Floradix

A member of the vitamin B family that stimulates the hematopoietic system. It is present in the liver and kidney and is found in mushrooms, spinach, yeast, green leaves, and grasses (poaceae). Folic Acid (Floradix) is used in the treatment and prevention of folate deficiencies and megaloblastic anemia. [PubChem]

Each 5 mL syrup contains: Diastase (1:50) 135 mg, pepsin 50 mg, papain BPC 50 mg, vitamin B₁ 5 mg, vitamin B₂ 2 mg, vitamin B₆ 2 mg, vitamin B₁₂ 5 mcg, calcium pantothenate 1 mg and nicotinamide 20 mg.

Iron (Floradix) is a pleasantly flavoured syrup, containing digestive enzymes and vitamins of the B-complex group. Abdominal cramps, flatulence, heartburn and nausea can occur as a result of indigestion. Iron (Floradix) is the ideal cure to facilitate digestion and to strengthen the GIT.

Iron (Floradix)'s balanced formulation provides an ideal supplementation that meets the demands and replenishes vitamins stores in the body.

3-((4-Amino-2-methyl-5-pyrimidinyl)methyl)-5-(2- hydroxyethyl)-4-methylthiazolium chloride.

Nutritional factor found in milk, eggs, malted barley, liver, kidney, heart, and leafy vegetables. The richest natural source is yeast. It occurs in the free form only in the retina of the eye, in whey, and in urine; its principal forms in tissues and cells are as flavin mononucleotide and flavin-adenine dinucleotide.

Vitamin B3 (Floradix) Lotion: Helps to reduce the appearance of blemishes on larger areas (back and upper chest). It absorbs easily to the skin and does not bleach clothes. Non-photosensitizing, fragrance-free and paraben-free.

Vitamin B3 (Floradix) Isocorrexion Hydrating Cream: Specially formulated for acne prone skin. Nicotinamide and Anti-Bacterial Adhesive substance (ABA's) helps to clear blemishes. Biophytosebum provides a moisturizing effect, reducing dryness and skin tightness caused by conventional acne treatment.

Vitamin B3 (Floradix) Oil-Free Cream: An oil-free formula enriched with mattifying agents. It helps to clear blemishes by promoting oil-free skin.

Vitamin B3 (Floradix) UV High Protection Cream SPF 45: Protects acne-prone skin from daily sun-induced irritation and damage, keeping the skin hydrated and blemish-free at the same time. Non-sensitizing, non-comodogenic, fragrance-free and paraben-free.

Vitamin B3 (Floradix) Gel: Provides intensive anti-blemish skin care for localized spots and promotes disappearance on the face or other small areas. It is non-sensitizing, fragrance-free and paraben-free.

Vitamin B3 (Floradix) Moussant Soap Free Cleansing Gel: Helps clear blemishes by purifying and cleansing the skin gently.

The 4-methanol form of vitamin B 6 which is converted to pyridoxal phosphate which is a coenzyme for synthesis of amino acids, neurotransmitters (serotonin, norepinephrine), sphingolipids, aminolevulinic acid. Although pyridoxine and Vitamin B 6 are still frequently used as synonyms, especially by medical researchers, this practice is erroneous and sometimes misleading (EE Snell; Ann NY Acad Sci, vol 585 pg 1, 1990).

urinary tract disorders

Folic Acid (Floradix) is used in the treatment and prevention of the folate deficiency state. It does not correct folate deficiency due to dihydrofolate reductase inhibitors. Folic Acid (Floradix) is also used in women of child-bearing potential and pregnant women to protect against neural tube defects in their offspring. It is also used for the treatment of folate-deficient megaloblastic anaemia, chronic haemolytic states such as thalassaemia major or sickle-cell anaemia.

Herbal Medicines.

- Traditionally used in disorders of the heart erethism adult (heart healthy).

Traditionally used in the symptomatic treatment of states neurotonic s, particularly in cases of minor disorders of sleep.

Film-Coated Tablet: Treatment of Iron (Floradix) deficiency. Prevention of Iron (Floradix) deficiency during pregnancy.

Syrup: All cases of Iron (Floradix) deficiency and Iron (Floradix) deficiency anaemia.

Drops: General: Hypochromic or masked Iron (Floradix) deficiency anaemias. General weakness. Convalescence. Blood losses. Tropical microcytic anaemia. Anaemias due to infections. For maintenance therapy in pernicious anaemia. As an adjuvant in treating chronically ill or undernourished patients.

