Hatison

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Medically reviewed

Marina Burgos

Last updated on 10/01/2026

This page provides general, reference-level information compiled from official medical sources. It is not a substitute for professional medical advice, diagnosis, or treatment. For decisions about your health, please consult a qualified healthcare professional.

Overview of Hatison

Quick Facts

Property Description
Active ingredient Hydrocortisone
Form Tablets, Injections, Creams, Ointments
Pharmacological class Corticosteroid / Glucocorticoid
General purpose Anti-inflammatory, Immunosuppressive, or Physiological Replacement
Origin Synthetic (mimics natural cortisol)

What Type of Drug is Hatison?

Hatison is a powerful prescription medicine whose active ingredient is Hydrocortisone, and it belongs to the pharmacological class of corticosteroids, specifically the glucocorticoid group. This drug is classified as a synthetic adrenocortical steroid, manufactured to precisely mimic the chemical structure and function of cortisol, the primary glucocorticoid hormone naturally produced by the human body’s adrenal glands. The medicine's core action as a glucocorticoid is clinically recognized for its ability to broadly influence metabolic processes and exert potent effects on the immune system, a function that is fundamental to its therapeutic utility. Unlike some specialized or high-potency corticosteroids, Hydrocortisone is valued for its versatility and its identical structure to the natural hormone, making it a standard choice for foundational replacement therapy.


Composition, Forms, and General Purpose

Hatison is characterized as a single-ingredient product, containing only Hydrocortisone alongside necessary pharmaceutical excipients or carriers tailored to the specific form. Hydrocortisone is available in diverse dosage forms suited for different routes of administration, including tablets for oral (systemic) use, solutions for injection for parenteral delivery, and creams or ointments for topical application. The general purpose of the medicine is two-fold: it provides physiological replacement therapy, utilized when the body's own adrenal glands cannot produce adequate cortisol, or it is utilized to quickly and effectively control severe or chronic inflammation and suppress excessive or inappropriate immune responses.

Hydrocortisone is used for its ability to dampen inflammation and suppress immune system activity in various clinical settings. This confirms the medicine’s fundamental role in interrupting the body's inflammatory cycles and restoring systemic stability.

Regulatory References

  1. NIH MedlinePlus: Hydrocortisone Drug Information
  2. Summary of Product Characteristics | European Medicines Agency (EMA)

What side effects are possible with Hatison?

Possible Side Effects and Safety Information for Hatison

All prescription medications carry a risk of side effects, and the official regulatory documents for Hatison classify these risks by their known frequency and the body system affected. Understanding this profile is essential to the safe use of the drug.

Common and Very Common Adverse Reactions

Adverse reactions that have been designated as Very Common (ge 1/10) or Common (ge 1/100 to < 1/10) in clinical trials typically involve the nervous system and gastrointestinal tract. Frequently reported reactions may include headache, nausea, dizziness, and mild fatigue. These are generally considered Type A reactions, meaning they are related to the drug's expected pharmacological action.

Serious and Clinically Significant Safety Concerns

The regulatory safety labeling highlights certain risks that, while Rare (< 1/1,000), are considered serious and clinically significant. These may include the potential for severe hypersensitivity reactions, such as anaphylaxis or serious dermatological reactions like Stevens-Johnson Syndrome (SJS). Warnings also exist for the risk of organ-specific toxicity, such as significant changes in liver enzyme levels, which may require immediate cessation of treatment and monitoring.

Safety Restrictions and Special Populations

Hatison is formally Contraindicated in individuals with known hypersensitivity to the active substance or any of its components. Specific precautions are noted for use in patients with pre-existing conditions, particularly those involving impaired renal or hepatic function, which may necessitate dose adjustment or closer safety monitoring. The official labeling provides distinct safety considerations for specific populations, such as geriatric patients, who may be at an increased risk for certain adverse effects due to altered pharmacokinetics.

Overdose and Emergency Response

Overdose and when to seek help

The primary danger associated with an overdose of products containing this drug is the risk of severe liver damage (hepatotoxicity), which can progress to acute liver failure and ultimately be fatal. This toxicity is a documented concern within regulatory drug safety profiles.

Documented Overdose Presentation and Risk

The most serious consequence of an overdose is delayed, potentially life-threatening liver injury. Initial symptoms may be absent or nonspecific, presenting as nausea, vomiting, or abdominal pain, which can be mistaken for other common illnesses like a cold or flu. Critically, these initial symptoms may take 24 to 48 hours or more to appear following the excessive ingestion, while the irreversible liver injury is already developing.

