Funazol

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Medically reviewed

Laura Arias

Last updated on 22/12/2025

This page provides general, reference-level information compiled from official medical sources. It is not a substitute for professional medical advice, diagnosis, or treatment. For decisions about your health, please consult a qualified healthcare professional.

Overview of Funazol

What is Funazol?

Funazol is an antifungal medication primarily used to treat a wide variety of fungal and yeast infections. It belongs to a class of drugs known as triazole antifungals. It works by interfering with the synthesis of ergosterol, a vital component of fungal cell membranes. By disrupting the formation of this membrane, the medication inhibits the growth and reproduction of the fungi, allowing the body's immune system to clear the infection.

Therapeutic Applications

This medication is frequently utilized for both localized and systemic fungal conditions. Common applications include:

  • Mucosal Candidiasis: This includes infections of the mouth (thrush), throat, and esophagus.
  • Genital Candidiasis: It is commonly used for the treatment of vaginal yeast infections and associated inflammation.
  • Skin and Nail Infections: It can be effective against fungal infections of the skin, such as athlete's foot, ringworm, and fungal nail bed infections.
  • Systemic Infections: In more severe cases, it is used to treat internal fungal infections that affect the bloodstream, urinary tract, or lungs.
  • Cryptococcal Meningitis: It is used to manage specific fungal infections that affect the brain and spinal cord.

Mechanism of Action

As a fungistatic agent, Funazol does not necessarily kill the fungi immediately but rather prevents them from multiplying. The depletion of ergosterol leads to increased membrane permeability and the leakage of essential intracellular elements, which ultimately results in the cessation of fungal growth. Because human cells use cholesterol rather than ergosterol, the medication is able to target the infecting organisms with high specificity.

What side effects are possible with Funazol?

Possible Side Effects and Safety Information

Funazol (Fluconazole/Ketoconazole, depending on formulation) is an antifungal medication. While generally well-tolerated, it is important to be aware of potential side effects and safety precautions.


Common Side Effects

Side effects that are generally mild and may resolve as the body adjusts to the medication often include:

  • Gastrointestinal issues: Nausea, vomiting, diarrhea, stomach pain, or upset stomach.
  • Neurological effects: Headache or dizziness.
  • Skin reactions: Rash.

Serious Side Effects

Although rare, some side effects require immediate medical attention. Stop taking Funazol and seek emergency care if you experience:

  • Signs of Liver Damage: Yellowing of the skin or eyes (jaundice), dark urine, pale stools, persistent nausea/vomiting, or severe abdominal pain.
  • Severe Allergic Reaction (Anaphylaxis): Swelling of the face, lips, tongue, or throat, difficulty breathing, or a widespread, blistering, or peeling rash.
  • Heart Rhythm Changes: Fast, irregular, or pounding heartbeat, severe dizziness, or fainting. This risk is higher if you have pre-existing heart conditions or low potassium/magnesium levels.

Important Safety Information

Condition Recommendation
Pregnancy/Breastfeeding Should generally be avoided unless the doctor determines the benefits outweigh the risks. Use effective contraception during and for a period after treatment.
Liver/Kidney Problems Use with caution. Your doctor may need to adjust the dosage and monitor your function with blood tests.
Drug Interactions Funazol can interact with numerous medications (e.g., blood thinners, certain cholesterol-lowering drugs, and other antifungals). Always inform your doctor of all current medications, supplements, and herbal products.
Alertness Funazol may cause dizziness or, rarely, seizures. Avoid driving or operating machinery until you know how the medication affects you.
Alcohol Avoid or limit alcohol intake, as it may increase the risk of liver damage when combined with Funazol.

Overdose and Emergency Response

Overdose and when to seek help for Funazol (Fluconazole)

Official regulatory information describes the overdose profile of Funazol (Fluconazole) through its specific effects on the central nervous system (CNS). Documented clinical presentations of over-ingestion include acute and severe CNS manifestations such as hallucinations (seeing or hearing things that do not exist), paranoia (extreme fearfulness or suspiciousness), and other distinct mental changes.