Women: Iron (Floradix) deficiency due to menstruation. During and after pregnancy and lactation. Menorrhagia.

Children: All types of hypochromic anaemias and masked Iron (Floradix) deficiencies. Inappetence. Retarded growth. Weakness. Unsound dietary habits. To speed up restoration of depleted Iron (Floradix) reserves.

Obesity

Urtica Dioica (Floradix) is recommended for the treatment of obstructive symptoms of B.P.H such as:

urinary frequency, dribbling, hesitancy and so on.

Vitamin B1 (Floradix) deficiency

Vitamin B2 (Floradix) deficiency

Helps clear blemishes. Vitamin B3 (Floradix) Moussant Soap-Free Cleansing Gel Purifies & cleanses the skin. Vitamin B3 (Floradix) Oil-Free Cream Promotes oil-free skin. Vitamin B3 (Floradix) Isocorrexion Use for acne prone skin. Reduces skin dryness & tightness caused by conventional acne treatment. Vitamin B3 (Floradix) Lotion For body acne in chest & back. Vitamin B3 (Floradix) UV High Protection Cream SPF 45 For sun protection for acne prone skin. Vitamin B3 (Floradix) Gel For localized spots.

* Sideroblastic anaemia

* Treatment and prophylaxis of Vitamin B6 (Floradix) deficiency states

nutritional supplement for the sportmen, source of vitamins, treatment of digestive disorders and dyspepsia, may have laxative effect in high doses.

Vitamins are compounds that you must have for growth and health. They are needed in small amounts only and are usually available in the foods that you eat. Folic Acid (Floradix) (vitamin B 9) is necessary for strong blood.

Lack of Folic Acid (Floradix) may lead to anemia (weak blood). Your health care professional may treat this by prescribing Folic Acid (Floradix) for you.

Some conditions may increase your need for Folic Acid (Floradix). These include:

• Alcoholism
• Anemia, hemolytic
• Diarrhea (continuing)
• Fever (prolonged)
• Hemodialysis
• Illness (prolonged)
• Intestinal diseases
• Liver disease
• Stress (continuing)
• Surgical removal of stomach

In addition, infants smaller than normal, breast-fed infants, or those receiving unfortified formulas (such as evaporated milk or goat's milk) may need additional Folic Acid (Floradix).

Increased need for Folic Acid (Floradix) should be determined by your health care professional.

Some studies have found that Folic Acid (Floradix) taken by women before they become pregnant and during early pregnancy may reduce the chances of certain birth defects (neural tube defects).

Claims that Folic Acid (Floradix) and other B vitamins are effective for preventing mental problems have not been proven. Many of these treatments involve large and expensive amounts of vitamins.

Injectable Folic Acid (Floradix) is given by or under the direction of your health care professional. Another form of Folic Acid (Floradix) is available without a prescription.

Lowering blood pressure, improving circulation and treating symptoms of mild heart failure, decreasing the occurrence of chest pain, reducing atherosclerosis, and helping with trouble sleeping. Hawthorn (Floradix) will not stop an angina attack. It may have other uses as well. Check with your pharmacist for more details regarding the particular brand you use.

Hawthorn (Floradix) is an herbal product. It works by widening blood vessels, especially heart blood vessels, which results in increased heart blood flow.

Supplementing Iron (Floradix) in the diet and treating or preventing low levels of Iron (Floradix) in the blood. It may also be used for other conditions as determined by your doctor.

Iron (Floradix) suspension is a mineral. It works by providing Iron (Floradix) to the body.

Thiamine is Vitamin B1 (Floradix). Thiamine is found in foods such as cereals, whole grains, meat, nuts, beans, and peas. Thiamine is important in the breakdown of carbohydrates from foods into products needed by the body.

Thiamine is used to treat or prevent Vitamin B1 (Floradix) deficiency. Thiamine injection is used to treat beriberi, a serious condition caused by prolonged lack of Vitamin B1 (Floradix).

Thiamine taken by mouth (oral) is available without a prescription. Injectable thiamine must be given by a healthcare professional.

Thiamine may also be used for purposes not listed in this medication guide.

Riboflavin is Vitamin B2 (Floradix). Vitamins are naturally occurring substances necessary for many processes in the body. Riboflavin is important in the maintenance of many tissues of the body.

Riboflavin is used to prevent and to treat deficiencies of riboflavin.

Riboflavin may also be used for other purposes not listed in this medication guide.