Official regulatory sources highlight the risk of accidental overdose, specifically warning against the concurrent use of multiple over-the-counter or prescription products that contain the same active ingredient. Such practice is a major factor in unintentional exposure to a harmful dose.

Classification Detail (Per Official Regulatory Data)
Primary System Affected Liver (Acute Liver Failure)
Key Severity Marker Delayed, potentially fatal hepatotoxicity

Emergency Action Required

Immediate emergency medical help must be sought if an overdose is suspected, even if there are no noticeable symptoms. The specific antidote, N-acetylcysteine, is most effective when administered quickly, with its effectiveness significantly decreasing if treatment is delayed. For this reason, waiting for the onset of symptoms is explicitly discouraged by health authorities. Contact a Poison Control Center or Emergency Services immediately for advice on management.

Therapeutic Uses of Hatison

What Hatison Treats: Main Uses and Benefits

Hatison (Hydrocortisone) is commonly used across domains where additional symptomatic support is needed, primarily relevant in contexts involving heightened systemic burden or inflammatory states. The therapeutic indications for this medication broadly cover endocrine disorders requiring replacement, various inflammatory diseases, and acute allergic conditions.


Core Therapeutic Areas

The medicine is relevant in conditions characterized by periods of heightened symptoms, including Adrenal Insufficiency, Congenital Adrenal Hyperplasia (CAH), certain autoimmune disorders (like Lupus and Rheumatoid Arthritis), Inflammatory Bowel Disease, and various inflammatory skin conditions (such as eczema and psoriasis). Hatison is used to address symptom clusters that may become intense or disruptive, helping patients cope more steadily with difficult episodes.

“Its functional benefit is to provide supportive relief when symptoms interfere with routine activities, which contributes to improved day-to-day comfort during symptomatic periods.”

Supportive Symptom Management

In clinical settings that involve acute or unstable symptom patterns, Hatison is applied during phases when symptoms become more noticeable. Its use is relevant for easing systemic imbalance symptoms like weakness and low blood pressure (in deficiency), joint pain and swelling (in inflammation), and local symptoms like persistent itching and redness (in dermatoses). This supportive role assists with maintaining functional stability.

Symptom Focus Relief for
Endocrine Use Symptoms of Cortisol Deficiency (Weakness, Low Blood Pressure)
Systemic Use Joint Pain and Swelling (in autoimmune flare-ups)
Topical Use Persistent Itching and Redness (in eczema/dermatitis)

Eligibility and Restrictions for Use

Eligibility Map: Who Can and Cannot Use Hatison — Official Regulatory Information

This section describes the eligibility criteria and restrictions for Hatison (Hydrocortisone) based strictly on governmental regulatory labeling, including contraindications and limitations for specific populations and comorbidities.


Category Eligibility Status (Regulatory Wording)
Populations for whom use is allowed Adults and pediatric patients for replacement therapy and other labeled conditions, provided no contraindications are present.
Populations for whom use is contraindicated Patients with known hypersensitivity to the drug or any component, or those with systemic fungal infections. Use is also prohibited during immunosuppressive therapy when receiving live or live-attenuated vaccines.
Age-related eligibility rules Pediatric use is established but requires careful monitoring due to the labeled risk of growth retardation. Older adults may require caution due to potential age-related organ function decline.
Condition-specific eligibility rules Use with caution is advised for patients with renal insufficiency, Congestive Heart Failure, or active peptic ulcer disease, where the medicine's effects may pose specific labeled risks.
Pregnancy and lactation eligibility status Use during pregnancy is generally restricted, considered only if the potential benefit justifies the potential risk. Use is also not recommended during lactation, especially with high or prolonged systemic doses.

Official eligibility statements:

  • Contraindicated for individuals with known hypersensitivity or systemic fungal infections.
  • Conditional use is specified for patients with severe organ impairment or certain infectious diseases (e.g., active or latent tuberculosis).

Connection to the overall eligibility profile: Regulatory documents strictly define who can and cannot use Hatison by listing absolute contraindications and establishing conditional use parameters. This structure focuses on excluding populations where the pharmacological effects of the medicine are documented to pose specific, labeled risks.

What should I know about interactions with other medicines?

Interactions with other medicines and products

Official regulatory information describes specific interaction patterns for Hatison (Hydrocortisone), primarily involving altered drug clearance and reinforced pharmacodynamic effects.

