Incresil

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Medically reviewed

Rosario Oropesa

Last updated on 22/12/2025

This page provides general, reference-level information compiled from official medical sources. It is not a substitute for professional medical advice, diagnosis, or treatment. For decisions about your health, please consult a qualified healthcare professional.

Overview of Incresil

Property Description
Active Ingredient Sildenafil (Sildenafil citrate)
Form Film-coated tablets
Pharmacological Class Selective Phosphodiesterase type 5 (PDE5) Inhibitor
General Purpose Enhancing localized blood flow
Origin Synthetic compound (derived)

What Type of Medicine is Incresil?

Incresil is a prescription-only synthetic medicine that contains the single active ingredient known as Sildenafil (Sildenafil citrate). It is classified pharmacologically as a selective Phosphodiesterase type 5 (PDE5) inhibitor. This categorization means the drug's primary function is to specifically block the action of the PDE5 enzyme, an action essential for its therapeutic effect. The structure of Incresil as a single-ingredient product focuses all its pharmacological activity solely on the effects generated by the Sildenafil molecule.

The synthetic origin of the compound ensures a high degree of purity and consistency in its chemical composition, a key feature that is clinically recognized for reliable bioavailability across various Sildenafil formulations.


Composition, Form, and General Purpose

The physical form of Incresil is most commonly manufactured as film-coated tablets, designed for oral administration via swallowing. Its core composition consists of the potent therapeutic agent, Sildenafil, combined with pharmaceutical excipients necessary to create the final stable tablet structure. The use of film-coated tablets represents a standard, patient-convenient dosage form often preferred for systemic medications.

The overall purpose of Incresil is to enhance the body’s natural process for promoting vasodilation, which is the widening of blood vessels. It achieves this by protecting a key natural chemical signal, cyclic guanosine monophosphate (cGMP), from premature breakdown by the PDE5 enzyme. This mechanism acts by promoting the relaxation of smooth muscle tissues. By facilitating this increased localized blood flow, the general function of Incresil is to support and restore physiological responses that rely heavily on sufficient circulation.

What side effects are possible with Incresil?

Possible Side Effects and Safety Information

The safety profile for medicines containing Sildenafil (the active ingredient in Incresil) is defined by official regulatory documents based on clinical trial data and post-marketing surveillance. Adverse reactions are classified by the frequency observed.


Documented Adverse Reactions

The most frequently reported adverse event, classified as Very Common, is Headache. Side effects classified as Common typically affect the nervous, vascular, and gastrointestinal systems, including Flushing, Dyspepsia (indigestion), Dizziness, and Abnormal Vision (such as a temporary color tinge to sight).

Less frequent, Uncommon reactions may include Palpitations, Nausea, Vomiting, Skin rash, and certain Eye disorders.

Serious Adverse Reactions and Safety Constraints

Official labeling mandates the reporting of rare but serious reactions, such as Priapism (a prolonged erection) and Non-arteritic anterior ischaemic optic neuropathy (NAION), a cause of sudden decrease or loss of vision. Serious cardiovascular events, including myocardial infarction and ventricular arrhythmia, have been reported post-marketing, often in individuals with pre-existing risk factors.

Use is absolutely contraindicated with all forms of organic nitrates and nitric oxide donors due to the risk of severe hypotension. Contraindications also apply to individuals with severe hepatic impairment, recent stroke or myocardial infarction, and those with resting hypotension (low blood pressure).

Population-Specific Notes

The clearance of Sildenafil is officially noted as being reduced in older adults and in patients with severe renal or hepatic impairment, which can lead to increased systemic exposure compared to other populations.

Overdose and Emergency Response

Overdose Map: Overdose and when to seek help — official regulatory information for Incresil

Overdose Scope

Documented overdose presentations of Incresil (Sildenafil) are primarily characterized by the potentiation of adverse effects seen at higher plasma levels. These include marked hypotension (decreased blood pressure), syncope (fainting), and pronounced visual color distortions. Significant dose-related effects are documented for the Cardiovascular system and the Ocular system.

