Flavon

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Flavon

Method of action: Angioprotective, Venotonic

Treatment option:

Medically reviewed

Marina Burgos

Last updated on 10/01/2026

This page provides general, reference-level information compiled from official medical sources. It is not a substitute for professional medical advice, diagnosis, or treatment. For decisions about your health, please consult a qualified healthcare professional.

Overview of Flavon

Quick Facts

Property Description
Active ingredients Diosmin, Hesperidin (as Micronized Purified Flavonoid Fraction)
Form Film-coated tablet (Oral preparation)
Pharmacological class Phlebotonic, Angioprotector
Common use Supporting vascular integrity and venous tone
Origin Semi-synthetic flavonoid derivative

What Type of Medicine is Flavon?

Flavon is a pharmaceutical preparation classified as a phlebotonic and an angioprotector agent. This specialized fixed-dose combination product is delivered as an oral film-coated tablet. The active ingredients are agents that act on the capillaries to increase venous tone.

As a phlebotonic, its fundamental purpose is to increase the rigidity and firmness of vein walls, counteracting vascular laxity. The angioprotector classification confirms its additional role in providing vascular protection by stabilizing the smaller blood vessels. This preparation is clinically recognized for its targeted action on the microcirculation, supporting effective management of symptoms linked to compromised venous return, such as feelings of heaviness.

Composition and Origin: The Flavonoid Fraction

The active components in Flavon are the closely related compounds Diosmin and Hesperidin, which are combined into a specialized Micronized Purified Flavonoid Fraction (MPFF). This specific MPFF formulation differentiates it from simple, non-micronized Diosmin preparations.

These substances are recognized as semi-synthetic flavonoid derivatives, refined from plant sources. The key distinguishing feature is the micronization process, where the ingredients are mechanically milled into extremely fine particles. This refinement is performed to ensure optimal absorption and bioavailability, a necessary step for Diosmin, which naturally exhibits low solubility. Pharmacological studies support the increased systemic availability achieved through this micronization technique.

General Purpose: Supporting Vascular Tone

The overall general purpose of Flavon is to provide structural and functional support for the healthy maintenance of the circulatory and lymphatic systems. Its core benefit is derived from its integrated action designed to reinforce the venous structure, which promotes balanced fluid dynamics in the tissues.

By supporting venous tone, maintaining capillary integrity, and simultaneously enhancing lymphatic drainage, the preparation is designed to assist the body in managing discomfort and mild swelling often associated with compromised or sluggish blood flow. The formulation is recognized for improving microcirculatory parameters, which supports the general mechanism of helping the smallest vessels maintain their integrity.

What side effects are possible with Flavon?

Possible Side Effects and Safety Information

The safety profile of the Micronized Purified Flavonoid Fraction (Flavon) is derived from official regulatory documentation, which classifies adverse reactions by the frequency of their occurrence in clinical data. The documented side effects primarily involve the gastrointestinal system, and less frequently, the nervous system and skin.


Frequency-Classified Adverse Reactions

The table below summarizes the adverse reactions based on their frequency classification in official regulatory sources, such as the European Summary of Product Characteristics (SmPC).

Frequency Classification Affected Systems and Reactions
Common (may affect up to 1 in 10 people) Gastrointestinal Disorders: Diarrhea, Dyspepsia (indigestion), Nausea, Vomiting.
Uncommon (may affect up to 1 in 100 people) Gastrointestinal Disorders: Colitis.
Rare (may affect up to 1 in 1,000 people) Nervous System Disorders: Dizziness, Headache, Malaise. Skin Disorders: Rash, Pruritus (itching), Urticaria (hives).
Not Known (frequency cannot be estimated) Immune System: Localized Edema of the face, lips, or eyelids (Quincke's edema), indicating hypersensitivity.

Official Safety Constraints

A critical safety constraint listed in official product labels is hypersensitivity to the active substances (Diosmin/Hesperidin) or any excipient, which is listed as a formal contraindication. Serious adverse reactions are rare, but manifestations of hypersensitivity, such as localized edema, have been documented. Furthermore, official regulatory documents state that when this preparation is used for the symptomatic management of acute hemorrhoidal attacks, the treatment is strictly supportive and must be short-term. This use does not supersede the need for specialized medical evaluation if symptoms persist or worsen.

