Fucid

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Medically reviewed

Rosario Oropesa

Last updated on 22/12/2025

This page provides general, reference-level information compiled from official medical sources. It is not a substitute for professional medical advice, diagnosis, or treatment. For decisions about your health, please consult a qualified healthcare professional.

Overview of Fucid

Property Description
Active ingredient Fusidic Acid (Acidum fusidicum)
Pharmacological Class Antibiotic (Steroid Antibacterial)
Common Forms Cream, Ointment, Eye drops, Tablet, Gel
Origin Semi-synthetic (derived from Fusidium coccineum)
Mechanism Type Bacteriostatic

What Type of Medicine Is Fucid and What Is Its Active Ingredient?

Fucid is a pharmaceutical preparation whose core active constituent is the potent antimicrobial substance, Fusidic Acid. It is classified as a prescription-only antibiotic and a bacteriostatic agent used to halt the growth of susceptible bacteria. Fucid is a specific trade name for formulations containing this ingredient, sharing the same core chemical entity as analogues like Fucidin.

Structurally, Fusidic Acid belongs to a unique pharmacological grouping known as steroid antibacterials, distinguishing it from common antibiotic types. This semi-synthetic compound was originally derived from the fungus Fusidium coccineum. Fusidic Acid maintains high effectiveness against the majority of Staphylococcal strains. This profile, characterized by its targeted efficacy against specific Gram-positive bacteria, makes it a viable option where resistance to other agents may be a concern.

Fusidic Acid Forms and General Therapeutic Purpose

The medicine containing Fusidic Acid is manufactured in diverse dosage forms to accommodate both topical (e.g., skin and ocular) and systemic applications, depending on the site of infection. These preparations commonly include a cream, ointment, eye drops, gel, and tablet, enabling various routes of administration.

The general therapeutic purpose of Fucid is fundamentally to control and clear up bacterial infections, with the drug displaying high potency against Gram-positive organisms, most notably various Staphylococcal infections. For instance, it is often utilized for managing localized skin infections. By reducing the bacterial load through its bacteriostatic action, the drug provides relief and aids the patient's immune system in resolving the underlying condition.

What side effects are possible with Fucid?

Official Safety Profile of Fusidic Acid

The safety profile of Fusidic Acid, the active ingredient in Fucid, is classified by frequency and the body system affected, based on official regulatory documents. Adverse reactions are grouped into categories ranging from Common to Rare.

Adverse Reactions by Frequency and System

Classification Topical Use (Skin/Ocular) Systemic Use (Oral/IV)
Common (1% to <10%) Application site reactions (pain, irritation, pruritus) Gastrointestinal disturbances (vomiting, diarrhea, nausea)
Uncommon (0.1% to <1%) Dermatitis, rash, hypersensitivity Headache, somnolence, skin reactions (e.g., urticaria)

System-Organ Classes involved include Skin and Subcutaneous Tissue Disorders and Immune System Disorders for both forms, and Hepatobiliary Disorders (e.g., jaundice, hepatic failure) for systemic use.

Serious Adverse Reactions and Restrictions

Regulatory documents highlight rare but clinically important events. For systemic Fusidic Acid, these include Anaphylactic Shock and severe Hepatobiliary Disorders like cholestatic jaundice. A critical safety restriction is the contraindication of systemic use with statins (HMG-CoA reductase inhibitors) due to the risk of severe muscle breakdown, Rhabdomyolysis.

Safety notes for specific populations include required caution and liver function monitoring in individuals with pre-existing hepatic impairment. Exposure-related patterns indicate that documented liver enzyme changes are often reversible following the withdrawal of systemic treatment.

Overdose and Emergency Response

Fucid Overdose and When to Seek Help

The official overdose profile for Fusidic Acid (Fucid) is structured around the formulation type and the necessary emergency response. Overdose from topical Fucid (cream or ointment) is classified as unlikely to occur due to its low systemic absorption. However, acute overdose following systemic (oral) exposure is officially documented in regulatory sources to present with gastrointestinal disturbances.

Regulatory warnings define a specific population consideration: accidental ingestion of a full tube of the topical cream may exceed the approved total daily oral dose for children aged less than 1 year and weighing le 10 kg.