Regulator-mandated emergency actions are directly linked to the severity of these documented presentations. Individuals must immediately call emergency services if a suspected overdose leads to severe and life-threatening outcomes, including seizures, collapse, severe trouble breathing, or inability to be awakened. For all other suspected over-ingestions, the official guidance is to call the poison control helpline for immediate professional advice.

No specific pharmacological antidote is known for Funazol overdose. Management procedures detailed in regulatory documents focus on symptomatic and supportive treatment. Additionally, hemodialysis is an officially documented measure that can be used for drug elimination; a three-hour session of hemodialysis is shown to decrease plasma concentrations by approximately 50%. The presence of any documented CNS symptom necessitates professional medical monitoring and evaluation.

Therapeutic Uses of Funazol

What Funazol Treats: Main Uses and Benefits

Funazol is commonly used as a systemic antifungal to address conditions characterized by periods of heightened symptoms caused by fungal pathogens throughout the body. The medication is relevant in clinical settings involving serious systemic infections like candidemia and meningitis; mucosal candidiasis of the mouth and esophagus; genital candidiasis; and persistent fungal skin and nail issues (dermatomycoses). It is applied in scenarios where additional management of discomfort is required.

In these conditions, the medication helps address symptom clusters that may become intense or disruptive, such as pain, severe itching, fever, and internal organ distress.

“The primary goal is to provide supportive relief that helps patients cope more steadily with symptom fluctuations during difficult episodes.”

It also plays a role in a proactive, prophylactic context for high-risk patients (e.g., those who are immunocompromised). This supportive use assists with maintaining functional stability by helping to reduce the risk of future symptomatic episodes.


Quick Fact: Relief for Systemic and Mucosal Discomfort Funazol is commonly used for managing symptoms associated with internal fungal spread and is relevant for addressing pain and irritation caused by localized infections like oral or vaginal thrush.

Regulatory References

  1. NIH MedlinePlus overview

Eligibility and Restrictions for Use

Funazol (an assumed antifungal agent) is typically prescribed to treat a variety of fungal infections. Its suitability, however, depends on individual health factors and the presence of other medical conditions or medications. Always consult a healthcare provider to determine if Funazol is appropriate for you.

Who Can Use Funazol?

Generally, Funazol may be suitable for adults and, in some cases, children, who are diagnosed with a susceptible fungal infection. This includes those with healthy liver and kidney function, as the drug is metabolized by the liver and excreted by the kidneys. Individuals who do not have a history of hypersensitivity to Funazol or related antifungal agents are also typically candidates.


Who Cannot Use Funazol? (Contraindications)

Funazol is contraindicated (should not be used) in patients with known hypersensitivity or allergic reactions to the drug or any of its inactive ingredients.

Special Caution is advised for the following groups due to potential risks or the need for dose adjustment:

  • Patients with Liver Disease: The drug can be toxic to the liver (hepatotoxicity). Patients with existing liver impairment may require lower doses and careful monitoring.
  • Patients with Certain Heart Conditions: Funazol can interact with other medications and may, in rare cases, affect heart rhythm. It is contraindicated with specific drugs that prolong the QT interval.
  • Pregnancy and Breastfeeding: Use during pregnancy is generally avoided unless the benefit outweighs the potential risk. It may pass into breast milk, requiring careful consideration by a physician.
  • Patients taking specific interacting medications, such as certain statins, blood thinners, or benzodiazepines, due to the risk of dangerous drug-drug interactions.

If any of these contraindications or cautions apply, an alternative treatment may be necessary.

What should I know about interactions with other medicines?

