Kfol-Z

A six carbon compound related to glucose. It is found naturally in citrus fruits and many vegetables. Ascorbic acid is an essential nutrient in human diets, and necessary to maintain connective tissue and bone. Its biologically active form, Vitamin C (Kfol-Z), functions as a reducing agent and coenzyme in several metabolic pathways. Vitamin C (Kfol-Z) is considered an antioxidant.

Zinc (Kfol-Z) Capsule: Each capsule contains Zinc (Kfol-Z) sulphate monohydrate 54.93 mg, thiamine nitrate 10 mg, riboflavin 10 mg, pyridoxine hydrochloride 3 mg, vitamin B12 (coated) equivalent to cyanocobalamin 15 mcg, ascorbic acid 150 mg, folic acid 1 mg, nicotinamide 50 mg and calcium pantothenate 12.5 mg.

Zinc (Kfol-Z) Syrup: Each 5 mL contains Zinc (Kfol-Z) gluconate 34.9 mg, thiamine mononitrate 2.5 mg, riboflavin 2.5 mg, pyridoxine hydrochloride 1 mg, cyanocobalamin 3 mcg, ascorbic acid 50 mg, d-panthenol 12.5 mg and niacinamide 25 mg in a flavoured liquid glucose sorbitol syrup base.

For systemic use of Vitamin C (Kfol-Z): prevention and treatment of hypo- and avitaminosis of Vitamin C (Kfol-Z); providing increased need for Vitamin C (Kfol-Z) during growth, pregnancy, lactation, with heavy loads, fatigue and during recovery after prolonged severe illness; in winter with an increased risk of infectious diseases.

For intravaginal use: chronic or recurrent vaginitis (bacterial vaginosis, nonspecific vaginitis) caused by the anaerobic flora (due to changes in pH of the vagina) in order to normalize disturbed vaginal microflora.

Patients with deficiency of B-complex vitamins, Zinc (Kfol-Z) and Zinc (Kfol-Z) or where supplementation of these vitamins and Zinc (Kfol-Z) can be beneficial. Such patients and conditions include: Patients who are on prolonged antibiotic therapy; those who are suffering from infection, injuries, burns, fever, illness; patients with diarrhoea and GI disorders; patients who have undergone surgical operations; patients on diet restrictions eg, in diabetes, anorexia and alcoholism and in elderly persons; pregnant and lactating women due to increased nutritional needs.

Carbonyl iron (Kfol-Z) is a form of the mineral iron. Iron is important for many functions in the body, especially for the transport of oxygen in the blood.

Carbonyl iron (Kfol-Z) is used as a dietary supplement, and to prevent and to treat iron deficiencies and iron deficiency anemia.

Carbonyl iron (Kfol-Z) may also be used for purposes other than those listed in this medication guide.

• Do NOT take more than the recommended dose without checking with your doctor.
• Do not take large doses of vitamins (megadoses or megavitamin therapy) while you use Carbonyl iron (Kfol-Z) unless otherwise instructed by your doctor.
• Carbonyl iron (Kfol-Z) has iron in it. Before you start any new medicine, check the label to see if it has iron in it too. If it does or if you are not sure, check with your doctor or pharmacist.
• Carbonyl iron (Kfol-Z) may cause darkened or green stools. This is normal and not a cause for concern.
• Some of these products contain sulfites, which can cause allergic reactions in certain individuals (eg, asthma patients). If you have previously had allergic reactions to sulfites, contact your pharmacist to determine if the product you are taking contains sulfites.
• Some of these products contain tartrazine dye (FD&C Yellow No. 5). This may cause an allergic reaction in some patients. If you have ever had an allergic reaction to tartrazine, ask your pharmacist if your product has tartrazine in it.
• Carbonyl iron (Kfol-Z) may interfere with certain lab tests, including tests used to check for blood in the stool. Be sure your doctor and lab personnel know you are taking Carbonyl iron (Kfol-Z).
• Lab tests, including hematocrit, hemoglobin levels, and blood iron levels, may be performed while you use Carbonyl iron (Kfol-Z). These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.
• PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Carbonyl iron (Kfol-Z) while you are pregnant. Carbonyl iron (Kfol-Z) is found in breast milk. If you are or will be breast-feeding while you use Carbonyl iron (Kfol-Z), check with your doctor. Discuss any possible risks to your baby.