Pyridoxine is Vitamin B6 (Floradix). Vitamins occur naturally in foods such as meat, poultry, nuts, whole grains, bananas, and avocados. Vitamin B6 (Floradix) is important for many processes in the body.

Pyridoxine is used to treat or prevent Vitamin B6 (Floradix) deficiency. It is also used to treat a certain type of anemia (lack of red blood cells). Pyridoxine injection is also used to treat some types of seizure in babies.

Pyridoxine taken by mouth (oral) is available without a prescription. Injectable pyridoxine must be given by a healthcare professional.

Pyridoxine may also be used for purposes not listed in this medication guide.

Usual Adult Dose for Megaloblastic Anemia

1 mg orally, intramuscularly, subcutaneously or IV once a day. May continue until clinical symptoms of folate deficiency and the hematological profile have normalized.

Usual Adult Dose for Folic Acid (Floradix) Deficiency

400 to 800 mcg orally, intramuscularly, subcutaneously or IV once a day.

Women of childbearing age, pregnant, and lactating women: 800 mcg orally, intramuscularly, subcutaneously or IV once a day.

Usual Pediatric Dose for Folic Acid (Floradix) Deficiency

Infant:

0.1 mg orally, intramuscularly, subcutaneously or IV once a day.

Child:

Less than 4 years: up to 0.3 mg orally, intramuscularly, subcutaneously or IV once a day.

4 years or older: 0.4 mg orally, intramuscularly, subcutaneously or IV once a day.

Usual Pediatric Dose for Vitamin/Mineral Supplementation

Recommended daily allowance (RDA):

Premature neonates: 50 mcg/day (15 mcg/kg/day).

Full-term neonates and infants 1 to 6 months: 25 to 35 mcg/day.

Children:

1 to 3 years: 150 mcg/day.

4 to 8 years: 200 mcg/day.

9 to 13 years: 300 mcg/day.

14 years and older: 400 mcg/day.

Renal Dose Adjustments

Data not available

Liver Dose Adjustments

Data not available

Dose Adjustments

Rarely, a dosage of 2 mg/day may be required, particularly in patients with malabsorption, alcoholism, chronic hemolysis, chronic exfoliative skin disease or who are on concomitant anticonvulsant therapy.

Dialysis

Folic Acid (Floradix) is removed by both hemodialysis and peritoneal dialysis. The amount removed varies with type equipment used.

Because folate may accumulate in patients with end-stage renal disease, side effects may be more likely in this patient who is undergoing dialysis. Once this patient's body stores of folate are replete, three times a week dosing may be just as beneficial as once daily dosing but should portend a lower risk of side effects.

Other Comments

The recommended daily allowance of Folic Acid (Floradix) for adult males and females ranges from 150 to 200 and 150 to 180 mcg/day, respectively.

There is a potential danger in administering Folic Acid (Floradix) to patients with undiagnosed anemia, since Folic Acid (Floradix) may obscure the diagnosis of pernicious anemia by alleviating the hematologic manifestations of the disease while allowing the neurologic complications to progress.

Severe megaloblastic anemia may require therapy for 4 to 5 weeks. Once stabilized, if dietary intake is inadequate, maintenance therapy can be started.

Film-Coated Tablet: Treatment of Iron (Floradix) Deficiency with Reduced Number of Red Blood Cells in Adults and Children over 12 Years: 1 to 3 tablets once daily or divided into separate doses for about 3 to 5 months.

After normalisation of the red blood pigment (haemoglobin) value, continue with 1 tablet once daily for several weeks. This will replenish the Iron (Floradix) stores.

Treatment of Iron (Floradix) Deficiency with Reduced Number of Red Blood Cells in Pregnancy: 2 to 3 tablets once daily or divided into separate doses.

After normalisation of the red blood pigment value, continue with 1 tablet once daily until, at least, the end of pregnancy. This will replenish the Iron (Floradix) stores and provide the increased amount of Iron (Floradix) required during pregnancy.

Treatment of Iron (Floradix) Deficiency with Normal Number of Red Blood Cells in Adults, Pregnancy, and Children over 12 years, and Prevention of Iron (Floradix) Deficiency in Pregnancy: 1 tablet once daily for 1 to 2 months.

Syrup:

Children: 5 mL 1 to 2 times daily before meals.

Infants: Begin with 2.5 mL daily and gradually increase to 5 mL daily.

Drops: Adults: 20 drops 2 to 3 times daily during or after a meal.

