Components:
Medically reviewed by Kovalenko Svetlana Olegovna, PharmD. Last updated on 28.04.2022
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Removal of foreign bodies and sutures, and for tonometry: 1 to 2 drops (in single instillations) in each eye before operating.
Deep ophthalmic anesthesia: 2 drops in each eye at 90 second intervals for 3 instillations.
NOTE: The use of an eye patch is recommended.
How supplied
Fluorescein; Benoxinate (Fluorescein (Fluorescein; Benoxinate) and benoxinate) is supplied as 5 mL contained in a 10 mL plastic bottle with a separate sterile dropper applicator. (NDC 17478-640-10)
Storage
Refrigerate at 2°-8°C (36°-46°F). User may store at room temperature for up to one month. Protect from light. Keep tightly closed.
Akorn Inc., Buffalo Grove, IL 60089. Rev 5/04
Topical application on mucous membranes, exposure to sunlight, hypersensitivity. Depressed bone marrow function, poor nutritional status, potentially serious infections. Pregnancy and lactation.
The metabolism of ester-type local anaesthetics may be inhibited by anticholinesterases, increasing the risk of systemic toxicity.
Ester derivatives such as tetracaine, benzocaine, or procaine that are hydrolysed to para-aminobenzoic acid may antagonise the activity of aminosalicylic acid or sulfonamides. Ester-type local anaesthetics such as procaine and cocaine that are hydrolysed by plasma cholinesterase may competitively enhance the neuromuscular blocking activity of suxamethonium; the amide local anaesthetic, lidocaine may have a similar effect.
There is an increased risk of myocardial depression when amide-type local anaesthetics such as bupivacaine, levobupivacaine, lidocaine, or ropivacaine are given with antiarrhythmics.
If local anaesthetics containing adrenaline are given for epidural or paracervical block during labour the use of an oxytocic drug post partum may lead to severe hypertension. Although there is no clinical evidence of dangerous interactions between adrenaline-containing local anaesthetics and MAOIs or tricyclic antidepressants, great care should nevertheless be taken to avoid inadvertent intravenous doses of the local anaesthetic preparation.
Occasional temporary stinging, burning and conjunctival redness have been reported after use of ocular anesthetics, as well as a rare, severe, immediate-type, apparent hyper-allergic corneal reaction, with acute, intense and diffuse epithelial keratitis, a gray, ground glass appearance, sloughing of large areas of necrotic epithelium, corneal filaments and sometimes, iritis with descemetitis.
Allergic contact dermatitis with drying and fissuring of the fingertips has been reported.
TO REPORT SUSPECTED ADVERSE REACTIONS, contact Altaire Pharmaceuticals, Inc., at 1-800-258-2471 or FDA at 1-800-FDA-1088 or www.fda.gov/medwatch.
Fluorescein; Benoxinate is the name of a local anesthetic, which is used especially in ophthalmology and otolaryngology. Fluorescein; Benoxinate binds to sodium channels and reversibly stabilizes the neuronal membrane which decreases its permeability to sodium ions.