The government-mandated action is to seek immediate medical attention for any suspected overdose or accidental ingestion. Individuals must contact a healthcare professional, hospital emergency department, or Poison Control Centre immediately, even if there are no symptoms present.

Management of an overdose is officially directed toward symptomatic and supportive treatment. The official prescribing information explicitly states that dialysis will not increase the clearance of fusidic acid from the body, reinforcing the focus on supportive care in the absence of a specific documented antidote.

Therapeutic Uses of Fucid

What Fucid Treats: Main Uses and Benefits

Fucid is commonly used to help with conditions presenting with systemic or localized discomfort, primarily those affecting the skin and eyes. The medication is commonly used across conditions characterized by periods of heightened symptoms where bacterial causes are relevant.


The medication is commonly used to help with conditions presenting with acute or disruptive episodes where symptoms cluster into patterns requiring supportive management, such as those seen in certain skin infections. It is also relevant in situations where conditions involving inflammatory or irritative processes become complicated by a bacterial cause. Fucid helps to address symptoms that become more disruptive during flare-ups, such as weeping, crusty sores, and pustules, which may assist in easing the overall symptom load during periods of symptomatic discomfort.

Fucid is also applied across domains where additional symptomatic support is needed to address conditions presenting with acute or disruptive episodes affecting the eye structures. The systemic form may be part of symptomatic management for certain infections that create noticeable physiological strain, such as specific bone or joint infections.


Quick Fact: Supportive management for symptoms related to inflammatory or irritative states

Fucid may be part of symptomatic management when symptoms interfere with daily functioning, which helps improve day-to-day comfort during symptomatic periods.

Eligibility and Restrictions for Use

The eligibility profile for Fucid is defined strictly by health authority regulatory classifications. Adults and children are generally eligible for use across most formulations. Pediatric use is established, with systemic forms approved for infants as young as one year of age.


The medicine must not be used in certain populations. An absolute contraindication exists for individuals with known hypersensitivity to Fusidic Acid or any of its excipients. Furthermore, the use of systemic Fucid is formally contraindicated in patients simultaneously taking specific cholesterol-lowering medicines (statins) due to regulatory warnings.


Eligibility is restricted for patients with hepatic dysfunction when using the systemic form, requiring caution and monitoring. For topical Fucid, use is generally permitted during pregnancy and breastfeeding; however, application on the breast should be avoided while nursing. Systemic use during pregnancy is preferable to avoid as a precautionary measure. Regulatory documentation may also classify the use of specific formulations in older adults as not authorized due to a lack of available data.

What should I know about interactions with other medicines?

Interactions with other medicines and products

Official regulatory information for systemic Fucid (Fusidic Acid) defines several significant interaction patterns, primarily impacting co-administered medicines through altered body exposure.

Documented Interaction Restrictions

Classification Interacting Agents Official Restriction and Outcome
Contraindicated Statins (HMG-CoA reductase inhibitors), including Simvastatin and Atorvastatin. Co-administration is formally prohibited due to the severe risk of rhabdomyolysis.
Clinically Significant HIV Protease Inhibitors (e.g., Ritonavir, Saquinavir). May cause increased plasma concentrations of both agents, leading to a documented risk of hepatotoxicity.
Clinically Significant Oral Anticoagulants (Coumarin derivatives). May alter the anticoagulant effect, requiring monitoring for changes in efficacy.

Timing and Population-Specific Notes

Statin therapy must be discontinued throughout Fucid treatment and for a mandatory seven-day period after the final dose of systemic Fucid. Patients with hepatic dysfunction require caution, and liver function should be monitored during treatment. For topical applications of Fucid (cream, ointment, eye drops), there are generally no known problematic interactions with other medicines, herbal remedies, or supplements. The interactions listed above are primarily relevant to systemic use.

Mechanism of Action

The action of Fusidic Acid (Fucid) is defined by its highly specific interference with the bacterial cell's core machinery for growth and replication. The drug's mechanism is purely bacteriostatic, causing the cessation of growth in susceptible organisms.

Fusidic Acid targets the bacterial Elongation Factor G (EF-G), a critical enzyme located on the 50S ribosomal subunit. By binding to EF-G, the drug prevents its necessary release after it performs its function in the protein-building process. This molecular interference halts the polypeptide chain elongation by preventing the ribosome from moving along the genetic code, resulting in the arrest of bacterial growth and proliferation.

