Infectoscab 5%

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Infectoscab 5%

Medically reviewed

Marina Burgos

Last updated on 22/12/2025

This page provides general, reference-level information compiled from official medical sources. It is not a substitute for professional medical advice, diagnosis, or treatment. For decisions about your health, please consult a qualified healthcare professional.

Overview of Infectoscab 5%

Quick Facts: Infectoscab 5%

Property Description
Active ingredient Permethrin (5%)
Form Cream (Topical)
Pharmacological class Ectoparasiticide, Scabicide
Common use Elimination of parasitic skin infestations
Origin Synthetic pyrethroid

What Type of Medicine is Infectoscab 5%?

Infectoscab 5% is a prescription topical preparation that is chemically defined by its active ingredient, Permethrin, which places it within the pharmacological class of ectoparasiticides. This classification means the medicine’s primary function is the eradication of small parasites, such as mites and lice, that live on the body’s surface. The preparation is specifically recognized as a potent scabicide against the mites that cause scabies, and its efficacy in this role is supported by pharmacological studies.

The product's inclusion on the World Health Organization (WHO) Model List of Essential Medicines in the 5% concentration underscores its importance for public health. This level of international recognition confirms that the medicine’s inherent function is based on verifiable evidence, allowing it to interrupt the life cycle of the parasitic organisms.

Composition, Form, and Origin (Permethrin 5% Cream)

This medicine is a single-ingredient product delivered as a smooth, semisolid cream base formulated for cutaneous administration. The cream contains Permethrin at a distinct concentration of 5%. Chemically, Permethrin is identified as a synthetic pyrethroid, a manufactured compound designed to reliably replicate the insecticidal properties of natural pyrethrins derived from chrysanthemum plants.

The cream base is strategically employed as a vehicle, ensuring that the 5% Permethrin is uniformly applied and maintained on the skin surface. This controlled, localized delivery is crucial for facilitating the reliable ectoparasite eradication that defines the product's function, particularly when treating persistent infestations like scabies.

Regulatory References

  1. World Health Organization (WHO)

What side effects are possible with Infectoscab 5%?

Possible Side Effects and Safety Information

Infectoscab 5% (Permethrin 5% cream) is generally associated with localized reactions at the application site. The official safety profile, based on government regulatory documentation, primarily describes these events by their frequency and the affected body system.


Documented Adverse Reactions

The most common adverse reactions are typically localized and transient, falling under the Skin and subcutaneous tissue disorders and Nervous system disorders System-Organ Classes.

Frequency Classification Examples of Adverse Reactions
Common (1 to 10 users in 100) Pruritus (itching), erythema (redness), oedema, paraesthesia (tingling, burning sensation), and general skin discomfort.
Uncommon (1 to 10 users in 1,000) Hypersensitivity (allergic reactions).
Not Known Urticaria (hives).

Serious adverse reactions are rare but center on the potential for severe hypersensitivity reactions, which include those classified at the highest tier of allergic response. These are tied to the Immune system disorders classification.


Regulatory Safety Patterns

Official labeling includes specific notes on the timing and restrictions related to use:

  • Time-Related Effects: Local sensations like stinging or burning are frequently reported at the start of treatment. Importantly, pruritus related to the infestation may persist for up to four weeks after successful treatment, a pattern documented in regulatory documents.
  • Contraindications: The medicine is contraindicated in individuals with known hypersensitivity to the active substance (Permethrin), other pyrethrins/pyrethroids, or any of the cream's excipients.
  • Application Restrictions: Contact with eyes and mucous membranes must be strictly avoided due to potential for local irritation.

The regulatory profile ensures that users are aware of these common local effects and critical safety limitations.

Overdose and Emergency Response

Overdose and When to Seek Help

The official regulatory documents specify distinct risks and required actions associated with an overdose of Infectoscab 5% (Permethrin 5% cream).

Documented Overdose Manifestations

Accidental oral ingestion of the cream contents is the exposure-related factor leading to systemic overdose risks. Officially documented manifestations following ingestion include nausea, vomiting, dizziness, and headache. The most severe outcome explicitly documented in regulatory labeling is convulsion, indicating the potential for Central Nervous System involvement. In contrast, excessive topical application of the cream may result in localized adverse reactions, including more severe skin reactions.