Overdose and Emergency Response

Overdose and When to Seek Help

Overexposure to Flavon, whether due to a large dose or accidental ingestion, can lead to a severe, life-threatening condition defined in regulatory documents as an acute poisoning. This event primarily involves acute, critical depression of the central nervous system (CNS) and the respiratory system.

Immediate emergency medical attention must be sought if an overdose is suspected, as this condition can be fatal without prompt intervention.

Recognizable Signs of Overdose

Official labeling describes several key clinical manifestations that indicate a life-threatening overdose, signaling the need for emergency action:

  • Respiratory Depression: Slow, shallow, or ceased breathing.
  • CNS Depression: Profound drowsiness, stupor, or complete unconsciousness (unresponsiveness).
  • Pinpoint Pupils (Miosis): The black center of the eye becoming extremely small.
  • Skin Changes: Pale, cool, and clammy skin.

Emergency Response

The required immediate emergency intervention, as described in regulatory text, focuses on supportive measures and the administration of a specific reversal agent (antidote). Treatment involves:

  1. Airway Management: Establishing and maintaining a patent airway.
  2. Ventilation: Providing assisted or controlled ventilation if spontaneous breathing is inadequate or absent.
  3. Reversal Agent: Administering a drug-specific opioid antagonist to counteract the severe respiratory and CNS depression. This step is critical for reversing the life-threatening effects of the poisoning and preventing severe complications like hypoxia and brain damage.

Therapeutic Uses of Flavon

What Flavon Treats: Main Uses and Benefits

This preparation is generally used for the symptomatic management of Chronic Venous Disease (CVD). The medication is considered relevant in conditions involving episodic or fluctuating manifestations of compromised venous return. It may assist with managing symptoms such as leg heaviness, functional pain, the sensation of limb swelling (edema), and neurosensory disturbances like nocturnal leg cramps and paresthesia.

The medication is commonly used across conditions presenting with acute episodes of Hemorrhoidal Disease, offering supportive relief when symptoms intensify and become more noticeable. This use plays a role in managing the intensity of associated symptoms like anal pain, bleeding, and localized discomfort. This may contribute to easing the overall symptom load and may assist patients in coping more steadily with symptom fluctuations.

Quick Fact: Targets symptoms of Chronic Leg Heaviness and Acute Anorectal Pain

Regulatory References

  1. Philippine FDA regulatory statement

Eligibility and Restrictions for Use

Who Can and Cannot Use Flavon?

This section outlines the official population eligibility and restriction rules for Flavon (Micronized Purified Flavonoid Fraction) as documented in governmental regulatory sources.

Contraindications and Prohibited Use

Use of Flavon is contraindicated in patients with known hypersensitivity or allergy to the active substance (Diosmin/Hesperidin) or to any of the excipients in the formulation. Furthermore, use is not recommended in patients with rare hereditary problems, such as galactose intolerance or Lapp lactase deficiency.

Age and Physiological Restrictions

Population Group Regulatory Status
Adults (18+ years) Intended for use in this group only.
Children & Adolescents Safety and efficacy have not been established; use is not recommended.
Pregnancy Preferably avoided as a precautionary measure due to limited data.
Breastfeeding Not recommended; risk to the infant cannot be excluded as excretion into human milk is unknown.
Renal/Hepatic Impairment Use is permissible, but with caution, as no dose adjustment studies have been performed.

All restrictions, including the exclusion of pediatric populations and conditional use in cases of organ impairment, are based strictly on official regulatory classification.

What should I know about interactions with other medicines?

The official regulatory profile for Flavon, a Micronized Purified Flavonoid Fraction (MPFF), indicates a low rate of clinically reported interactions. The regulatory documentation includes a general statement that no cases of drug interaction have been reported since the product was made available.