The drug's mechanism is highly selective, exploiting the structural differences between prokaryotic (bacterial) and eukaryotic (human) EF-G, resulting in high selective toxicity. This mechanism is constrained by genetic factors, as mutations in the bacterial fusA gene or the presence of resistance proteins like fusB can override the drug's trapping effect, resulting in functional restoration of the protein synthesis pathway.

Dosage and Administration Information

Fucid (Fusidic Acid) is administered through several routes, which are dictated by the specific formulation: Oral (tablets or suspension), Intravenous (IV) (infusion), Topical (cream or ointment), and Ophthalmic (drops or gel). These routes define whether the medicine is used systemically or locally.

Systemic administration, used for more extensive infections, follows a fixed schedule. The standard adult total daily dose for oral or IV use is 1,500 mg of sodium fusidate, which is to be taken in three equal divided doses (TID). For the management of severe systemic infections, the total daily dose may be increased up to 3,000 mg. This fixed frequency establishes a pattern for systemic exposure.

The medicine requires specific procedural adherence for certain routes. The IV infusion must be performed slowly, taking at least two hours to complete, and the concentrate must be properly diluted prior to administration. Topical use involves applying the cream or ointment multiple times daily; however, this frequency may be reduced (e.g., to once daily) when an occlusive gauze dressing is applied over the treated area.

Specific population rules are defined, notably that no dosage adjustment is generally necessary for patients with impaired renal function, reflecting the primary non-renal elimination pathway. If a dose is missed, a patient must not take a double dose to compensate.

Recent Clinical Evidence

Research Evidence for Fucid (Fusidic Acid)


Evidence for Use in Localized Skin Infections (Topical Fucid)

The research exploring Fucid for skin conditions like impetigo relies primarily on short-term Randomized Controlled Trials (RCTs) and Systematic Reviews that analyze results from many studies. These research efforts were used in contexts exploring how symptoms change over time and focused on outcomes related to physical discomfort. Studies monitored how symptoms evolved in the observed populations, with researchers measuring the disappearance of crusts and lesions (clinical cure) and the elimination of the causative Staphylococcus aureus bacteria (bacteriological cure).

What remains uncertain is the long-term follow-up data; follow-up durations were limited, meaning there is limited information regarding outcomes after the treatment period concludes, such as the pattern of infection return. Research has examined the impact of the medicine in areas where the bacteria have developed resistance to this specific agent, and findings indicate that resistance status was a factor tracked in the observed outcomes.


Evidence for Use in Acute Eye Infections (Ocular Fucid)

Fucid eye preparations was studied for acute infectious conjunctivitis, conditions associated with acute or disruptive episodes affecting the eye. The evidence base includes controlled clinical trials where the ophthalmic solution was evaluated in patients with red eyes and discharge. Researchers monitored how symptoms like discharge and redness evolved in the observed populations, and the trials included comparisons against a non-active solution (placebo) or other approved eye antibiotics.

Studies reported on the evolution of symptoms in the observed populations, and the patterns of recovery were monitored, often separately for patients whose bacterial infection was confirmed. Certainty remains low in some areas because a number of the existing RCTs have methodological concerns, such as small sample sizes or lack of full blinding.


What Remains Uncertain and Gaps in the Research

A key uncertainty that research continues to examine relates to bacterial resistance. Studies have monitored the development and spread of bacterial resistance to Fusidic Acid, and research describes how resistance patterns were tracked as a factor in the study results. For the systemic treatment of severe infections, the contribution of Fucid alone is challenging to isolate from the companion drug it is almost always paired with in clinical trials.

Key Studies & References

  1. Recommendations | Impetigo: antimicrobial prescribing | Guidance - NICE (NG153)
  2. Public Assessment Report Scientific discussion Fusidinezuur Basic Pharma 20 mg/g cream (Regulatory Document)

Frequently Asked Questions (FAQ)

Common questions about Fucid (FAQ)


Q: Does Fucid require a prescription in most places?

Fucid (fusidic acid) is classified differently depending on the country and specific formulation. While some countries may allow certain low-strength products to be sold over the counter, in many regions, topical Fucid is classified as a prescription-only medication.