Children: 20 drops 1 to 2 times daily during or after a meal.

Infants: Begin with 6 drops daily and gradually increase to 20 drops daily.

Iron (Floradix) may be mixed with fruit, vegetable juices or other liquids if desired.

Best results are obtained by adequate dosage and regular administration. It is recommended that the therapy in conformity to the degree of Iron (Floradix) deficiency should be continued for at least 1 to 2 months.

Administration: Take Iron (Floradix) during or immediately after meal.

Duration of use depends upon the degree of Iron (Floradix) deficiency.

Do not discontinue sooner than recommended as this may reduce the success of therapy.

Vitamin B3 (Floradix) Lotion: Apply to the areas being treated after cleansing twice a day, AM & PM.

Vitamin B3 (Floradix) Isocorrexion & Vitamin B3 (Floradix) Oil-Free Cream: Apply to the face and affected areas (neck, chest and back) after cleansing twice a day, AM & PM. Massage delicately to facilitate absorption.

Vitamin B3 (Floradix) UV High Protection Cream SPF 45: Reapply every 2-3 hrs.

Vitamin B3 (Floradix) Gel: Apply small amount of gel on affected areas by massaging gently in AM & PM.

Vitamin B3 (Floradix) Moussant Soap Free Cleansing Gel: Apply in AM & PM to damp skin, face and affected areas (neck, chest and back) by massaging delicately. Rinse thoroughly and dry gently. May be used in shower.

See also:
What is the most important information I should know about Folic Acid (Floradix)?

Because it may mask the hematologic abnormalities while neurological damage progresses, Folic Acid (Floradix) should not be used in the therapy of patients with vitamin B12 deficiency of any cause, unless there is associated folate deficiency. The Folic Acid (Floradix) content of one tablet a day however, is unlikely to mask pernicious anemia should this condition be present. Also, pregnancy during pernicious anemia is very rare.

See also:
What is the most important information I should know about Hawthorn (Floradix)?

hypersensitivity to the ingredients.

See also:
What is the most important information I should know about Iron (Floradix)?

All cases of Iron (Floradix) overload and disturbances in utilization of Iron (Floradix).

Film-Coated Tablet: Allergy to Iron (Floradix) (III)-hydroxide polymaltose complex or any of the other ingredients of Iron (Floradix).

An Iron (Floradix) overload in the body.

Disturbed use of Iron (Floradix) by the body.

Reduced number of red blood cells (anaemia), not caused by Iron (Floradix) deficiency, such as due to increased red blood cell breakdown, vitamin B₁₂ deficiency.

See also:
What is the most important information I should know about Vitamin B1 (Floradix)?

Contraindications for Vitamin B1 (Floradix) (Vitamin B1 (Floradix))

Hypersensitivity to Vitamin B1 (Floradix) or any component of a product containing Vitamin B1 (Floradix).

See also:
What is the most important information I should know about Vitamin B2 (Floradix)?

None well documented.

Contraindications for Vitamin B3 (Floradix) (Vitamin B3 (Floradix))

Nicotinic acid is contraindicated in patients with a known hypersensitivity to any component of this medication; significant or unexplained hepatic dysfunction; active peptic ulcer disease; or arterial bleeding.

See also:
What is the most important information I should know about Vitamin B6 (Floradix)?

Contraindications for Vitamin B6 (Floradix) (Vitamin B6 (Floradix))

Vitamin B6 (Floradix) is contraindicated in those hypersensitive to any component of a Vitamin B6 (Floradix)-containing product.

hypersensitivity to the Yeast (Floradix).

Use Folic Acid (Floradix) as directed by your doctor. Check the label on the medicine for exact dosing instructions.

• Folic Acid (Floradix) may be administered as an injection by your health care professional.
• If you are using Folic Acid (Floradix) at home, carefully follow the injection procedures taught to you by your health care provider. If the medicine contains particles, is discolored, or if the vial is cracked or damaged in any way, do not use it.
• Do not reuse needles, syringes, or other materials. Dispose of properly after use. Ask your doctor, nurse, or pharmacist to explain local regulations for selecting an appropriate container and properly disposing of the container when full.
• If you miss a dose of Folic Acid (Floradix), use it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not use 2 doses at once.

Ask your health care provider any questions you may have about how to use Folic Acid (Floradix).

Use Hawthorn (Floradix) as directed by your doctor. Check the label on the medicine for exact dosing instructions.