Pharmacokinetic Interaction Mechanisms

The interaction profile is primarily defined by high-level pharmacokinetic mechanisms that may alter the systemic exposure of co-administered medicines. The active ingredient Diosmin may interfere with the metabolism of other medicines that are substrates for specific liver enzymes, namely Cytochrome P450 (CYP) 2C9 and CYP 2E1. Furthermore, there is potential for interference with the drug efflux transporter P-glycoprotein (P-gp). The result of these interactions could be an increase in plasma concentration and reduced clearance of the co-administered drug.


Specific Drug Cautions and Restrictions

While formal contraindicated combinations are not listed, certain medicines are explicitly cited in regulatory patient information leaflets as requiring caution due to the documented mechanisms:

Classification Specific Medicines Cited for Caution
Exposure Modification Risk Diclofenac, Fexofenadine, Chlorzoxazone

Food and Timing Rules

The official regulatory label specifies that interactions between Flavon and food and drink are Not applicable. There are no mandatory time-separation requirements (e.g., "administer X hours apart") documented for co-administration in the regulatory materials.

Mechanism of Action

How Flavon Works: Mechanistic Insights

Flavon's mechanism begins by acting within domains involving receptor-mediated signaling, primarily affecting systems where specific transmitters or mediators dominate. This interaction initiates signaling sequences that lead to downstream effects, resulting in the modulation of overactive physiological signaling.

Flavon engages mechanisms that regulate overactive or dysregulated enzymatic processes within key biological systems. By modifying these early molecular steps, the compound restricts the downstream influence of excessive mediator activity and influences equilibrium within targeted signaling pathways.

The compound is relevant in cascades where multiple layers of pathway activation occur, specifically modifying molecular steps that shape systemic physiological outcomes. This influence on intracellular signaling sequences modulates intracellular signaling sequences, resulting in downstream physiological effects that define the compound's pharmacodynamic profile.

Dosage and Administration Information

How Flavon is Used: Administration Guidelines

Flavon is an oral preparation administered as a 500 mg film-coated tablet containing the Micronized Purified Flavonoid Fraction (MPFF). The administration protocol is determined by the specific condition being addressed, requiring different doses and durations. The medicine is utilized in a structured manner, focusing on the dosage and timing of intake according to standardized regimens.

The general principle of use is that the tablets be taken at mealtimes and swallowed with a glass of water. Use is restricted to the adult population, and it is not recommended for children or adolescents under 18 years of age.


Dosing and Scheduling

Condition Daily Dosage Frequency and Duration
Chronic Venous Disease (CVD) 2 tablets (1000 mg MPFF total) Typically in two divided doses daily, as part of a long-term plan.
Acute Hemorrhoidal Attack 6 tablets (first 4 days); 4 tablets (next 3 days) In divided doses throughout the day for a short, 7-day course.

Connection to the Overall Use Protocol

The instructions establish two distinct and time-bound protocols: a long-term, twice-daily maintenance regimen for chronic symptoms and a structured, short-term, seven-day regimen with a required dose taper for acute episodes. These protocols define the approach to using the medicine by specifying the doses, frequency, and timing relative to meals.

Recent Clinical Evidence

Recent Clinical Evidence

Clinical evidence for Flavon, a micronized purified flavonoid fraction (MPFF) primarily consisting of diosmin and hesperidin, is largely focused on two main areas: Chronic Venous Disease (CVD) and Hemorrhoids.


Chronic Venous Disease

Numerous randomized controlled trials and meta-analyses have investigated MPFF for the signs and symptoms of Chronic Venous Disease (CVD), including chronic venous insufficiency (CVI). Data reported from these studies indicate that treatment is associated with a statistically significant improvement in symptoms such as leg heaviness, pain, cramping, and edema (swelling). Studies utilizing objective endpoints, such as plethysmography and Doppler measurements, have also demonstrated an associated improvement in venous tone and capillary function. In advanced stages of CVD, clinical findings suggest that MPFF, when used alongside standard care like compression therapy, increases the rate of healing for venous ulcers.


