications like bleeding and ulcers.


Q: Is Kifen safe to use during pregnancy or while breastfeeding?

A: Regulatory documents state that the medicine is contraindicated after 20 weeks of pregnancy due to documented risks to the fetus.

Regarding breastfeeding, while minimal amounts pass into breast milk, the safety summary indicates that professional medical input is required for individual situations.


Q: Can Kifen be used by people who are over 65 years old?

A: Official usage guidelines emphasize caution for older adults. Regulatory information indicates that patients over 65 are at a greater risk for serious side effects, including events affecting the digestive system and heart.

Prescribing instructions emphasize that the lowest effective dose should be considered for the shortest necessary time in this population.


Q: What is known about Kifen's effect on mental clarity or mood?

A: Product labeling lists dizziness, nervousness, and headache as possible side effects, which are listed under nervous system disorders.

These effects may indirectly impact a person's perceived mental clarity or state of mind.


Q: Are there any specific foods or drinks that should be avoided when using Kifen?

A: The product label includes a warning regarding the concomitant consumption of alcohol.

This is because using the medicine with alcohol may increase the risk of serious side effects, such as gastrointestinal bleeding.


Q: Why does my doctor need to know all the medicines I take before prescribing Kifen?

A: Official labeling documents numerous known interactions between this medicine and other drugs.

For instance, combining it with anticoagulants or certain blood pressure medications can increase the risk of serious adverse events like bleeding or kidney problems, which necessitates disclosure.


Q: What types of allergic reactions are people most concerned about with Kifen?

A: Official safety documentation lists serious allergic-type reactions (hypersensitivity) that require immediate attention.

These include anaphylaxis, severe skin reactions like Stevens-Johnson Syndrome (SJS), and asthma that may be worsened by NSAID use.


Q: Do children or teenagers use Kifen?

A: The use of this medicine in the pediatric population, including specific age groups, is described in the product information.

Regulatory guidelines describe the administration approach for children over a specified age (often six months) but may state that use in older teenagers is not fully established.


Q: What does the evidence say about Kifen's effectiveness for its approved uses?

A: Official medicine use is granted based on the results of controlled clinical trials and research studies.

This body of evidence describes the medicine's intended effect on the specific conditions for which it has received regulatory approval.


Q: Can Kifen be crushed or split if someone has trouble swallowing pills?

A: Reference to the specific product label is important, as this depends on the formulation.

While some standard tablets may be split, regulatory documents state that certain forms, such as extended-release or combination products, are not intended to be chewed, divided, or crushed.


Q: Can taking Kifen affect my fertility?

A: Some official regulatory information indicates that this class of medicines may temporarily affect female fertility.

The information does not confirm whether the medicine can make it harder to become pregnant, and official regulatory summaries indicate that this area requires further evaluation.


Q: What kind of monitoring is typically required while taking Kifen?

A: For patients on long-term use, official warnings describe the need for periodic monitoring of effectiveness and adverse effects.

This monitoring may involve checking the patient's blood pressure and kidney function as part of the assessment for continued administration.


Q: Can Kifen affect my ability to drive or operate machinery?

A: Official product labeling indicates that common side effects can include dizziness, headache, or nervousness.

If you experience these effects after taking the medicine, your ability to safely drive or operate heavy machinery may be impaired.


Q: Are there any known interactions between Kifen and common supplements like Vitamin D or fish oil?

A: Official drug labels include a warning regarding certain herbal supplements.

Those supplements with known blood-thinning effects (such as ginger, ginkgo, or garlic) may increase the risk of bleeding when taken concurrently with this medicine.

How should Kifen be stored and disposed of?

Storage and Disposal of Kifen (Ibuprofen)

The official storage conditions for Kifen are defined by regulatory labeling to maintain the product's quality and stability.

Storage Requirements

  • Temperature: Store at room temperature, generally not exceeding 30°C. Liquid suspensions must be kept from freezing.
  • Protection: The medicine must be protected from excessive heat, moisture, and direct light.
  • Packaging: Keep the medication in its original package with the container tightly closed to protect it from the environment.
  • Child Safety: It is mandatory to store Kifen out of the sight and reach of children.

Disposal Instructions

Disposal of unused or expired Kifen must be done in accordance with local regulations. Authorities recommend returning unwanted product to a drug take-back program or pharmacy drop-off point. Kifen must not be flushed down the toilet or disposed of via wastewater, as this is prohibited by official guidelines. If a take-back program is unavailable, follow the labeled procedure for household trash disposal, which involves mixing the drug with an undesirable substance and sealing it.

Attention! Always consult to a doctor or pharmacist before using pills or medicines.

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