Immediate Emergency Action Required

Regulatory guidance mandates that immediate medical attention must be sought following any accidental oral ingestion of the cream. The official action required includes contacting a Poison Control Center or emergency services. This urgent help-seeking action is required immediately upon recognition of the ingestion event.

Officially Described Supportive Measures

Management of overdose is defined as primarily symptomatic and supportive. Specific procedures noted in the regulatory text include the consideration of gastric lavage following accidental ingestion, particularly if consultation is achieved within two hours of the event. Overdose management protocols give special consideration to accidental ingestion by a child.

Therapeutic Uses of Infectoscab 5%

What Infectoscab 5% Treats: Main Uses and Benefits

The therapeutic application of Infectoscab 5% (Permethrin 5% cream) is applied in addressing conditions involving inflammatory or irritative processes related to specific parasitic skin infestations and contributes to easing the associated distress. This medication is a scabicide relevant for managing infestations in adults and children 2 months of age and older.

The medication is relevant for managing active parasitic skin conditions, specifically scabies caused by the Sarcoptes scabiei mite. This application is used to address the source of the infestation, which supports the management of the condition's symptomatic burden.

In clinical settings, Infectoscab 5% is relevant for easing symptoms related to the condition, notably the intense, debilitating pruritus (itching) that typically intensifies at night, and the accompanying inflammatory rash and bumps. The medicine is used in standard therapeutic contexts across various clinical settings, and is considered relevant as a topical option for a wide range of patients, including infants over two months old and pregnant individuals.


Quick Fact: Symptom Management
The cream helps address symptom clusters that may become intense or disruptive, contributing to improved comfort during symptomatic periods, which supports the management of the persistent itching.

Regulatory References

  1. NIH MedlinePlus overview

Eligibility and Restrictions for Use

Eligibility Profile: Who Can and Cannot Use Infectoscab 5%

The official population eligibility for Infectoscab 5% (Permethrin 5% cream) is defined by regulatory guidelines based primarily on age, allergy status, and reproductive health. The medicine is contraindicated for any individual with a known hypersensitivity to the active ingredient, permethrin, other synthetic pyrethroids or pyrethrins, or any component of the cream. Absolute prohibition extends to infants less than 2 months of age, as safety and effectiveness have not been established in this population.

Use is generally allowed for all other adults, adolescents, and children aged 2 months and older. However, use is restricted for infants aged 2 to 23 months, who must be treated only under close medical supervision due to limited clinical data. For use during pregnancy, it is permitted only if clearly needed. Lactating mothers are advised to consider temporarily discontinuing nursing or withholding the medication.


Population Status Official Regulatory Classification
Absolute Contraindications Hypersensitivity to permethrin/pyrethroids; Infants under 2 months of age.
Restricted Use Infants 2 to 23 months (requires close medical supervision).
Conditional Use Pregnancy (permitted only if clearly needed); Lactation (discontinue nursing is advised).
No Specific Restrictions Hepatic or renal impairment (not listed as a contraindication).

What should I know about interactions with other medicines?

Interactions with other medicines and products

Official regulatory documents indicate that no systemic medicinal interactions are known for Infectoscab 5% (Permethrin 5% cream) when used topically as directed. This is due to the minimal absorption of the active ingredient into the bloodstream following cutaneous application.


Documented Interaction Cautions

Despite the absence of known systemic drug interactions, official product labeling includes specific cautions related to co-administered topical treatments and excipients.

Interacting Substance/Product Official Regulatory Statement
Corticosteroids (Topical) Treatment of eczematous-like reactions with corticosteroids must be withheld prior to applying Permethrin 5% cream.
Latex Products Excipients (such as liquid and white soft paraffin) can reduce the function and reliability of latex products (e.g., condoms, diaphragms) used concurrently.

Official Regulatory Classifications

  • Contraindicated Combinations: None are listed based on interaction risk.
  • Pharmacokinetic Interactions: No interactions involving metabolic enzymes (e.g., CYP) or drug transporters are documented.
  • Food or Alcohol Interactions: No interactions with food, alcohol, or herbal products have been established in official regulatory documents.