Ascorbic acid (Vitamin C (Kfol-Z)) occurs naturally in foods such as citrus fruit, tomatoes, potatoes, and leafy vegetables. Vitamin C (Kfol-Z) is important for bones and connective tissues, muscles, and blood vessels. Vitamin C (Kfol-Z) also helps the body absorb iron, which is needed for red blood cell production.

Ascorbic acid is used to treat and prevent Vitamin C (Kfol-Z) deficiency.

Ascorbic acid may also be used for purposes not listed in this medication guide.

Zinc (Kfol-Z) is a naturally occurring mineral. Zinc (Kfol-Z) is important for growth and for the development and health of body tissues.

Zinc (Kfol-Z) sulfate is used to treat and to prevent Zinc (Kfol-Z) deficiency.

Zinc (Kfol-Z) sulfate may also be used for purposes not listed in this medication guide.

Usual Adult Dose for Iron Deficiency Anemia:

50 mg orally three times a day.

Usual Pediatric Dose for Iron Deficiency Anemia:

Premature neonates:

2 to 4 mg Carbonyl iron (Kfol-Z)/kg/day divided every 12 to 24 hours (maximum daily dose = 15 mg).

Infants and children <12 years:

Prophylaxis: 1 to 2 mg Carbonyl iron (Kfol-Z)/kg/day (maximum 15 mg) in 1 to 2 divided doses.

Mild to moderate iron deficiency anemia:

3 mg Carbonyl iron (Kfol-Z)/kg/day in 1 to 2 divided doses.

Severe iron deficiency anemia:

4 to 6 mg Carbonyl iron (Kfol-Z)/kg/day in 3 divided doses.

This medication administered orally, IM, IV, intravaginally.

For the prevention of deficiency conditions Vitamin C (Kfol-Z) dose is 25-75 mg / day, for the treatment - 250 mg / day or more in divided doses.

For intravaginal used ascorbic acid drugs in appropriate dosage forms.

Zinc (Kfol-Z) 1 mg/mL (Zinc (Kfol-Z) Chloride Injection, USP) contains 1 mg Zinc (Kfol-Z)/mL and is administered intravenously only after dilution. The additive should be diluted prior to administration in a volume of fluid not less than 100 mL. For the metabolically stable adult receiving TPN, the suggested intravenous dosage is 2.5 to 4 mg Zinc (Kfol-Z)/day (2.5 to 4 mL/day). An additional 2 mg Zinc (Kfol-Z)/day (2 mL/day) is suggested for acute catabolic states. For the stable adult with fluid loss from the small bowel, an additional 12.2 mg Zinc (Kfol-Z)/liter of small bowel fluid lost (12.2 mL/liter of small bowel fluid lost), or an additional 17.1 mg Zinc (Kfol-Z)/kg of stool or ileostomy output (17.1 mL/kg of stool or ileostomy output) is recommended. Frequent monitoring of Zinc (Kfol-Z) blood levels is suggested for patients receiving more than the usual maintenance dosage level of Zinc (Kfol-Z).

For full term infants and children up to 5 years of age, 100 mcg Zinc (Kfol-Z)/kg/day

(0.1 mL/kg/day) is recommended. For premature infants (birth weight less than 1500 g) up to 3 kg in body weight, 300 mcg Zinc (Kfol-Z)/kg/day (0.3 mL/kg/day) is suggested.

Parenteral drug products should be inspected visually for particulate matter and discoloration prior to administration, whenever solution and container permit. See PRECAUTIONS.

How supplied

Zinc (Kfol-Z) 1 mg/mL (Zinc (Kfol-Z) Chloride Injection, USP) is supplied in 10 mL Plastic Vials (List No. 4090).

Store at 20 to 25°C (68 to 77°F).

HOSPIRA, INC., LAKE FOREST, IL 60045 USA. Revised: October, 2004

AV-block II and III degree, sinoatrial block, SSS, bradycardia (HR < 40 bpm), hypotension (in case of myocardial infarction, systolic blood pressure less than 100 mm Hg), cardiogenic shock, congestive heart failure IIB-III stages, acute heart failure, Prinzmetal's angina, lactation, concomitant use of MAO inhibitors, hypersensitivity to atenolol.

See also:
What is the most important information I should know about Zinc (Kfol-Z)?

Hypersensitivity to any of the ingredients of Zinc (Kfol-Z).

Use Carbonyl iron (Kfol-Z) as directed by your doctor. Check the label on the medicine for exact dosing instructions.