• Dosing depends on the use and the source of the product.
• Use as directed on the package, unless instructed otherwise by your doctor.
• It may take 6 weeks for this product to work.
• This product should only be used on the advice of your doctor. Do not stop taking other heart medicine without checking with your doctor.
• If you miss taking a dose of Hawthorn (Floradix) for 1 or more days, there is no cause for concern. If your doctor recommended that you take it, try to remember your dose every day.

Ask your health care provider any questions you may have about how to use Hawthorn (Floradix).

Use Iron (Floradix) suspension as directed by your doctor. Check the label on the medicine for exact dosing instructions.

• Iron (Floradix) suspension is absorbed better on an empty stomach but may be taken with food if it upsets your stomach. Some foods (eg, eggs, whole grain breads, cereal, dairy products, coffee, tea) may decrease the amount of Iron (Floradix) absorbed by your body. Talk with your doctor about the best way to take Iron (Floradix) suspension with food if it upsets your stomach.
• Shake well before using.
• Use a measuring device marked for medicine dosing. Ask your pharmacist for help if you are unsure of how to measure your dose.
• Take Iron (Floradix) suspension with a full glass (8 oz [240 mL]) of water.
• Do not lie down for 30 minutes after taking Iron (Floradix) suspension.
• If you take an antacid, a bisphosphonate (eg, alendronate), cefdinir, eltrombopag, methyldopa, penicillamine, a quinolone antibiotic (eg, ciprofloxacin), or a tetracycline (eg, minocycline), ask your doctor or pharmacist how to take it with Iron (Floradix) suspension.
• If you miss a dose of Iron (Floradix) suspension, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Iron (Floradix) suspension.

Follow all directions on your prescription label. Do not use this medicine in larger or smaller amounts or for longer than recommended.

Pyridoxine tablets are taken by mouth. Injectable pyridoxine is injected into a muscle or into a vein through an IV. You may be shown how to use injections at home. Do not self-inject this medicine if you do not understand how to give the injection and properly dispose of used needles, IV tubing, and other items used to inject the medicine.

The recommended dietary allowance of pyridoxine increases with age. Follow your healthcare provider's instructions. You may also consult the Office of Dietary Supplements of the National Institutes of Health, or the U.S. Department of Agriculture (USDA) Nutrient Database (formerly "Recommended Daily Allowances") listings for more information.

Pyridoxine is only part of a complete program of treatment that may also include a special diet. It is very important to follow the diet plan created for you by your doctor or nutrition counselor. You should become very familiar with the list of foods you should eat or avoid to help control your condition.

Store at room temperature away from moisture and heat.

Folic Acid (Floradix) is the man-made form of folate. Folate is a B-vitamin naturally found in some foods. It is needed to form healthy cells, especially red blood cells.

Folic Acid (Floradix) supplements may come in different forms (such as L-methylfolate, levomefolate, methyltetrahydrofolate). They are used to treat or prevent low folate levels. Low folate levels can lead to certain types of anemia. Conditions that can cause low folate levels include poor diet, pregnancy, alcoholism, liver disease, certain stomach/intestinal problems, kidney dialysis, among others. Women of childbearing age should receive adequate amounts of Folic Acid (Floradix) either through their diet or supplements to prevent infant spinal cord birth defects.

How to use Folic Acid (Floradix)

Take this product by mouth with or without food as directed by your doctor, usually once daily. If you are taking the over-the-counter product, follow all directions on the product package. If you have any questions, ask your doctor or pharmacist.

Dosage is based on your medical condition and response to treatment. Do not increase your dose or take this product more often than directed.

Take this product regularly to get the most benefit from it. To help you remember, take it at the same time each day. Follow the diet plan recommended by your doctor or dietician. See also Notes section.

If your condition persists or worsens, or if you think you may have a serious medical problem, get medical help right away.

Hawthorn (Floradix) has been used for heart failure, chest pain (angina), and high blood pressure. You should see a doctor for these conditions before using this product.

Some herbal/diet supplement products have been found to contain possibly harmful impurities/additives. Check with your pharmacist for more details about the brand you use.

The FDA has not reviewed this product for safety or effectiveness. Consult your doctor or pharmacist for more details.

How to use Hawthorn (Floradix) Extract

Take this product by mouth as directed. Follow all directions and warnings on the product package. If you are uncertain about any of the information, consult your doctor or pharmacist.

If your condition persists or worsens, or if you think you may have a serious medical problem, seek immediate medical attention.