Interactions with other medicines and products

Funazol (Fluconazole) is formally classified as a potent inhibitor of the cytochrome P450 enzymes CYP2C9 and CYP2C19, and a moderate inhibitor of CYP3A4. This official regulatory status means that co-administration with other medicines metabolized by these pathways may significantly increase the plasma concentrations of the other drugs, thereby reducing their clearance.

Formal Interaction Restrictions

Co-administration is strictly contraindicated with several specific medicines due to a documented risk of serious cardiac events (QTc prolongation), including Cisapride, Astemizole, Pimozide, Quinidine, and Erythromycin. The restriction for Terfenadine is also a formal contraindication when Funazol doses are at or above 400 mg/day.

Documented Exposure Alterations

Official labeling describes that Funazol increases the systemic exposure of several substances, such as Abrocitinib and HMG-CoA Reductase Inhibitors (statins), which increases the potential for adverse effects like myopathy. Conversely, co-administration with Rifampicin is documented to decrease the systemic exposure (AUC) of Funazol itself. Absorption of Funazol is unaffected by food.

Population-Specific Notes

The pharmacokinetics of Funazol are officially noted as being affected by reduced renal function, which results in increased systemic exposure of the antifungal agent.

Mechanism of Action

Targeted Inhibition of the Fungal Life Cycle

The mechanism of Funazol (Fluconazole) is centered on lanosterol 14alpha-demethylase (C14alpha DM), a crucial enzyme within fungal cells. By acting as a selective non-competitive inhibitor, the drug blocks the enzyme's function, thereby preventing a key step in the ergosterol biosynthesis pathway. This targeted action immediately initiates a cascade resulting in the arrest of fungal cell proliferation.


Disruption of Fungal Cell Structure and Homeostasis

The enzymatic blockade leads to a critical depletion of ergosterol, the necessary structural component of the fungal cell membrane, and simultaneously causes the accumulation of toxic intermediate sterols. This process compromises the integrity and fluidity of the membrane, resulting in a structurally defective cell boundary with impaired cellular homeostasis and division capacity. This failure of cellular homeostasis is the direct mechanism leading to the fungistatic action.


Mechanisms of Pathogen Resistance

The drug's effectiveness is constrained by biological counter-mechanisms developed by the fungal pathogen, primarily through upregulation of efflux pumps (e.g., CDR and MDR transporters) or mutations in the target enzyme gene (ERG11). These resistance mechanisms actively lower the concentration of Funazol at the enzyme target or reduce its binding affinity, which functionally limits the core inhibitory action required to maintain enzymatic blockade.

Dosage and Administration Information

How to Use Funazol: Official Administration Guidelines

Funazol, containing the active substance Fluconazole, is officially administered via the oral route (as tablets, capsules, or suspension) or by intravenous (IV) infusion in clinical settings. The high oral bioavailability of the drug means that the total daily dosage remains equivalent regardless of whether it is delivered orally or intravenously.


Dosing Principles and Schedule

Regimens are scenario-dependent, ranging from a single 150 mg oral dose for specific acute conditions to multi-day therapies typically administered once daily. For systemic infections, official instructions often mandate a loading dose—double the standard daily dose—given on the first day of treatment to rapidly achieve appropriate drug levels.


Preparation and Specialized Use

Oral Funazol may be taken with or without food. If the liquid oral suspension is used, it must be shaken well before measuring the dose with a calibrated device. Intravenous Funazol must be administered as a slow infusion, with the official rate constraint stipulating it must not exceed 200 mg per hour.

Dosage adjustments are a critical component of the official use protocol. For adult patients with significant renal impairment, a reduction of the recommended daily dose (typically to 50%) is generally required after the initial dose. Pediatric dosing is calculated based on the patient’s body weight (mg/kg). Treatment duration is highly variable, ranging from short-term courses of a few weeks to long-term suppressive protocols lasting several months or more.

Recent Clinical Evidence

Research evidence / Overview of Studies for Funazol

This section details the types of studies available, the specific patient groups and outcomes that research has measured, and where evidence may still be limited or uncertain. This information is strictly descriptive of the research landscape and does not constitute medical advice or treatment recommendations.