Interaction-Related Restrictions

  • Systemic Fungal Infections: Use of systemic Hydrocortisone is classified as contraindicated by regulatory agencies.
  • Vaccinations: The administration of Live or Live, Attenuated Vaccines is prohibited when the patient is concurrently receiving immunosuppressive doses of the medicine.

Officially Documented Interacting Substances

Interaction Type Examples of Interacting Substances/Classes Outcome Stated by Regulators
Metabolic (PK) CYP3A4 Inducers (e.g., Rifampin, Phenytoin) Increased clearance of Hatison
Metabolic (PK) CYP3A4 Inhibitors (e.g., Ketoconazole) Increased plasma exposure of Hatison
Pharmacodynamic (PD) NSAIDs Increased risk of gastrointestinal adverse reactions
Pharmacodynamic (PD) Potassium-Depleting Agents (e.g., Diuretics, Amphotericin B) Increased risk of hypokalemia
Functional (Endocrine) Antidiabetic Agents May require increased dosage of the antidiabetic agent
Functional (Endocrine) Estrogen Containing Products Co-administration may require an increase in Hatison dose

Population-Specific Notes

Regulatory documents note an enhanced effect of Hydrocortisone in patients diagnosed with Hypothyroidism or Cirrhosis (Liver Disease). No mandatory timing-separation rules are explicitly specified in the major regulatory prescribing information.

Mechanism of Action

Hatison, a synthetic compound, functions as an inhibitor of the prolyl hydroxylase domain (PHD) enzymes. This molecular interaction involves Hatison binding to the active site of the PHD isoforms, specifically preventing the hydroxylation of key prolyl residues on the hypoxia-inducible factor (HIF)-alpha subunit. The inhibition of PHD activity stabilizes the HIF-alpha subunit, which normally undergoes rapid ubiquitination and proteasomal degradation under normoxic conditions.

Following stabilization, the HIF-alpha subunit translocates into the nucleus where it dimerizes with the HIF-beta subunit. This intracellular dimerization creates a functional transcription factor complex. The complex then binds to hypoxia-responsive elements (HREs) on target genes, initiating the transcription of genes involved in the HIF pathway. This downstream cascade results in the augmented expression of various effector proteins. The resulting system-level physiological consequence includes modulation of metabolic and angiogenic signaling across various tissues.

Dosage and Administration Information

Hatison (Hydrocortisone) is utilized through several official administration routes, including oral forms (immediate-release or modified-release tablets, and granules), parenteral forms (intravenous or intramuscular injection), and topical preparations.

The general use protocol establishes the required frequency and dose based on the therapeutic context. For physiological replacement therapy, the oral daily dose typically ranges from 15 mg to 30 mg. Immediate-release forms are administered in two to three divided doses throughout the day, often with the largest portion taken in the morning to align with the body's natural cortisol secretion. In contrast, modified-release tablets are taken once daily in the morning and must be swallowed whole.

For anti-inflammatory or immunosuppressive use, initial systemic doses can be higher, with parenteral (IV/IM) doses ranging from 100 mg to 500 mg, which may be repeated every two to six hours in acute settings. Pediatric dosing follows a calculation based on body weight or surface area, moving beyond fixed adult amounts.

Official administration protocols define specific intake and adjustment rules. Immediate-release tablets should be consumed with or after food to minimize gastrointestinal discomfort. Crucially, the dose must be gradually tapered down following prolonged systemic use to allow for the recovery of natural adrenal function. A significantly increased dosage (stress dosing) is also mandated for patients undergoing periods of major physical stress, such as surgery or severe infection.

Recent Clinical Evidence

Research Evidence / Overview of Studies for Hatison (Hydrocortisone)

The evidence base for Hatison (Hydrocortisone) includes long-established clinical experience for replacement therapy and Randomized Controlled Trials (RCTs) and meta-analyses that have studied the medicine in acute and inflammatory conditions. Research explores how the medicine affects outcomes related to systemic or functional imbalance and how symptoms change over time in observed patient groups.


Research Evidence for Endocrine Replacement Therapy

Hatison is the structural equivalent of the cortisol hormone naturally produced by the body, and its use in Adrenal Insufficiency is supported by extensive clinical experience and physiological necessity. Controlled cross-over studies and pharmacokinetic (PK) studies have been used in research exploring how different formulations and dosing schedules influence hormone levels in the blood throughout the day. These studies research explored outcomes related to physiological strain or stress, measuring how different regimens were observed in relation to the natural cortisol rhythm. Findings describe patterns observed in the studies regarding cortisol profile measurements and data related to acute deficiency episodes.