This interaction profile confirms that regulatory constraints are focused on localized topical co-administration and excipient-based effects rather than systemic drug-drug interactions.

Mechanism of Action

Infectoscab 5% (Permethrin) works by specifically engaging the biological machinery of the target ectoparasite to cause sustained modulation of the parasite's nervous system leading to functional failure. This action is rooted in two primary mechanistic domains: direct molecular targeting and the consequence of parasitic resistance factors.

Targeted Modulation of Arthropod Sodium Channels

Permethrin functions as a modulator by binding directly to the voltage-gated sodium channels (VGSCs) in the parasite's nerve membranes. This binding prevents the channel from closing (inactivating), forcing a sustained influx of sodium ions that overloads the nerve cell. This initiates a cascade of hyperexcitation and results in systemic paralysis of the target organism.

Functional Limitations via Parasitic Molecular Defenses

This neurotoxic action is constrained by specific defense mechanisms in the target parasite. Structural limitations include gene mutations in the VGSC, which reduce Permethrin's ability to bind to its target. Additionally, the parasite's internal defense system, involving enzymes like Glutathione S-transferase (GST), can accelerate the metabolic degradation of the Permethrin molecule, limiting its effective concentration at the nerve channels.

Dosage and Administration Information

How to Use Infectoscab 5%: Official Administration Principles

Infectoscab 5% (Permethrin cream) is used according to a standardized, short-course regimen. The medicine is formulated for cutaneous use only and must not be swallowed or applied to mucous membranes or eyes.


Administration Route and Dosing Regimens

The standard administration involves a single topical application to clean, dry, cool skin. The dose is determined by age, focusing on complete body coverage:

Age Group Standard Single Dose (Approximate) Application Area Detail (High-Level)
Adults and Adolescents (>12 years) Up to 30 grams (one tube) Entire body from neck to soles of feet.
Children (6–12 years) Up to 15 grams (half tube) Entire body from neck to soles of feet.

Frequency, Contact Time, and Population Rules

Treatment is typically defined by a single application. The cream must be left on the skin for a mandatory contact period of 8 to 14 hours, after which the entire application must be thoroughly washed off (e.g., via shower or bath). A second application may be performed 7 to 14 days after the first, only if signs of a continuing infestation are observed.

High-level application rules exist for specific populations to ensure proper coverage:

  • Infants (2 months to 2 years) and Older Adults (>65 years): The cream must also be applied to the face, ears, and scalp, in addition to the entire body, while carefully avoiding areas around the mouth and eyes.
  • Special Condition: If hands are washed during the 8-to-14 hour contact period, the cream must be reapplied to the hands to maintain coverage.

Recent Clinical Evidence

Research Evidence / Overview of Studies for Infectoscab 5%

This overview describes the types of clinical research and the focus of the studies that have examined Infectoscab 5% (Permethrin 5% cream), according to information published by regulatory bodies and in peer-reviewed literature.


Evidence for Use in Scabies Infestation

The research base for Permethrin 5% cream primarily relies on Randomized Controlled Trials (RCTs) and comprehensive Systematic Reviews that synthesize the data from multiple trials. These studies were structured to examine the cream's performance when used for conditions involving periods of heightened symptoms, specifically infestations by the Sarcoptes scabiei mite.

Research examined two main types of outcomes. The first was the clinical success rate, which was monitored by researchers to see if the parasitic organisms were eliminated, often through microscopic checks. The second focus was on patient-reported outcomes describing perceived discomfort, such as tracking how symptoms evolved in the observed populations, particularly the intense pruritus and the accompanying inflammatory skin changes.

Findings describe patterns observed in the studies related to measurements of clinical success and symptom change. Research examined the use of the preparation during periods of increased symptom activity. Research has explored bioequivalence studies, which compare generic versions of the 5% cream to the reference product; research examined the aim of achieving comparable measurements.


Comparison of Outcomes in Clinical Trials

In clinical research, Permethrin 5% was studied for how the measured outcomes compared against other treatments used for scabies. These comparative trials included other topical options as well as some oral medicines.