Evidence for Systemic and Central Nervous System Fungal Infections

Research for serious, invasive fungal conditions, such as Systemic Candidiasis and Cryptococcal Meningitis, relies heavily on high-quality Randomized Controlled Trials (RCTs). These studies focused on outcomes such as all-cause mortality (survival rates) and the achievement of laboratory biomarkers, including mycological eradication (a measurement of fungal clearance from the bloodstream or CSF). Populations examined included critically ill adults, non-neutropenic adults, and pediatric patients. For Cryptococcal Meningitis, observation periods were extended, often spanning many years in long-term cohort studies to track relapse frequency.


Evidence for Mucosal and Superficial Fungal Infections

The research base for localized conditions like Mucosal Candidiasis and Vaginal Candidiasis involved various RCTs and comparative studies. These trials often included comparisons between Funazol and topical treatments. Studies were designed to examine outcomes related to physical discomfort and inflammation, measuring the achievement of clinical resolution of physical symptoms and mycological cure rates. For tinea unguium (nail infection), studies monitored changes in nail appearance or mycological status over time. Data on long-term outcomes following repeated therapy for mucosal infections are often heterogeneous.


Evidence for Prophylaxis (Preventive Use) in High-Risk Patients

The use of Funazol in the prophylaxis research context was evaluated in highly controlled, often placebo-controlled RCTs. The studies focused specifically on patient groups at a significantly high risk of developing an invasive fungal infection, such as those undergoing bone marrow or stem cell transplants. The primary outcome studied was the incidence of invasive fungal infection (IFI), alongside survival measured during the study period. The evidence mainly reports findings related to the prevention of Candida species; research comparing outcomes against certain mold infections is a continuous area of study.


What Is Still Uncertain About Funazol's Research Base

The research provides context regarding group patterns but addresses areas where certainty remains low. Research is ongoing regarding the clinical significance of finding non-Candida albicans species, which may show varying susceptibility to Funazol. In some specialized studies, sample sizes were modest, meaning subgroup findings are uncertain, and data for certain patient cohorts remain insufficient. Additionally, the evidence for research exploring Cryptococcal infections at sites outside the central nervous system (e.g., in the lungs) is limited.

Frequently Asked Questions (FAQ)

Common questions about Funazol (FAQ)


Q: What is Funazol used for besides its main purpose?

A: Official prescribing information describes Funazol (Fluconazole) as being indicated for treating multiple types of infections caused by fungi, including vaginal, oropharyngeal, and esophageal candidiasis. It is also used to treat more serious systemic candidiasis and cryptococcal meningitis, and for preventing fungal infections in high-risk patients (prophylaxis).

Q: How quickly does Funazol start working?

A: The speed at which Funazol works can vary depending on the condition being treated. For example, in the case of vaginal candidiasis, the median time reported for the beginning of symptom relief after a single dose is one day. The full time required for recovery depends on the specific infection and its severity.

Q: What happens if I miss a dose of Funazol?

A: If a dose is missed, patients should talk with a healthcare provider immediately. Official patient information advises that a provider will determine whether the patient should take the missed dose or skip it and continue with the next scheduled dose. Patients are generally advised not to take two doses to make up for a missed dose.

Q: Can Funazol be taken with pain relievers like ibuprofen?

A: Regulatory data indicates that taking Funazol alongside ibuprofen, a common nonsteroidal anti-inflammatory drug (NSAID), may increase the systemic exposure of the pain reliever. In these situations, monitoring for adverse effects such as stomach discomfort or gastrointestinal bleeding is described in clinical practice.

Q: Does Funazol cause weight gain?

A: Weight gain is not explicitly listed as either a common or uncommon side effect in regulatory documents such as the Summary of Product Characteristics (SmPC). Rarely reported side effects related to metabolism, such as a decrease in appetite (anorexia), have been noted.

