Hicee 25%

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Medically reviewed

Laura Arias

Last updated on 22/12/2025

This page provides general, reference-level information compiled from official medical sources. It is not a substitute for professional medical advice, diagnosis, or treatment. For decisions about your health, please consult a qualified healthcare professional.

Overview of Hicee 25%

Property Description
Active ingredient Sodium Ascorbate (Vitamin C)
Form Sterile Solution for Injection
Pharmacological class Vitamin Preparation, Antioxidant
Common use Micronutrient support, Restoration of Vitamin C status
Origin Synthetic

Hicee 25% is a prescription-only injectable medicine classified as a Vitamin preparation and an Essential micronutrient used for therapeutic administration of Vitamin C. It is formulated as a high-potency, sterile solution intended for parenteral delivery when rapid or high-dose systemic availability is required.


1. Hicee 25%: A High-Potency Vitamin Preparation

Hicee 25% is a therapeutic Vitamin C product belonging to the pharmacological class of water-soluble vitamins and antioxidants. This medicine is defined by its ability to provide a concentrated dose of an essential substance that the human body cannot synthesize on its own. Ascorbic acid and its salts are recognized for their fundamental medical importance and are included in various essential medicine classifications.

The drug entity, marketed under the trade name Hicee, is a specialized injectable form, distinguishing it from common dietary supplements. The active component is typically manufactured through synthetic processes to ensure the pharmaceutical-grade purity required for a sterile product. This formulation is frequently used in a hospital or clinical setting when managing specific nutritional needs.


2. Composition and Form: Sodium Ascorbate Sterile Solution

The active ingredient in Hicee 25% is Sodium Ascorbate, which is the mineral salt of L-Ascorbic Acid (Vitamin C). It is prepared as a sterile aqueous solution for injection with a high 25% concentration.

This specific chemical form is crucial because Sodium Ascorbate is chemically buffered, making the solution less acidic than pure Ascorbic Acid. This buffering is a distinguishing feature of high-concentration parenteral solutions, necessary for safe administration via the parenteral route (intravenous or intramuscular injection).


3. General Purpose: Essential Micronutrient Support

The general purpose of Hicee 25% is to restore and maintain crucial Vitamin C levels in the body to support fundamental physiological functions. The active ingredient, a potent antioxidant, provides a cellular shield by neutralizing unstable molecules.

Beyond its role as a key redox agent, the medicine supports essential processes, including serving as a cofactor necessary for the synthesis of collagen, a protein vital for the integrity and repair of connective tissues, skin, and blood vessels. Vitamin C is involved in the physiological processes of collagen formation and wound healing. Providing this essential micronutrient through injection ensures its rapid availability for these general, systemic maintenance, and support functions.

Regulatory References

  1. WHO Essential Medicines List

What side effects are possible with Hicee 25%?

Possible Side Effects and Safety Information

The safety profile for injectable Sodium Ascorbate (Hicee 25%) is based on adverse reactions and constraints documented in official government regulatory sources, classified by system and frequency. The profile is segmented into common, expected effects and specific serious risks confined to defined patient populations.


Adverse Reaction Classifications

Adverse effects are grouped into System-Organ Classes (SOCs) in regulatory labeling. Common reactions often relate to the administration process or general systemic responses. Vascular Disorders (flushing, temporary dizziness) and General Disorders (local pain, irritation at the injection site) are frequently documented.

System-Organ Class Examples of Documented Effects
Renal and Urinary Disorders Oxalate crystal formation, Oxalate nephropathy (acute kidney injury)
Gastrointestinal Disorders Nausea, Vomiting
Nervous System Disorders Headache
Blood and Lymphatic System Disorders Hemolysis (in susceptible patients)

Serious Adverse Reactions and Constraints

Two principal safety constraints are highlighted in regulatory documents due to the high-concentration formulation:

  1. Hemolysis (Red Blood Cell Breakdown): This serious reaction is a specific risk for individuals with Glucose-6-Phosphate Dehydrogenase (G6PD) deficiency) and is listed as a contraindication.
  2. Oxalate Nephropathy: The precipitation of oxalate crystals, which can lead to acute kidney injury, is a major documented risk, especially in patients with existing renal impairment.

