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Medically reviewed by Kovalenko Svetlana Olegovna, PharmD. Last updated on 26.06.2023
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Hermin is a short-acting sedative-hypnotic medication used to treat insomnia. Regular use leads to tolerance, and it is usually not effective for more than 7 days. Structurally, it does not resemble the barbituates, but it shares many effects with this class of drugs; the depressant effects of ethinamate are, however, generally milder than those of most barbiturates.
Those of parenteral nutrition, or combined with total enteral nutrition when oral feeding is impossible or insufficient.
Hermin 2 is more perfectly suited to parenteral nutrition in patients with moderate and catabolic nitrogen savings plans.
Adult Chronic renal failure 200 mL daily infused via peripheral vein or 400 mL daily infused via central vein by TPN. Acute renal failure 600 mL daily infused via central vein by TPN.
Hermin should not be administered to patients with severe hepatic function disorder. Imbalance of Hermin may be aggravated with the use of Hermin resulting in the induction of hepatic coma.
Homocystinuria, infections, malnutrition, negative nitrogen balance, phenylketonuria, severe burns.
Hermin may add to or potentiate the action of other antihypertensive drugs. Potentiation occurs with ganglionic peripheral adrenergic blocking drugs.
Medication such as digitalis may also influence serum electrolytes. Warning signs, irrespective of cause, are: dryness of mouth, thirst, weakness, lethargy, drowsiness, restlessness, muscle pains or cramps, muscular fatigue, hypotension, oliguria, tachycardia, and gastrointestinal disturbances such as nausea and vomiting.
Insulin requirements in diabetic patients may be increased, decreased, or unchanged. Higher dosage of oral hypoglycemic agents may be required. Latent diabetes mellitus may become manifest during chlorthalidone administration.
Hermin and related drugs may increase the responsiveness to tubocurarine.
Hermin and related drugs may decrease arterial responsiveness to norepinephrine. This diminution is not sufficient to preclude effectiveness of the pressor agent for therapeutic use.
Adverse reactions to Hermin was observed in 132 (2.37%) of total 5,564 cases. The most frequently observed adverse reactions were nausea or queasy in 70 reactions (1.26%), anorexia in 41 reactions (0.74%), vomiting in 24 reactions (0.43%), abdominal bloating in 19 reactions (0.34%), oral discomfort (including dry mouth feeling, thirst) in 14 reactions (0.25%) and increased aspartate aminotransferase (glutamic oxaloacetic transaminase) [AST (GOT)] and alanine aminotransferase (glutamate-pyruvate transaminase) [ALT (GPT)] in 9 reactions (0.16%), at the end of the re-examination.