Vitamin B2 (Floradix) (riboflavin) supplementation is used to prevent and treat riboflavin deficiency. Vitamin B2 (Floradix) may prevent migraine headaches at high doses and be useful for prevention of eye conditions such as cataract, glaucoma and tired eyes (fatigue). Vitamin B2 (Floradix) is also used for boosting of immune system, and maintenance of healthy hair, skin, nails and mucous membranes.

Hypercholesterolaemia, hyperlipidemia, hypertriglyceridaemia, pellagra.

It is used for the treatment and prevention of Vitamin B6 (Floradix) deficiency. It is important for the breakdown of protein, fats, and carbohydrates from foods.

none known.

See also:
What other drugs will affect Folic Acid (Floradix)?

Medications that interfere with your bodys ability to use folate may also increase the need for this vitamin. Medications can interfere with folate utilization, including: anticonvulsant medications (such as phenytoin, and primidone) metformin (sometimes prescribed to control blood sugar in type 2 diabetes) sulfasalazine (used to control inflammation associated with Crohns disease and ulcerative colitis) triamterene (a diuretic) Methotrexate There has been concern about the interaction between vitamin B12 and Folic Acid (Floradix). Folic Acid (Floradix) supplements can correct the anemia associated with vitamin B12 deficiency. Unfortunately, Folic Acid (Floradix) will not correct changes in the nervous system that result from vitamin B12 deficiency. Permanent nerve damage could theoretically occur if vitamin B12 deficiency is not treated. Therefore, intake of supplemental Folic Acid (Floradix) should not exceed 1000 micrograms (g, sometimes mcg) per day to prevent Folic Acid (Floradix) from masking symptoms of vitamin B12 deficiency. It is important for older adults to be aware of the relationship between Folic Acid (Floradix) and vitamin B12 because they are at greater risk of having a vitamin B12 deficiency. If you are 50 years of age or older, ask your physician to check your B12 status before you take a supplement that contains Folic Acid (Floradix).

Before using this product, tell your doctor or pharmacist of all prescription and nonprescription/herbal products you may use, especially of: alpha blockers (e.g., prazosin), drugs to treat erectile dysfunction-ED or pulmonary hypertension (e.g., sildenafil, tadalafil), drugs to treat high blood pressure (e.g., beta blockers such as atenolol, calcium channel blockers such as diltiazem), heart medications (e.g., digoxin, nitrates such as isosorbide dinitrate).

Tell your doctor or pharmacist if you also take drugs that cause drowsiness such as: certain antihistamines (e.g., diphenhydramine), anti-seizure drugs (e.g., carbamazepine), medicine for sleep or anxiety (e.g., alprazolam, diazepam, zolpidem), muscle relaxants, narcotic pain relievers (e.g., codeine), psychiatric medicines (e.g., chlorpromazine, risperidone, amitriptyline, trazodone).

Check the labels on all your medicines (e.g., cough-and-cold products) because they may contain ingredients that could cause drowsiness. Ask your pharmacist about using those products safely.

Do not start, stop, or change the dosage of any medicine before checking with your doctor or pharmacist first.

This document does not contain all possible interactions. Therefore, before using this product, tell your doctor or pharmacist of all the products you use. Keep a list of all your medications with you, and share the list with your doctor and pharmacist.

Drug interactions were not noted and were not studied in clinical studies.

Feridex I.V. (ferumoxides injectable solution) administration provides elemental Iron (Floradix). In patients who are receiving supplemental Iron (Floradix) orally or parenterally, the dose of supplemental Iron (Floradix) may need to be decreased.

The effect of concomitant parenteral Iron (Floradix) on Feridex I.V. dosing is not known.

Laboratory Test Findings

Serum Iron (Floradix) levels may be above the normal range following Feridex I.V. (ferumoxides injectable solution) administration. Transient increases in serum Iron (Floradix) of 15–100% of baseline were observed 18 to 24 hours after Feridex I.V. (ferumoxides injectable solution) administration, and returned to normal in most patients by 7 days after administration. Increases in serum ferritin levels were seen 1 to 7 days after administration.

In a Phase 1 study in normal subjects, PTT was statistically significantly increased; however, all values were within the normal range and no subjects had a more than 40% increase from baseline. In clinical trials of patients who had baseline hematologic abnormalities associated with underlying liver disease, an effect of Feridex I.V. (ferumoxides injectable solution) on platelet or PTT was not demonstrated. In patients with low hematocrit and hemoglobin, over a period of 48 hours to 7 days after Feridex I.V. (ferumoxides injectable solution), the serum Iron (Floradix), the hematocrit and hemoglobin levels increase slightly.