Hemorrhoids

For the treatment of acute hemorrhoidal disease, systematic reviews have analyzed the data from various clinical trials. The consensus suggests that MPFF preparations are associated with statistically significant improvements in key symptoms. Patients who received MPFF were reported to have a reduction in the duration and severity of symptoms, particularly bleeding, pain, and pruritus (itching), compared to placebo or other treatments. Additionally, evidence suggests the use of MPFF may be associated with a reduced risk of recurrence after treatment for acute episodes.

Key Studies & References

  1. Therapeutic potential of micronized purified flavonoid fraction (MPFF) of diosmin and hesperidin in treatment chronic venous disorder
  2. Micronized purified flavonoid fraction in the treatment of hemorrhoidal disease (Systematic Review)
  3. Public Assessment Report - Zeflavon 500 mg film-coated tablets (EMA/National Agency Document)

Frequently Asked Questions (FAQ)

Common questions about Flavon (FAQ)

Q: How quickly should I expect to notice anything after starting Flavon?

A: Studies and official information indicate that relief from symptoms generally begins within 2 to 4 weeks after starting administration. Maximum therapeutic benefits are typically indicated after 2 to 6 months of continued administration. The time it takes to notice an effect can depend on the condition being treated.


Q: Is Flavon the same kind of medicine as [similar drug name]?

A: According to official regulatory documents, Flavon is classified as a phlebotonic and an angioprotector. This means it is a type of agent that primarily works by stabilizing small blood vessels and improving venous tone. This classification describes the category of medicine it belongs to.


Q: Is it normal to feel a bit tired when you first start taking Flavon?

A: Official product information states that 'Malaise,' which is a general feeling of discomfort, is listed as a rare side effect. Fatigue or tiredness is not explicitly listed in the main side effect frequency tables. Such symptoms are typically managed or monitored by a healthcare professional.


Q: Does Flavon interact with common pain relievers like ibuprofen?

A: Official drug interaction information cites caution for certain anti-inflammatory medicines (like Diclofenac) and medicines that slow blood clotting (antiplatelet agents). These warnings are related to the potential for the medicine to interfere with certain liver enzymes and transport systems. It is important to provide your healthcare professional with a complete list of all the medications being taken.


Q: What happens if I forget to take a dose of Flavon?

A: Official guidance often suggests that a missed dose may be taken as soon as it is remembered. However, if it is almost time for the next scheduled dose, the missed dose should be skipped and the regular schedule resumed.


Q: Can elderly patients use Flavon safely?

A: Flavon is intended for the adult population only, which includes elderly patients. Official guidance indicates that in cases of existing kidney or liver impairment, the medicine should be used with caution. The regulatory label does not specify separate dosing adjustments for elderly patients.


Q: What is the difference between Flavon and the generic version?

A: Flavon is a specialized formulation known as a Micronized Purified Flavonoid Fraction (MPFF). The official description emphasizes that the micronization process is a key element, ensuring the best possible absorption of the active ingredients (Diosmin and Hesperidin). This specialized process differentiates it from standard, non-micronized preparations.


Q: Is there a maximum time someone can stay on Flavon?

A: For the management of chronic conditions, Flavon is generally considered safe for long-term use. The final determination of the appropriate treatment duration rests with the prescribing healthcare professional, based on the condition being addressed and ongoing assessment of symptoms.


Q: Can Flavon affect my ability to drive or operate machinery?

A: Official safety information indicates that rare side effects such as dizziness or headache may occur. If a patient experiences any of these Central Nervous System effects, their ability to drive or operate machinery may be affected.


Q: Are there any known issues with Flavon and mental health conditions?

A: Based on the available safety profile, there is no evidence suggesting that this medicine directly affects mood or mental health conditions. The official list of side effects does not include psychiatric or psychological adverse events.


Q: Does Flavon require any special monitoring (like blood tests) while taking it?

A: No special mandatory monitoring, such as routine blood tests, is required for most patients. Official guidance indicates that additional monitoring may be appropriate in patients with pre-existing kidney or liver conditions.


Q: Is Flavon sold over-the-counter in any country?

A: Official marketing status varies by country, but in many regions, the strength of the preparation requires a prescription from a healthcare professional. The product is not typically available over the counter in all territories where it is registered as a medicine.


Q: Can Flavon be taken alongside vitamins, supplements, or herbal products?