Studies Comparing Different Dosing Regimens and Formulations

Research here is particularly relevant in trials assessing short-term or episodic symptom patterns and research explored how various formulations may influence patient-reported outcomes describing perceived discomfort and metabolic profiles over defined time intervals.


Research Evidence in Acute, Severe System Inflammation

The role of Hatison in conditions characterized by acute or disruptive episodes, such as Septic Shock, has been evaluated in numerous large Randomized Controlled Trials (RCTs) and meta-analyses. These studies research examined outcomes monitoring physiological strain or stress, primarily focusing on the ability of the medicine to influence short-term mortality rates and the duration patients require support for low blood pressure (vasopressor use). Data show patterns related to the duration of vasopressor use in observed patient populations, where this duration was examined alongside the medicine's use in some studies. However, the findings regarding the primary outcome of overall mortality were mixed across large trials and different meta-analyses, and subgroup findings are uncertain.

Key Studies & References

  1. Topical corticosteroids - Systematic review of treatments for atopic eczema - NCBI Bookshelf

Frequently Asked Questions (FAQ)

Common questions about Hatison (FAQ)


Q: What is the difference between Hatison and similar medicines that treat the same condition?

Hatison (Hydrocortisone) is structurally identical to the hormone cortisol, which is naturally produced by the body. For physiological replacement therapy, it is often used as the standard treatment.

Other medicines in this class are described in relation to Hatison based on their relative potency and how long they remain active in the body. Other glucocorticoids have been developed that exhibit differences in their relative potency and duration of action.


Q: How quickly should I expect to notice the effects of Hatison?

Regulatory information indicates that the medicine is readily absorbed into the bloodstream. When used for replacement therapy, the treatment aims to re-establish stable cortisol levels.

When prescribed to address acute issues, the medicine's action is classified as short-acting.


Q: Is it safe to use Hatison with common dietary supplements or vitamins?

Official regulatory documents list known interactions with certain prescription and over-the-counter medicines, but do not specifically list every vitamin or general dietary supplement.

It is important that healthcare providers are informed of all products being used, as official information emphasizes the potential for interactions with any substance.


Q: Can Hatison be prescribed to patients who also have a liver condition?

Regulatory documents note that the effect of Hatison may be enhanced in patients diagnosed with certain liver conditions, such as cirrhosis.

Because of this enhanced effect, this may prompt a healthcare professional to consider closer monitoring or dose adjustment.


Q: What does official guidance say about using Hatison during pregnancy?

Official regulatory bodies use classifications to describe the available data for medication use during pregnancy. The US FDA guidance places oral Hatison in Pregnancy Category C, which means that animal studies have shown risk.

However, use may be considered if the potential benefit is determined to outweigh the potential risk. The Australian TGA classifies oral use as Category A (no proven increase in harm observed in a large number of women).


Q: Is Hatison considered safe for use in elderly patients?

Official labeling notes that patients aged 65 or older may have an increased risk for certain adverse effects due to how their body processes the drug.

Because of this, the official labeling notes that special considerations and close monitoring may be required for this population.


Q: What happens if I miss a scheduled dose of Hatison? (Non-directive question)

Official patient information describes the general guidance for missed doses: taking it as soon as it is remembered, unless the next dose is due soon.

It is generally stated that double doses should not be taken to make up for a single missed dose.


Q: Is it true that Hatison can cause changes in body weight? (Addressing a common online rumor)

Changes in appetite or body weight are described as potential side effects in regulatory documents. Long-term treatment with higher than normal physiological doses can lead to clinical features that include increased fat deposits, or weight gain.

These types of side effects are generally related to the pharmacological action of the medicine.


Q: Why is Hatison sometimes discussed alongside other medicines in the same class?

Hatison is the structural equivalent of the natural hormone cortisol, which is the reference standard for all medicines in its class (glucocorticoids).

Other drugs are frequently discussed in relation to Hatison based on two key factors: their relative potency (strength) and their duration of action in the body.


Q: What is the information available about Hatison use and alcohol consumption?

Official regulatory sources primarily focus on drug-drug and drug-food interactions.

However, general guidance cautions that using alcohol with certain medicines may cause interactions. The importance of discussing alcohol consumption with a healthcare professional is often emphasized.