Overdose Classifications (High-Level)

Severity classification: Overdose outcomes range from exaggerated vasodilatory effects to severe, potentially permanent or life-threatening outcomes, including priapism and serious post-marketing cardiac events. Overdose-context constraints: Treatment is symptomatic and supportive, as no specific antidote is known for Sildenafil.

Resulting Overdose Structure

Official overdose statements:

  • If a patient accidentally takes too much, they are instructed to call their doctor or go to the nearest hospital emergency room right away.
  • Seek immediate medical assistance if an erection persists longer than 4 hours to prevent permanent penile tissue damage and loss of potency.
  • Stop taking the medicine and consult a physician immediately upon the sudden occurrence of loss of vision or loss of hearing.

Connection to the overall overdose profile (2–4 sentences): The regulatory profile emphasizes that excessive exposure can lead to severe cardiovascular and ocular complications, defining precise, non-negotiable time thresholds for seeking urgent help. This structured guidance on mandated emergency actions dictates when patients must escalate care to prevent irreversible severe outcomes.

Therapeutic Uses of Incresil

This medication is indicated for use as part of supportive treatment to help manage symptoms related to physical discomfort in adult patients with a specific, long-term respiratory condition.

Incresil is considered relevant for easing symptom clusters that become more disruptive during flare-ups and is applied in clinical settings marked by noticeable physiological strain. It may help contribute to comfort across conditions involving episodic or fluctuating manifestations, symptoms related to physical discomfort, and symptoms that interfere with daily functioning. This medicine is generally used to provide short-term symptomatic assistance during phases when symptoms become more noticeable.


Quick Fact: Support for Symptoms that Interfere with Daily Functioning


In situations requiring additional management of discomfort, Incresil supports the patient during recurrent difficult episodes. It generally supports the patient during difficult episodes by easing distress and may assist with maintaining a sense of stability when symptoms are more noticeable.

Regulatory References

  1. European Medicines Agency summary for Incruse Ellipta

Eligibility and Restrictions for Use

Incresil (umeclidinium) is officially indicated for the maintenance treatment of Chronic Obstructive Pulmonary Disease (COPD) in adults and is subject to several eligibility constraints based on regulatory labeling.

Populations Who Must Not Use Incresil (Contraindications)

The medicine is contraindicated (must not be used) in:

  • Patients with a known hypersensitivity to umeclidinium or any excipients in the product.
  • Patients with a severe hypersensitivity to milk proteins, as the formulation contains lactose (a milk protein derivative).

Eligibility Restrictions and Cautionary Use

The product is not appropriate for use:

  • For the relief of acute symptoms (it is not a rescue inhaler).
  • During rapidly deteriorating or potentially life-threatening episodes of COPD.
Eligibility Status Official Regulatory Rule
Age Pediatric Population (Under 18): Use is not recommended; safety and efficacy have not been established.
Glaucoma Use with caution in patients with narrow-angle glaucoma (risk of worsening).
Urinary Issues Use with caution in patients with urinary retention, especially those with prostatic hyperplasia or bladder-neck obstruction.
Organ Function Severe Hepatic Impairment: Use with caution as its safety and use have not been studied in this specific population.
Pregnancy/Lactation Pregnancy: Use is typically reserved only if the expected benefit justifies the potential risk to the fetus (limited human data). Lactation: It is unknown if the drug is excreted in human milk; caution is advised.

What should I know about interactions with other medicines?

Interactions with other medicines and products

Incresil (Sildenafil) has officially documented interaction patterns primarily concerning its effects on blood pressure and how its own plasma levels are maintained in the body.

Contraindicated Combinations

Co-administration of Incresil is strictly contraindicated with certain classes of medicines due to the risk of severe pharmacodynamic interactions. This includes Organic Nitrates (e.g., nitroglycerin) in any formulation, and the soluble guanylate cyclase (sGC) stimulator Riociguat. These combinations are formally prohibited in regulatory documents due to the potential for fatal potentiation of hypotensive effects.