Time-Related Patterns: Regulatory texts state that rapid intravenous administration may lead to temporary dizziness or faintness, and long-term, high-dose use is associated with an increased risk of renal calculi. Additionally, high concentrations of ascorbic acid may interfere with certain laboratory diagnostic tests.

Overdose and Emergency Response

Overdose and when to seek help — Official Regulatory Information

Regulatory sources define the risks of overdose primarily in the context of high doses, prolonged use, and specific patient risk factors. If accidental overdose is suspected, consultation with a doctor or pharmacist is required.

Overdose presents as two main severe conditions impacting specific physiological systems:

  • Oxalate Nephropathy (Kidney Damage/Stones): Acute and chronic oxalate nephropathy has been reported, particularly with prolonged administration of high doses of ascorbic acid. The acidification of urine caused by ascorbic acid may increase the risk of forming oxalate, urate, or cysteine kidney stones.
  • Severe Hemolysis (Red Blood Cell Destruction): This risk is specifically associated with patients who have Glucose-6-Phosphate Dehydrogenase (G6PD) deficiency. High-dose ascorbic acid can trigger severe hemolysis in this population.

Population-Specific Overdose Risks

Specific patient populations are considered to be at an increased risk of overdose-related manifestations and require careful monitoring of renal function, hemoglobin, and blood count:

  • Patients with renal disease (including renal impairment) or a history of oxalate kidney stones.
  • Geriatric patients (older adults).
  • Pediatric patients less than 2 years of age due to immature kidneys.
  • Patients with G6PD deficiency.

Required Emergency Actions

In the event that oxalate nephropathy or hemolysis is suspected or diagnosed, official documentation requires discontinuation of the drug and treatment for the condition. Patients are instructed to consult a healthcare professional if symptoms such as nausea, vomiting, or diarrhea occur.

Therapeutic Uses of Hicee 25%

The injectable form of Vitamin C (Hicee 25%) is used for high systemic repletion when oral administration is insufficient or when the body requires high concentrations. Its use is generally applied in addressing severe symptomatic deficiencies.

The primary therapeutic domain for this high-potency injection is the management of Severe Vitamin C Deficiency, known as Scurvy, particularly when oral intake is compromised or insufficient. The medication is also relevant in clinical settings for supportive care in patients with certain malabsorption disorders or those in high-demand clinical states such as intensive care or post-major surgery.

This support helps address clusters of symptoms related to systemic imbalance. For patients, this means the injection may assist in the management of severe deficiency manifestations, including hemorrhagic symptoms (easy bruising, bleeding gums) and impaired wound healing.

“The therapeutic benefit supports the integrity of connective tissues, which contributes to easing the overall symptom load and helping improve day-to-day comfort.”


Quick Fact: Relief for Deficiency Symptoms Hicee 25% is primarily used for Severe Vitamin C Deficiency (Scurvy) and is applied when patients experience severe systemic symptoms due to acute micronutrient depletion.

Eligibility and Restrictions for Use

The eligibility for Hicee 25% (Sodium Ascorbate Injection) is determined by official regulatory documents, which establish specific age minimums and comorbidity-related restrictions.

Eligibility Scope

Classification Eligibility Status (as per regulatory labels)
Populations Allowed Adults and pediatric patients age 5 months and older who have severe Vitamin C deficiency.
Contraindications None explicitly listed in the dedicated Contraindications section of the official prescribing information.