Q: Can Fucid be used for non-bacterial skin issues?

No, Fucid is an antibiotic and is intended only to treat infections caused by susceptible bacteria. Official product information indicates that it is not effective against skin conditions caused by viruses, fungi, or other non-bacterial causes.


Q: Are there generic versions of Fucid available?

Yes, the active ingredient in Fucid is fusidic acid. This ingredient is well-established and is available globally under multiple brand names and generic preparations. The availability of generic alternatives depends on local regulatory approvals in your region.


Q: Is Fucid safe to use near the eyes or mouth?

When applying Fucid cream or ointment, application near the eyes and other mucous membranes, such as the mouth or genital area, must be avoided as irritation may occur. There are specific ophthalmic (eye) formulations of fusidic acid available for eye infections.


Q: Can Fucid treat fungal or viral infections?

Fucid is an antibacterial medication and will only treat bacterial infections. According to official product information, it is not effective against infections caused by fungi or viruses.

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Q: Does Fucid work on MRSA (general information)?

Fusidic acid is generally effective against Staphylococcus aureus, which includes many MRSA strains. However, official information notes that bacterial resistance to fusidic acid has been reported, meaning its effectiveness can depend on the specific resistance pattern of the bacteria in question.


Q: What are the long-term side effects associated with Fucid?

Official documents highlight that extended or recurrent use of topical antibiotics like Fucid may carry an increased risk of developing antibiotic resistance and a localized hypersensitivity reaction called contact sensitization.


Q: Is Fucid safe for use on newborns (general query)?

Most adults and children are generally eligible for Fucid cream, ointment, and eye drops. The use of systemic formulations in newborns and very young infants is associated with a need for particular caution according to regulatory information.


Q: What should I do if I accidentally swallow a small amount of Fucid?

Regulatory information indicates that accidental ingestion of a small amount of the cream or ointment is generally considered unlikely to cause serious harm. If serious symptoms occur following ingestion, contact a healthcare professional or poison control center.


Q: Can Fucid make a bacterial infection worse initially?

Official product monographs advise that if the infection worsens or does not improve within a few days of starting treatment, this may signal that the bacteria are not susceptible to Fucid. If the infection worsens or fails to improve, it is important to check with a healthcare professional before continuing use.


Q: Are there any dietary restrictions when using Fucid?

For the topical forms of Fucid (cream, ointment, eye drops), official sources indicate that there are generally no dietary restrictions. You can eat and drink as normal while using this medication.


Q: Is Fucid widely available globally?

Fusidic acid, the active ingredient in Fucid, is a widely established antibiotic. It is registered and used in many countries worldwide, including major regions like the UK, Canada, and Australia.


Q: Can I use Fucid on cracked or broken skin?

Fucid is indicated for treating primary skin infections, which can occur with cuts and broken skin. Regulatory documents indicate that while Fucid is used for skin infections, its application to extensive open wounds requires caution.


Q: Does Fucid interact with vitamins or herbal supplements?

Official safety data confirms that there are no known problematic interactions when using topical Fucid (cream, ointment, or eye drops) at the same time as taking vitamins, herbal remedies, or supplements.


Q: Are there specific body parts where Fucid should not be used?

Fucid cream or ointment must not be applied in or near the eye. Additionally, certain formulations (especially those containing a corticosteroid) may advise caution on sensitive areas like the face, skin folds, and genital areas.


Q: What is the maximum duration Fucid is usually prescribed for?

To minimize the risk of bacterial resistance, regulatory documents recommend that topical treatment should be limited. The typical course lasts one to two weeks, and therapy is typically limited to a maximum of 14 days at a time to minimize resistance risks.


Q: Can Fucid be used on insect bites or stings?

Fucid is prescribed to treat infections caused by susceptible bacteria. It may be indicated if an insect bite or sting has become secondarily infected with bacteria, but it does not treat the inflammatory reaction of the bite or sting itself.


Q: Is it common to see skin peeling after using Fucid?

The most common local reactions reported include application site pain, irritation, or rash. Skin peeling is not frequently listed in the official safety profile, though any unusual skin changes should be brought to a healthcare provider’s attention.