Q: Is it common to feel tired while taking Funazol?

A: Some neurological and general side effects have been reported in official product information, including fatigue, a general feeling of discomfort (malaise), and somnolence (drowsiness). As with any persistent or severe change, these symptoms are often reviewed with a healthcare provider if they occur.

Q: Can older people use Funazol safely?

A: Funazol is addressed in the regulatory documents for use in older patients (65 years and older). Normal dosage recommendations generally apply to older patients who have healthy kidney function. Dosage adjustments, however, are required if the patient has impaired kidney function.

Q: How long after starting Funazol will I see results?

A: The time it takes to see results varies depending on the type and severity of the infection. Studies have shown that for certain acute infections, patients may notice symptom relief beginning within about one day after starting treatment, but full resolution takes longer.

Q: How does Funazol interact with birth control pills?

A: Official studies indicate that low daily doses of Funazol (Fluconazole) do not significantly affect the systemic exposure of the estrogen and progestin components found in most oral contraceptives. Higher doses may result in a small increase in the exposure of these components.

Q: Is it okay to stop taking Funazol once I feel better?

A: Official information emphasizes that the full course of therapy must be continued until laboratory tests or clinical examination confirm the fungal infection is completely gone. Stopping treatment early may lead to the fungal infection coming back (recurrence).

Q: Can Funazol be cut in half or crushed?

A: Regulatory instructions state that Funazol capsules should be swallowed whole. The oral suspension must be measured using a calibrated device after being shaken well. There are no official instructions that permit cutting or crushing the tablets or capsules.

Q: Are there any long-term side effects associated with Funazol?

A: For patients on prolonged therapy, long-term clinical experience has included reports of effects such as hair loss (alopecia) and dry skin, which are typically reversible upon stopping the medication. The long-term potential for serious side effects, such as liver or heart rhythm problems, is managed through ongoing monitoring by a healthcare provider.

Q: What should I do if I experience a mild side effect from Funazol?

A: Official patient information generally references the importance of contacting a healthcare provider if any side effects become severe, worsen, or do not go away. For mild side effects, such as nausea, official patient information often refers patients to general strategies described in the Administration section, such as taking the dose with food, to help manage the symptom.

Q: What time of day is Funazol usually taken?

A: The official product information advises that Funazol should be taken at the same time each day to maintain consistent drug levels in the body. It may be taken with or without food.

Q: Is there a generic version of Funazol available?

A: Yes. Funazol is a brand name for the active ingredient, Fluconazole, which is available through generic formulations. This means different manufacturers may produce and market the same active medicine.

Q: How long does Funazol stay in my system after the last dose?

A: According to the official pharmacokinetics data, the plasma elimination half-life of Funazol (Fluconazole) is approximately 30 hours. This means it takes roughly 30 hours for half of the drug to be eliminated from the body.

Q: Can I take Funazol if I have diabetes?

A: Official warnings and precautions state that Funazol should be used with caution in patients who have diabetes. This is because the medication has been associated with changes in blood glucose levels in some cases, and regulatory warnings mention that specialized monitoring of blood sugar may be utilized during treatment.

Q: Where can I find the official prescribing information for Funazol?

A: The complete, official prescribing information (drug label) for Funazol (Fluconazole) can be accessed on government-operated health websites. These include sites maintained by regulatory bodies such as the FDA's DailyMed in the United States or the EMA's Summary of Product Characteristics (SmPC) in Europe.

Q: Why is it important to complete the full course of Funazol?

A: Official documents stress that the full duration of treatment must be completed to ensure the fungal infection has been fully suppressed and removed. Taking an inadequate course of treatment may leave some pathogens remaining, which can lead to a return of the active infection (recurrence).

Q: Is Funazol a controlled substance?

A: Regulatory classifications indicate that Funazol (Fluconazole) is not classified as a controlled substance under the U.S. Controlled Substances Act.

