Kantrexil

Treatment of specific and non-specific gastro-enteritis.

Hypersensitivity to any of the ingredients, or to other amino-glycoside antibiotics. Patients with glaucoma, myasthenia gravis and in patients with prostatic hypertrophy.

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The following side-effects may occur following oral Kanamycin (Kantrexil) administration although less than 1% of a dose is absorbed following oral administration.

Kanamycin (Kantrexil) may cause irreversible ototoxicity. Kanamycin (Kantrexil) is more likely to cause auditory than vestibular toxicity. Kantrexil should be withdrawn immediately if symptoms of ototoxicity occur. Reversible nephrotoxicity may occur and acute renal failure has been reported, often in association with the concurrent administration of other nephrotoxic medicines. Patients especially at risk from ototoxicity and nephrotoxicity are those whose condition may lead to raised plasma concentrations such as in patients with renal failure.

Kanamycin (Kantrexil) may cause hypersensitivity reactions and cross-sensitivity between other aminoglycosides have been reported. Hypomagnesaemia, hypocalcaemia and hypokalaemia have occurred when Kanamycin (Kantrexil) has been given for prolonged periods. Infrequent side-effects which may occur are anaemia, purpura, convulsions, visual disturbances, increased serum aminotransferase values and increased serum bilirubin concentrations. Other side-effects include headache and paraesthesia., Antiemetics may mask ototoxic symptoms.

Kanamycin (Kantrexil) should be administered separately when concomitant therapy with a betalactam antibiotic is required.

Side-effects of aminopentamide include dry mouth, dimmed vision and cerebral excitation.

Bismuth has been associated with reversible encephalopathy and bone and joint disorders. Bismuth can cause black discolouration of the faeces.