Eligibility-Related Restrictions

Use is not indicated for infants younger than 5 months old. Use in certain populations requires heightened monitoring or a reduced dose due to increased risk:

  • Renal Risk: Patients with renal disease or a history of oxalate kidney stones are at increased risk for oxalate crystal formation and require close observation.
  • Hemolytic Risk: Patients with Glucose-6-Phosphate Dehydrogenase (G6PD) deficiency are at risk of severe hemolysis; a reduced dose is recommended.
  • Age and Risk: Pediatric patients under 2 years old and geriatric patients may also be at elevated risk for oxalate nephropathy.
  • Reproductive Status: For pregnant and lactating women being treated for deficiency, the administered dose must not exceed the U.S. Recommended Dietary Allowance (RDA) for their condition.

What should I know about interactions with other medicines?

Interactions with other medicines and products

Official regulatory documentation identifies several clinically significant interaction patterns for Hicee 25% (Sodium Ascorbate Injection), primarily stemming from its nature as a strong reducing agent and its effect on urinary pH.


Documented Interaction Patterns

Interaction Type Interacting Substance(s) Official Outcome
Antagonism of Effect Bleomycin Ascorbic acid is documented to inactivate Bleomycin in vitro.
Contraindicated/Caution Deferoxamine Co-administration is not recommended in cardiac-compromised patients due to documented risk of cardiotoxicity.
Pharmacokinetic (PK) - pH-Dependent Amphetamine, Tricyclic Anti-depressants Urinary acidification increases renal excretion and decreases plasma concentration of these basic drugs.
Absorption Modification Iron, Ethinyloestradiol Increases the absorption of iron and increases the bioavailability of Ethinyloestradiol.

Procedural and Timing Constraints

High-dose ascorbic acid, as a strong reducing agent, may decrease the activities of certain antibiotics, including Erythromycin and Kanamycin. Furthermore, the compound significantly interferes with numerous oxidation-reduction based laboratory tests (e.g., blood/urine glucose, nitrite). Regulatory information requires that these tests be delayed until 24 hours after infusion to ensure reliable diagnostic results. The regulatory profile is limited to these documented chemical and pharmacokinetic interaction outcomes.

Mechanism of Action

Core Mechanism: Essential Enzymatic Cofactor

Sodium Ascorbate's primary action is serving as an essential co-substrate to activate specific metalloenzymes, including iron- and copper-containing hydroxylases. By maintaining the metal ion in its reduced state (Fe^2+), it ensures the function of enzymes like prolyl and lysyl hydroxylases, which are critical for the formation of the stable, functional collagen triple helix. This foundational mechanism contributes to the formation of the structural matrix of connective tissues, capillaries, and bone.

Direct Free Radical Scavenging

The molecule is a highly effective, water-soluble reducing agent that functions as an immediate electron donor. It actively quenches destructive Reactive Oxygen Species (ROS), such as the hydroxyl radical, by neutralizing them into less-reactive species. This direct antioxidant mechanism shields cellular membranes, DNA, and proteins from oxidative stress, influencing the maintenance of cellular function and epithelial barrier structures.

Support for Metabolic and Neurochemical Pathways

Beyond structural roles, the molecule acts as a required cofactor for key biosynthetic enzymes, including those necessary for the production of the catecholamine norepinephrine and for the synthesis of carnitine. This mechanism influences neurotransmitter balance and facilitates fatty acid transport into mitochondria, thereby supporting core cellular energy metabolism.

Dosage and Administration Information

How to Use Hicee 25%

The administration of Hicee 25% (Ascorbic Acid Injection) follows a standardized protocol. As a high-concentration, sterile solution, its use involves a controlled, short-term regimen delivered via the parenteral route.