Pharmacokinetic and Exposure-Altering Interactions

The medicine is primarily cleared via the CYP3A4 metabolic pathway. Co-administration with strong CYP3A4 inhibitors (e.g., Ritonavir, Ketoconazole) causes a significant increase in Sildenafil's plasma concentrations and overall exposure (AUC). For example, a mandatory restriction applies to the Sildenafil dose over a 48-hour period when co-administered with Ritonavir to manage this pharmacokinetic increase.

Alpha-blockers (e.g., doxazosin) may lead to additive blood pressure-lowering effects, with the highest risk of symptomatic hypotension documented within four hours of co-administration. Additionally, consumption with a high-fat meal reduces the rate of absorption and delays the time to reach maximum concentration of Sildenafil. The interaction profile notes that increased exposure risks are exacerbated in patients with severe hepatic impairment due to reduced clearance.

Mechanism of Action

The mechanism of Incresil is focused on potentiating a natural signaling pathway, resulting in localized vasodilation (blood vessel widening).


Selective Inhibition of the PDE5 Enzyme

Incresil's active ingredient, Sildenafil, works by acting as a highly selective competitive inhibitor of the enzyme Phosphodiesterase type 5 (PDE5). This targets the enzyme specifically in vascular smooth muscle, blocking its ability to break down the crucial chemical messenger cyclic Guanosine Monophosphate (cGMP).


Potentiating the NO-cGMP Signal Cascade

By preventing the destruction of cGMP, Incresil potentiates the signaling effect initiated by endogenously released Nitric Oxide (NO). This accumulation of cGMP activates a cascade that ultimately reduces intracellular calcium levels in the smooth muscle cells. This core mechanism results directly in the relaxation of vascular smooth muscle and a corresponding modulation of localized hemodynamic perfusion.


Functional Constraints and Off-Target Activity

The mechanism is dependent on the physiological release of NO to initiate the cGMP signal; Incresil does not start the process but rather enhances the response to a natural trigger. The drug also exhibits a lower affinity for the Phosphodiesterase type 6 (PDE6) enzyme, an off-target activity which defines a specific structural limitation of its selectivity profile.

Dosage and Administration Information

How to Use Incresil: Administration Guidelines

Incresil (sildenafil) is administered according to two primary dosing protocols: an as-needed regimen and a scheduled continuous regimen. The administration route is primarily oral, though an intravenous (IV) injection is approved for hospital use.

Administration Detail As-Needed Regimen (e.g., 50 mg, 100 mg) Scheduled Continuous Regimen (e.g., 20 mg TID)
Standard Dosing Starting dose is 50 mg; dose range is 25 mg to 100 mg maximum. Recommended dose is 20 mg three times a day (TID). Oral doses are taken 4 to 6 hours apart.
Frequency/Timing Maximum frequency is once per day. Taken approximately 1 hour before activity (range: 30 minutes to 4 hours). Administered three times a day (TID).
Food Intake May be taken with or without food. Onset may be delayed if taken with a high-fat meal. May be taken with or without food.
Required Condition Requires sexual stimulation to be effective. Not applicable.

Population-Specific Starting Dose Considerations

The official labeling recommends considering a lower initial dose of 25 mg for the as-needed regimen in specific populations due to anticipated higher drug levels in the bloodstream. This includes patients with severe renal impairment (creatinine clearance < 30 mL/min), those with hepatic impairment, and in some cases, patients over 65 years of age.

Missed Dose and Preparation

For the scheduled continuous regimen, if a dose is missed, patients should take the next dose as soon as possible and then continue with the normal schedule; a double dose should not be taken to compensate. The oral suspension formulation requires reconstitution with water prior to use and must be measured with a calibrated dosing device.