• Carbonyl iron (Kfol-Z) is absorbed better on an empty stomach but may be taken with food if it upsets your stomach. Some foods (eg, eggs, whole grain breads, cereal, dairy products, coffee, tea) may decrease the amount of iron absorbed by your body. Talk with your doctor about the best way to take Carbonyl iron (Kfol-Z) with food if it upsets your stomach.
• Shake well before using.
• Use a measuring device marked for medicine dosing. Ask your pharmacist for help if you are unsure of how to measure your dose.
• Take Carbonyl iron (Kfol-Z) with a full glass (8 oz [240 mL]) of water.
• Do not lie down for 30 minutes after taking Carbonyl iron (Kfol-Z).
• If you take an antacid, a bisphosphonate (eg, alendronate), cefdinir, eltrombopag, methyldopa, penicillamine, a quinolone antibiotic (eg, ciprofloxacin), or a tetracycline (eg, minocycline), ask your doctor or pharmacist how to take it with Carbonyl iron (Kfol-Z).
• If you miss a dose of Carbonyl iron (Kfol-Z), take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Carbonyl iron (Kfol-Z).

Iron supplements are takrn orally to treat and prevent anemia due to iron deficiency (lack of enough iron that affects development of red blood cells causing reduction in number of red blood cells in the body).Iron is also used in the form of iron dextran injection is used to treat iron deficiencies and iron deficiency anemia (low red blood cells) in severe deficiencies or when the patient cannot tolerate iron orally. Iron sucrose injection is used to treat iron deficiency anemia in people with kidney disease. It is usually given with another medication to promote the growth of red blood cells

Ascorbic acid (Vitamin C (Kfol-Z)) is used to prevent or treat low levels of Vitamin C (Kfol-Z) in people who do not get enough of the vitamin from their diets. Most people who eat a normal diet do not need extra ascorbic acid. Low levels of Vitamin C (Kfol-Z) can result in a condition called scurvy. Scurvy may cause symptoms such as rash, muscle weakness, joint pain, tiredness, or tooth loss.

Vitamin C (Kfol-Z) plays an important role in the body. It is needed to maintain the health of skin, cartilage, teeth, bone, and blood vessels. It is also used to protect your body's cells from damage. It is known as an antioxidant.

OTHER USES: This section contains uses of this drug that are not listed in the approved professional labeling for the drug but that may be prescribed by your health care professional. Use this drug for a condition that is listed in this section only if it has been so prescribed by your health care professional.

This vitamin may also be used with other vitamins for a certain eye condition (macular degeneration).

How to use Vitamin C (Kfol-Z)

Take this vitamin by mouth with or without food, usually 1 to 2 times daily. Follow all directions on the product package, or take as directed by your doctor.

If you are taking the extended-release capsules, swallow them whole. Do not crush or chew extended-release capsules or tablets. Doing so can release all of the drug at once, increasing the risk of side effects. Also, do not split extended-release tablets unless they have a score line and your doctor or pharmacist tells you to do so. Swallow the whole or split tablet without crushing or chewing. Take this product with a full glass of water (8 ounces/240 milliliters) unless your doctor directs you otherwise.

If you are taking the wafers or chewable tablets, chew them thoroughly and then swallow. If you are taking the lozenges, place the lozenge in your mouth and allow it to slowly dissolve.

If you are taking the powder, mix it thoroughly in the proper amount of liquid and stir well. Drink all of the liquid right away. Do not prepare a supply for future use. If you are using the liquid form of this vitamin, carefully measure the dose using a special measuring device/spoon. Do not use a household spoon because you may not get the correct dose.

Dosage is based on your medical condition and response to treatment.

Use this vitamin regularly to get the most benefit from it. To help you remember, take it at the same time(s) each day.

If you think you may have a serious medical problem, seek immediate medical attention.

In an application with barbiturates, primidone increases the excretion of ascorbic acid in the urine.

With the simultaneous use of oral contraceptives reduces the concentration of ascorbic acid in blood plasma.

In an application of Vitamin C (Kfol-Z) with iron preparations ascorbic acid, due to its regenerative properties, transforms ferric iron in the bivalent, which improves its absorption.

Ascorbic acid in high doses can decrease urine pH that while the application reduces the tubular reabsorption of amphetamine and tricyclic antidepressants.

With the simultaneous use of aspirin reduces the absorption of ascorbic acid by about a third.

Vitamin C (Kfol-Z) in an application with warfarin may decrease effects of warfarin.

With the simultaneous application of ascorbic acid increases the excretion of iron in patients receiving deferoxamine. In the application of ascorbic acid at a dose of 500 mg / day possibly left ventricular dysfunction.