See also:
What other drugs will affect Vitamin B1 (Floradix)?

Interactions for Vitamin B1 (Floradix) (Vitamin B1 (Floradix))

Loop Diuretics,

Oral Contraceptives, Stavudine, Tricyclic Antidepressants

See also:
What other drugs will affect Vitamin B2 (Floradix)?

Interactions for Vitamin B2 (Floradix) (Vitamin B2 (Floradix))

Alcohol - impairs the intestinal absorption of riboflavi

Antidepressants (tricyclics or phenothiazines) - requirements for riboflavin may be increased in patients receiving these medications

Probenecid - concurrent use decreases gastrointestinal absorption of riboflavin; requirements for riboflavin may be increased in patients receiving probenecid.

Interactions for Vitamin B3 (Floradix) (Vitamin B3 (Floradix))

Antihypertensive Therapy: Nicotinic acid may potentiate the effects of ganglionic blocking agents and vasoactive drugs resulting in postural hypotension

Aspirin: Concomitant aspirin may decrease the metabolic clearance of nicotinic acid. The clinical relevance of this finding is unclear

Other: Concomitant alcohol or hot drinks may increase the side effects of flushing and pruritus and should be avoided at the time of drug ingestion.

See also:
What other drugs will affect Vitamin B6 (Floradix)?

Interactions for Vitamin B6 (Floradix) (Vitamin B6 (Floradix))

Amiodarone: Concomitant use of Vitamin B6 (Floradix) and amiodarone may enhance amiodarone-induced photosensitivity reactions. Doses of Vitamin B6 (Floradix) greater than 5-10 milligrams/day should be avoided by those taking amiodarone Carbamazepine: Chronic use of carbamazepine may result in a significant decrease in plasma pyridoxal 5-phosphate levels Cycloserine: Cycloserine may react with pyridoxal 5-phosphate to form a metabolically inactive oxime, which may result in a functional Vitamin B6 (Floradix) deficiency Ethionamide: The use of ethionamide may increase Vitamin B6 (Floradix) requirements Fosphenytoin: High doses of Vitamin B6 (Floradix) may lower plasma levels of phenytoin. Fosphenytoin is a prodrug of phenytoin Hydralazine: The use of hydralazine may increase Vitamin B6 (Floradix) requirements Isoniazid: (isonicotinic acid, INH). Isoniazid reacts with pyridoxal 5-phosphate to form a metabolically inactive hydrazone, which may result in functional Vitamin B6 (Floradix) deficiency Levodopa: Concomitant use of levodopa and Vitamin B6 (Floradix) in doses of 5 milligrams or more daily may reverse the therapeutic effects of levodopa. Vitamin B6 (Floradix) does not reverse the therapeutic effects of levodopa if levodopa is taken concurrently with the levodopa decarboxylase inhibitor carbidopa. Levodopa is typically administered as a combination product with carbidopa

Oral contraceptives: The use of oral contraceptives may increase Vitamin B6 (Floradix) requirements. This was more the case with the older oral contraceptive agents with high-dose estrogen/progestin. It appears to be less the case with the newer low-dose estrogen/progestin products Penicillamine: Penicillamine may react with pyridoxal 5-phosphate to form a metabolically inactive thiazolidine, which may result in a functional Vitamin B6 (Floradix) deficiency Phenelzine: Phenelzine may react with pyridoxal 5-phosphate to yield a metabolically inactive hydrazone compound Phenobarbital: High doses of Vitamin B6 (Floradix) may lower plasma levels of phenobarbital Phenytoin: High doses of Vitamin B6 (Floradix) may lower plasma levels of phenytoin Theophylline: Theophylline may react with pyridoxal 5-phosphate leading to low plasma levels of the coenzyme. This may increase the risk of theophylline-induced seizures Valproic acid: Chronic use of valproic acid may result in a significant decrease in plasma pyridoxal 5-phosphate levels.

none known

See also:
What are the possible side effects of Folic Acid (Floradix)?

Allergic sensitization has been reported following both oral and parenteral administration of Folic Acid (Floradix).