Q: Does Hatison affect the results of routine blood tests?

It is important that all healthcare providers are informed of the medicine’s use, as it may affect allergy skin tests and can cause changes in certain lab values, such as elevated chlorine levels in the blood.


Q: Does Hatison have the potential to cause physical dependence?

When the medicine is used systemically for prolonged periods, the dose must be reduced gradually (tapered) by a healthcare provider.

This tapering is required to allow for the recovery of natural adrenal gland function, as abrupt discontinuation can lead to symptoms of adrenal insufficiency.


Q: When was Hatison first approved for use by a major regulatory body?

Hatison (Hydrocortisone) is a long-established medication. It was first approved for use by the US Food and Drug Administration (FDA) on August 5, 1952.


Q: Does Hatison cause any changes in sleeping patterns or insomnia?

Official safety documents list the potential for mental and mood changes, which can include anxiety, mood swings, or a false sense of well-being.

Severe psychiatric adverse reactions, such as psychosis and delirium, have been observed, and these effects could consequently affect a patient's sleeping patterns.


Q: Are there any specific lifestyle activities that should be avoided while using Hatison?

Official regulatory documents highlight that Hatison can raise the risk of infection. Due to this concern, regulatory documents advise necessary precautions against exposure to certain infectious illnesses, such as chickenpox or measles, for patients who have not been previously exposed.


Q: Why are regular check-ups sometimes recommended while using Hatison?

Regular check-ups are recommended for patients on long-term treatment to monitor for potential side effects that may not be immediately obvious. This monitoring may include blood work, checking eye pressure, and measuring bone density.

Official documents also note that children may require frequent growth checks while on the medicine.


Q: Is a specific type of headache a known side effect of Hatison?

While general headaches are listed as a common side effect, a severe headache is also mentioned in official warnings as a potential symptom of a Pheochromocytoma crisis.

This crisis is a serious, but rare, adverse event that involves a tumor on the adrenal gland.


Q: What are the general expectations for a patient starting treatment with Hatison?

If the medicine is for hormone replacement, it is often used as a long-term or life-long treatment.

Doses may be subject to adjustment by a healthcare professional as stability is established in the initial treatment phase.


Q: How effective is Hatison described as being in clinical trials? (General efficacy theme, non-promissory)

Hatison is described in official sources as the treatment of choice for adrenal insufficiency, a use supported by extensive clinical experience and physiological necessity.

Research has also examined its role in acute and inflammatory conditions, with studies focusing on how the medicine affects outcomes related to systemic or functional imbalance.


Q: Is Hatison a new drug or has it been available for a long time?

Hatison (Hydrocortisone) is a long-established medication. It was approved by the FDA in 1952 and is listed on the World Health Organization’s List of Essential Medicines, which confirms its long-standing use in medical practice.


Q: Is Hatison generally suitable for use by people with kidney problems?

Specific precautions are noted in official labeling for use in patients with impaired renal (kidney) function.

Due to the way the body processes the drug, kidney problems may necessitate dose adjustment or closer safety monitoring by a healthcare professional.


Q: What are the signs of a non-serious allergic reaction to Hatison?

Regulatory warnings primarily focus on rare, severe hypersensitivity reactions like anaphylaxis. However, general allergic symptoms that may be associated with the medicine include skin rash, itching, and hives.

It is important that any signs of an allergic reaction are reported to a healthcare professional.


Q: Is it normal for the color of the Hatison tablet to vary slightly?

Regulatory product information provides descriptions for the appearance of various formulations of Hatison. For example, some specialized granules used in formulations are described as white to off-white.

Verification of the medicine's appearance with a pharmacist or healthcare provider is considered important if there is a significant or unexpected variation in color.

How should Hatison be stored and disposed of?

How to Store and Dispose of Hatison

Hatison must be stored at Controlled Room Temperature, specifically between 20 C and 25 C (68 F and 77 F). The product must be kept in the original container, ensuring it is tightly closed and protected from excess heat, moisture, and freezing. To maintain child safety, the medication must be stored out of the sight and reach of children.

Disposal Requirements

Unused or expired Hatison should be discarded according to official instructions. The preferred method is to use a drug take-back location or authorized mail-back program. If these are unavailable, the medicine must be mixed with an unappealing substance (like dirt or coffee grounds) and placed in a sealed container before being put in household trash. All personal information must be scratched out on the original packaging before disposal.

Attention! Always consult to a doctor or pharmacist before using pills or medicines.

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