Q: Is the name Funazol a brand name or generic name?

A: Funazol is typically a brand name used for the active ingredient, which is known by the generic name Fluconazole. Generic drugs contain the same active ingredient as their brand-name counterparts.

Q: Do I need to avoid any specific foods or drinks while on Funazol?

A: Official regulatory warnings advise patients to avoid or limit alcohol intake while taking Funazol due to the risk of liver damage. Otherwise, Funazol can be taken with or without food, as its absorption is not affected by food.

Q: What is the maximum amount of time Funazol can be used?

A: The treatment duration is highly individualized based on the infection being treated. While short courses exist, treatment for certain conditions, such as long-term suppressive protocols (e.g., to prevent the recurrence of meningitis), may be continued for years as determined by a healthcare professional.

Q: Does Funazol interact with common supplements like vitamin D?

A: Funazol is known to inhibit certain liver enzymes (CYP2C9, CYP2C19, and CYP3A4) that are responsible for breaking down many substances, including some supplements. Patients should inform their doctor of all supplements and vitamins they take, as an interaction may occur that changes drug levels.

Q: Are there studies on Funazol use in younger children?

A: Yes, regulatory documents provide specific dosing regimens that apply to newborns and infants. This includes detailed guidelines for term newborn infants (0 to 14 days old) and infants from 15 to 27 days old, with dosage calculated based on body weight.

Q: Will Funazol make my other medications less effective?

A: Funazol most commonly increases the concentration of other drugs by slowing their breakdown. However, regulatory documents specifically note that co-administration with Rifampicin significantly reduces the systemic exposure of Funazol itself, potentially making the antifungal treatment less effective.

Q: Can Funazol interact with herbal teas?

A: Because Funazol interacts with certain liver enzymes, patients should disclose the use of all herbal products to their healthcare provider, including herbal teas. Some herbs, such as St. John's Wort, are known to alter how the body processes medicines.

Q: Can Funazol be taken with multivitamins?

A: Regulatory information advises informing a doctor of all supplements and vitamins. While there is no universal warning against all multivitamins, Funazol may interact with certain components or minerals in these supplements. Patients should confirm with their doctor how their specific multivitamin may be affected.

Q: Are there different strengths or dosages available for Funazol?

A: Yes. Official product information lists that Funazol (Fluconazole) is available in multiple tablet strengths, including 50 mg, 100 mg, 150 mg, and 200 mg. The oral liquid suspension is also available in two different concentrations (10 mg/mL and 40 mg/mL).

Q: What happens if Funazol expires?

A: Official disposal guidelines advise that expired medicine should be properly discarded, typically using a community drug take-back program. Expired Funazol cannot guarantee its stated strength or efficacy and should not be used.

How should Funazol be stored and disposed of?

️ Storage Guidelines

Funazol (Fluconazole) tablets and dry powder for oral suspension should be stored at controlled room temperature, generally not exceeding 30 C (86 F). The medication must be kept in its original, tightly closed container and protected from freezing and excessive heat.

Formulation Recommended Storage Temperature
Tablets / Dry Powder Below 30 C (86 F)
Reconstituted Suspension 5 C to 30 C (41 F to 86 F)

Note that the liquid suspension, once mixed, must typically be discarded after 14 days. Always check the specific instructions on the packaging. Keep Funazol and all medicines out of the reach of children and pets.

Disposal of Unused Medicine

The most recommended method for disposing of unused or expired Funazol is to utilize a community drug take-back program or a disposal kiosk offered by certain pharmacies. If these options are not readily available, most medicines (excluding those on a specific flush list) can be disposed of in your household trash by mixing them with an undesirable substance like used coffee grounds or cat litter. This mixture should then be placed in a sealed bag or container to prevent leakage before disposal. Always scratch out all personal information on the prescription label before discarding the container.

Attention! Always consult to a doctor or pharmacist before using pills or medicines.

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