Recent Clinical Evidence

Evidence for Use in Pulmonary Arterial Hypertension (PAH)

The research base includes multiple Randomized Controlled Trials (RCTs) and Long-term Extension Studies examining Incresil's active ingredient in adults with Pulmonary Arterial Hypertension (PAH). Studies focused on outcomes reflecting daily functioning or activity level, such as the distance walked in six minutes and documentation of changes in the WHO Functional Class. Researchers also examined complex combined endpoints related to clinical worsening and hospitalization. Studies reported measurements of changes in functional capacity and describe patterns observed over short time intervals. Evidence from these studies contributes to the broader evidence landscape regarding patterns observed in the studied interventions.


Evidence for Use in Erectile Dysfunction (ED)

The active ingredient was evaluated in a large number of Randomized Controlled Trials (RCTs) focused on men diagnosed with Erectile Dysfunction (ED). These studies primarily examined patient-reported experiences using validated questionnaires to capture outcomes related to systemic or functional imbalance. Findings indicated that the observed physiological responses in studies were associated with the presence of sexual stimulation. The research describes patterns where the magnitude of reported observations may vary based on the underlying cause (etiology) of the dysfunction, and results apply only to the populations studied. Additionally, there is limited information for long-term outcomes when assessing the persistence of documented changes.


Research Gaps and What Remains Uncertain

Scientific discussion highlights several areas where certainty remains low. A primary gap is that long-term outcomes are not fully established regarding the drug's influence on survival rates in adults with PAH. Additionally, evidence for use across all pediatric age groups remains limited, and evidence quality varies across studies when evaluating certain subgroups. Comparative evidence is lacking for a direct, systematic evaluation against every other available treatment option. Research does not determine whether an individual will respond similarly to the group patterns documented in the trials, and findings describe group patterns, not personal outcomes.

Frequently Asked Questions (FAQ)

Common questions about Incresil (FAQ)

Q: Are there any specific foods or drinks that should be avoided when using Incresil?

A: Official product information states that taking Incresil with a high-fat meal may slow down the rate at which the medicine is absorbed by the body. This could result in a delay in the onset of the medicine's effect. Beyond this specific effect, no other common foods are explicitly advised against in official labeling.

Q: What are the guidelines regarding driving or operating machinery while using Incresil?

A: According to official regulatory documents, the medicine may cause adverse reactions such as dizziness and abnormal vision (which includes a temporary color tinge to sight). This information is intended to inform individuals of the documented risks, allowing them to assess potential risks before driving or operating machinery.

Q: What is the official classification of Incresil (e.g., controlled substance)?

A: Incresil, which contains the active ingredient Sildenafil, is classified as a prescription-only medicine in most regions. It is important to note that Sildenafil is not listed as a controlled substance in the United States regulatory schedules.

Q: Is the maximum recommended use duration for Incresil defined in regulatory documents?

A: Official documents indicate the medicine can be used on an as-needed basis or as maintenance treatment for chronic conditions. The regulatory labeling does not typically specify a maximum time limit for how long maintenance treatment can continue, though research summaries note limited information on very long-term outcomes.

Q: Does Incresil cause weight gain or loss, according to user reports?

A: Official regulatory safety documents and clinical trial summaries for Incresil's active ingredient do not typically list weight gain or weight loss among the frequently reported adverse reactions documented in studies.

Q: Is Incresil safe to use with common over-the-counter pain relievers like ibuprofen?

A: Official drug interaction information for the active ingredient of Incresil does not report a specific, known interaction with common over-the-counter pain relievers, such as non-steroidal anti-inflammatory drugs (NSAIDs).

Q: Is it common for people to feel fatigued or tired when first starting Incresil?

A: While not listed among the very common side effects, official regulatory documents list reactions such as somnolence (drowsiness) and asthenia (weakness or lack of energy) as less common or uncommon adverse reactions.

Q: Are there any known issues with using Incresil while traveling or flying?

A: Official documents specify that the tablets must be stored at or below 30 C and protected from moisture and light to maintain stability. Following these specified storage conditions, which include keeping the medicine in its original packaging, helps to maintain product stability while traveling.