Studies explored changes measured during the study period across different treatment groups. Findings indicate that outcomes related to the elimination of the mite infestation and the measured changes in patient-reported outcomes describing perceived discomfort were evaluated in these comparative research settings. The evidence contributes to understanding symptom patterns across various therapeutic approaches.


Uncertainty and Research Gaps in the Evidence

Official research and scientific syntheses highlight certain areas where data are still emerging or where complete clarity is not yet established.

One key gap is related to mite sensitivity. Some research has described patterns observed in the studies suggesting localized instances where the mite population appears to have reduced sensitivity to the cream, which may be linked to variations in the consistency of results reported in those regions. Additionally, a lack of historical standardization in study design means that comparing success rates across all trials can be challenging.

Frequently Asked Questions (FAQ)

Common questions about Infectoscab 5% (FAQ)


Q: Can other topical medications, like a steroid cream, be used at the same time as Infectoscab 5%?

Official product information notes that topical corticosteroid treatment, often used for related skin reactions, must be withheld prior to applying Infectoscab 5% cream. This is to avoid potentially masking (hiding) the symptoms of the scabies infestation. Information regarding when to resume use of other topical creams is a topic for discussion with a prescribing physician.


Q: What does available research suggest about the amount of the active ingredient absorbed through the skin?

Official studies indicate that the active ingredient, permethrin, is only minimally absorbed into the body when applied to the skin. Generally, less than 2% of the dose is absorbed systemically (into the bloodstream). This minimal absorption is a key factor in the drug's profile for topical use.


Q: Why is it common for the severe itching to continue for several weeks after the treatment is completed?

Itching (pruritus) is often one of the last symptoms to resolve and may continue for up to four weeks following successful treatment. Official guidelines suggest this persistent itching is typically a temporary hypersensitivity response to the dead mites, rather than a sign that the treatment was unsuccessful. This is considered a common pattern documented in clinical use.


Q: Is it still possible to use Infectoscab 5% if a person has a known allergy to chrysanthemums?

Regulatory documents state that the cream is contraindicated (may not be used) in individuals who have a known hypersensitivity or allergy to the active substance, permethrin, or other substances called pyrethrins and pyrethroids. Since pyrethrins are chemically related to extracts from chrysanthemum plants, this caution is included in the official labeling for the product.


Q: Is it described as essential to apply the cream under the fingernails and toenails?

Application instructions from regulatory bodies advise that the cream should be applied to all areas of the body from the neck down to the soles of the feet. This specifically includes applying the cream under the fingernails and toenails to ensure complete coverage, as mites can shelter in these hard-to-reach areas.


Q: Does Infectoscab 5% kill both the adult scabies mites and their eggs as well?

Official pharmacological information indicates that the active ingredient, permethrin, is an effective ectoparasiticide. Its mechanism of action is designed to be toxic to the parasites, resulting in the destruction of the adult mites, as well as their eggs.


Q: Does Infectoscab 5% also treat other issues like head lice or pubic lice?

Infectoscab 5% cream is officially indicated only for the treatment of scabies infestations. While the active ingredient, permethrin, is used to treat lice, it is typically used in a different concentration (such as 1% lotion) for those specific conditions.


Q: What is the difference between post-scabies itch and a sign of re-infestation after using the cream?

The post-scabies itch is a common residual symptom that can last up to four weeks after successful treatment. Re-infestation or treatment failure is typically suspected only if the patient develops new lesions or if live mites are confirmed by clinical examination 14 days or more after the first application.


Q: Is a persistent or worsening rash a definite sign that Infectoscab 5% did not work?

Official information indicates that a persistent or worsening rash is typically not interpreted as an immediate sign of treatment failure. Regulatory documents note that the skin reaction and inflammation associated with the infestation may be temporarily exacerbated (made worse) by the treatment itself. This is often part of the natural healing process.


Q: How is the success of Infectoscab 5% treatment typically measured by healthcare professionals?

Treatment success is evaluated clinically, usually in a follow-up appointment two to four weeks after treatment. Success is determined by a physician based on the absence of new burrow marks or lesions and the demonstration of no live mites during a physical check.