In an application with tetracycline is increased excretion of ascorbic acid in the urine.

There is a described case of reducing the concentration of fluphenazine in plasma in patients treated with ascorbic acid 500 mg 2 times / day.

May increase the concentration of ethinyl estradiol in the blood plasma in its simultaneous application in the oral contraceptives.

See also:
What other drugs will affect Zinc (Kfol-Z)?

Pyridoxine reduces the effects of levodopa (but this does not occur if a dopa decarboxylase is also given); decreases serum concentrations of phenobarbitone. Concurrent administration of drugs eg, isoniazid, penicillamine and oral contraceptives increase the requirement for pyridoxine.

Absorption of cyanocobalamin from the GIT may be reduced by neomycin, aminosalicylic acid, histamine H₂-receptor antagonists and colchicine. Serum concentrations may be decreased by concurrent administration of oral contraceptives. Many of these interactions are unlikely to be of clinical significance but should be taken into account when performing assays for blood concentrations.

Parenteral chloramphenicol may attenuate the effect of vitamin B12 in anaemia.

Folate deficiency states may be produced by a number of drugs including antiepileptics, oral contraceptives, antituberculous drugs, alcohol and folic acid antagonists eg, aminopterin, methotrexate, pyrimethamine, trimethoprim and sulphonamides; folic acid may decrease serum-phenytoin concentrations.

There may be an increased risk of myopathy or rhabdomyolysis when nicotinic acid is used concurrently with statins. Nicotinamide may increase the requirements for insulin or oral hypoglycaemics.

Ascorbic acid may increase the absorption of iron-deficiency states.

Ascorbic acid is often given in addition to desferrioxamine to patients with iron overload (thalassemia) to achieve better iron excretion. However, early on in treatment when there is excess tissue iron, there is some evidence that ascorbic acid may worsen the iron toxicity, particularly to the heart. Thus, ascorbic acid should not be given for the first month after starting desferrioxamine treatment.

The absorption of Zinc (Kfol-Z) may be reduced by iron supplements, penicillamine, phosphorus-containing preparations and tetracyclines. Zinc (Kfol-Z) supplements reduce the absorption of copper, ciprofloxacin, iron, norfloxacin, penicillamine and tetracyclines.

See also:
What are the possible side effects of Carbonyl iron (Kfol-Z)?

Applies to Carbonyl iron (Kfol-Z): suspension

Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Constipation; darkened or green stools; diarrhea; loss of appetite; nausea; stomach cramps, pain, or upset; vomiting.

Seek medical attention right away if any of these SEVERE side effects occur while taking Carbonyl iron (Kfol-Z) (the active ingredient contained in Carbonyl iron (Kfol-Z))

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); black or tarry stools; blood or streaks of blood in the stool; fever; severe or persistent nausea, stomach pain, or vomiting; vomit that looks like blood or coffee grounds.

Applies to ascorbic acid: oral capsule, oral capsule extended release, oral capsule liquid filled, oral granule, oral liquid, oral lozenge/troche, oral powder, oral powder for solution, oral powder for suspension, oral solution, oral syrup, oral tablet, oral tablet chewable, oral tablet extended release, oral wafer

As well as its needed effects, ascorbic acid (the active ingredient contained in Vitamin C (Kfol-Z)) may cause unwanted side effects that require medical attention.

Severity: Moderate

If any of the following side effects occur while taking ascorbic acid, check with your doctor or nurse as soon as possible:

Less common or rare: - with high doses

• Side or lower back pain

Minor Side Effects

Some ascorbic acid side effects may not need any medical attention. As your body gets used to the medicine these side effects may disappear. Your health care professional may be able to help you prevent or reduce these side effects, but do check with them if any of the following side effects continue, or if you are concerned about them:

Less common or rare: - with high doses

• Diarrhea
• dizziness or faintness (with the injection only)
• flushing or redness of skin
• headache
• increase in urination (mild)
• nausea or vomiting
• stomach cramps

See also:
What are the possible side effects of Zinc (Kfol-Z)?

Applies to Zinc (Kfol-Z) sulfate: capsules, tablets

Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Nausea; vomiting.

Seek medical attention right away if any of these SEVERE side effects occur while taking Zinc (Kfol-Z) sulfate (the active ingredient contained in Zinc (Kfol-Z))

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); severe vomiting; unusual restlessness; very dry mouth, eyes, or skin.