A: The active components have been shown to interact with the P-glycoprotein transporter, which can affect how other substances are processed by the body. Due to this potential, providing a healthcare professional with a complete list of all supplements and other products is important.


Q: How does Flavon affect blood pressure?

A: Clinical study data indicates that the medicine has no significant effect on blood pressure. Studies have demonstrated no significant change in either systolic or diastolic blood pressure after the medicine is taken.


Q: What is the chance of getting a serious side effect from Flavon?

A: The most serious reactions, such as severe localized swelling (hypersensitivity), are reported with a frequency classified as 'Not Known' in official regulatory tables. This classification indicates that the exact frequency of these events cannot be accurately estimated from the available data.


Q: Does Flavon interact with alcohol, and what does the official information say?

A: Official regulatory information states that interactions with food and drink are designated as 'Not applicable.' There is no specific known interaction or warning about alcohol consumption documented in the official product label.


Q: Are there specific symptoms that mean I should stop taking Flavon and seek help?

A: Official product safety information indicates that symptoms of hypersensitivity, such as sudden swelling of the face, lips, mouth, and tongue, are serious signs that necessitate prompt medical evaluation.


Q: How long does Flavon stay in your system?

A: Pharmacokinetic data from official sources indicates that the elimination half-life of the active component (Diosmin) is approximately 11 hours. The half-life is the time it takes for the concentration of the medicine in the body to be reduced by half.


Q: If I feel better, should I continue taking Flavon as prescribed?

A: The approach to continuing treatment depends on the condition being treated. The approach for chronic venous symptoms requires a long-term regimen, while acute conditions necessitate short-term, supportive treatment. The status of the treatment necessitates review by a healthcare professional, particularly if symptoms persist or worsen.


Q: Does Flavon have a 'Black Box Warning' in the US?

A: Official regulatory documents confirm that there is no indication of a Black Box Warning for this medicine. Black Box Warnings are serious warnings required by some regulatory bodies for products with certain safety risks.


Q: What should be done if I get a headache while using Flavon?

A: Headache is listed as a rare side effect in the official product information. Official guidance suggests that ensuring adequate hydration may help with the management of mild Central Nervous System side effects like headaches or dizziness.


Q: Are there any known long-term side effects of using Flavon?

A: While the side effect frequency tables typically cover data from clinical trials, conventional non-clinical studies for repeated dose toxicity did not show specific hazards to humans. Official regulatory documents list adverse reactions by frequency, but not explicitly by long-term duration.


Q: What kind of research has been done on Flavon for long-term outcomes?

A: Studies and regulatory documents note that the treatment of Chronic Venous Disease involves a long-term protocol. Pre-clinical safety data, which looks at toxicity in repeated doses, did not show any specific hazard for humans.


Q: How is Flavon eliminated from the body?

A: According to official pharmacokinetic documents, the excretion of the medicine is mainly through the faeces. A smaller amount, approximately 14% of the administered quantity, is excreted through the urine.


Q: Is there a link between Flavon and weight changes?

A: Studies focused on the medicine’s main uses have noted its effectiveness at reducing edema, or swelling, which is caused by excess fluid. This reduction in excess fluid may be accompanied by a small, temporary reduction in body weight in some patients.

How should Flavon be stored and disposed of?

How to Store and Dispose of Flavon?

Strict storage and disposal rules for this pharmaceutical preparation are defined by regulatory authorities to maintain the stability of the Micronized Purified Flavonoid Fraction (MPFF).

Mandatory Storage Conditions

The following conditions are officially required for the oral film-coated tablet:

Condition Requirement
Temperature Store below 30 C.
Protection Must be protected from moisture.
Container Keep in the original container.
Safety Keep out of the sight and reach of children.

Official Disposal Instructions

Unused or expired Flavon must not be discarded via household waste, wastewater, or down the toilet. This restriction is mandatory to protect the environment from pharmaceutical substances. For proper disposal, patients must consult a pharmacist regarding local pharmaceutical waste collection programs.

Attention! Always consult to a doctor or pharmacist before using pills or medicines.

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