Administration Guidelines

Feature Guideline
Route of Administration Intravenous (IV) Infusion only. Must be administered as a slow infusion
Standard Dosing 200 mg once daily for adults (11 years and older). Pediatric doses are lower, specifically 100 mg or 50 mg, depending on the age group
Course Duration Maximum daily treatment is seven days (one week). The course may be repeated if symptoms persist after the initial period
Frequency Administered once daily

Preparation and Procedural Requirements

Due to its high concentration, Hicee 25% must be diluted prior to administration to ensure an appropriate solution concentration and osmolarity. Standard procedures involve dilution in a suitable infusion fluid, such as 5% Dextrose Injection. The final admixture concentration is maintained between 1 and 25 mg/mL for infusion.

As a Pharmacy Bulk Package, the vial is subject to time-sensitive handling; all single doses are dispensed and used within four hours of the initial puncture. The final diluted solution is administered as a slow intravenous infusion and is not mixed with incompatible solutions, such as those containing elemental reducing agents like copper.

Recent Clinical Evidence

Hicee 25%: Recent Clinical Evidence

Clinical evidence regarding Hicee 25% generally relates to the active ingredient, ascorbic acid (Vitamin C), or its specialized derivatives. Research explores its role in general health maintenance, immune function support, and specific clinical applications, often involving intravenous administration.


General Health and Antioxidant Studies

Studies frequently evaluate the role of Vitamin C supplementation in supporting the body’s antioxidant capacity. Research has demonstrated its involvement in managing oxidative stress, a process implicated in various chronic conditions. Trials in healthy populations focus on evaluating how supplementation influences key biomarkers, such as changes in plasma antioxidant levels and immune cell activity.


Immune Function Research

Clinical investigations have monitored the potential impact of Vitamin C on immune response, particularly in the context of infections.

Research has explored whether high-dose administration affects the duration or severity of symptoms in conditions like the common cold. Trial data typically measure outcomes such as patient-reported symptom scores and the incidence of upper respiratory tract infections over a defined study period.


Advanced Therapeutic Investigations

Recent, more specific research has investigated the use of high-concentration ascorbic acid in certain advanced clinical settings. This includes observational studies and pilot trials focused on:

  • Critical Care: Evaluation of the effects of high-dose intravenous Vitamin C on outcomes, including the duration of stay in intensive care units and markers of organ function.
  • Nutritional Status: Research into correcting severe Vitamin C deficiency (scurvy) in patient groups where oral supplementation may be ineffective or insufficient.

Key Studies & References

  1. Vitamin C in infectious diseases
  2. Clinical Practice Guideline: Management of Scurvy in Adults

Frequently Asked Questions (FAQ)

Common questions about Hicee 25% (FAQ)

Q: Is Hicee 25% the same as other vitamin C supplements?

Hicee 25% is a specialized, high-potency injectable sterile solution used for therapeutic administration, as noted in official product descriptions. The high concentration and parenteral route of delivery are distinguishing characteristics described in regulatory documents that set it apart from typical oral vitamin C supplements.

Q: Is there a maximum time period for which Hicee 25% can be used continuously?

The recommended maximum duration for daily treatment outlined in regulatory documents is seven days (one week). Official guidance also indicates that the product is intended for short-term, therapeutic regimens. Furthermore, regulatory warnings note that long-term, high-dose use is associated with an increased risk of kidney stone formation (renal calculi).

Q: Does Hicee 25% contain any common allergens like gluten or lactose?

Official labeling lists all active ingredients and inactive components (excipients). While standard injectable formulations of the active ingredient typically do not contain gluten or lactose, it is important to review the complete official label for the final list of inert ingredients relevant to individual patient concerns.

Q: Can Hicee 25% be used alongside blood thinners?

Regulatory documents suggest that a healthcare provider should review the use of Hicee 25% alongside anticoagulant therapy (blood thinners). Official summaries advise patients on anticoagulant therapy to avoid taking excessive doses of the active ingredient over an extended period.

Q: How is the safety profile of Hicee 25% described in clinical summaries?

The safety profile, as described in official documents, highlights two serious documented risks associated with high-concentration use: hemolysis (red blood cell breakdown) in patients with G6PD deficiency and oxalate nephropathy (kidney injury) in those with pre-existing renal issues. Less serious, common reactions such as nausea or headache are also documented.