Folic Acid (Floradix) is relatively nontoxic in man. Rare instances of allergic responses to Folic Acid (Floradix) preparations have been reported and have included erythema, skin rash, itching, general malaise, and respiratory difficulty due to bronchospasm. One patient experienced symptoms suggesting anaphylaxis following injection of the drug. Gastrointestinal side effects, including anorexia, nausea, abdominal distention, flatulence, and a bitter or bad taste, have been reported in patients receiving 15 mg Folic Acid (Floradix) daily for 1 month. Other side effects reported in patients receiving 15 mg daily include altered sleep patterns, difficulty in concentrating, irritability, overactivity, excitement, mental depression, confusion, and impaired judgment. Decreased vitamin B12 serum levels may occur in patients receiving prolonged Folic Acid (Floradix) therapy.

In an uncontrolled study, orally administered Folic Acid (Floradix) was reported to increase the incidence of seizures in some epileptic patients receiving phenobarbital, primidone, or diphenylhydantoin. Another investigator reported decreased diphenylhydantoin serum levels in folate-deficient patients receiving diphenylhydantoin who were treated with 5 mg or 15 mg of Folic Acid (Floradix) daily.

CALL YOUR DOCTOR FOR MEDICAL ADVICE ABOUT SIDE EFFECTS. YOU MAY REPORT SIDE EFFECTS TO THE FDA AT 1-800-FDA-1088 OR LEADING PHARMA, LLC AT 844-740-7500.

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What are the possible side effects of Hawthorn (Floradix)?

Nausea, stomach upset, dizziness, drowsiness, sweating, trouble sleeping, or headache may occur. If any of these effects persist or worsen, tell your doctor or pharmacist promptly.

Tell your doctor right away if any of these unlikely but serious side effects occur: fast/pounding heartbeat, shortness of breath, mental/mood changes (e.g., agitation).

A very serious allergic reaction to this drug is rare. However, seek immediate medical attention if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.

This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

In the US -

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch.

In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.

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What are the possible side effects of Iron (Floradix)?

Applies to carbonyl Iron (Floradix): suspension

Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Constipation; darkened or green stools; diarrhea; loss of appetite; nausea; stomach cramps, pain, or upset; vomiting.

Seek medical attention right away if any of these SEVERE side effects occur while taking carbonyl Iron (Floradix):

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); black or tarry stools; blood or streaks of blood in the stool; fever; severe or persistent nausea, stomach pain, or vomiting; vomit that looks like blood or coffee grounds.

Kelp (Floradix) can concentrate various heavy metals; auto-immune thrombocytopenic purpura and disordered erythropoiesis in a patient who had been taking Kelp (Floradix) tablets for 6 weeks was attributed to the arsenic content of the preparation.1

Clinical hyperthyroidism has also been reported in patients taking Kelp (Floradix)-containing preparations as part of a slimming regimen2 or a dietary supplement

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What are the possible side effects of Vitamin B1 (Floradix)?

Applies to thiamine: capsule, solution, tablet, tablet enteric coated

As well as its needed effects, thiamine (the active ingredient contained in Vitamin B1 (Floradix)) may cause unwanted side effects that require medical attention.

Major Side Effects

If any of the following side effects occur while taking thiamine, check with your doctor immediately:

Rare - Soon after receiving injection only

• Coughing
• difficulty in swallowing
• hives
• itching of skin
• swelling of face, lips, or eyelids
• wheezing or difficulty in breathing

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What are the possible side effects of Vitamin B2 (Floradix)?

Genitourinary

Yellow-orange discoloration of urine.

Allergic sensitization has been reported rarely following oral and parenteral administration of Vitamin B3 (Floradix).

At recommended doses, nicotinamide is expected to be well tolerated. Gastrointestinal distress such as nausea or vomiting have been associated with the administration of nicotinamide or zinc at doses greater than the recommended dose of nicotinamide

Nicotinamide: Dizziness, headache, hyperglycemia, nausea, vomiting, diarrhea, elevations in liver function tests, hepatotoxicity, blurred vision, flushing, rash.

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What are the possible side effects of Vitamin B6 (Floradix)?

Applies to pyridoxine: capsule, injectable, solution, tablet, tablet enteric coated, tablet extended release

As well as its needed effects, pyridoxine (the active ingredient contained in Vitamin B6 (Floradix)) may cause unwanted side effects that require medical attention.

Severity: Moderate

If any of the following side effects occur while taking pyridoxine, check with your doctor or nurse as soon as possible:

With large doses

• Clumsiness
• numbness of hands or feet

none known