Q: Does Incresil have a 'black box warning,' and what does that mean?

A: The active ingredient in Incresil, Sildenafil, does not have a Boxed Warning (which is sometimes referred to as a 'Black Box Warning') in its US regulatory labeling. This type of warning is the most serious advisory from the FDA and is used to call attention to severe adverse reactions.

Q: Is there a generic version of Incresil available?

A: The active ingredient in Incresil, Sildenafil, is widely available in generic formulations in many regulated markets. Generic versions are required by regulatory bodies to meet the same strict quality, safety, and effectiveness standards as the original branded product.

Q: Do official documents mention any effects of Incresil on mood or anxiety levels?

A: Official safety documents list certain effects on the nervous system, such as dizziness, and psychiatric effects, such as insomnia (difficulty sleeping). However, specific changes to mood or generalized anxiety are not typically reported among the common adverse reactions.

Q: Is it possible to become dependent on Incresil?

A: Official regulatory labeling for Sildenafil has not reported evidence of tolerance, physical dependence, or abuse potential. The medicine is not classified as a controlled substance.

Q: Does Incresil require any special monitoring or regular blood tests?

A: While dose adjustments are recommended for specific populations (such as those with severe kidney or liver impairment), the standard regulatory labeling does not mandate routine blood tests or specific medical monitoring for all patients using the medicine.

Q: Are there any specific ethnic or population groups where Incresil has different reported effects?

A: Regulatory documents specifically address usage considerations for populations such as older adults and patients with organ impairment. These documents generally indicate that no clinically relevant differences in the safety or effectiveness profile based on race or ethnicity have been reported.

Q: Does Incresil affect the way birth control pills work?

A: Official drug interaction information for the active ingredient in Incresil does not list an interaction with hormonal contraceptives, such as birth control pills.

Q: If Incresil is stopped, are there any known withdrawal effects mentioned in studies?

A: Official safety documents for the active ingredient do not mention or report specific withdrawal symptoms or rebound effects that occur when patients stop using the medicine.

Q: Does Incresil interact with any common herbal supplements like St. John's Wort?

A: Certain supplements, such as St. John’s Wort, may affect how the body processes the medicine, potentially leading to a reduced level of the active ingredient in the bloodstream.

Q: How quickly does Incresil leave the body after the last use?

A: The active ingredient, Sildenafil, and its primary active metabolite have a terminal half-life of approximately 3 to 4 hours. This measure relates to the time it takes for the concentration of the substance in the body to be reduced by half.

Q: Do any official drug labels mention possible impacts of Incresil on sleep patterns?

A: The official list of adverse reactions includes insomnia (difficulty sleeping) as an uncommon effect documented during clinical development.

Q: Are there any known interactions between Incresil and alcohol?

A: Official patient information materials generally include a caution that excessive consumption of alcohol may increase the risk of experiencing certain side effects, such as headache, dizziness, or fainting when using the medicine.

Q: Do official documents clarify if Incresil can be crushed or split?

A: Regulatory documents specify that the medicine is supplied as film-coated tablets designed for oral administration. Since the official labeling generally does not provide instructions for crushing or splitting these tablets, they are intended to be taken whole.

How should Incresil be stored and disposed of?

How to Store and Dispose of Incresil?

Incresil (Sildenafil) must be stored and disposed of according to official regulatory labeling to ensure product stability and safety.


Storage Conditions

  • Temperature: Store at or below 30 C (some labels specify below 25 C). Do not freeze.
  • Protection: The tablets must be protected from light and moisture.
  • Packaging: Keep the medicine in its original container or sealed blister pack.
  • Child Safety: Store the product out of the sight and reach of children.

Disposal Instructions

  • Prohibited: Do not throw away any unused or expired medicine via wastewater or household trash.
  • Required: Disposal must be done in accordance with local requirements for medicinal products, often through a designated take-back program.

Attention! Always consult to a doctor or pharmacist before using pills or medicines.

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