Q: What does it mean if Hicee 25% has a listed interaction with iron supplements?

Official drug interaction summaries state that Hicee 25% increases the absorption of iron. This means that when the two substances are administered together, the regulatory documents state this interaction may result in the body taking in a greater amount of the iron supplement.

Q: How quickly does Hicee 25% start to work for its approved uses?

As an intravenous solution, the active ingredient bypasses the digestive system and enters the bloodstream rapidly. Regulatory documents indicate that high concentrations may lead to a quick resolution of certain symptoms of deficiency. However, the complete resolution of clinical symptoms is a biological process that may require ongoing support.

Q: How long does the effect of Hicee 25% last in the body?

Following intravenous infusion, the active ingredient circulates in the bloodstream. According to pharmacology data, any surplus not required by the body is filtered by the kidneys and eliminated primarily through renal excretion (via urine).

Q: Why do some official drug documents list 'fatigue' as both a symptom it treats and a possible side effect?

This occurs because fatigue is a common symptom of the severe Vitamin C deficiency (scurvy) the medicine is indicated to treat. Separately, fatigue or malaise has also been reported as a possible, non-serious side effect in a limited number of patients during routine adverse event reporting.

Q: Is the effect of Hicee 25% immediate or does it build up over time?

The active ingredient achieves high plasma levels immediately after intravenous administration. However, for functions like the full repair of connective tissues, the necessary biological processes (such as collagen synthesis) may require ongoing support and a longer period to complete.

Q: What official information is available about the long-term use of Hicee 25%?

Hicee 25% is indicated for short-term use, typically for up to one week, as directed in the administration guidelines. Official warnings specifically associate long-term, high-dose use with an increased potential for the formation of kidney stones.

Q: Does Hicee 25% need to be refrigerated or stored in a specific way?

Official storage instructions mandate that the solution must be kept at Controlled Room Temperature (20 C to 25 C). It is crucial that the product is not frozen and is stored away from light to maintain its stability.

Q: What is the primary way the body removes Hicee 25%?

The body primarily removes the active ingredient through a process called renal excretion. This means that any amount of the substance not used by the body is filtered by the kidneys and eliminated in the urine, according to pharmacology data.

Q: Does Hicee 25% require any special monitoring while being used?

Official guidance requires that certain oxidation-reduction-based laboratory tests (such as blood or urine glucose) be delayed until 24 hours after the infusion to prevent interference and ensure reliable diagnostic results.

Q: What are the general expectations about the benefit of Hicee 25%?

The primary expected benefit described in official documents is the treatment and reversal of the symptoms of scurvy (severe Vitamin C deficiency). It is indicated for patients for whom adequate oral intake is not possible or sufficient for necessary micronutrient support.

Q: What types of research have been conducted on Hicee 25%?

Official evidence summaries cite studies that include rigorous formats such as randomized clinical trials (RCTs) focused on general health biomarkers and immune function. There are also observational or pilot trials investigating its use in specialized environments like critical care settings.

How should Hicee 25% be stored and disposed of?

Storage and Disposal Requirements for Hicee 25%

The official labeling mandates strict storage conditions to maintain the stability of this injectable product.


Storage Conditions

  • Temperature: Store at Controlled Room Temperature (20 C to 25 C). The solution must not be frozen.
  • Protection: The vial must be protected from light and kept in the original container until use.
  • Child Safety: Store this medicine out of the sight and reach of children.
  • Stability: Visually inspect the solution; it must be clear and colorless or slightly yellow. Any unused portion must be discarded immediately after opening.

Disposal Instructions

Disposal must be conducted in accordance with federal, state, and local requirements for pharmaceutical waste. The product and its packaging must not be placed in household trash or poured into wastewater.

Attention! Always consult to a doctor or pharmacist before using pills or medicines.

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