Q: Is there evidence of scabies mites developing resistance to the active ingredient in Infectoscab 5%?

Scientific literature and research overviews note localized instances of reduced mite sensitivity to the cream in certain geographical areas. This reduced sensitivity may be a factor in some treatment outcomes, and official sources recommend careful consideration of this pattern when evaluating efficacy.


Q: What are the excipients (non-active ingredients) in Infectoscab 5% and why are they listed?

Excipients are the non-active ingredients, such as the cream base or preservatives. These are listed in official documents because some, like parahydroxybenzoates or butylhydroxytoluene, may cause local skin reactions or mild irritation in sensitive individuals. The list ensures patients are aware of all components.


Q: What should a person do if Infectoscab 5% cream is accidentally swallowed?

Infectoscab 5% is for cutaneous use only and must not be swallowed. In the event of accidental ingestion, official guidance directs contact with a physician or Poison Control Centre for assessment.


Q: How should clothing, towels, and bedding be cleaned after treatment with Infectoscab 5%?

Public health guidelines advise decontaminating any items that came into contact with the patient in the days prior to treatment. This typically involves washing in hot water and drying in a hot dryer, dry-cleaning, or sealing items in a plastic bag for at least 72 hours.


Q: Is it standard practice for all close contacts or family members to receive treatment with the cream?

Yes, regulatory and public health guidelines advise that all close contacts and family members who have had prolonged skin-to-skin contact with the infested person should be treated at the same time. This is recommended even if the contacts do not currently show any symptoms.


Q: When is a person considered no longer contagious and able to return to work or school?

According to public health guidelines, a person is generally considered no longer contagious 24 hours after the completion of the first treatment. As the mites are quickly killed, return to work or school can often resume the following day.


Q: Can Infectoscab 5% make existing eczema or dermatitis temporarily worse?

Official precautions note that the cream may cause a temporary exacerbation of pre-existing skin conditions that involve inflammation, pruritus, or rash. Patients with such conditions should be aware of this possibility, though it does not generally preclude use.


Q: Why is a single application of Infectoscab 5% usually considered sufficient in many cases?

Official labeling states that one application is generally curative when applied thoroughly and left on for the full required duration. The medication is highly effective at killing the mites and eggs within the application window, making a second treatment unnecessary for most individuals.


Q: Is there specific clinical data or research on the use of Infectoscab 5% in pregnant women?

The active ingredient, permethrin, is classified as Pregnancy Category B by the FDA. This indicates that while animal studies have shown no harm to the fetus, there are no adequate and well-controlled clinical studies in pregnant women. Use during pregnancy is permitted only when considered clearly needed.


Q: Why do official guidelines often mention a risk of fire hazard related to treated fabrics?

This caution is related to the cream base, which contains excipients (such as paraffin) that are flammable. Users are explicitly warned that if the product comes into contact with clothing, bedding, or dressings, the fabric can be easily ignited by a naked flame, and users should keep away from fire sources.


Q: Are there specific medical conditions that generally make a person ineligible to use Infectoscab 5%?

The medicine is contraindicated (may not be used) primarily for individuals with known hypersensitivity to the ingredients or related substances. Absolute prohibition also extends to infants less than 2 months of age due to limited data on safety and effectiveness in that group.

How should Infectoscab 5% be stored and disposed of?

Permethrin 5% cream (Infectoscab 5%) must be stored according to official regulatory specifications to maintain its stability and prevent environmental harm. The required storage temperature is 20 C to 25 C (68 F to 77 F), corresponding to Controlled Room Temperature. The cream must not be frozen. [Source 1.3, 2.2]


Storage and Handling

  • The product must be kept in its original container, tightly closed, and stored out of the sight and reach of children. [Source 2.3, 1.4]

Disposal Instructions

  • Unused or expired medication must be disposed of in accordance with local regulations and should not be discarded via household waste or wastewater. [Source 1.4, 4.3]
  • A critical environmental warning notes the product is toxic to aquatic organisms; therefore, contamination of aquaria and terraria is to be avoided. [Source 4.1, 4.4]

Attention! Always consult to a doctor or pharmacist before using pills or medicines.

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