Q: What is the role of Fucid in managing eczema flare-ups (general question)?

Fucid treats bacterial skin infections, which can occur during an eczema flare-up (known as secondarily infected eczema). While it treats the bacterial component, Fucid does not treat the underlying eczema unless it is prescribed as part of a combination product that also contains a corticosteroid.


Q: Can Fucid be used in combination with pain relievers like ibuprofen?

Official information indicates that there are no known problematic drug interactions between topical Fucid (cream, ointment) and common over-the-counter pain relievers such as ibuprofen.


Q: Why is Fucid sometimes prescribed when other antibiotics failed?

Fusidic acid belongs to a distinct class of antibiotics called fusidanes. This unique pharmacological profile and its known high effectiveness against Staphylococcal strains mean it may be considered for bacteria that have shown resistance to other common antibiotic agents.


Q: Is Fucid effective against bacteria that cause folliculitis?

Yes, Fucid is officially indicated for the treatment of primary skin infections, which includes superficial folliculitis, provided the condition is caused by susceptible strains of bacteria like Staphylococcus aureus.


Q: How quickly does Fucid start to work for a skin infection?

Fucid works by stopping the growth and replication of susceptible bacteria. While studies track symptom progression, official documents do not typically specify an exact timeframe for clinical improvement. If an infection is susceptible to Fucid, improvement is typically observed within a few days.


Q: Can Fucid be used on the face?

Fucid is commonly used for localized bacterial skin infections, including those on the face. However, application near the sensitive areas of the eyes and other mucous membranes must be avoided.


Q: Is it normal to feel a slight burning sensation when first applying Fucid?

Official safety data lists application site reactions, such as pain, irritation, or rash, as common side effects. While a specific 'burning' sensation is not listed, these common reactions may include a temporary stinging or burning feeling at the site of application.


Q: Is Fucid suitable for children with skin infections?

Official eligibility profiles confirm that both adults and pediatric populations are generally suitable for Fucid use. It is commonly used in children for topical skin infections.


Q: Why do doctors often prescribe Fucid for specific types of wounds?

Fucid displays high potency against Gram-positive bacteria, particularly Staphylococcus aureus, which is a frequent cause of infection in wounds or cuts. Its targeted action makes it a suitable choice for treating localized bacterial wound infections.


Q: What are some signs that Fucid is not working for an infection?

Signs of a non-response include the infection not improving or appearing to worsen (e.g., increased redness or spread) after the first few days of use. If the infection is not improving, it is important to check with a healthcare professional before continuing or stopping the medication.


Q: What is the success rate of Fucid in clinical trials?

Clinical trials track the effectiveness of Fucid by measuring the physical clearing of lesions (clinical cure) and elimination of bacteria. While official documents confirm its effectiveness, they do not generally provide a single, fixed 'success rate' percentage, as outcomes vary by infection type and patient population.


Q: What is the typical duration of Fucid treatment for impetigo?

Fucid is a recognized treatment for impetigo. As with most topical antibiotic courses, regulatory guidance recommends that treatment should be limited, and the typical course lasts for one or two weeks.


Q: Can I use Fucid at the same time as a moisturizer?

Official product information is silent on the co-application of Fucid with general cosmetic products or moisturizers. However, regulatory documents do note that application frequency may be reduced if an occlusive dressing (like gauze) is used over the treated area.

How should Fucid be stored and disposed of?

How to Store and Dispose of Fucid?

Fucid (Fusidic Acid) must be stored and disposed of according to official regulatory labeling to ensure product integrity and environmental safety.

Official Storage Requirements

Condition Requirement
Temperature Store at room temperature, typically not exceeding 25 C or 30 C.
Protection Keep away from moisture, direct light, and freezing. Keep containers tightly closed.
Child Safety Keep this medicine out of the sight and reach of children.
Stability (In-Use) The topical cream/ointment must generally be discarded 4 weeks (28 days) after the first opening. Do not use after the expiry date.

Disposal Mandates

Do not throw away any medicines via wastewater or household waste. Unused or expired product must be disposed of in accordance with local environmental and pharmaceutical waste requirements. Consult a pharmacist for specific local instructions.

Attention! Always consult to a doctor or pharmacist before using pills or medicines.

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